1. Articles from Federico Corvi

    1-23 of 23
    1. Comparison between Widefield Optical Coherence Tomography Devices in Eyes with High Myopia

      Comparison between Widefield Optical Coherence Tomography Devices in Eyes with High Myopia

      Background: To compare four different optical coherence tomography (OCT) devices for visualization of retinal and subretinal layers in highly myopic eyes. Methods: In this prospective, observational, cross-sectional study, consecutive patients with high myopia and control subjects were imaged by four OCT devices: Spectralis OCT2, PlexElite 2.0 100 kHz, PlexElite 2.0 200 kHz and the Canon Xephilio OCT-S1. The acquisition protocol for comparison consisted of single vertical and horizontal line scans centered on the fovea. Comparison between the devices in the extent of visible retina, presence of conjugate image or mirror artifacts, visibility of the sclerochoroidal interface and retrobulbar ...

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      Mentions: UCLA
    2. Optical Coherence Tomography Signs of Early Atrophy in Age-related Macular Degeneration: Inter-Reader Agreement. CAM Report 6

      Optical Coherence Tomography Signs of Early Atrophy in Age-related Macular Degeneration: Inter-Reader Agreement. CAM Report 6

      Objective: To determine the inter-reader agreement for incomplete and complete retinal pigment epithelium and outer retinal atrophy (iRORA and cRORA respectively) and their related features in age-related macular degeneration (AMD). Design: Inter-reader agreement study. Participants: Twelve readers from six reading centers. Methods: Following formal training, readers qualitatively assessed 60 optical coherence tomography (OCT) B-scans from 60 eyes with AMD for nine individual features associated with early atrophy and performed seven different annotations to quantify the spatial extent of OCT features within regions-of-interests. The qualitative and quantitative features were used to derive the presence of iRORA and cRORA, and also in ...

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    3. Comparison of Spectralis and Cirrus optical coherence tomography for the detection of incomplete and complete retinal pigment epithelium and outer retinal atrophy

      Comparison of Spectralis and Cirrus optical coherence tomography for the detection of incomplete and complete retinal pigment epithelium and outer retinal atrophy

      Purpose: To evaluate and compare the detection of incomplete and complete retinal pigment epithelial and outer retinal atrophy (iRORA and cRORA) using Spectralis and Cirrus optical coherence tomography (OCT) devices. Methods: Subjects with late age-related macular degeneration (AMD) were imaged on the same day with Spectralis and Cirrus OCT. Two masked, independent and experienced retina specialist graders evaluated each case for the presence of cRORA and iRORA lesions. Results: A significantly higher number of lesions were observed using Spectralis compared with Cirrus (239 vs 226 and 223 vs 209). Higher number of iRORA lesions were identified with Spectralis (105 vs ...

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    4. Optical Coherence Tomography Angiography of the Choriocapillaris in Age-Related Macular Degeneration

      Optical Coherence Tomography Angiography of the Choriocapillaris in Age-Related Macular Degeneration

      The advent of optical coherence tomography angiography (OCTA) has allowed for remarkable advancements in our understanding of the role of the choriocapillaris in age-related macular degeneration (AMD). As a relatively new imaging modality, techniques to analyze and quantify choriocapillaris images are still evolving. Quantification of the choriocapillaris requires careful consideration of many factors, including the type of OCTA device, segmentation of the choriocapillaris slab, image processing techniques, and thresholding method. OCTA imaging shows that the choriocapillaris is impaired in intermediate non-neovascular AMD, and the severity of impairment may predict the advancement of disease. In advanced atrophic AMD, the choriocapillaris is ...

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    5. Peripheral Optical Coherence Tomography Findings in a Choroideremia Carrier

      Peripheral Optical Coherence Tomography Findings in a Choroideremia Carrier

      Purpose: To describe the peripheral optical coherence tomography (OCT) findings in a female choroideremia carrier. Methods: Case report. Patient: A 56 year-old woman was referred for visual disturbance complaining of some occasional photopsias and increasing difficulty with her vision at night in both eyes. Best-corrected visual acuity was 20/20 in the right eye and 20/150 in the left eye. Fundus examination revealed mildly tilted disks and peripapillary atrophy with subtle retinal pigment epithelial changes in the periphery. Results: Macular OCT in the right eye appeared unremarkable but the in the left eye there was diffuse ellipsoid zone (EZ ...

