1. Articles from Takashi Nishida

    1-12 of 12

    1. Combining OCT and OCT-Angiography Longitudinal Data for the Detection of Visual Field Progression in Glaucoma

      Explore American Journal of Ophthalmology Ophthalmology
      Combining OCT and OCT-Angiography Longitudinal Data for the Detection of Visual Field Progression in Glaucoma

      PURPOSE To use longitudinal optical coherence tomography (OCT) and OCT-Angiography (OCTA) data to detect glaucomatous visual field (VF) progression with a supervised machine learning approach. DESIGN Prospective cohort study. METHODS 110 eyes of glaucoma suspect (33.6%) and glaucoma (66.4%) patients with a minimum of five 24-2 VF tests and three optic nerve head and macula images over an average follow-up duration of 4.1 years were included. VF progression was defined using a composite measure including either a “likely progression event” on Guided Progression Analysis, a statistically significant negative slope of VF mean deviation or VF index, or ...

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      Mentions: UCSD

    2. Deep Learning Estimation of 10-2 Visual Field Map Based on Circumpapillary Retinal Nerve Fiber Layer Thickness Measurements

      Explore American Journal of Ophthalmology Ophthalmology
      Deep Learning Estimation of 10-2 Visual Field Map Based on Circumpapillary Retinal Nerve Fiber Layer Thickness Measurements

      PURPOSE : To estimate central 10° visual field (VF) map from spectral-domain optical coherence tomography (SD-OCT) retinal nerve fiber layer thickness (RNFL) measurements in glaucoma with artificial intelligence. DESIGN : Artificial intelligence (convolutional neural networks) study. METHODS : This study included 5352 SD-OCT and 10-2 VF pairs from 1365 eyes of 724 healthy, glaucoma suspect and glaucoma patients. Convolutional neural networks (CNN) were developed to estimate the 68 individual sensitivity thresholds of 10-2 VF map using all-sectors (CNN A ) and temporal-sectors (CNN T ) RNFL thickness information of the SD-OCT circle scan (768 thickness points). 10-2 indices including pointwise total deviation (TD) values, mean ...

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      Mentions: UCSD

    3. Association of macular OCT and OCTA parameters with visual acuity in glaucoma

      Explore BJO Online Ophthalmology
      Association of macular OCT and OCTA parameters with visual acuity in glaucoma

      Background/aims: To investigate the association of macular optical coherence tomography (OCT)/OCT angiography (OCTA) parameters with visual acuity (VA) in glaucoma. Methods: 144 pseudophakic primary open-angle glaucoma eyes were included. Foveal (fVD), parafoveal (pf), perifoveal (perifVD) and whole-image vessel densities (wiVD) of superficial and deep layers, and their corresponding ganglion cell complex (GCC) thicknesses were obtained from OCTA 6×6 mm 2 macula scans. Foveal avascular zone (FAZ) area, FAZ circumference and foveal density-300 (FD300) were measured. Correlation between OCT/OCTA parameters and Logarithm of the Minimum Angle of Resolution VA (logMAR VA) in early and moderate-advanced glaucoma was ...

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      Mentions: UCSD

    4. Factors associated with choroidal microvascular dropout change

      Explore BJO Online Ophthalmology
      Factors associated with choroidal microvascular dropout change

      Background/aims To investigate the factors associated with choroidal microvasculature drop-out (MvD) enlargement detected by optical coherence tomography angiography (OCT-A) in glaucomatous eyes. Methods Ninety-one eyes of 68 primary open-angle glaucoma patients were enrolled. Only eyes with a minimum of four good quality OCT-A and OCT scans of the optic nerve head acquired at least and with a minimum of 2 years follow-up were included. Area and angular circumference of MvD were analysed on en face images. Univariable and multivariable mixed effects models were constructed to identify the factors contributing to MvD area and angular circumference change over time. Results ...

