1. Articles from Gopi Maguluri

    1-10 of 10
    1. Synchronized, concurrent optical coherence tomography and videostroboscopy for monitoring vocal fold morphology and kinematics

      Synchronized, concurrent optical coherence tomography and videostroboscopy for monitoring vocal fold morphology and kinematics

      Voice disorders affect a large number of adults in the United States, and their clinical evaluation heavily relies on laryngeal videostroboscopy, which captures the medial-lateral and anterior-posterior motion of the vocal folds using stroboscopic sampling. However, videostroboscopy does not provide direct visualization of the superior-inferior movement of the vocal folds, which yields important clinical insight. In this paper, we present a novel technology that complements videostroboscopic findings by adding the ability to image the coronal plane and visualize the superior-inferior movement of the vocal folds. The technology is based on optical coherence tomography, which is combined with videostroboscopy within the ...

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    2. Evaluation of a Combined Reflectance Confocal Microscopy–Optical Coherence Tomography Device for Detection and Depth Assessment of Basal Cell Carcinoma

      Evaluation of a Combined Reflectance Confocal Microscopy–Optical Coherence Tomography Device for Detection and Depth Assessment of Basal Cell Carcinoma

      Importance The limited tissue sampling of a biopsy can lead to an incomplete assessment of basal cell carcinoma (BCC) subtypes and depth. Reflectance confocal microscopy (RCM) combined with optical coherence tomography (OCT) imaging may enable real-time, noninvasive, comprehensive three-dimensional sampling in vivo, which may improve the diagnostic accuracy and margin assessment of BCCs. Objective To determine the accuracy of a combined RCM-OCT device for BCC detection and deep margin assessment. Design, Setting, and Participants This pilot study was carried out on 85 lesions from 55 patients referred for physician consultation or Mohs surgery at Memorial Sloan Kettering Skin Cancer Center ...

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      Mentions: Nicusor Iftimia
    3. Investigation of tissue cellularity at the tip of the core biopsy needle with optical coherence tomography

      Investigation of tissue cellularity at the tip of the core biopsy needle with optical coherence tomography

      We report the development and the pre-clinical testing of a new technology based on optical coherence tomography (OCT) for investigating tissue composition at the tip of the core biopsy needle. While ultrasound, computed tomography, and magnetic resonance imaging are routinely used to guide needle placement within a tumor, they still do not provide the resolution needed to investigate tissue cellularity (ratio between viable tumor and benign stroma) at the needle tip prior to taking a biopsy core. High resolution OCT imaging, however, can be used to investigate tissue morphology at the micron scale, and thus to determine if the biopsy ...

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    4. Handheld optical coherence tomography–reflectance confocal microscopy probe for detection of basal cell carcinoma and delineation of margins

      Handheld optical coherence tomography–reflectance confocal microscopy probe for detection of basal cell carcinoma and delineation of margins

      We present a hand-held implementation and preliminary evaluation of a combined optical coherence tomography (OCT) and reflectance confocal microscopy (RCM) probe for detecting and delineating the margins of basal cell carcinomas (BCCs) in human skin in vivo . A standard OCT approach (spectrometer-based) with a central wavelength of 1310 nm and 0.11 numerical aperture (NA) was combined with a standard RCM approach (830-nm wavelength and 0.9 NA) into a common path hand-held probe. Cross-sectional OCT images and enface RCM images are simultaneously displayed, allowing for three-dimensional microscopic assessment of tumor morphology in real time. Depending on the subtype and ...

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    5. Integrating optical coherence tomography with laryngeal videostroboscopy

      Integrating optical coherence tomography with laryngeal videostroboscopy

      During clinical voice assessment, laryngologists and speech-language pathologists rely heavily on laryngeal endoscopy with videostroboscopy to evaluate pathology and dysfunction of the vocal folds. The cost effectiveness, ease of use, and synchronized audio and visual feedback provided by videostroboscopic assessment serve to maintain its predominant clinical role in laryngeal imaging. However, significant drawbacks include only two-dimensional spatial imaging and the lack of subsurface morphological information. A novel endoscope will be presented that integrates optical coherence tomography that is spatially and temporally co-registered with laryngeal videoendoscopic technology through a common path probe. Optical coherence tomography is a non-contact, micron-resolution imaging technology ...

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    6. Investigation of middle ear anatomy and function with combined video otoscopy-phase sensitive OCT

      Investigation of middle ear anatomy and function with combined video otoscopy-phase sensitive OCT

      We report the development of a novel otoscopy probe for assessing middle ear anatomy and function. Video imaging and phase-sensitive optical coherence tomography are combined within the same optical path. A sound stimuli channel is incorporated as well to study middle ear function. Thus, besides visualizing the morphology of the middle ear, the vibration amplitude and frequency of the eardrum and ossicles are retrieved as well. Preliminary testing on cadaveric human temporal bone models has demonstrated the capability of this instrument for retrieving middle ear anatomy with micron scale resolution, as well as the vibration of the tympanic membrane and ...

