1. Articles from Wenyong Huang

    1-14 of 14
    1. Retinal Microvasculature and Choriocapillaris Flow Deficit in Relation to Serum Uric Acid Using Swept-Source Optical Coherence Tomography Angiography

      Retinal Microvasculature and Choriocapillaris Flow Deficit in Relation to Serum Uric Acid Using Swept-Source Optical Coherence Tomography Angiography

      Purpose: To explore the relationship between serum uric acid (SUA) and retinochoroidal microcirculation in the Chinese population. Methods: This prospective cross-sectional study was conducted among the residents of Guangzhou, southern China. A commercially available optical coherence tomography angiography (OCTA) device was used to obtain the superficial vessel density (SVD) and deep vessel density in the retina and the choriocapillaris flow deficit (CFD) in the macular region. Univariable and multivariable linear regression models were used to assess the association of hyperuricemia and SUA levels with OCTA parameters. Results: A total of 638 participants with normal SUA and 296 participants with hyperuricemia ...

      Read Full Article
    2. Peripapillary Microvasculature Predicts the Incidence and Development of Diabetic Retinopathy: An SS-OCTA Study

      Peripapillary Microvasculature Predicts the Incidence and Development of Diabetic Retinopathy: An SS-OCTA Study

      Purpose : To examine the associations of peripapillary microvascular metrics with diabetic retinopathy (DR) incidence and development using swept-source optical coherence tomography angiography (SS-OCTA). Design : Prospective cohort study. Methods : 1033 eyes from 1033 type II diabetes mellitus (T2D) patients were included with 2-year follow-up. The peripapillary microvascular metrics at the superficial capillary plexus (SCP) were measured by SS-OCTA at the baseline, including peripapillary vascular density (pVD) and vascular length density (pVLD). The DR incidence and progression were evaluated with seven standard fields of stereoscopic color fundus photographs. The associations were tested with logistic regression models after adjusting established risk factors and ...

      Read Full Article
    3. Prediction of Retinal Ganglion Cell Counts Considering Various Displacement Methods From OCT-Derived Ganglion Cell-Inner Plexiform Layer Thickness

      Prediction of Retinal Ganglion Cell Counts Considering Various Displacement Methods From OCT-Derived Ganglion Cell-Inner Plexiform Layer Thickness

      Purpose: To compare various displacement models using midget retinal ganglion cell to cone (mRGC:C) ratios and to determine viability of estimating RGC counts from optical coherence tomography (OCT)-derived ganglion cell-inner plexiform layer (GCIPL) measurements. Methods: Four Drasdo model variations were applied to macular visual field (VF) stimulus locations: (1) using meridian-specific Henle fiber length along the stimulus circumference; (2) using meridian-specific differences in RGC receptive field and counts along the stimulus circumference; (3) per method (2), averaged across principal meridians; and (4) per method (3), with the stimulus center displaced only. The Sjöstrand model was applied (5 ...

      Read Full Article
    4. Choriocapillaris flow deficit and the risk of referable diabetic retinopathy: a longitudinal SS-OCTA study

      Choriocapillaris flow deficit and the risk of referable diabetic retinopathy: a longitudinal SS-OCTA study

      Aims To investigate the association between the choriocapillaris flow deficit percentage (CC FD%) and the 1-year incidence of referable diabetic retinopathy (RDR) in participants with type 2 diabetes mellitus (DM). Methods This prospective cohort study included participants with type 2 DM. The DR status was graded based on the ETDRS-7 photography. The CC FD% in the central 1 mm area, inner circle (1.5 mm to 2.5 mm), outer circle (2.5 mm to 5.0 mm) and the entire area in the macular region were measured using swept-source optical coherence tomography angiography (SS-OCTA). Logistic regression analysis was used ...

      Read Full Article
    5. Choriocapillaris perfusion assessed using swept source optical coherence tomographic angiography and the severity of diabetic retinopathy

      Choriocapillaris perfusion assessed using swept source optical coherence tomographic angiography and the severity of diabetic retinopathy

      Aims: To investigate the relationship between choriocapillaris (CC) blood perfusion and the severity of diabetic retinopathy (DR) using swept-source optical coherence tomography angiography (SS-OCTA). Methods: Type 2 diabetes mellitus in the Guangzhou was recruited. DR was graded according to the standardised seven-field colour retinal images adhering to the ETDRS scale. CC perfusion was quantified by evaluating the flow deficit (FD) density, FD number and FD size using SS-OCTA. Multivariable linear regressions were used to evaluate the correlation between CC FD metrics and DR severity. Results: A total of 1692 patients (eyes) were included in the final analysis. Participants with DR ...

