1. Articles from William B. Armstrong

    1-7 of 7
    1. The Use of Optical Coherence Tomography and Convolutional Neural Networks to Distinguish Normal and Abnormal Oral Mucosa

      The Use of Optical Coherence Tomography and Convolutional Neural Networks to Distinguish Normal and Abnormal Oral Mucosa

      Incomplete surgical resection of head and neck squamous cell carcinoma (HNSCC) is the most common cause of local HNSCC recurrence. Currently, surgeons rely on pre‐operative imaging, direct visualization, palpation, and frozen section to determine the extent of tissue resection. It has been demonstrated that optical coherence tomography (OCT), a minimally invasive, non‐ionizing near infrared mesoscopic imaging modality can resolve subsurface differences between normal and abnormal head and neck mucosa. Previous work has utilized 2‐D OCT imaging which is limited to the evaluation of a small regions of interest generated frame by frame. OCT technology is capable of ...

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    2. Emerging applications for OCT in the head and neck

      Emerging applications for OCT in the head and neck
      Objectives: To describe the current and promising new applications of Optical Coherence Tomography (OCT) as a helpful tool when imaging the different sites in the head and neck. We used the OCT Niris system, which is the first commercially available OCT device for applications outside the field of ophthalmology. Methods: OCT images were obtained of normal, benign, premalignant and malignant lesions in different areas of the head and neck. The OCT imaging system has a tissue penetration depth of approximately 1-2mm, a scanning range of 2mm and a spatial depth resolution of approximately 10-20µm. Imaging was performed using a flexible ...
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    3. Feature Of The Week 11/15/09: A Comparison between Optical Coherence Tomography and Histology of Laryngeal Epithelial Thickness

      Feature Of The Week 11/15/09: A Comparison between Optical Coherence Tomography and Histology of Laryngeal Epithelial Thickness
      Feature Of The Week 11/15/09: While applications of optical coherence tomography in ophthalmology and cardiology have very successfully transitioned from the research world to the commercial world many other fields have lagged behind. One such area is the field of Otolaryngology. While much of the technology developed in both the academic and commercial worlds is directly applicable to applications in otolaryngology there remain some unique features such as probe design and a need for additional clinical data to determine where OCT will be most beneficial. Numerous researchers around the world are working in this field. Researchers from the ...
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    4. Optical coherence tomography using the Niris system in otolaryngology

      Objectives: To determine the feasibility and accuracy of the Niris Optical Coherence Tomography (OCT) system in imaging of the mucosal abnormalities of the head and neck. The Niris system is the first commercially available OCT device for applications outside ophthalmology. Methods: We obtained OCT images of benign, premalignant and malignant lesions throughout the head and neck, using the Niris OCT imaging system (Imalux, Cleveland, OH). This imaging system has a tissue penetration depth of approximately 1-2mm, a scanning range of 2mm and a spatial depth resolution of approximately 10-20µm. Imaging was performed in the outpatient setting and in the operating ...
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    5. In Vivo Optical Coherence Tomography of the Human Oral Cavity and Oropharynx

      Optical coherence tomography (OCT) is an evolving imaging modality that combines interferometry with low-coherence light to produce high-resolution tissue imaging. Cross-sectional in vivo images were obtained using an OCT device consisting of a Michelson interferometer, 1.3-µm broadband light source, and a handheld fiberoptic imaging probe. Image pixel resolution approached 10 µm. The mucosa of the oral cavity and oropharynx were examined in 41 patients during operative endoscopy. Optical coherence tomographic imaging was combined with endoscopic photography for gross and histologic image correlation. Optical coherence tomographic images of the oral cavity and oropharynx provided microanatomical information on the epithelium, basement ...
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    6. Optical Coherence Tomography–Enhanced Microlaryngoscopy: Preliminary Report of a Noncontact Optical Coherence Tomography System Integrated With a Surgical Microscope

      Objectives: Optical coherence tomography (OCT) is a new imaging modality that uses near-infrared light to produce cross-sectional images of tissue with a resolution approaching that of light microscopy. We have previously reported use of OCT imaging of the vocal folds (VFs) during direct laryngoscopy with a probe held in contact or near-contact with the VFs. This aim of this study was to develop and evaluate a novel OCT system integrated with a surgical microscope to allow hands-free OCT imaging of the VFs, which could be performed simultaneously with microscopic visualization. Methods: We performed a prospective evaluation of a new method ...
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    7. Optical coherence tomography of the larynx in the awake patient

      Objective To demonstrate the feasibility of performing optical coherence tomography of the human larynx on the awake patient with a novel flexible fiberoptic delivery system. Study Design Prospective clinical trial. Subjects and Methods Imaging was performed in 17 awake patients. A flexible optical coherence tomography probe was inserted through the nose and placed in near or gentle contact with laryngeal tissues under direct endoscopic visualization. Results Images were successfully obtained from all laryngeal subsites and clearly identified laryngeal mucosal microanatomy. Several critical probe design modifications improved rotational and angular control of the distal tip while allowing linear translation of the ...
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    1-7 of 7
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  2. Topics in the News

    1. (7 articles) UC Irvine
    2. (7 articles) Brian J. F. Wong
    3. (7 articles) William B. Armstrong
    4. (6 articles) Zhongping Chen
    5. (4 articles) Shuguang Guo
    6. (3 articles) Roger L. Crumley
    7. (3 articles) Marc Rubinstein
    8. (3 articles) James M. Ridgway
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    Feature Of The Week 11/15/09: A Comparison between Optical Coherence Tomography and Histology of Laryngeal Epithelial Thickness Emerging applications for OCT in the head and neck The Use of Optical Coherence Tomography and Convolutional Neural Networks to Distinguish Normal and Abnormal Oral Mucosa Optical coherence tomography in an eyelid lesion due to Molluscum contagiosum Lung adenocarcinoma choroidal metastasis studied by optical coherence tomography angiography Early detection of enamel demineralization by optical coherence tomography Deep spectral learning for label-free optical imaging oximetry with uncertainty quantification AS-OCT Guided Treatment Of Diffuse Conjunctival Squamous Cell Carcinoma With Resection ... The Eyes Behind Surgical Robots Ophthalmology/Functional Imaging: OCT + AO for functional imaging Optical Coherence Tomography Angiography Assessed Retinal and Choroidal Microvasculature Features in Patients with Retinitis Pigmentosa: A Meta-Analysis The vascular densities of the macula and optic disc in normal eyes from children by optical coherence tomography angiography