1. Articles from Le A. Trinh

    1-3 of 3
    1. 3D in vivo imaging with extended-focus optical coherence microscopy

      3D in vivo imaging with extended-focus optical coherence microscopy

      Optical coherence microscopy (OCM) has unique advantages of non-invasive 3D imaging without the need of exogenous labels for studying biological samples. However, the imaging depth of this technique is limited by the tradeoff between the depth of focus (DOF) and high lateral resolution in Gaussian optics. To overcome this limitation, we have developed an extended-focus OCM (xf-OCM) imaging system using quasi-Bessel beam illumination to extend the DOF to ∼100 μm, about 3-fold greater than standard OCM. High lateral resolution of 1.6 μm ensured detailed identification of structures within live animal samples. The insensitivity to spherical aberrations strengthened the capability ...

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    2. Phase variance optical coherence microscopy for label-free imaging of the developing vasculature in zebrafish embryos

      Phase variance optical coherence microscopy for label-free imaging of the developing vasculature in zebrafish embryos

      A phase variance optical coherence microscope (pvOCM) has been created to image blood flow in the microvasculature of zebrafish embryos, without the use of exogenous labels. The pvOCM imaging system has axial and lateral resolutions of 2.8    μ m 2.8  μm in tissue and imaging depth of more than 100    μ m 100  μm . Images of 2 to 5 days postfertilization zebrafish embryos identified the detailed anatomical structure based on OCM intensity contrast. Phase variance contrast offered visualization of blood flow in the arteries, veins, and capillaries. The pvOCM images of the vasculature were confirmed by direct comparisons with fluorescence ...

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    3. Label-free imaging of developing vasculature in zebrafish with phase variance optical coherence microscopy

      Label-free imaging of developing vasculature in zebrafish with phase variance optical coherence microscopy

      A phase variance optical coherence microscope (pvOCM) has been created to visualize blood flow in the vasculature of zebrafish embryos, without using exogenous labels. The pvOCM imaging system has axial and lateral resolutions of 2 μm in tissue, and imaging depth of more than 100 μm. Imaging of 2–5 days post-fertilization zebrafish embryos identified the detailed structures of somites, spinal cord, gut and notochord based on intensity contrast. Visualization of the blood flow in the aorta, veins and intersegmental vessels was achieved with phase variance contrast. The pvOCM vasculature images were confirmed with corresponding fluorescence microscopy of a zebrafish ...

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    1-3 of 3
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    1. (3 articles) University of Southern California
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    Label-free imaging of developing vasculature in zebrafish with phase variance optical coherence microscopy Phase variance optical coherence microscopy for label-free imaging of the developing vasculature in zebrafish embryos 3D in vivo imaging with extended-focus optical coherence microscopy Postdoctoral position in optical coherence tomography Department of Bioengineering, UC Riverside Multimodality coronary imaging to predict periprocedural myocardial necrosis after an elective percutaneous coronary intervention SURGICAL REMOVAL OF EPIRETINAL MEMBRANE WITH AND WITHOUT REMOVAL OF INTERNAL LIMITING MEMBRANE: Comparative Study of Visual Acuity, Features of Optical Coherence Tomography, and Recurrence Rate Automatic Side Branch Ostium Detection and Main Vascular Segmentation in Intravascular Optical Coherence Tomography Images Optical Coherence Tomography in Patients With Chronic Migraine: Literature Review and Update IMAGING OF VITELLIFORM MACULAR LESIONS USING POLARIZATION-SENSITIVE OPTICAL COHERENCE TOMOGRAPHY Post Doc Position for Adaptive Optics Optical Coherence Tomography at the Medical University Vienna Retinal thickness measured with optical coherence tomography and risk of disability worsening in multiple sclerosis: a cohort study In Vivo Non-Destructive Monitoring of Capsicum Annuum Seed Growth with Diverse NaCl Concentrations Using Optical Detection Technique