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    6. Evaluation of the inner choroid using OCT angiography

      Evaluation of the inner choroid using OCT angiography

      The advent of optical coherence tomography angiography (OCTA) has allowed a qualitative and quantitative analysis of the retinal vasculature and the choriocapillaris. With the use of OCTA, several studies evaluated the changes in the choriocapillaris showing how this vascular structure plays a significant role in the pathogenesis of different conditions. This article reviews the current methods of analysis of the choriocapillaris and the relevant findings in different chorioretinal diseases.

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    7. Comparison and Repeatability of High Resolution and High Speed Scans from Spectralis Optical Coherence Tomography Angiography

      Comparison and Repeatability of High Resolution and High Speed Scans from Spectralis Optical Coherence Tomography Angiography

      Purpose : The purpose of this study was to evaluate and compare the repeatability of optical coherence tomography angiography (OCTA) derived retinal vascular quantitative metrics using high resolution (HR) versus high speed (HS) acquisition modes. Methods : Macular 4.4 × 2.9-mm OCTA images from normal, healthy volunteers were captured using both HR (768 A-scans × 256 B-scans) and HS (384 A-scans × 256 B-scans) acquisition protocols. Vessel density and vessel length density of the superficial capillary plexus and deep capillary plexus, as well as choriocapillaris flow deficit were computed. In a subset of eyes, the OCTA scans were repeated twice 2 days later ...

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    8. Optical coherence tomography angiography for detection of macular neovascularization associated with atrophy in age-related macular degeneration

      Optical coherence tomography angiography for detection of macular neovascularization associated with atrophy in age-related macular degeneration

      Purpose To evaluate the ability of optical coherence tomography angiography (OCTA) to detect macular neovascularization (MNV) in eyes with atrophy compared with fluorescein angiography (FA), indocyanine green angiography (ICGA), and optical coherence tomography (OCT). Methods In this prospective study, eyes with MNV and atrophy (termed macular atrophy or MA) secondary to age-related macular degeneration (AMD), and AMD eyes with geographic atrophy (GA) without MNV underwent multimodal imaging with FA, ICGA, structural OCT, and OCTA. The presence of MNV was determined using all imaging modalities by senior retina specialists and was considered the gold standard reference. Each individual imaging modality was ...

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    9. Microaneurysms visualisation using five different optical coherence tomography angiography devices compared to fluorescein angiography

      Microaneurysms visualisation using five different optical coherence tomography angiography devices compared to fluorescein angiography

      Background To compare fluorescein angiography (FA) and five different optical coherence tomography angiography (OCTA) devices and to test their reproducibility in the evaluation of retinal microaneurysms (MAs) secondary to diabetic retinopathy (DR). Methods On the same day, patients with DR were imaged with FA and five OCTA devices: prototype Spectralis OCTA, prototype PlexElite, RTVue XR Avanti, AngioPlex and DRI OCT Triton. For all OCTA devices, a 3×3 volume scan pattern was performed. MAs were evaluated for the superficial capillary plexus (SCP) and deep capillary plexus (DCP). Results Twenty eyes of 15 patients with DR were included. FA counted a ...

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    10. Thresholding strategies to measure vessel density by optical coherence tomography angiography

      Thresholding strategies to measure vessel density by optical coherence tomography angiography

      Objective A variety of binarization strategies have been used to measure vessel density by optical coherence tomography angiography (OCT-A), but it is uncertain if they produce similar results. The purpose of the study was to evaluate the impact of different thresholding methods and contrast and brightness adjustment on OCT-A vessel density metrics. Design Observational, cross-sectional case series. Participants Consecutive healthy volunteers. Methods Healthy volunteers underwent fovea-centred 3 mm × 3 mm OCT-A scans using PlexElite 9000. Images of the superficial vascular plexus were generated using the instrument’s automated segmentation. Images were thresholded with 5 different threshold tools in ImageJ (Default ...

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    11. Comparison of wide field optical coherence tomography angiography with extended field imaging and fluorescein angiography in retinal vascular disorders

      Comparison of wide field optical coherence tomography angiography with extended field imaging and fluorescein angiography in retinal vascular disorders

      Purpose To compare swept source OCTA device, with and without the extended field imaging (EFI) technique, to standard fluorescein angiography (FA) in the clinical practice. Methods Consecutive patients with vascular disorder patients underwent FA with 55-degree lens (Spectralis Heidelberg Engineering, Heidelberg, Germany) and OCTA with the prototype PlexElite (Carl Zeiss Meditec, Dublin, CA) using a 12 mm x 12 mm volume scan pattern centered on the fovea and a prototype of + 20.00-diopter designed specifically by Zeiss. The imaging methods were compared for visible field of view, extension of non-perfused areas, presence and number of neovessels, vessel density (VD) and ...

