1. Articles from Ali Sepehr

    1-6 of 6
    1. Gradient-index lens rod based probe for office-based optical coherence tomography of the human larynx

      Optical coherence tomography (OCT) is an evolving noninvasive imaging modality that has been used to image the human larynx during surgical endoscopy. The design of a long gradient-index lens-based probe capable of capturing images of the human larynx by use of spectral domain OCT during a typical o ... [J. Biomed. Opt. 14, 014017 (2009)] published Wed Feb 11, 2009.
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    2. Imaging the Human Tympanic Membrane Using Optical Coherence Tomography In Vivo.

      Objective: Optical coherence tomography (OCT) is a diagnostic imaging modality that combines low coherence light with interferometry to produce high-resolution cross-sectional images of living tissues. Using this technology, we have imaged in vivo the human tympanic membrane (TM) in the office clinic setting and characterized TM microstructure in normal and pathologic conditions. Study Design: Prospective clinical trial. Materials and Methods: The normal and diseased TMs in 10 adult subjects were examined. Each subject underwent direct microscopic examination before OCT imaging to provide visual coregistration of associated subsites including the anulus fibrosus, pars tensa, pars flaccida, and umbo. The probe from ...
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    3. Optical Coherence Tomography of the Newborn Airway

      Objectives: Acquired subglottic stenosis in a newborn is often associated with prolonged endotracheal intubation. This condition is generally diagnosed during operative endoscopy after airway injury has occurred. Unfortunately, endoscopy is unable to characterize the submucosal changes observed in such airway injuries. Other modalities, such as magnetic resonance imaging, computed tomography, and ultrasound, do not possess the necessary level of resolution to differentiate scar, neocartilage, and edema. Optical coherence tomography (OCT) is an imaging modality that produces high-resolution, cross-sectional images of living tissue (8 to 20 μm). We examined the ability of this noninvasive technique to characterize the newborn airway in ...
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    4. Optical Coherence Tomography of the Cochlea in the Porcine Model.

      Abstract: Objectives/Hypothesis: To demonstrate the feasibility of optical coherence tomography in microstructural imaging of the porcine cochlea. Study Design: Ex vivo, porcine model. Methods: Optical coherence tomographic images of the porcine cochlea were obtained by thinning the bone from the basal turn of the cochlea leaving the endosteum intact. The images were compared with the corresponding histological sections. Results: In the areas of thinned bone, images were obtained of the stria vascularis, Reissner's membrane, basilar membrane, tectorial membrane, scala media, scala tympani, and scala vestibuli. The bone was too thick for adequate light penetration in the areas where ...
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    5. Optical coherence tomography of the larynx in the awake patient

      Objective To demonstrate the feasibility of performing optical coherence tomography of the human larynx on the awake patient with a novel flexible fiberoptic delivery system. Study Design Prospective clinical trial. Subjects and Methods Imaging was performed in 17 awake patients. A flexible optical coherence tomography probe was inserted through the nose and placed in near or gentle contact with laryngeal tissues under direct endoscopic visualization. Results Images were successfully obtained from all laryngeal subsites and clearly identified laryngeal mucosal microanatomy. Several critical probe design modifications improved rotational and angular control of the distal tip while allowing linear translation of the ...
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    6. In vivo three-dimensional spectral domain endoscopic optical coherence tomography using a microelectromechanical system mirror

      Woonggyu Jung, Daniel T. McCormick, Yeh-Chan Ahn, Ali Sepehr, Matt Brenner, Brian Wong, Norman C. Tien, Zhongping Chen A biopsy is a well-known medical test used to evaluate tissue abnormality. Biopsy specimens are invasively taken from part of a lesion and visualized by microscope after chemical treatment. However, diagnosis by means of biopsy is not only variable due to depth and location of specimen but may also ... [Opt. Lett. 32, 3239-3241 (2007)]
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    1-6 of 6
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  2. Topics in the News

    1. (6 articles) UC Irvine
    2. (6 articles) Zhongping Chen
    3. (5 articles) Brian J. F. Wong
    4. (3 articles) Shuguang Guo
    5. (2 articles) James M. Ridgway
    6. (1 articles) David E. Vokes
    7. (1 articles) Lingfeng Yu
    8. (1 articles) William B. Armstrong
    9. (1 articles) Imalux
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