1. Articles from Shuguang Guo

    1-22 of 22
    1. Ophthalmic optical coherence tomography system and method for quick switching to realize anterior and posterior eye segments imaging

      Ophthalmic optical coherence tomography system and method for quick switching to realize anterior and posterior eye segments imaging

      An ophthalmic optical coherence tomography system and a method for quick switching to realize anterior and posterior eye segments imaging are provided, the system includes: an OCT interferometer primary module and a sample arm module, the OCT interferometer primary module includes an OCT light source, a fiber coupler, a reference arm, a detection module, an X-direction scanning unit, and a Y-direction scanning unit; the sample arm module includes an anterior eye segment imaging module and a posterior eye segment imaging module; the Y-direction scanning unit is rotatable; when the Y-direction scanning unit is at a first rotation angle, the Y-direction ...

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    2. Ophthalmic Optical Coherence Tomography System And PROTOMERITE/DEUTOMERITE Imaging Method By Quick Switching

      Ophthalmic Optical Coherence Tomography System And PROTOMERITE/DEUTOMERITE Imaging Method By Quick Switching

      An ophthalmic optical coherence tomography (OCT) system and protomerite/deutomerite imaging method by using the system for quick switching, the system comprising an OCT interferometer primary module, and a sample arm module; the OCT interferometer primary module comprises an OCT light source (101), an optical fiber coupler (102), a reference arm (104), a detection module (106), an X direction scanning unit (109), and a Y direction scanning unit (110). The sample arm module comprises an eye protomerite imaging module and an eye deutomerite imaging module; the Y direction scanning unit (110) is rotatable; when the Y direction scanning unit (110 ...

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      Mentions: Shuguang Guo Lei Wu
    3. Ophthalmic Optical Coherence Tomography (OCT) System And Ophthalmic OCT Imaging Method

      Ophthalmic Optical Coherence Tomography (OCT) System And Ophthalmic OCT Imaging Method

      An ophthalmic optical coherence tomography (OCT) system includes an OCT imaging system for a posterior segment of an eye and an OCT imaging system for an anterior segment of an eye. The OCT imaging system for the posterior segment of the eye includes a light path conversion device, and the OCT imaging system for the anterior segment of the eye includes a probe imaging device for the anterior segment of the eye. The probe imaging device for the anterior segment of the eye includes an ophthalmoscope, a first dichroscope and a first lens. When the ophthalmic OCT system is scanning ...

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      Mentions: Shuguang Guo Lei Wu
    4. 3D In Vivo optical coherence tomography based on a low-voltage, large-scan-range 2D MEMS mirror

      3D In Vivo optical coherence tomography based on a low-voltage, large-scan-range 2D MEMS mirror
      3D in vivo optical imaging on a mouse has been obtained using a 2D MEMS mirror for lateral scanning in a time-domain optical coherence tomography (OCT) system. The MEMS mirror aperture size is 1 × 1 mm2, and the device footprint is 2 × 2 mm2. The MEMS mirror scans ± 30° optical angles about both x and y-axis at only 5.5V DC voltage. An endoscopic probe with an outer diameter of 5.8 mm has been designed, manufactured and packaged. The probe scans an average transverse area of 2 mm × 2 mm. The imaging speed of the probe is about 2 ...
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    5. The potential of optical coherence tomography for diagnosing meniscal pathology

      The potential of optical coherence tomography for diagnosing meniscal pathology
      Meniscal tears are often associated with anterior cruciate ligament (ACL) injury and may lead to pain and discomfort in humans. Maximal preservation of meniscal tissue is highly desirable to mitigate the progression of osteoarthritis. Guidelines of which meniscal tears are amenable to repair and what part of damaged tissues should be removed are elusive and lacking consensus. Images of microstructural changes in meniscus would potentially guide the surgeons to manage the meniscal tears better, but the resolution of current diagnostic techniques is limited for this application. In this study, we demonstrated the feasibility of using optical coherence tomography (OCT) for ...
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    6. In vivo 3D and Doppler OCT imaging using electrothermal MEMS scanning mirrors