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    12. COMPARISON BETWEEN SEVERAL OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY DEVICES AND INDOCYANINE GREEN ANGIOGRAPHY OF CHOROIDAL NEOVASCULARIZATION

      COMPARISON BETWEEN SEVERAL OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY DEVICES AND INDOCYANINE GREEN ANGIOGRAPHY OF CHOROIDAL NEOVASCULARIZATION

      Purpose: To compare indocyanine green angiography and four different optical coherence tomography angiography (OCTA) devices and to test their reproducibility in the evaluation of choroidal neovascularization (CNV). Methods: This study was an observational case series of Type 1 and Type 2 CNV presenting at the Eye Clinic, Department of Biomedical and Clinical Sciences, Luigi Sacco Hospital, University of Milan, imaged with indocyanine green angiography and four different OCTA devices: prototype PlexElite (Carl Zeiss Meditec), prototype Spectralis OCTA (Spectralis; Heidelberg Engineering, Heidelberg, Germany), Optovue RTVue XR Avanti (Optovue, Inc, Fremont, CA), and AngioPlex (Cirrus 5000 HD-OCT; Carl Zeiss Meditec, Inc, Dublin ...

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    13. SWEPT-SOURCE OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY IN CHOROIDAL MELANOMA: An Analysis of 22 Consecutive Cases

      SWEPT-SOURCE OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY IN CHOROIDAL MELANOMA: An Analysis of 22 Consecutive Cases

      Purpose: To describe the imaging features of choroidal melanoma using swept-source optical coherence tomography angiography (SS- OCT-A ) and to evaluate its ability to display tumor intrinsic vasculature. Methods: Consecutive patients diagnosed with choroidal melanoma underwent a complete ophthalmic evaluation, including best-corrected visual acuity, color fundus photography, B-scan ultrasound, fluorescein angiography , indocyanine green angiography , and SS- OCT-A ( PLEX Elite 9000; Carl Zeiss Meditec, Inc, Dublin, CA). Results: Twenty-two eyes of 22 consecutive patients were included in the study; 11 cases (50%) were treatment naive. Three lesions (14%) were located at the macula, 14 (63%) between the macula and equator, and 5 ...

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    14. OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY FINDINGS IN A CASE OF CHOROIDAL NEOVASCULARIZATION SECONDARY TO TRAUMATIC CHOROIDAL RUPTURE

      OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY FINDINGS IN A CASE OF CHOROIDAL NEOVASCULARIZATION SECONDARY TO TRAUMATIC CHOROIDAL RUPTURE

      Background/Purpose: To document by optical coherence tomography angiography , the onset of a choroidal neovascularization ( CNV ) secondary to traumatic choroidal rupture and describe its changes after an intravitreal injection of bevacizumab . Methods: Case report. Results: A 20-year-old woman presented referring vision loss after a blunt ocular trauma in her left eye. The patient underwent a complete ophthalmic examination. Best-corrected visual acuity was 20/200. Fundus examination, fluorescein angiography, indocyanine green angiography, and optical coherence tomography displayed a choroidal rupture with no evidence of CNV . Optical coherence tomography angiography showed the choroidal rupture as a line of choriocapillaris rarefaction because of ...

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    15. OPTICAL COHERENCE TOMOGRAPHY 2: DIAGNOSTIC TOOL TO STUDY PERIPHERAL VITREORETINAL PATHOLOGIES

      OPTICAL COHERENCE TOMOGRAPHY 2: DIAGNOSTIC TOOL TO STUDY PERIPHERAL VITREORETINAL PATHOLOGIES

      Purpose: To investigate the utility of new wide-field optical coherence tomography (OCT) device in the evaluation of mid and far retinal periphery and to show its feasibility and advantages in clinical practice. Methods: Consecutive patients underwent a complete ophthalmologic examination including standard OCT and new prototype OCT2 derived from Heidelberg Spectralis. Results: Thirty-one eyes of 31 patients were studied with a total of 44 lesions, including 18 retinal detachments, 15 retinal holes and tears, 9 retinoschisis, and 2 retinal tufts. Fourteen (32%) lesions were found in mid and 30 (68%) in far periphery with 9 (20%) lesions in the superior ...