      Read Full Article
    6. Segmentation Errors in the Measurement of Volumetric Parameters by Swept-Source Anterior Segment Optical Coherence Tomography

      Segmentation Errors in the Measurement of Volumetric Parameters by Swept-Source Anterior Segment Optical Coherence Tomography

      Purpose: To investigate the error rate of segmentation in the automatic measurement of anterior chamber volume (ACV) and iris volume (IV) by swept-source anterior segment optical coherence tomography (SS-ASOCT) in narrow-angle and wide-angle eyes. Methods: In this study, fifty eyes from 25 narrow-angle subjects and fifty eyes from 25 wide-angle subjects were enrolled. SS-ASOCT examinations were performed and each SS-ASOCT scan was reviewed, and segmentation errors in the automatic measurement of ACV and IV were classified and manually corrected. Error rates were compared between the narrow-angle and the wide-angle groups, and ACV and IV before and after manual correction were ...

      Read Full Article
    7. Analysis of Iris volume using swept-source optical coherence tomography in patients with type 2 diabetes mellitus

      Analysis of Iris volume using swept-source optical coherence tomography in patients with type 2 diabetes mellitus

      Purpose: To evaluate iris volume before and after pupil dilation using swept-source anterior segment optical coherence tomography (SS-ASOCT) and investigate the associated factors of iris volume and iris volume change after pupil dilation in patients with type 2 diabetes mellitus (T2DM). Methods: A cross-sectional study was conducted in Zhongshan Ophthalmic Center among T2DM registered patients in the community of Guangzhou, China. Anterior chamber volume (ACV), iris volume, anterior chamber depth (ACD), angle opening distance at 500 μm (AOD 500) and pupil diameter were estimated using SS-ASOCT (CASIA; Tomey, Nagoya, Japan). Venous blood was taken for the measurement of glycosylated haemoglobin ...

      Read Full Article
    8. Macular vessel density in diabetes and diabetic retinopathy with swept-source optical coherence tomography angiography

      Macular vessel density in diabetes and diabetic retinopathy with swept-source optical coherence tomography angiography

      Purpose Previous studies on the association between macular vessel density (VD) and diabetic retinopathy had conflicting conclusions. This study assessed the alterations of macular VD, as well as other factors, in diabetic patients using swept-source optical coherence tomography angiography (SS-OCTA) in a large-scale sample from Chinese communities. Methods Patients with type 2 diabetes without history of ocular treatment were recruited from 2017 to 2018. The average and quadrant parafoveal vessel density (PVD) were obtained with a commercial SS-OCTA device (Triton, Topcon, Japan). The univariate and multivariate linear regression was used to analyse the correlation of PVD with diabetic retinopathy (DR ...

      Read Full Article
    9. Relationship Between Renal Function and Choroidal Thickness in Type 2 Diabetic Patients Detected by Swept-Source Optical Coherence Tomography

      Relationship Between Renal Function and Choroidal Thickness in Type 2 Diabetic Patients Detected by Swept-Source Optical Coherence Tomography

      Purpose : To investigate the relationship between renal function and choroidal thickness (CT) in ocular treatment-naïve patients with diabetes mellitus using swept-source optical coherence tomography (SS-OCT). Methods : This cross-sectional study recruited type 2 diabetes mellitus (T2DM) patients with no history of ocular treatment from communities in Guangzhou, China. The estimated glomerular filtration rates (eGFR) were calculated by using the Xiangya formula. The impaired renal function was defined as eGFR < 60 mL/(min 1.73 m 2 ). The choroid was imaged by using an SS-OCT, and the macular CT was quantified automatically in Early Treatment Diabetic Retinopathy Study maps, and only ...

      Read Full Article
    10. Association of renal function with retinal vessel density in patients with type 2 diabetes by using swept-source optical coherence tomographic angiography

      Association of renal function with retinal vessel density in patients with type 2 diabetes by using swept-source optical coherence tomographic angiography

      Aims To investigate the relationship between retinal vessel density and renal function in patients with diabetes mellitus (DM) using non-invasive optical coherence tomographic angiography (OCTA). Methods This prospective cross-sectional study recruited ocular-treatment-naïve patients with DM registered in the community of Guangzhou, China. The retinal vessel density of the superficial capillary plexus in the macula was obtained by using swept-source OCTA imaging. The Xiangya equation was used to calculate the estimated glomerular filtrate rate (eGFR). Participants were divided into the following groups by eGFR: no chronic kidney disease (non-CKD), mild CKD and moderate-to-severe CKD (MS-CKD). Results A total of 874 ...

      Read Full Article
    11. Macular vessel density in diabetes and diabetic retinopathy with swept-source optical coherence tomography angiography

      Macular vessel density in diabetes and diabetic retinopathy with swept-source optical coherence tomography angiography

      Purpose: Previous studies on the association between macular vessel density (VD) and diabetic retinopathy had conflicting conclusions. This study assessed the alterations of macular VD, as well as other factors, in diabetic patients using swept-source optical coherence tomography angiography (SS-OCTA) in a large-scale sample from Chinese communities. Methods: Patients with type 2 diabetes without history of ocular treatment were recruited from 2017 to 2018. The average and quadrant parafoveal vessel density (PVD) were obtained with a commercial SS-OCTA device (Triton, Topcan, Japan). Univariate and multivariate linear regression was used to analyse the correlation of PVD with diabetic retinopathy (DR), diabetic ...