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      Mentions: UCSD

    5. OCT Angiography Face Mask-associated Artifacts During the COVID-19 Pandemic

      Explore LWW Online Ophthalmology
      OCT Angiography Face Mask-associated Artifacts During the COVID-19 Pandemic

      Prcis: Face mask wearing has no significant effects on artifacts or vessel density measurements in optic nerve head and macular OCT-Angiography scans. Purpose: To assess the difference in area of artifacts observed in optical coherence tomography angiography (OCT-A) scans with and without face mask wear and to verify if mask wear interferes with OCT-A vessel density measurements. Subjects and controls: 64 eyes of 10 healthy subjects, 4 ocular hypertensive, 8 glaucoma suspects, and 17 glaucoma patients were included. Methods: High density optic nerve head (ONH) and macula OCT-A scans were obtained in patients with and without surgical masks. Seven different ...

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      Mentions: UCSD

    6. Association of Initial Optical Coherence Tomography Angiography Vessel Density Loss With Faster Visual Field Loss in Glaucoma

      Explore The JAMA Network Ophthalmology
      Association of Initial Optical Coherence Tomography Angiography Vessel Density Loss With Faster Visual Field Loss in Glaucoma

      Importance: Rapid vessel density loss during an initial follow-up period may be associated with the rates of visual field loss over time. Objectives: To evaluate the association between the rate of vessel density loss during initial follow-up and the rate of visual field loss during an extended follow-up period in patients suspected of having glaucoma and patients with primary open-angle glaucoma. Design, setting, and participants: This retrospective cohort study assessed 124 eyes (86 with primary open-angle glaucoma and 38 suspected of having glaucoma) of 82 patients who were followed up at a tertiary glaucoma center for a mean of 4 ...

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      Mentions: UCSD

    7. Relationship of macular ganglion cell complex thickness to choroidal microvasculature drop-out in primary open-angle glaucoma

      Explore BJO Online Ophthalmology
      Relationship of macular ganglion cell complex thickness to choroidal microvasculature drop-out in primary open-angle glaucoma

      Background/aims To investigate the rate of ganglion cell complex (GCC) thinning in primary open-angle glaucoma (POAG) patients with and without deep-layer microvasculature drop-out (MvD). Methods POAG patients who had at least 1.5 years of follow-up and a minimum of three visits were included from the Diagnostic Innovations in Glaucoma Study. MvD was detected at baseline by optical coherence tomography angiography (OCT-A). Area and angular circumference of MvD were evaluated on en face choroidal vessel density images and horizontal B-scans. Rates of global and hemisphere GCC thinning were compared in MvD and non-MvD eyes using linear mixed-effects models. Results ...

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      Mentions: UCSD

    8. Performances of machine learning in detecting glaucoma using fundus and retinal optical coherence tomography images: A meta-analysis

      Explore American Journal of Ophthalmology Ophthalmology
      Performances of machine learning in detecting glaucoma using fundus and retinal optical coherence tomography images: A meta-analysis

      Purpose To evaluate the performance of machine learning (ML) in detecting glaucoma using fundus and retinal optical coherence tomography (OCT) images. Design Meta-analysis. Methods PubMed and EMBASE were searched on August 11, 2021. Bivariate random-effects model was used to pool ML's diagnostic sensitivity, specificity, and area under the curve (AUC). Subgroup analyses were performed based on ML classifier categories and dataset types. Results 105 (3.3%) studies were retrieved. 73 (69.5%), 30 (28.6%), and 2 (1.9%) studies tested ML using fundus, OCT, and both image types, respectively. Total testing data size was 197174 for fundus and ...

