1. Articles from Nikolaus Feucht

    1-6 of 6
    1. Optical coherence tomography angiography indicates subclinical retinal disease in neuromyelitis optica spectrum disorders

      Optical coherence tomography angiography indicates subclinical retinal disease in neuromyelitis optica spectrum disorders

      Background: Neuromyelitis optica spectrum disorders (NMOSD) are neuroinflammatory diseases of the central nervous system. Patients suffer from recurring relapses and it is unclear whether relapse-independent disease activity occurs and whether this is of clinical relevance. Objective: To detect disease-specific alterations of the retinal vasculature that reflect disease activity during NMOSD. Methods: Cross-sectional analysis of 16 patients with NMOSD, 21 patients with relapsing-remitting multiple sclerosis, and 21 healthy controls using retinal optical coherence tomography (OCT), optical coherence tomography angiography (OCT-A), measurement of glial fibrillary acidic protein (GFAP) serum levels, and assessment of visual acuity. Results: Patients with NMOSD but not multiple ...

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    2. Functional recovery after macula involving retinal detachment and its correlation with preoperative biomarkers in optical coherence tomography

      Functional recovery after macula involving retinal detachment and its correlation with preoperative biomarkers in optical coherence tomography

      To introduce an ETDRS grid-based classification for macula involving retinal detachment (MIRD) with or without center (foveal) involvement and to identify biomarkers in preoperative optical coherence tomography (OCT) associated with a favorable postoperative functional outcome in eyes with center involving retinal detachment (CIRD). One hundred and two eyes of 102 consecutive patients (f/m: 35/67) with primary rhegmatogenous retinal detachment, preoperative evidence of MIRD (perifoveal involvement of ≤ 6.0 mm), and successful retinal surgery were included in this retrospective cohort study. Eyes were assigned to 5 grades of MIRD (G1-G5), based on the extent of detachment in the ETDRS ...

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    3. Choriocapillaris Flow Density Negatively Correlates With Advancing Age on Spectral-Domain Optical Coherence Tomography Angiography

      Choriocapillaris Flow Density Negatively Correlates With Advancing Age on Spectral-Domain Optical Coherence Tomography Angiography

      BACKGROUND AND OBJECTIVE: To correlate subfoveal choriocapillaris (CC) flow density with age using spectral-domain optical coherence tomography angiography (SD-OCTA). PATIENTS AND METHODS: One hundred eighty-three eyes of 94 subjects (66 female, 28 male) were enrolled. Included were healthy subjects between the ages of 21 and 82 years without any history of vitreoretinal disease. Measurements were obtained with software from the OCT device. Significance was defined as a P value of less than .05. RESULTS: The mean age was 43.43 years ± 17.63 years. Correlation between decreasing CC flow density and increasing age was significant ( P < .001), with a mean ...

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    4. Choriocapillary Blood Flow in Myopic Subjects Measured With OCT Angiography

      Choriocapillary Blood Flow in Myopic Subjects Measured With OCT Angiography

      BACKGROUND AND OBJECTIVE: To investigate choriocapillary blood flow in myopic eyes using optical coherence tomography angiography. PATIENTS AND METHODS: Seventy-eight myopic and 79 age-matched healthy eyes were included in this study, with myopia defined as a spherical equivalent refraction (SER) between −1 diopters (D) and −6 D. Quantitative measurements of the choriocapillaris were obtained using the Avanti RTVue XR with AngioVue. Choroidal thickness (CT) was assessed using the single-line enhanced high-definition scan of the same device. RESULTS: CT correlated positively with SER ( P = .017) and negatively with bulbus axial length (AL) ( P = .180). Subfoveal choriocapillary blood flow did not show ...

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    5. Optical coherence tomography angiography indicates associations of the retinal vascular network and disease activity in multiple sclerosis

      Optical coherence tomography angiography indicates associations of the retinal vascular network and disease activity in multiple sclerosis

      Background: Patients with multiple sclerosis (MS) and clinically isolated syndrome (CIS) may show alterations of retinal layer architecture as measured by optical coherence tomography. Little is known about changes in the retinal vascular network during MS. Objective: To characterize retinal vessel structures in patients with MS and CIS and to test for associations with MS disease activity. Method: In all, 42 patients with MS or CIS and 50 healthy controls underwent retinal optical coherence tomography angiography (OCT-A) with analysis of the superficial and deep vascular plexuses and the choriocapillaries. We tested OCT-A parameters for associations with retinal layer volumes, history ...

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    6. OCT Angiography Findings in Acute Central Serous Chorioretinopathy

      OCT Angiography Findings in Acute Central Serous Chorioretinopathy

      BACKGROUND AND OBJECTIVE: To describe optical coherence tomography angiography (OCTA) findings in patients with acute central serous chorioretinopathy (CSC) compared to conventional imaging methods. PATIENTS AND METHODS: A consecutive series of 11 eyes from 10 healthy patients with acute CSC were included and underwent fluorescein angiography (FA), indocyanine green angiography (ICGA), OCT, fundus autofluorescence (FAF), and OCTA. Obtained OCTA images were evaluated for the presence of serous detachments of the neurosensory retina, leakage points, or other altered findings and compared to conventional imaging devices. RESULTS: In four out of 11 eyes, it was possible to detect detached retina adjacent to ...

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    1-6 of 6
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    OCT Angiography Findings in Acute Central Serous Chorioretinopathy Optical coherence tomography angiography indicates associations of the retinal vascular network and disease activity in multiple sclerosis Choriocapillary Blood Flow in Myopic Subjects Measured With OCT Angiography Choriocapillaris Flow Density Negatively Correlates With Advancing Age on Spectral-Domain Optical Coherence Tomography Angiography Functional recovery after macula involving retinal detachment and its correlation with preoperative biomarkers in optical coherence tomography Optical coherence tomography angiography indicates subclinical retinal disease in neuromyelitis optica spectrum disorders Structural abnormalities associated with glaucoma using swept-source optical coherence tomography in patients with systemic sclerosis Clinical presentation does not affect acute mechanical performance of the Novolimus-eluting bioresorbable vascular scaffold as assessed by optical coherence tomography Evaluating optical coherence tomography (OCT) findings as potential biomarkers in central nervous system (CNS) lymphoma with or without ocular involvement Polarization sensitive optical coherence tomography with single input for imaging depth-resolved collagen organizations Etanercept Therapy for Nails Psoriasis Monitoring With Noninvasive Imaging The Use of Optical Coherence Tomography to Asscess Water Transport Through The Urothelium of The Porcine Bladder