1. Articles from Clement Apelian

    1-5 of 5
    1. Full-Field Optical Coherence Tomography as a Diagnosis Tool: Recent Progress with Multimodal Imaging

      Full-Field Optical Coherence Tomography as a Diagnosis Tool: Recent Progress with Multimodal Imaging

      Full-field optical coherence tomography (FF-OCT) is a variant of OCT that is able to register 2D en face views of scattering samples at a given depth. Thanks to its superior resolution, it can quickly reveal information similar to histology without the need to physically section the sample. Sensitivity and specificity levels of diagnosis performed with FF-OCT are 80% to 95% of the equivalent histological diagnosis performances and could therefore benefit from improvement. Therefore, multimodal systems have been designed to increase the diagnostic performance of FF-OCT. In this paper, we will discuss which contrasts can be measured with such multimodal systems ...

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    2. Extracting relevant information for cancer diagnosis from dynamic full field OCT through image processing and learning

      Extracting relevant information for cancer diagnosis from dynamic full field OCT through image processing and learning

      For a large number of cancer surgeries, the lack of reliable intraoperative diagnosis leads to reoperations or bad outcomes for the patients. To deliver better diagnosis, we developed Dynamic Full Field OCT (D-FFOCT) as a complement to FFOCT. FFOCT already presents interesting results for cancer diagnosis e.g. Mohs surgery and reaching 96% accuracy on prostate cancer. D-FFOCT accesses the dynamic processes of metabolism and gives new tools to diagnose the state of a tissue at the cellular level to complement FFOCT contrast. We developed a processing framework that intends to maximize the information provided by the FFOCT technology as ...

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    3. En face coherence microscopy [Invited]

      En face coherence microscopy [Invited]

      En face coherence microscopy or flying spot or full field optical coherence tomography or microscopy (FF-OCT/FF-OCM) belongs to the OCT family because the sectioning ability is mostly linked to the source coherence length. In this article we will focus our attention on the advantages and the drawbacks of the following approaches: en face versus B scan tomography in terms of resolution, coherent versus incoherent illumination and influence of aberrations, and scanning versus full field imaging. We then show some examples to illustrate the diverse applications of en face coherent microscopy and show that endogenous or exogenous contrasts can add ...

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    4. Dynamic full field optical coherence tomography: subcellular metabolic contrast revealed in tissues by interferometric signals temporal analysis

      Dynamic full field optical coherence tomography: subcellular metabolic contrast revealed in tissues by interferometric signals temporal analysis

      We developed a new endogenous approach to reveal subcellular metabolic contrast in fresh ex vivo tissues taking advantage of the time dependence of the full field optical coherence tomography interferometric signals. This method reveals signals linked with local activity of the endogenous scattering elements which can reveal cells where other OCT-based techniques fail or need exogenous contrast agents. We benefit from the micrometric transverse resolution of full field OCT to image intracellular features. We used this time dependence to identify different dynamics at the millisecond scale on a wide range of organs in normal or pathological conditions.

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    5. Dynamic full field optical coherence tomography: subcellular metabolic contrast revealed in tissues by temporal analysis of interferometric signals

      Dynamic full field optical coherence tomography: subcellular metabolic contrast revealed in tissues by temporal analysis of interferometric signals

      We developed a new endogenous approach to reveal subcellular metabolic contrast in fresh ex vivo tissues taking advantage of the time dependence of the full field optical coherence tomography interferometric signals. This method reveals signals linked with local activity of the endogenous scattering elements which can reveal cells where other imaging techniques fail or need exogenous contrast agents. We benefit from the micrometric transverse resolution of full field OCT to image intracellular features. We used this time dependence to identify different dynamics at the millisecond scale on a wide range of organs in normal or pathological conditions.

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    1-5 of 5
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  2. Topics in the News

    1. (5 articles) ESPCI ParisTech
    2. (5 articles) Claude Boccara
    3. (2 articles) Fabrice Harms
    4. (2 articles) LLTech
    5. (1 articles) Kate Grieve
    6. (1 articles) Amir Nahas
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    Dynamic full field optical coherence tomography: subcellular metabolic contrast revealed in tissues by temporal analysis of interferometric signals Dynamic full field optical coherence tomography: subcellular metabolic contrast revealed in tissues by interferometric signals temporal analysis En face coherence microscopy [Invited] Extracting relevant information for cancer diagnosis from dynamic full field OCT through image processing and learning Full-Field Optical Coherence Tomography as a Diagnosis Tool: Recent Progress with Multimodal Imaging Optical coherence tomography angiography in pituitary tumor The multiple scattering limit in optical microscopy Plaque Progression: Slow Linear or Rapid Stepwise? The use of optical coherence tomography angiography in pachychoroid spectrum diseases: a concurrent comparison with dye angiography Visualizing Micro-anatomical Structures of the Posterior Cornea with Micro-optical Coherence Tomography Deep capillary plexus impairment in patients with type 1 diabetes mellitus with no signs of diabetic retinopathy revealed using optical coherence tomography angiography Tissue characterization with depth-resolved attenuation coefficient and backscatter term in intravascular optical coherence tomography images