      In vivo 3D and Doppler OCT imaging using electrothermal MEMS scanning mirrors
      Most cancers occur inside human body, so endoscopic high-resolution imaging modalities are required for early cancer detection and surgical removal. This paper reports in vivo endoscopic 3D imaging based on optical coherence tomography (OCT). Endoscopic imaging is enabled by integrating rapid-scanning MEMS mirror into a miniature imaging probe. The MEMS mirror has an aperture size of 1 mm by 1 mm and a chip size of 2 mm by 2 mm. The optical scan angle exceeds ±25 V at 6 Vdc, and thus large, constant-velocity, linear scan can be realized. The outer diameter of the probe is only 5 mm ...
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    7. 3D endoscopic optical coherence tomography based on rapid-scanning MEMS mirrors

      The paper reports 3D in vivo endoscopic imaging enabled by integrating rapid-scanning MEMS mirrors into an optical coherence tomography (OCT) imaging probe. OCT provides high-resolution cross-sectional information suitable for in vivo noninvasive early cancer diagnosis. However, conventional OCT systems are bulky and slow, and thus are difficult to apply to internal organs where most cancers are originated. Microelectromechanical systems (MEMS) technology offers the advantages of small size and fast speed and can be used to miniaturize optical imaging probes. The MEMS mirrors have large aperture size (1 mm × 1 mm), large scan range (> ±25°) and low drive voltage (< 10 V ...
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    8. Feature Of The Week 11/15/09: A Comparison between Optical Coherence Tomography and Histology of Laryngeal Epithelial Thickness

      Feature Of The Week 11/15/09: A Comparison between Optical Coherence Tomography and Histology of Laryngeal Epithelial Thickness
      Feature Of The Week 11/15/09: While applications of optical coherence tomography in ophthalmology and cardiology have very successfully transitioned from the research world to the commercial world many other fields have lagged behind. One such area is the field of Otolaryngology. While much of the technology developed in both the academic and commercial worlds is directly applicable to applications in otolaryngology there remain some unique features such as probe design and a need for additional clinical data to determine where OCT will be most beneficial. Numerous researchers around the world are working in this field. Researchers from the ...
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    9. Detection and monitoring of early airway injury effects of half-mustard (2-chloroethylethylsulfide) exposure using high-resolution optical coherence tomography

      Optical coherence tomography (OCT) is a noninvasive, high-resolution imaging technology capable of delivering real-time, near-histologic images of tissues. Mustard gas is a vesicant-blistering agent that can cause severe and lethal damage to airway and lungs. The ability to detect and assess airway injury in the clinical setting of mustard exposure is currently limited. The purpose of this study is to assess the ability to detect and monitor progression of half-mustard [2-chloroethylethylsulfide (CEES)] airway injuries with OCT techniques. A ventilated rabbit mustard exposure airway injury model is developed. A flexible fiber optic OCT probe is introduced into the distal trachea to ...
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    10. In vivo diagnosis of oral dysplasia and malignancy using optical coherence tomography: Preliminary studies in 50 patients

      In vivo, non-invasive optical coherence tomography (OCT) permits high-resolution imaging of tissue surfaces and subsurfaces, with the potential capability for detection and mapping of epithelial pathologies.To evaluate the clinical capability of non-invasive in vivo OCT for diagnosing oral dysplasia and malignancy.In 50 patients with oral lesions, conventional clinical examination was followed by OCT imaging, then standard biopsy and histopathology. Two blinded, pre-standardized investigators separately diagnosed each lesion based on (1) OCT and (2) histopathology.Intra- and inter-observer agreement between diagnoses based on histopathology and imaging data was excellent, with [kappa] values between 0.844 and 0.896. Sensitivity ...
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    11. In-vivo office-based dynamic imaging of vocal cords in awake patients with swept-source optical coherence tomography

      Optical coherence tomography (OCT) is an evolving noninvasive imaging modality and has been used to image the human larynx during surgical endoscopy. The design of a long GRIN lens based probe capable of capturing images of the human larynx by use of swept-source OCT during a typical office-based laryngoscopy examination is presented. In vivo OCT imaging of the human larynx is demonstrated with 40 fame/second. Dynamic vibration of the vocal folds is recorded to provide not only high-resolution cross-sectional tissue structures but also vibration parameters, such as the vibration frequency and magnitude of the vocal cord, which provide important ...
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    12. The potential of optical coherence tomography in meniscal tear characterization

