1. Articles from Bin Liu

    1-16 of 16
    1. A Multicenter RCT of OCT-Guided Reperfusion in STEMI With Early Infarct Artery Patency

      A Multicenter RCT of OCT-Guided Reperfusion in STEMI With Early Infarct Artery Patency

      Objectives The aim of this study was to test whether optical coherence tomographic (OCT) guidance would provide additional useful information beyond that obtained by angiography and lead to a shift in reperfusion strategy and improved clinical outcomes in patients with ST-segment elevation myocardial infarction (STEMI) with early infarct artery patency. Background Angiography is limited in assessing the underlying pathophysiological mechanisms of the culprit lesion. Methods EROSION III (Optical Coherence Tomography–Guided Reperfusion in ST-Segment Elevation Myocardial Infarction With Early Infarct Artery Patency) is an open-label, prospective, multicenter, randomized, controlled study approved by the ethics committees of participating centers. Patients with ...

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    2. Optical coherence tomography-guided drug coated balloon in non-small de novo coronary artery lesions: a prospective clinical research

      Optical coherence tomography-guided drug coated balloon in non-small de novo coronary artery lesions: a prospective clinical research

      Purpose: The combined use of drug coated balloon (DCB) and optical coherence tomography (OCT) for the treatment of non-small coronary de novo lesion remains to be evaluated. We investigated the safety and efficacy of OCT-guided DCB in non-small coronary de novo lesion patients with predilation of cutting balloon. Methods: https://clinicaltrials.gov/, ClinicalTrials.gov Identifier: NCT04795144. This study was a prospective, and open-label study. We enrolled patients with non-small de novo lesions treated with OCT-guided DCB. The non-small de novo lesions indicated vessel lesions with a diameter ≥ 2.5 mm. The primary endpoints were the success rate of the procedure ...

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    3. System and method for calibrated spectral domain optical coherence tomography and low coherence interferometry

      System and method for calibrated spectral domain optical coherence tomography and low coherence interferometry

      Systems and methods for enhancing spectral domain optical coherence tomography (OCT] are provided. In particular, a system and method for calibration of spectral interference signals using an acquired calibration signal are provided. The calibration signal may be logarithmically amplified to further improve the accuracy of the calibration. From the calibration signal, a series of more accurate calibration data are calculated. An acquired spectral interference signal is calibrated using these calibration data. Moreover, systems that include logarithmic amplification of the spectral interference signal and variable band-pass filtering of the spectral interference signal are provided. Such systems increase the dynamic range and ...

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    4. Fossilized Teeth as a New Robust and Reproducible Standard for Polarization-Sensitive Optical Coherence Tomography

      Fossilized Teeth as a New Robust and Reproducible Standard for Polarization-Sensitive Optical Coherence Tomography

      A clinical need exists for a cheap and efficient standard for polarization sensitive optical coherence tomography (PS-OCT). We utilize prehistoric fossilized teeth from the Megalodon shark and European horse as an unconventional, yet robust standard. Given their easy accessibility and the microstructural consistency conferred by the process of fossilization, they provide a means of calibration to reduce error from sources such as catheter bending and temperature changes. We tested the maximum difference in birefringence values in each tooth and found the fossilized teeth to be fast and repeatable. The results were compared to measurements from bovine meniscus, tendon, and destroyed ...

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    5. The Application of Optical Coherence Tomography in Musculoskeletal Disease

      The Application of Optical Coherence Tomography in Musculoskeletal Disease

      Many musculoskeletal disorders (MDs) are associated with irreversible bone and cartilage damage; this is particularly true for osteoarthritis (OA). Therefore, a clinical need exists for modalities which can detect OA and other MDs at early stages. Optical coherence tomography (OCT) is an infrared-based imaging, currently FDA approved in cardiology and ophthalmology, which has a resolution greater than 10 microns and acquisition rate of 120 frames/second. It has shown feasibility for imaging early OA, identifying changes prior to cartilage thinning both in vitro and in vivo in patients and in OA animal models. In addition, OCT has shown an ability ...

