1. Articles from Xinyu Li

    1-7 of 7
    1. Balanced detection spectral-domain optical coherence tomography with a single line-scan camera

      Balanced detection spectral-domain optical coherence tomography with a single line-scan camera

      This paper describes a balanced detection spectral-domain optical coherence tomography (BD-SD-OCT) system for suppressing autocorrelation (AC) artifacts and increasing the signal-to-noise ratio (SNR). The system employed three optical fiber couplers to generate two phase-opposed interference spectra that were acquired by a single line-scan camera simultaneously. When compared with conventional unbalanced detection SD-OCT systems, the developed BD-SD-OCT system improved the SNR by 5.4-6 dB and suppressed the AC term by 5-10 dB. The imaging quality of the BD-SD-OCT system was evaluated by in vivo imaging of human nail folds and retinas.

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    2. Higher choroidal thickness and lower choriocapillaris blood flow signal density based on optical coherence tomography angiography in diabetics

      Higher choroidal thickness and lower choriocapillaris blood flow signal density based on optical coherence tomography angiography in diabetics

      Diabetes mellitus (DM) is one of the fastest growing chronic diseases in the world and one of the main causes of vision loss. Whether or not diabetic choroidopathy (DC) is involved in the initiation and progression of diabetic ocular complications needs to be explored. We included 54 diabetic eyes from 36 diabetic patients, and 54 healthy eyes from 32 control subjects after propensity scores matching. All of the subjects were given pupil light and dark adaptation examination and optical coherence tomography angiography (OCTA). Scotopic pupil diameter (SPD), pupil contraction amplitude, and velocity of pupil contraction of the diabetic group were ...

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    3. Dynamic-range compression and contrast enhancement in swept-source optical coherence tomography systems with a frequency gain compensation amplifier

      Dynamic-range compression and contrast enhancement in swept-source optical coherence tomography systems with a frequency gain compensation amplifier

      Significance: Optical coherence tomography (OCT) has been widely used in clinical studies. However, the image quality of OCT decreases with increasing imaging depth since the light is rapidly attenuated in biological tissues. Aim: We present a compensation approach to preserve weak high-frequency signals from deep structures and compress the dynamic range of the detected signal for superior analog-to-digital conversion and image display capability. Approach: A homemade frequency gain compensation amplifier is designed and fabricated to amplify the electrical signal from a balanced photodetector and compensate for the signal attenuation in swept-source OCT (SSOCT). Results: It is demonstrated in imaging various ...

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    4. Integrated Multifunctional Laryngoscope for Medical Diagnosis and Treatment

      Integrated Multifunctional Laryngoscope for Medical Diagnosis and Treatment

      Laryngeal lesions can cause great inconvenience to patients. Early diagnosis and corresponding treatments are critical to the survival of patients. However, the diagnosis and precise removal of tumors remain a challenge under the use of a white light laryngoscope. In this work, an integrated, multifunctional laryngoscope was designed and tested for the imaging evaluation and precision laser surgery for laryngeal tissue. This integrated diagnostic and therapeutic endoscopic system included two imaging modes (i.e., optical coherence tomography and white light endoscopy) and a laser ablation treatment mode. The endoscope had a common-path design to ensure that the same position could ...

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    5. Correction of saturation effects in endoscopic swept-source optical coherence tomography based on dual-channel detection

      Correction of saturation effects in endoscopic swept-source optical coherence tomography based on dual-channel detection

      Saturation artifacts that are commonly observed in endoscopic swept-source optical coherence tomography (SSOCT) images cause image degradation and loss of image information. We present work on the correction of saturation effects in endoscopic SSOCT imaging. This method utilizes a broadband power divider with excellent pick-off flatness to divide the detected interference signal into the two channels of an analog-to-digital converter. Based on the precise calibration of the splitting ratio between the two channels, the maximum measurable signal power of the system was drastically increased by using the low level signal in one channel to correct the saturated signal in the ...

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    6. Contrast improvement for swept source optical coherence tomography image of sub-surface tissue

      Contrast improvement for swept source optical coherence tomography image of sub-surface tissue

      Swept source optical coherence tomography (SSOCT) is an attractive biological imaging technology due to its advantages of simple setup and high imaging speed. As the light intensity attenuated rapidly in high scattering biological tissues, the contrast of OCT image will drop with depth. In this paper a new method was introduced to compensate the attenuation of imaging contrast in SSOCT. The interference signal was divided into two channels of analog to digital converter (ADC) with a splitting ratio of 1:5. The higher level signal in one channel was used to reconstruct deeper structure of tissue and the lower level ...

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    7. Suppression of saturation artifacts in swept source optical coherence tomography using dual channel detection

      Suppression of saturation artifacts in swept source optical coherence tomography using dual channel detection

      A technique to suppress saturation artifacts in swept source optical coherence tomography (SSOCT) system was presented. The detected signal was split into two channels of a high speed data acquisition card with two levels by a power divider. The signal in one channel with higher level was used to reconstruct OCT images and the signal in the other channel with lower level was used to compensate the saturated signal in the first channel by calibrating the splitting ratio between the two channels. Based on dual channel detection, this technique can enhance the dynamic range of SSOCT system and remove saturation ...

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    1-7 of 7
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    1. (6 articles) Sun Yat-Sen University
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    Suppression of saturation artifacts in swept source optical coherence tomography using dual channel detection Contrast improvement for swept source optical coherence tomography image of sub-surface tissue Correction of saturation effects in endoscopic swept-source optical coherence tomography based on dual-channel detection Integrated Multifunctional Laryngoscope for Medical Diagnosis and Treatment Dynamic-range compression and contrast enhancement in swept-source optical coherence tomography systems with a frequency gain compensation amplifier Higher choroidal thickness and lower choriocapillaris blood flow signal density based on optical coherence tomography angiography in diabetics Balanced detection spectral-domain optical coherence tomography with a single line-scan camera Comparison of Anterior Segment Measurements with a New Multifunctional Unit and Five Other Devices Efficacy of Notal Vision Home OCT demonstrated by a series of scientific and clinical work Synergy Between morpHOlogical and inflammatoRy Evaluation in Predicting Long-term Coronary Plaque Progression Altered ocular microvasculature in patients with systemic sclerosis and very early disease of systemic sclerosis using optical coherence tomography angiography Assessment of macular findings by OCT angiography in patients without clinical signs of diabetic retinopathy: radiomics features for early screening of diabetic retinopathy