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      Mentions: UCSD

    9. Measurements of OCTA Complement OCT for Diagnosing Early Primary Open Angle Glaucoma

      Explore ophthalmologyglaucoma.org Ophthalmology
      Measurements of OCTA Complement OCT for Diagnosing Early Primary Open Angle Glaucoma

      Purpose: To compare measurements of global and regional circumpapillary capillary density (cpCD) with retinal nerve fiber layer (RNFL) thickness, and characterize their relationship with visual function in early primary open-angle glaucoma (POAG). Design: Cross-sectional study PARTICIPANTS: Eighty healthy eyes, 64 pre-perimetric, and 184 mild POAG eyes from the Diagnostic Innovations in Glaucoma Study. Methods: Global and regional RNFL thickness and cpCD measurements were obtained using optical coherence tomography (OCT) and OCT angiography (OCTA). For direct comparison at the individual and diagnostic group level, RNFL thickness and capillary density values were converted to a normalized relative loss scale. Main outcome measures ...

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      Mentions: UCSD

    10. Central macular OCTA parameters in glaucoma

      Explore BJO Online Ophthalmology
      Central macular OCTA parameters in glaucoma

      Background/aims: To investigate the relationship between the foveal avascular zone (FAZ) parameters assessed by optical coherence tomography angiography (OCTA) and central visual field parameters in glaucoma and healthy subjects. Methods: One hundred and eighty-eight subjects (248 eyes), including 24 healthy (38 eyes), 37 glaucoma suspect (42 eyes, and 127 primary open angle glaucoma (POAG) patients (168 eyes), underwent imaging using OCTA and standard automated perimetry using the 24-2 and 10-2 Swedish Interactive Thresholding Algorithm. OCTA-based and OCT-based FAZ parameters (superficial FAZ area, FAZ circumference), foveal vessel density (FD300) and foveal thickness were measured. The correlation between FAZ parameters and ...

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      Mentions: UCSD

    11. Long-Term Reproducibility of Optical Coherence Tomography Angiography in Stable Glaucomatous Eyes

      Explore IOVS Journal
      Long-Term Reproducibility of Optical Coherence Tomography Angiography in Stable Glaucomatous Eyes

      Purpose : To assess and compare long-term reproducibility of optical coherence tomography angiography (OCTA) vascular parameters and spectral-domain optical coherence tomography (OCT) thickness parameters in stable glaucoma, glaucoma suspect, and healthy eyes. Methods : A total of 88 eyes (15 healthy, 38 glaucoma suspect, and 35 non-progressive POAG) of 68 subjects were enrolled who had at least 3 visits within 1 to 1.5 years and both OCT and OCTA (Optovue Inc, Fremont, California, USA) imaging on the same day. A series of vascular and thickness parameters were measured including macula whole image vessel density (wiVD), optic nerve head (ONH) circumpapillary capillary ...

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      Mentions: Visionix Carl Zeiss Meditec UCSD
    1-12 of 12
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    Sequential Optical Coherence Tomography Images of Early Macular Necrosis Caused by Acute Retinal Necrosis in Non-Human Immunodeficiency Virus Patients Long-Term Reproducibility of Optical Coherence Tomography Angiography in Stable Glaucomatous Eyes Central macular OCTA parameters in glaucoma Measurements of OCTA Complement OCT for Diagnosing Early Primary Open Angle Glaucoma Performances of machine learning in detecting glaucoma using fundus and retinal optical coherence tomography images: A meta-analysis Relationship of macular ganglion cell complex thickness to choroidal microvasculature drop-out in primary open-angle glaucoma Association of Initial Optical Coherence Tomography Angiography Vessel Density Loss With Faster Visual Field Loss in Glaucoma OCT Angiography Face Mask-associated Artifacts During the COVID-19 Pandemic Association of macular OCT and OCTA parameters with visual acuity in glaucoma Deep Learning Estimation of 10-2 Visual Field Map Based on Circumpapillary Retinal Nerve Fiber Layer Thickness Measurements Association of retinal thickness and microvasculature with cognitive performance and brain volumes in elderly adults A Deep Learning Framework for the Detection and Quantification of Reticular Pseudodrusen and Drusen on Optical Coherence Tomography