1. Articles from Marina A. Sirotkina

    1-5 of 5
    1. Histological validation of in vivo assessment of cancer tissue inhomogeneity and automated morphological segmentation enabled by Optical Coherence Elastography

      Histological validation of in vivo assessment of cancer tissue inhomogeneity and automated morphological segmentation enabled by Optical Coherence Elastography

      We present a non-invasive (albeit contact) method based on Optical Coherence Elastography (OCE) enabling the in vivo segmentation of morphological tissue constituents, in particular, monitoring of morphological alterations during both tumor development and its response to therapies. The method uses compressional OCE to reconstruct tissue stiffness map as the first step. Then the OCE-image is divided into regions, for which the Young’s modulus (stiffness) falls in specific ranges corresponding to the morphological constituents to be discriminated. These stiffness ranges (characteristic "stiffness spectra") are initially determined by careful comparison of the "gold-standard" histological data and the OCE-based stiffness map for ...

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    2. Low-scattering volumes visualisation from optical coherence tomography data and its applications in otolaryngology

      Low-scattering volumes visualisation from optical coherence tomography data and its applications in otolaryngology

      The method for visualization of the low-scattering objects inside the bulk of the high-scattering tissue is presented. The method can contrast the low-scattering object of interest not only from the high scattering surroundings but from the noise region below the tissue image as well. The proposed method was applied for the visualization of the rodent and human cochlea volume.

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    3. Optical coherence angiography without motion correction preprocessing

      Optical coherence angiography without motion correction preprocessing

      The method for vessel visualization from optical coherence tomography (OCT) data is presented. The method is based on high-frequency filtration of the normalized absolute values of the scattered field measured with OCT. It is shown that in contrast with optical coherence angiography based on the processing of complex values of a scattered field, the proposed processing does not require motion correction preprocessing while providing resulting angiographic images of comparable quality.

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    4. Multimodal optical coherence tomography for in vivo imaging of brain tissue structure and microvascular network at glioblastoma

      Multimodal optical coherence tomography for in vivo imaging of brain tissue structure and microvascular network at glioblastoma

      In the case of infiltrative brain tumors the surgeon faces difficulties in determining their boundaries to achieve total resection. The aim of the investigation was to evaluate the performance of multimodal OCT (MM OCT) for differential diagnostics of normal brain tissue and glioma using an experimental model of glioblastoma. The spectral domain OCT device that was used for the study provides simultaneously two modes: cross-polarization and microangiographic OCT. The comparative analysis of the both OCT modalities images from tumorous and normal brain tissue areas concurrently with histologic correlation shows certain difference between when accordingly to morphological and microvascular tissue features.

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    5. Vessel-contrast enhancement in label-free optical coherence angiography based on phase and amplitude speckle variability

      Vessel-contrast enhancement in label-free optical coherence angiography based on phase and amplitude speckle variability

      Recently proposed in vivo label-free optical coherence angiography techniques based on phase and amplitude speckle variability often require additional signal pre- and post processing operations to enhance vessel-contrast. We observe here 1) contrast enhancement by optimizing the signal normalization/weighing before processing; 2) algorithm based on Kasai estimator for phase compensation between processed A-scans to reduce masking role of motion artifacts; and 3) image projection through the imaging depth for en face plotting. We demonstrate the efficiency of proposed additional algorithms as for the microcirculation imaging of hamsters cheek in vivo as for the preliminary microcirculation imaging of patients after ...

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    1-5 of 5
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  2. Topics in the News

    1. (5 articles) Institute of Applied Physics
    2. (4 articles) Natalia D. Gladkova
    3. (3 articles) Nizhny Novgorod State Medical Academy
    4. (3 articles) Grigory V. Gelikonov
    5. (3 articles) Elena B. Kiseleva
    6. (2 articles) Valentin M. Gelikonov
    7. (2 articles) Maria M. Karabut
    8. (1 articles) University of Toronto
    9. (1 articles) Dmitry A. Terpelov
    10. (1 articles) I. Alex Vitkin
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    Vessel-contrast enhancement in label-free optical coherence angiography based on phase and amplitude speckle variability Multimodal optical coherence tomography for in vivo imaging of brain tissue structure and microvascular network at glioblastoma Optical coherence angiography without motion correction preprocessing Low-scattering volumes visualisation from optical coherence tomography data and its applications in otolaryngology Histological validation of in vivo assessment of cancer tissue inhomogeneity and automated morphological segmentation enabled by Optical Coherence Elastography Plaque mOrphology iMpact on Side Branch Occlusion at oPtical Coherence Tomography Evaluation in Percutaneous Coronary Interventions Full-range space-division multiplexing optical coherence tomography angiography Measuring 3D Optic Nerve Head Deformations using Digital Volume Correlation of in vivo Optical Coherence Tomography Data (Thesis) Optical coherence tomography for characterization of nanocomposite materials (Thesis) In Vivo Corneal Microstructural Changes in Herpetic Stromal Keratitis: A Spectral-Domain Optical Coherence Tomography Analysis Non-invasive optical screening of Streptococcus Pneumonia based inflammatory changes of the tympanic membrane and mastoid mucosa in guinea pig otitis media using optical coherence tomography Visual function tests including the role of optical coherence tomography in neurofibromatosis