1. Articles from Gavrielle R. Untracht

    1-5 of 5
    1. OCTAVA: An open-source toolbox for quantitative analysis of optical coherence tomography angiography images

      OCTAVA: An open-source toolbox for quantitative analysis of optical coherence tomography angiography images

      Optical coherence tomography angiography (OCTA) performs non-invasive visualization and characterization of microvasculature in research and clinical applications mainly in ophthalmology and dermatology. A wide variety of instruments, imaging protocols, processing methods and metrics have been used to describe the microvasculature, such that comparing different study outcomes is currently not feasible. With the goal of contributing to standardization of OCTA data analysis, we report a user-friendly, open-source toolbox, OCTAVA (OCTA Vascular Analyzer), to automate the pre-processing, segmentation, and quantitative analysis of en face OCTA maximum intensity projection images in a standardized workflow. We present each analysis step, including optimization of filtering ...

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    2. Imaging the small with the small: Prospects for photonics in micro-endomicroscopy for minimally invasive cellular-resolution bioimaging

      Imaging the small with the small: Prospects for photonics in micro-endomicroscopy for minimally invasive cellular-resolution bioimaging

      Many bioimaging studies, including those in engineered tissue constructs, intravital microscopy in animal models, and medical imaging in humans, require cellular-resolution imaging of structures deep within a sample. Yet, many of the current approaches are limited in terms of resolution, but also in invasiveness, repeatable imaging of the same location, and accessible imaging depth. We coin the term micro-endomicroscope to describe the emerging class of small, cellular-resolution endoscopic imaging systems designed to image cells in situ while minimizing perturbation of the sample. In this Perspective, we motivate the need for further development of micro-endomicroscopes, highlighting applications that would greatly benefit ...

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    3. Photonic force optical coherence elastography for three-dimensional mechanical microscopy

      Photonic force optical coherence elastography for three-dimensional mechanical microscopy

      Optical tweezers are an invaluable tool for non-contact trapping and micro-manipulation, but their ability to facilitate high-throughput volumetric microrheology of biological samples for mechanobiology research is limited by the precise alignment associated with the excitation and detection of individual bead oscillations. In contrast, radiation pressure from a low-numerical aperture optical beam can apply transversely localized force over an extended depth range. Here we present photonic force optical coherence elastography (PF-OCE), leveraging phase-sensitive interferometric detection to track sub-nanometer oscillations of beads, embedded in viscoelastic hydrogels, induced by modulated radiation pressure. Since the displacements caused by ultra-low radiation-pressure force are typically obscured ...

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    4. Photonic force optical coherence elastography for threedimensional mechanical microscopy

      Photonic force optical coherence elastography for threedimensional mechanical microscopy

      Optical tweezers are an invaluable tool for non-contact trapping and micro-manipulation, but their ability to facilitate high-throughput volumetric microrheology of biological samples for mechanobiology research is limited by the precise alignment associated with the excitation and detection of individual bead oscillations. In contrast, radiation pressure from a low numerical aperture optical beam can apply transversely localized force over an extended depth range. We propose photonic force optical coherence elastography (PF-OCE), leveraging phase-sensitive interferometric detection to track sub-nanometre oscillations of beads, embedded in viscoelastic hydrogels, induced by modulated radiation pressure. Since the displacements caused by ultra-low radiation-pressure force are typically obscured ...

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    5. GPU-based computational adaptive optics for volumetric optical coherence microscopy

      GPU-based computational adaptive optics for volumetric optical coherence microscopy

      Optical coherence tomography (OCT) is a non-invasive imaging technique that measures reflectance from within biological tissues. Current higher-NA optical coherence microscopy (OCM) technologies with near cellular resolution have limitations on volumetric imaging capabilities due to the trade-offs between resolution vs. depth-of-field and sensitivity to aberrations. Such trade-offs can be addressed using computational adaptive optics (CAO), which corrects aberration computationally for all depths based on the complex optical field measured by OCT. However, due to the large size of datasets plus the computational complexity of CAO and OCT algorithms, it is a challenge to achieve high-resolution 3D-OCM reconstructions at speeds suitable ...

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    1-5 of 5
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    1. (4 articles) University of Western Australia
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    GPU-based computational adaptive optics for volumetric optical coherence microscopy Photonic force optical coherence elastography for threedimensional mechanical microscopy Photonic force optical coherence elastography for three-dimensional mechanical microscopy Imaging the small with the small: Prospects for photonics in micro-endomicroscopy for minimally invasive cellular-resolution bioimaging OCTAVA: An open-source toolbox for quantitative analysis of optical coherence tomography angiography images New insights from non-invasive imaging: from prospection of skin photodamages to training with mobile application Short-sighted woman assumes debilitating headaches mean she needs new glasses but discovers she has multiple sclerosis Shedding light on the impact of microplastics on lentil seedling growth Comparison of radial peripapillary capillary density results of individuals with and without Helicobacter pylori infection Ai, Oct Operate in Tandem to Detect Plaque Erosion in the Heart Noninvasive, in vivo, characterization of cutaneous metastases using a novel multimodal RCM-OCT imaging device: A case-series Mimickers of punctate inner retinal toxoplasmosis on optical coherence tomography