      Read Full Article
    12. The influence of insulin therapy on measurements of optical coherence tomography parameters in diabetic patients without retinopathy

      The influence of insulin therapy on measurements of optical coherence tomography parameters in diabetic patients without retinopathy

      Purpose To determine whether there was a change in the fundus of the eye in diabetic patients without retinopathy after insulin therapy. Methods The diabetic patients without retinopathy were included in this study. A swept-source optical coherence tomography/angiography (SS-OCT/A) was used to obtain the measurements of macular retinal nerve fibre layer (mRNFL) thickness, ganglion cell-inner plexiform layer (GC-IPL) thickness, retinal thickness (RT), macular choroidal thickness (MCT), peripapillary retinal nerve fibre layer (pRNFL) thickness, peripapillary choroidal thickness (PCT), and perfused vascular density (PVD). Univariable and multivariable regression analyses were performed to explore the influence of insulin use on measurements ...

      Read Full Article
    13. Qualitative and quantitative assessment of posterior segment optical coherence tomography images using standard photos: the Liwan Eye Study

      Qualitative and quantitative assessment of posterior segment optical coherence tomography images using standard photos: the Liwan Eye Study

      Background/aims To develop a standardised grading scheme, using standard photos, for spectral-domain ocular coherence tomography (SD-OCT) images of the posterior eye and evaluate the interobserver agreement among trained ophthalmologists in identifying pathological changes. Methods Subjects were recruited from Liwan District, Guangzhou, with SD-OCT data collection from June 2013 to November 2013 as part of 10-year follow-up visits from the Liwan Eye Study. All subjects underwent SD-OCT imaging of the macula with scanning lines analysed by two ophthalmologists to assess for the presence of 12 different posterior segment lesions. Per cent agreement for each lesion between the graders and quantitative ...

      Read Full Article
    14. Choroidal thickness changes in obstructive sleep apnea syndrome: a systematic review and meta-analysis

      Choroidal thickness changes in obstructive sleep apnea syndrome: a systematic review and meta-analysis

      Purpose Obstructive sleep apnea syndrome (OSAS) is a common chronic disorder associated with hypoxia and endothelial and vascular dysfunction. Many studies have analyzed choroidal thickness measurements in patients with different severities of OSAS versus normal subjects by optical coherence tomography (OCT), but the results have been inconsistent. Therefore, a meta-analysis was performed to evaluate the choroidal thickness changes in OSAS measured by OCT. Methods Pertinent studies were retrieved by a comprehensive search of PubMed, Embase, Web of Science, and the Cochrane Library from inception to August 2015. For continuous outcomes, the weighted mean difference (WMD) and 95 % confidence interval (CI ...

      Read Full Article
    1-14 of 14
  1. Categories

    1. Applications:

      Art, Cardiology, Dentistry, Dermatology, Developmental Biology, Gastroenterology, Gynecology, Microscopy, NDE/NDT, Neurology, Oncology, Ophthalmology, Other Non-Medical, Otolaryngology, Pulmonology, Urology
    2. Business News:

      Acquisition, Clinical Trials, Funding, Other Business News, Partnership, Patents
    3. Technology:

      Broadband Sources, Probes, Tunable Sources
    4. Miscellaneous:

      Jobs & Studentships, Student Theses, Textbooks
  2. Topics in the News

    1. (13 articles) Sun Yat-Sen University
    2. (2 articles) Topcon Medical Systems
    3. (1 articles) Harvard University
    4. (1 articles) The Chinese University of Hong Kong
    5. (1 articles) University of Melbourne
    6. (1 articles) Tomey Corporation
    7. (1 articles) University of Maryland
    8. (1 articles) University of Copenhagen
    9. (1 articles) Harbin Medical University
    10. (1 articles) Tianjin University
    11. (1 articles) Baylor College of Medicine
  3. Popular Articles

  4. Picture Gallery

    Choroidal thickness changes in obstructive sleep apnea syndrome: a systematic review and meta-analysis Qualitative and quantitative assessment of posterior segment optical coherence tomography images using standard photos: the Liwan Eye Study The influence of insulin therapy on measurements of optical coherence tomography parameters in diabetic patients without retinopathy Macular vessel density in diabetes and diabetic retinopathy with swept-source optical coherence tomography angiography Association of renal function with retinal vessel density in patients with type 2 diabetes by using swept-source optical coherence tomographic angiography Relationship Between Renal Function and Choroidal Thickness in Type 2 Diabetic Patients Detected by Swept-Source Optical Coherence Tomography Macular vessel density in diabetes and diabetic retinopathy with swept-source optical coherence tomography angiography Analysis of Iris volume using swept-source optical coherence tomography in patients with type 2 diabetes mellitus Segmentation Errors in the Measurement of Volumetric Parameters by Swept-Source Anterior Segment Optical Coherence Tomography Choriocapillaris perfusion assessed using swept source optical coherence tomographic angiography and the severity of diabetic retinopathy Peripapillary Vessel Density in Relation to Optic Disc Drusen: A Multimodal Optical Coherence Tomography Study Repeatability and reliability of semi-automated anterior segment-optical coherence tomography imaging compared to manual analysis in normal and keratoconus eyes