1. Articles from Shuai Yuan

    1-11 of 11
    1. Feature Of The Week 9/25/11: University of Maryland and NIH Researchers Investigate Combined OCT and Fluorescence Imaging for Improved Colon Cancer Detection

      Feature Of The Week 9/25/11: University of Maryland and NIH Researchers Investigate Combined OCT and Fluorescence Imaging for Improved Colon Cancer Detection
      Optical Coherence Tomography (OCT) offers high-resolution imaging of the tissue microstructure. But there are numerous limitations to OCT including providing direct molecular imaging capability. A popular research thrust has recently been to combine OCT with other imaging technology such as Raman, Fluorescence, and other molecular imaging techniques to achieve a multi-modality imaging capability. This multi-modality imaging offers improved capabilities including all the normal OCT benefits as well as allowing the molecular imaging signals to be spatial registered within the tissue microstructure. This can lead to significant improvements in clinical capability including cancer detection. Researchers at the University of Maryland and ...
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    2. Rh-I-UEA-1 Polymerized Liposomes Target and Image Adenomatous Polyps in the APCMin/+ Mouse Using Optical Colonography

      Rh-I-UEA-1 Polymerized Liposomes Target and Image Adenomatous Polyps in the APCMin/+ Mouse Using Optical Colonography
      Mutated adenomatous polyposis coli (APC) genes predispose transformations to neoplasia, progressing to colorectal carcinoma. Early detection facilitates clinical management and therapy. Novel lectin-mediated polymerized targeted liposomes (Rh-I-UEA-1), with polyp specificity and incorporated imaging agents were fabricated to locate and image adenomatous polyps in APCMin/+ mice. The biomarker α-l-fucose covalently joins the liposomal conjugated lectin Ulexeuropaeus agglutinin (UEA-1), via glycosidic linkage to the polyp mucin layer. Multispectral optical imaging (MSI) corroborated a global perspective of specific binding (rhodamine B 532 nm emission, 590–620 nm excitation) of targeted Rh-I-UEA-1 polymerized liposomes to polyps with 1.4-fold labeling efficiency. High-resolution coregistered optical ...
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    3. Feature Of The Week 9/26/10: Researchers from University of Maryland Demonstrated Multimodality Optical Coherence Tomography and Fluorescence Laminar Optical Tomography Imaging

      Feature Of The Week 9/26/10: Researchers from University of Maryland Demonstrated Multimodality Optical Coherence Tomography and Fluorescence Laminar Optical Tomography Imaging
      Feature Of The Week 9/26/10: Multimodal imaging represents one of the current trends in the development of biophotonics imaging technologies for the integration of molecular and physiological information with structural information, enabling in vivo visualization and quantification of disease biomarkers and their progression over time. Multimodal imaging therefore improves the understanding of disease development, enables early diagnosis, and ultimately enhances treatment efficacy. This work presents an integration of optical coherence tomography (OCT) and fluorescence laminar optical tomography (FLOT), which combines the advantages of high-resolution structural imaging from OCT with high-sensitivity functional imaging from FLOT. This platform provides contextual ...
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    4. Integrated Optical Coherence Tomography (OCT) and Fluorescence Laminar Optical Tomography (FLOT)

      Integrated Optical Coherence Tomography (OCT) and Fluorescence Laminar Optical Tomography (FLOT)
      Multimodal imaging represents one of the current trends in the development of biophotonics imaging technologies. This paper briefly reviews current multimodal biophotonics imaging platforms in macroscopic, microscopic, and mesoscopic (or millimeter) scales. We also present a combined optical coherence tomography and line-scan fluorescence laminar optical tomography system for co-registered structural and molecular imaging with millimeter-scale imaging depth. Experimental results using a capillary phantom filled with the fluorescence dye Cy5.5 and a human breast cancer xenograft model are presented.
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    5. Integrated Optical Coherence Tomography (OCT) and Fluorescence Laminar Optical Tomography (FLOT) for Depth-Resolved Subsurface Cancer Imaging

      Integrated Optical Coherence Tomography (OCT) and Fluorescence Laminar Optical Tomography (FLOT) for Depth-Resolved Subsurface Cancer Imaging
      We developed a combined optical coherence tomography (OCT) and fluorescence laminar optical tomography (FLOT) system for co-registered depth-resolved structural and molecular imaging. Experimental results using a mouse model with human breast cancer xenograft are presented.
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    6. Co-registered optical coherence tomography and fluorescence molecular imaging for simultaneous morphological and molecular imaging

      Abstract. Optical coherence tomography (OCT) provides high-resolution, cross-sectional imaging of tissue microstructure in situ and in real time, while fluorescence molecular imaging (FMI) enables the visualization of basic molecular processes. There is a great deal of interest in combining these two modalities so that the tissue's structural and molecular information can be obtained simultaneously. This could greatly benefit biomedical applications such as detecting early diseases and monitoring therapeutic interventions. In this research, an optical system that combines OCT and FMI was developed. The system demonstrated that it could co-register en face OCT and FMI images with a 2.4 ...
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    7. Multi-modality optical tomography for simultaneous morphological and molecular imaging