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    7. Combined reflectance confocal microscopy-optical coherence tomography for delineation of basal cell carcinoma margins: an ex vivo study

      Combined reflectance confocal microscopy-optical coherence tomography for delineation of basal cell carcinoma margins: an ex vivo study

      We present a combined reflectance confocal microscopy (RCM) and optical coherence tomography (OCT) approach, integrated within a single optical layout, for diagnosis of basal cell carcinomas (BCCs) and delineation of margins. While RCM imaging detects BCC presence (diagnoses) and its lateral spreading (margins) with measured resolution of ∼ 1    μ m ∼1  μm , OCT imaging delineates BCC depth spreading (margins) with resolution of ∼ 7    μ m ∼7  μm . When delineating margins in 20 specimens of superficial and nodular BCCs, depth could be reliably determined down to ∼600    μ m ∼600  μm , and agreement with histology was within about ±50    μ m ±50  μm .

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    8. Hand scanning optical coherence tomography imaging using encoder feedback

      Hand scanning optical coherence tomography imaging using encoder feedback

      We present a new method for generating micron-scale OCT images of interstitial tissue with a hand scanning probe and a linear optical encoder that senses probe movement relative to a fixed reference point, i.e., tissue surface. Based on this approach, we demonstrate high resolution optical imaging of biological tissues through a very long biopsy needle. Minor artifacts caused by tissue noncompliance are corrected using a software algorithm which detects the simple repetition of the adjacent A-scans. This hand-scanning OCT imaging approach offers the physician the freedom to access imaging sites of interest repeatedly.

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    9. In vivo imaging of human burn injuries with polarization-sensitive optical coherence tomography

      In vivo imaging of human burn injuries with polarization-sensitive optical coherence tomography

      The accurate determination of burn depth is critical in the clinical management of burn wounds. Polarization-sensitive optical coherence tomography (PS-OCT) has been proposed as a potentially non-invasive method for determining burn depth by measuring thermally induced changes in the structure and birefringence of skin, and has been investigated in pre-clinical burn studies with animal models and ex vivo human skin. In this study, we applied PS-OCT to the in-vivo imaging of two pediatric burn patients. Deep and superficial burned skins along with contralateral controls were imaged in 3D. The imaging size was 8  mm×6  mm×2  mm in width ...

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    10. Three dimensional tracking for volumetric spectral-domain optical coherence tomography

      Gopi Maguluri, Mircea Mujat, B. H. Park, K. H. Kim, Wei Sun, N. V. Iftimia, R. D. Ferguson, Daniel X. Hammer, Teresa C. Chen, Johannes F. de BoerWe present a three-dimensional (3D) tracker for a clinical ophthalmic spectral domain optical coherence tomography (SD-OCT) system that combines depth-tracking with lateral tracking, providing a stabilized reference frame for 3D data recording and post acquisition analysis. The depth-tracking ... [Opt. Express 15, 16808-16817 (2007)]

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    1-10 of 10
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  2. Topics in the News

    1. (9 articles) Nicusor Iftimia
    2. (8 articles) Physical Sciences Incorporated
    3. (5 articles) Harvard University
    4. (5 articles) Massachusetts General Hospital
    5. (3 articles) Ernest W. Chang
    6. (2 articles) Massachusetts Eye and Ear Infirmary
    7. (2 articles) Ki Hean Kim
    8. (2 articles) B. Hyle Park
    9. (2 articles) R. Daniel Ferguson
    10. (2 articles) Johannes F. de Boer
    11. (2 articles) Harvard University
    12. (2 articles) Massachusetts General Hospital
    13. (2 articles) Carl Zeiss Meditec
    14. (1 articles) Medical University of Vienna
    15. (1 articles) University of Hong Kong
    16. (1 articles) Guillermo J. Tearney
    17. (1 articles) Desmond C. Adler
    18. (1 articles) Matthew J. Everett
    19. (1 articles) Nathan D. Shemonski
    20. (1 articles) Ursula Schmidt-Erfurth
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    In vivo imaging of human burn injuries with polarization-sensitive optical coherence tomography Hand scanning optical coherence tomography imaging using encoder feedback Combined reflectance confocal microscopy-optical coherence tomography for delineation of basal cell carcinoma margins: an ex vivo study Investigation of middle ear anatomy and function with combined video otoscopy-phase sensitive OCT Integrating optical coherence tomography with laryngeal videostroboscopy Handheld optical coherence tomography–reflectance confocal microscopy probe for detection of basal cell carcinoma and delineation of margins Investigation of tissue cellularity at the tip of the core biopsy needle with optical coherence tomography Evaluation of a Combined Reflectance Confocal Microscopy–Optical Coherence Tomography Device for Detection and Depth Assessment of Basal Cell Carcinoma Synchronized, concurrent optical coherence tomography and videostroboscopy for monitoring vocal fold morphology and kinematics Artificial intelligence, the internet of things, and virtual clinics: ophthalmology at the digital translation forefront Detecting glaucoma based on spectral domain optical coherence tomography imaging of peripapillary retinal nerve fiber layer: a comparison study between hand-crafted features and deep learning model Comparison of line‐field confocal optical coherence tomography images with histological sections: Validation of a new method for in vivo and non‐invasive quantification of superficial dermis thickness