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    16. Reproducibility of vessel density, fractal dimension and foveal avascular zone using 7 different optical coherence tomography angiography devices

      Reproducibility of vessel density, fractal dimension and foveal avascular zone using 7 different optical coherence tomography angiography devices

      Purpose To evaluate the reproducibility of parafoveal microvascular anatomy of 7 different optical coherence tomography angiography (OCT-A) devices by comparing vessels density (VD), fractal dimension (FD) and foveal avascular zone (FAZ) of superficial and deep capillary plexus in healthy volunteers. Design Reliability analysis. Methods Consecutive healthy volunteers presenting at the Eye Clinic, Department of Biomedical and Clinical Sciences, Luigi Sacco Hospital, University of Milan in the same clinic visit were imaged by 7 different OCT-A devices: Optovue RTVue XR Avanti (Optovue, Inc, Fremont, CA), prototype Spectralis OCT-A (Spectralis Heidelberg Engineering, Heidelberg, Germany), AngioPlex (Cirrus 5000 HD-OCT, Carl Zeiss Meditec, Inc ...

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    17. OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY FEATURES OF CHOROIDAL NEOVASCULARIZATION ASSOCIATED WITH CHOROIDAL NEVUS

      OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY FEATURES OF CHOROIDAL NEOVASCULARIZATION ASSOCIATED WITH CHOROIDAL NEVUS

      Purpose: To describe the imaging features of choroidal neovascularization (CNV) associated with choroidal nevus using optical coherence tomography angiography (OCT-A) imaging. Methods: Retrospective observational case series. Patients with CNV secondary to choroidal nevus underwent full imaging examination including fundus photography, fluorescein angiography, indocyanine green angiography, spectral domain OCT, and OCT-A. The OCT-A features were analyzed and correlated with conventional angiography findings and spectral domain OCT. Results: There were 11 eyes from 11 patients (6 men and 5 women, mean age of 65 +/- 20.4 years) included in the analysis. Fluorescein angiography and indocyanine green angiography disclosed CNV in 90% and ...

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    18. Demonstration of Choroidal Neovascularization Associated With an Intraretinal Lesion on Indocyanine Green Angiography Independent of Choroidal New Vessel on Optical Coherence Tomography

      Demonstration of Choroidal Neovascularization Associated With an Intraretinal Lesion on Indocyanine Green Angiography Independent of Choroidal New Vessel on Optical Coherence Tomography

      This case report describes woman in her late 70s with decreased visual acuity in the right eye, which on imaging showed leakage at the level of the inner retina due to an intraretinal vascular complex and, separately, choroidal neovascularization under the retinal pigment epithelium. A woman in her late 70s presented with decreased visual acuity in her right eye. Imaging showed leakage at the level of the inner retina ( Figure , A) due to an intraretinal vascular complex and, separately, choroidal neovascularization under the retinal pigment epithelium. The choroidal new vessel was visualized on optical coherence tomography ( Figure , B) and was ...

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    19. Optical coherence tomography angiography of myopic choroidal neovascularisation

      Optical coherence tomography angiography of myopic choroidal neovascularisation

      Background/aims To describe the morphological features of choroidal neovascularisation (CNV) and to report the ability of optical coherence tomography angiography (OCT-A) to detect the presence of myopic CNV by means of this new technique. Methods Myopic CNV cases were individuated from a pool of patients with pathological myopia consecutively presenting between October 2015 and March 2016. OCT-A images were assessed for classification of morphological features, and to estimate sensitivity and specificity. Results Thirty-six eyes of 28 consecutive patients with myopic CNV were included. In 4 out of 36 eyes it was not possible to classify the CNV ‘shape’, ‘core ...

