1. Articles from Le A. Trinh

    1-3 of 3
    1. 3D in vivo imaging with extended-focus optical coherence microscopy

      3D in vivo imaging with extended-focus optical coherence microscopy

      Optical coherence microscopy (OCM) has unique advantages of non-invasive 3D imaging without the need of exogenous labels for studying biological samples. However, the imaging depth of this technique is limited by the tradeoff between the depth of focus (DOF) and high lateral resolution in Gaussian optics. To overcome this limitation, we have developed an extended-focus OCM (xf-OCM) imaging system using quasi-Bessel beam illumination to extend the DOF to ∼100 μm, about 3-fold greater than standard OCM. High lateral resolution of 1.6 μm ensured detailed identification of structures within live animal samples. The insensitivity to spherical aberrations strengthened the capability ...

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    2. Phase variance optical coherence microscopy for label-free imaging of the developing vasculature in zebrafish embryos

      Phase variance optical coherence microscopy for label-free imaging of the developing vasculature in zebrafish embryos

      A phase variance optical coherence microscope (pvOCM) has been created to image blood flow in the microvasculature of zebrafish embryos, without the use of exogenous labels. The pvOCM imaging system has axial and lateral resolutions of 2.8    μ m 2.8  μm in tissue and imaging depth of more than 100    μ m 100  μm . Images of 2 to 5 days postfertilization zebrafish embryos identified the detailed anatomical structure based on OCM intensity contrast. Phase variance contrast offered visualization of blood flow in the arteries, veins, and capillaries. The pvOCM images of the vasculature were confirmed by direct comparisons with fluorescence ...

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    3. Label-free imaging of developing vasculature in zebrafish with phase variance optical coherence microscopy

      Label-free imaging of developing vasculature in zebrafish with phase variance optical coherence microscopy

      A phase variance optical coherence microscope (pvOCM) has been created to visualize blood flow in the vasculature of zebrafish embryos, without using exogenous labels. The pvOCM imaging system has axial and lateral resolutions of 2 μm in tissue, and imaging depth of more than 100 μm. Imaging of 2–5 days post-fertilization zebrafish embryos identified the detailed structures of somites, spinal cord, gut and notochord based on intensity contrast. Visualization of the blood flow in the aorta, veins and intersegmental vessels was achieved with phase variance contrast. The pvOCM vasculature images were confirmed with corresponding fluorescence microscopy of a zebrafish ...

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    1-3 of 3
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    1. (3 articles) University of Southern California
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    Label-free imaging of developing vasculature in zebrafish with phase variance optical coherence microscopy Phase variance optical coherence microscopy for label-free imaging of the developing vasculature in zebrafish embryos 3D in vivo imaging with extended-focus optical coherence microscopy Eckhaus Instability in the Fourier-Domain Mode Locked Fiber Laser Cavity Swept-Source Optical Coherence Tomography Angiography in West Nile Virus Chorioretinitis and Associated Occlusive Retinal Vasculitis Optical Coherence Tomography Angiography of Retinal Cavernous Hemangioma Distinguishing White Dot Syndromes With Patterns of Choroidal Hypoperfusion on Optical Coherence Tomography Angiography Feature of the Week 08/17/2017: In Vivo Assessment of Periodontal Structures and Measurement of Gingival Sulcus with Optical Coherence Tomography: A Pilot Study Massachusetts General Hospital Receives NIH Grant for Multimodal Mapping of the Neurocircuitry of the Human Prefontal Cortex LX Medical Corporation Receives a NIH Grant for High-Resolution Multi-modality Endoscopic Imaging Probes for Diagnosing Rejection in Lung Transplant Recipients New York University School of Medicine Receives NIH Grant for Novel Glaucoma Diagnostics for Structure and Function University of Alabama at Birmingham Receives NIH Grant for $43,191 for Occular Phenotyping Core