      Meniscal tear is one of the most common knee injuries leading to pain and discomfort. Partial and total meniscectomies have been widely used to treat the avascular meniscal injuries in which tears do not heal spontaneously. However, the meniscectomies would cause an alteration of the tibiofemoral co ... [Proc. SPIE 7168, 71682O (2009)] published Fri Feb 20, 2009.
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    13. Office-based laryngeal imaging in awake patients with swept-source optical coherence tomography

      Optical coherence tomography (OCT) is an evolving noninvasive imaging modality and has been used to image the human larynx during surgical endoscopy. The design of a long GRIN lens based probe capable of capturing images of the human larynx by use of a swept-source OCT during a typical office-based ... [Proc. SPIE 7168, 71682A (2009)] published Fri Feb 20, 2009.
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    14. Gradient-index lens rod based probe for office-based optical coherence tomography of the human larynx

      Optical coherence tomography (OCT) is an evolving noninvasive imaging modality that has been used to image the human larynx during surgical endoscopy. The design of a long gradient-index lens-based probe capable of capturing images of the human larynx by use of spectral domain OCT during a typical o ... [J. Biomed. Opt. 14, 014017 (2009)] published Wed Feb 11, 2009.
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    15. In Vivo Optical Coherence Tomography of the Human Oral Cavity and Oropharynx

      Optical coherence tomography (OCT) is an evolving imaging modality that combines interferometry with low-coherence light to produce high-resolution tissue imaging. Cross-sectional in vivo images were obtained using an OCT device consisting of a Michelson interferometer, 1.3-µm broadband light source, and a handheld fiberoptic imaging probe. Image pixel resolution approached 10 µm. The mucosa of the oral cavity and oropharynx were examined in 41 patients during operative endoscopy. Optical coherence tomographic imaging was combined with endoscopic photography for gross and histologic image correlation. Optical coherence tomographic images of the oral cavity and oropharynx provided microanatomical information on the epithelium, basement ...
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    16. Topographical variations in the polarization sensitivity of articular cartilage as determined by polarization-sensitive optical coherence tomography and polarized light microscopy

      Tuqiang Xie, Yang Xia, Shuguang Guo et al. To understand the influence of topographical variations in collagen fibril orientation of articular cartilage on optical phase images of polarization-sensitive optical coherence tomography (PS-OCT), we use polarized light microscopy (PLM) to quantify the orientation and phase retardation of the coll ... [J. Biomed. Opt. 13, 054034 (2008)] published Fri Sep 5, 2008.
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    17. Optical Coherence Tomography–Enhanced Microlaryngoscopy: Preliminary Report of a Noncontact Optical Coherence Tomography System Integrated With a Surgical Microscope

      Objectives: Optical coherence tomography (OCT) is a new imaging modality that uses near-infrared light to produce cross-sectional images of tissue with a resolution approaching that of light microscopy. We have previously reported use of OCT imaging of the vocal folds (VFs) during direct laryngoscopy with a probe held in contact or near-contact with the VFs. This aim of this study was to develop and evaluate a novel OCT system integrated with a surgical microscope to allow hands-free OCT imaging of the VFs, which could be performed simultaneously with microscopic visualization. Methods: We performed a prospective evaluation of a new method ...
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    18. In vivo optical coherence tomography detection of differences in regional large airway smoke inhalation induced injury in a rabbit model

      Matthew Brenner, Kelly Kreuter, Johnny Ju et al. Smoke inhalation injury causes acute airway injury that may result in airway compromise with significant morbidity and mortality. We investigate the ability of high resolution endobronchial optical coherence tomography (OCT) to obtain real-time images for quantitatively assessing regional difference ... [J. Biomed. Opt. 13, 034001 (2008)] published Mon Jun 23, 2008.
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    19. Optical Coherence Tomography of the Newborn Airway

      Objectives: Acquired subglottic stenosis in a newborn is often associated with prolonged endotracheal intubation. This condition is generally diagnosed during operative endoscopy after airway injury has occurred. Unfortunately, endoscopy is unable to characterize the submucosal changes observed in such airway injuries. Other modalities, such as magnetic resonance imaging, computed tomography, and ultrasound, do not possess the necessary level of resolution to differentiate scar, neocartilage, and edema. Optical coherence tomography (OCT) is an imaging modality that produces high-resolution, cross-sectional images of living tissue (8 to 20 μm). We examined the ability of this noninvasive technique to characterize the newborn airway in ...
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    20. Optical coherence tomography of the larynx in the awake patient