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    20. Optical coherence tomography angiography: a useful tool for diagnosis of treatment-naïve quiescent choroidal neovascularization

      Optical coherence tomography angiography: a useful tool for diagnosis of treatment-naïve quiescent choroidal neovascularization

      Purpose To describe the optical coherence tomography angiography (OCT-A) features of treatment-naïve quiescent choroidal neovascularization (CNV) secondary to age-related macular degeneration, and to estimate the detection rate for neovascularization by means of OCT-A. Design Diagnostic tool validity assessment. Methods Treatment-naïve quiescent CNV were identified from a pool of patients at 2 retina referral centers. Patients underwent a complete ophthalmologic examination including fluorescein angiography, indocyanine green angiography, spectral-domain OCT and OCT-A. Detection rates of CNV by means of OCT-A were estimated with a second cohort of patients without CNV (negative controls) Results Twenty-two eyes of 20 consecutive patients with ...

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    21. Optical Coherence Tomography Angiography Demonstration of Choroidal Neovascularization in Malattia Leventinese

      Optical Coherence Tomography Angiography Demonstration of Choroidal Neovascularization in Malattia Leventinese

      In a case of Malattia Leventinese, optical coherence tomography angiography led to the diagnosis of type 1 neovascularization, despite absence of evidence on conventional dye-based angiography. The authors hypothesize that, at least in some cases, accumulation of subretinal fluid in Malattia Leventinese could be due to a subretinal pigment epithelium (RPE) neovascular component rather than creation of hydrophobic barrier at the RPE and Bruch's membrane.

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    22. Choroidal structure in eyes with drusen and reticular pseudodrusen determined by binarisation of optical coherence tomographic images

      Choroidal structure in eyes with drusen and reticular pseudodrusen determined by binarisation of optical coherence tomographic images

      Purpose To compare luminal and stromal area of the choroid in eyes with drusen and reticular pseudodrusen (RPD) and to investigate their changes over 24 months. Methods In eyes with drusen and RPD and control subjects, total choroidal, luminal and stromal area were measured on optical coherence tomography B-scans converted to binary images, at baseline and after 24 months. Results Eighteen eyes of 18 subjects for each group were included. In drusen and RPD, we found reduction of mean total choroidal (p=0.0005 and p<0.0001, respectively), luminal (p=0.003 and p<0.0001, respectively) and stromal ...

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    23. Optical coherence tomography angiography in adult-onset foveomacular vitelliform dystrophy

      Optical coherence tomography angiography in adult-onset foveomacular vitelliform dystrophy

      Purpose To describe structural features of eyes with adult-onset foveomacular vitelliform dystrophy (AFVD) on optical coherence tomography angiography (OCT-A) and to evaluate the ability to detect the presence of choroidal neovascularisation (CNV). Methods Consecutive patients presenting at the University Eye Clinic of Creteil with diagnosis of AFVD were included. All patients underwent a complete ophthalmological examination, including fundus autofluorescence, fluorescein angiography, indocyanine green angiography, spectral domain optical coherence tomography and OCT-A by Optovue RTVue XR Avanti. Results Twenty-two eyes of 18 consecutive patients (8 women and 10 men; 68±12.8 years) were included. On OCT-A the presence of subretinal ...

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    1-23 of 23
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    Optical coherence tomography angiography in adult-onset foveomacular vitelliform dystrophy Choroidal structure in eyes with drusen and reticular pseudodrusen determined by binarisation of optical coherence tomographic images Optical Coherence Tomography Angiography Demonstration of Choroidal Neovascularization in Malattia Leventinese Optical coherence tomography angiography: a useful tool for diagnosis of treatment-naïve quiescent choroidal neovascularization Optical coherence tomography angiography of myopic choroidal neovascularisation Demonstration of Choroidal Neovascularization Associated With an Intraretinal Lesion on Indocyanine Green Angiography Independent of Choroidal New Vessel on Optical Coherence Tomography OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY FEATURES OF CHOROIDAL NEOVASCULARIZATION ASSOCIATED WITH CHOROIDAL NEVUS Reproducibility of vessel density, fractal dimension and foveal avascular zone using 7 different optical coherence tomography angiography devices OPTICAL COHERENCE TOMOGRAPHY 2: DIAGNOSTIC TOOL TO STUDY PERIPHERAL VITREORETINAL PATHOLOGIES OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY FINDINGS IN A CASE OF CHOROIDAL NEOVASCULARIZATION SECONDARY TO TRAUMATIC CHOROIDAL RUPTURE Post-Doctoral and Graduate Student Research Positions at the University of Illinois Urbana-Champaign Multiscale correlation of microvascular changes on optical coherence tomography angiography with retinal sensitivity in diabetic retinopathy