      Optical coherence tomography (OCT) is an emerging medical imaging technology that can generate high resolution cross-sectional imaging (1-2 mm in depth) of tissue microstructure in situ and in real time. Fluorescence imaging provides tissue biochemical, metabolism, and molecular information by measuring fluorescence intensity or spectroscopy of either intrinsic fluorophores or exogenous contrast agents. The combination of these two modalities provides complementary morphological, functional and molecular information to comprehensively assess tissue status. There is a great interest to further extend the fluorescence imaging into tomography in order to provide depth-resolved molecular function that can be coregistered with 3-D tissue morphology provided ...
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    8. Feature Of The Week 9/6/09: Automated Quantification of Microstructural Dimensions of the Human Kidney using Optical Coherence Tomography

      Feature Of The Week 9/6/09: Automated Quantification of Microstructural Dimensions of the Human Kidney using Optical Coherence Tomography
      Feature Of The Week 9/6/09: Optical coherence tomography (OCT) is a rapidly emerging imaging modality that can non-invasively provide cross-sectional, high-resolution images of tissue morphology in situ and in real-time. Recent development in high-speed OCT enables the acquisition of a large amount of three-dimensional image d
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    9. Automated quantification of microstructural dimensions of the human kidney using optical coherence tomography (OCT)

      Automated quantification of microstructural dimensions of the human kidney using optical coherence tomography (OCT)
      Optical coherence tomography (OCT) is a rapidly emerging imaging modality that can non-invasively provide cross-sectional, highresolution images of tissue morphology in situ and in real-time. We previously demonstrated that OCT is capable of visualizing characteristic kidney anatomic structures, including blood vessels, uriniferous tubules,glomeruli, and renal capsules on a Munich–Wistar rat model. Because the viability of a donor kidney is closely correlated with its tubular morphology, and a large amount of image datasets are expected when using OCT to scan the entire kidney to provide a global assessment of its viability, it is necessary to develop automatic image analysis ...
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    10. Three-dimensional coregistered optical coherence tomography and line-scanning fluorescence laminar optical tomography

      Three-dimensional coregistered optical coherence tomography and line-scanning fluorescence laminar optical tomography
      We present a combined optical coherence tomography (OCT) and line-scanning fluorescence laminar optical tomography (FLOT) system. This hybrid system enables coregistered structural and molecular imaging in 3D with 10–100 um resolution and millimeter-scale imaging depth. Experimental results on a capillary phantom with fluorescence dye Cy5.5 using an OCT/FLOT imaging system have been demonstrated.
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    11. Combining optical coherence tomography with fluorescence molecular imaging: towards simultaneous morphology and molecular imaging

      Optical coherence tomography (OCT) provides high-resolution, cross-sectional imaging of tissue microstructure in situ and in real-time, while fluorescence molecular imaging (FMI) enables the visualization of basic molecular processes. There are great interests in combining these two modalities so that the tissue's structural and molecular information can be obtained simultaneously. This could greatly benefit biomedical applications such as detecting early diseases and monitoring therapeutic interventions. In this research, a new optical system that combines OCT and FMI was developed. The system demonstrated that it could co-register en face OCT and FMI images with a 2.4 x 2.4 mm ...
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    1-11 of 11
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    1. (11 articles) University of Maryland
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    Three-dimensional coregistered optical coherence tomography and line-scanning fluorescence laminar optical tomography Automated quantification of microstructural dimensions of the human kidney using optical coherence tomography (OCT) Feature Of The Week 9/6/09: Automated Quantification of Microstructural Dimensions of the Human Kidney using Optical Coherence Tomography Integrated Optical Coherence Tomography (OCT) and Fluorescence Laminar Optical Tomography (FLOT) Feature Of The Week 9/26/10: Researchers from University of Maryland Demonstrated Multimodality Optical Coherence Tomography and Fluorescence Laminar Optical Tomography Imaging Rh-I-UEA-1 Polymerized Liposomes Target and Image Adenomatous Polyps in the APCMin/+ Mouse Using Optical Colonography Feature Of The Week 9/25/11: University of Maryland and NIH Researchers Investigate Combined OCT and Fluorescence Imaging for Improved Colon Cancer Detection PREcise Percutaneous Coronary Intervention for Stent OptimizatION in Treatment of COMPLEX Lesion (PRECISION-COMPLEX) Real-Time Risk Score for Glaucoma Mass Screening by Spectral Domain Optical Coherence Tomography: Development and Validation Macrophages in close proximity to the vitreoretinal interface are potential biomarkers of inflammation during retinal vascular disease Vertical scan imaging of Anterior Segment Optical Coherence Tomography for descemet anchoring caterpillar seta: A case report and review of literature Evaluation of signal degradation due to birefringence in a multiple reference optical coherence tomography system with polarization-based balanced detection