      Objective To demonstrate the feasibility of performing optical coherence tomography of the human larynx on the awake patient with a novel flexible fiberoptic delivery system. Study Design Prospective clinical trial. Subjects and Methods Imaging was performed in 17 awake patients. A flexible optical coherence tomography probe was inserted through the nose and placed in near or gentle contact with laryngeal tissues under direct endoscopic visualization. Results Images were successfully obtained from all laryngeal subsites and clearly identified laryngeal mucosal microanatomy. Several critical probe design modifications improved rotational and angular control of the distal tip while allowing linear translation of the ...
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    21. Imaging of the Pediatric Airway Using Optical Coherence Tomography

      Objectives: Optical coherence tomography (OCT) is an imaging modality that uses a broadband light source to produce high‐resolution cross‐sectional images in living tissue (8–20 μm). A prospective study of normal, benign, and pathologic tissues in the pediatric airway was conducted to assess the utility of OCT technology in characterizing the microanatomy of the pediatric upper aerodigestive tract in vivo. Study Design: Prospective clinical trial. Materials and Methods: Fifteen patients from 1 to 17 years of age underwent surgical endoscopy and OCT for various airway disorders. OCT imaging was performed at a frame rate of 1 Hz using ...

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    22. Detection of acute smoke-induced airway injury in a New Zealand white rabbit model using optical coherence tomography

      Matthew Brenner, Kelly Kreuter, David Mukai et al. Optical coherence tomography (OCT) is a micron scale high-resolution optical technology that can provide real-time in vivo images noninvasively. The ability to detect airway mucosal and submucosal injury rapidly will be valuable for a range of pulmonary applications including assessment of acute inh ... [J. Biomed. Opt. 12, 051701 (2007)] published Mon Oct 29, 2007.
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    1-22 of 22
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  2. Topics in the News

    1. (22 articles) Shuguang Guo
    2. (14 articles) UC Irvine
    3. (12 articles) Zhongping Chen
    4. (9 articles) Brian J. F. Wong
    5. (6 articles) Lei Wu
    6. (6 articles) James M. Ridgway
    7. (6 articles) National Institutes of Health
    8. (5 articles) University of Florida
    9. (5 articles) Huikai K. Xie
    10. (4 articles) William B. Armstrong
    11. (3 articles) David E. Vokes
    12. (3 articles) Center for Ophthalmic Optics and Lasers
    13. (3 articles) Oregon Health & Science University
    14. (3 articles) David Huang
    15. (2 articles) Harvard University
    16. (2 articles) Massachusetts General Hospital
    17. (2 articles) University of Southern California
    18. (2 articles) Brett E. Bouma
    19. (2 articles) Johannes F. de Boer
    20. (2 articles) Mohamed Abou Shousha
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    Feature Of The Week 11/15/09: A Comparison between Optical Coherence Tomography and Histology of Laryngeal Epithelial Thickness In vivo 3D and Doppler OCT imaging using electrothermal MEMS scanning mirrors The impact of blood pressure variability on coronary arterial lumen dimensions as assessed by optical coherence tomography in patients with ST-elevation myocardial infarction Clinical diversity in macular corneal dystrophy: an optical coherence tomography study Imaging Amblyopia: Insights from Optical Coherence Tomography (OCT) Three-Dimensional Optical Coherence Tomography Imaging for Glaucoma Associated with Boston Keratoprosthesis Type I and II Velocity range estimation for liquid flow based on optical micro-angiography Spectral optical coherence tomography findings in an adult patient with syphilitic bilateral posterior uveitis and unilateral punctate inner retinitis In-stent restenosis caused by calcified nodule 11 years after paclitaxel eluting stent implantation treated with drug-coated balloon following rotational atherectom Plaque erosion or coronary artery embolism? Findings from clinical presentation, optical coherence tomographic and histopathological analysis in a case with acute coronary syndrome Imaging assessment and accuracy in coronary artery autopsy: comparison of frequency-domain optical coherence tomography with intravascular ultrasound and histology Longitudinal vasculature changes in branch retinal vein occlusion with projection-resolved optical coherence tomography angiography