The potential mediating effects of inflammation on the association between Type D personality and coronary plaque vulnerability in patients with coronary artery disease: An optical coherence tomography study

Objective: Type D personality involves the interaction between negative affectivity with social inhibition and has been associated with an increased risk of coronary artery disease (CAD) progression and coronary plaque vulnerability. However, the underlying mechanisms in the relationship between Type D personality and coronary plaque vulnerability remain indeterminate. The present study examined the potential mediating effects of inflammation biomarkers on the association between Type D personality and coronary plaque vulnerability in patients with CAD. Methods: A total of 347 patients(mean age = 56.6 ± 11.2 years; 29.3 % women) with CAD who had culprit coronary plaques were examined for ...