1. Articles from Ali Sepehr

    1-6 of 6
    1. Gradient-index lens rod based probe for office-based optical coherence tomography of the human larynx

      Optical coherence tomography (OCT) is an evolving noninvasive imaging modality that has been used to image the human larynx during surgical endoscopy. The design of a long gradient-index lens-based probe capable of capturing images of the human larynx by use of spectral domain OCT during a typical o ... [J. Biomed. Opt. 14, 014017 (2009)] published Wed Feb 11, 2009.
      Read Full Article
    2. Imaging the Human Tympanic Membrane Using Optical Coherence Tomography In Vivo.

      Objective: Optical coherence tomography (OCT) is a diagnostic imaging modality that combines low coherence light with interferometry to produce high-resolution cross-sectional images of living tissues. Using this technology, we have imaged in vivo the human tympanic membrane (TM) in the office clinic setting and characterized TM microstructure in normal and pathologic conditions. Study Design: Prospective clinical trial. Materials and Methods: The normal and diseased TMs in 10 adult subjects were examined. Each subject underwent direct microscopic examination before OCT imaging to provide visual coregistration of associated subsites including the anulus fibrosus, pars tensa, pars flaccida, and umbo. The probe from ...
      Read Full Article
    3. Optical Coherence Tomography of the Newborn Airway

      Objectives: Acquired subglottic stenosis in a newborn is often associated with prolonged endotracheal intubation. This condition is generally diagnosed during operative endoscopy after airway injury has occurred. Unfortunately, endoscopy is unable to characterize the submucosal changes observed in such airway injuries. Other modalities, such as magnetic resonance imaging, computed tomography, and ultrasound, do not possess the necessary level of resolution to differentiate scar, neocartilage, and edema. Optical coherence tomography (OCT) is an imaging modality that produces high-resolution, cross-sectional images of living tissue (8 to 20 μm). We examined the ability of this noninvasive technique to characterize the newborn airway in ...
      Read Full Article
    4. Optical Coherence Tomography of the Cochlea in the Porcine Model.

      Abstract: Objectives/Hypothesis: To demonstrate the feasibility of optical coherence tomography in microstructural imaging of the porcine cochlea. Study Design: Ex vivo, porcine model. Methods: Optical coherence tomographic images of the porcine cochlea were obtained by thinning the bone from the basal turn of the cochlea leaving the endosteum intact. The images were compared with the corresponding histological sections. Results: In the areas of thinned bone, images were obtained of the stria vascularis, Reissner's membrane, basilar membrane, tectorial membrane, scala media, scala tympani, and scala vestibuli. The bone was too thick for adequate light penetration in the areas where ...
      Read Full Article
    5. Optical coherence tomography of the larynx in the awake patient

      Objective To demonstrate the feasibility of performing optical coherence tomography of the human larynx on the awake patient with a novel flexible fiberoptic delivery system. Study Design Prospective clinical trial. Subjects and Methods Imaging was performed in 17 awake patients. A flexible optical coherence tomography probe was inserted through the nose and placed in near or gentle contact with laryngeal tissues under direct endoscopic visualization. Results Images were successfully obtained from all laryngeal subsites and clearly identified laryngeal mucosal microanatomy. Several critical probe design modifications improved rotational and angular control of the distal tip while allowing linear translation of the ...
      Read Full Article
    6. In vivo three-dimensional spectral domain endoscopic optical coherence tomography using a microelectromechanical system mirror

      Woonggyu Jung, Daniel T. McCormick, Yeh-Chan Ahn, Ali Sepehr, Matt Brenner, Brian Wong, Norman C. Tien, Zhongping Chen A biopsy is a well-known medical test used to evaluate tissue abnormality. Biopsy specimens are invasively taken from part of a lesion and visualized by microscope after chemical treatment. However, diagnosis by means of biopsy is not only variable due to depth and location of specimen but may also ... [Opt. Lett. 32, 3239-3241 (2007)]
      Read Full Article
    1-6 of 6
  1. Categories

    1. Applications:

      Art, Cardiology, Dentistry, Dermatology, Developmental Biology, Gastroenterology, Gynecology, Microscopy, NDE/NDT, Neurology, Oncology, Ophthalmology, Other Non-Medical, Otolaryngology, Pulmonology, Urology
    2. Business News:

      Acquisition, Clinical Trials, Funding, Other Business News, Partnership, Patents
    3. Technology:

      Broadband Sources, Probes, Tunable Sources
    4. Miscellaneous:

      Jobs & Studentships, Student Theses, Textbooks
  2. Topics in the News

    1. (6 articles) UC Irvine
    2. (6 articles) Zhongping Chen
    3. (5 articles) Brian J. F. Wong
    4. (3 articles) Shuguang Guo
    5. (2 articles) James M. Ridgway
    6. (2 articles) Topcon Medical Systems
    7. (1 articles) David E. Vokes
    8. (1 articles) Lingfeng Yu
    9. (1 articles) William B. Armstrong
    10. (1 articles) Imalux
    11. (1 articles) Imalux Niris
    12. (1 articles) Tohoku University
    13. (1 articles) Fudan University
    14. (1 articles) Massachusetts Institute of Technology
    15. (1 articles) James G. Fujimoto
    16. (1 articles) Benjamin M. Potsaid
    17. (1 articles) Hiroshi Mashimo
    18. (1 articles) Osman O. Ahsen
    19. (1 articles) Thorlabs
    20. (1 articles) Topcon 3D OCT-2000
  3. Popular Articles

  4. Picture Gallery

    Spectral Domain Optical Coherence Tomography Imaging Performance Improvement Based on Field Curvature Aberration-Corrected Spectrometer Pentosan polysulfate maculopathy versus inherited macular dystrophies: comparative assessment with multimodal imaging Complementary Use of Active Infrared Thermography and Optical Coherent Tomography in Non-destructive Testing Inspection of Ancient Marquetries Spectral domain optical coherence tomography–based prevalence of hydroxychloroquine maculopathy in Indian patients on hydroxychloroquine therapy: A utopia of underdiagnosis Consistency Between Optical Coherence Tomography and Humphrey Visual Field for Evaluating Glaucomatous Defects in High Myopic Eyes Tethered capsule en face optical coherence tomography for imaging Barrett’s esophagus in unsedated patients Radial peripapillary capillary density in superior segmental optic hypoplasia measured with OCT angiography Interobserver reproducibility and interocular symmetry of the macular ganglion cell complex: assessment in healthy children using optical coherence tomography Evaluation of Neurodegenerative and Inflammatory Processes in Temporomandibular Joint Disorders Using Optical Coherence Tomography Systems and methods for eye tracking for motion corrected ophthalmic optical coherence tomography Linear sensor for a spectroscopic optical coherence tomography imaging apparatus Systems and methods for optimizing focus for imaging-based overlay metrology