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    6. Single-Detector Polarization-Sensitive Optical Coherence Tomography for Assessment of Rotator Cuff Tendon Integrity

      Single-Detector Polarization-Sensitive Optical Coherence Tomography for Assessment of Rotator Cuff Tendon Integrity

      This preliminary study assessed trimmed supraspinatus tendons from rotator cuff repairs (RCRs) to compare the samples’ surgically cut ends and torn ends with histopathology and polarization-sensitive optical coherence tomography (PS-OCT) imaging. PS-OCT can be used to assess collagen content and organization in birefringent tissue and shows promise in RCR. The data were compared to determine correlations between luminosity measured from histopathology and PS-OCT. Bivariate plots and a simple regression were performed to assess the linearity of the 2 groups, with a predictive value of less than .05 showing significant correlation. Approximately 50% of the visually inspected supraspinatus tendons acceptable for ...

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    7. Towards Improved Collagen Assessment: Polarization-Sensitive Optical Coherence Tomography with Tailored Reference Arm Polarization

      Towards Improved Collagen Assessment: Polarization-Sensitive Optical Coherence Tomography with Tailored Reference Arm Polarization

      Single channel PS-OCT has advantages for assessing birefringent tissue components in various clinical scenarios, with implications for assessing pathology, ranging from osteoarthritis to myocardial infarction. While the technique has been successfully used both in vitro and in vivo, there have been limited attempts to optimize single channel PS-OCT with respect to performance, particularly paddle rotation. In this study, we developed and tested a new approach for the real-time assessment of birefringence through tailoring of reference arm polarization. Different polarization rotation patterns, as depicted on a Poincare sphere, were assessed with polarization filters and retarders. When further tested in tissue, PS-OCT ...

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    8. System And Method For Calibrated Spectral Domain Optical Coherence Tomography And Low Coherence Interferometry

      System And Method For Calibrated Spectral Domain Optical Coherence Tomography And Low Coherence Interferometry
      Systems and methods for enhancing spectral domain optical coherence tomography (OCT] are provided. In particular, a system and method for calibration of spectral interference signals using an acquired calibration signal are provided. The calibration signal may be logarithmically amplified to further improve the accuracy of the calibration. From the calibration signal, a series of more accurate calibration data are calculated. An acquired spectral interference signal is calibrated using these calibration data. Moreover, systems that include logarithmic amplification of the spectral interference signal and variable band-pass filtering of the spectral interference signal are provided. Such systems increase the dynamic range and ...
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    9. True logarithmic amplification of frequency clock in SS-OCT for calibration

      True logarithmic amplification of frequency clock in SS-OCT for calibration
      With swept source optical coherence tomography (SS-OCT), imprecise signal calibration prevents optimal imaging of biological tissues such as coronary artery. This work demonstrates an approach using a true logarithmic amplifier to precondition the clock signal, with the effort to minimize the noises and phase errors for optimal calibration. This method was validated and tested with a high-speed SS-OCT. The experimental results manifest its superior ability on optimization of the calibration and improvement of the imaging performance. Particularly, this hardware-based approach is suitable for real-time calibration in a high-speed system where computation time is constrained.
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    10. In Vivo Micron-Scale Arthroscopic Imaging of Human Knee Osteoarthritis With Optical Coherence Tomography: Comparison With Magnetic Resonance Imaging and Arthroscopy

      In Vivo Micron-Scale Arthroscopic Imaging of Human Knee Osteoarthritis With Optical Coherence Tomography: Comparison With Magnetic Resonance Imaging and Arthroscopy
      Current treatments for osteoarthritis are pain relief and total joint arthroplasty. There is a clinical need for early osteoarthritis diagnostic methods for potential preventive interventions. The resolution achieved with radiography, magnetic resonance imaging (MRI), and arthroscopy is too limited for the assessment of early disease. The high resolution, small fiber-optic probes, and real-time imaging of optical coherence tomography (OCT) makes this method ideal for assessing articular cartilage. In this article, we describe in vivo human arthroscopic OCT with qualitative baseline comparisons made with MRI and arthroscopy. Two-year MRI follow-ups are under way to quantitatively compare OCT with MRI and to ...
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    11. Improvement in dynamic range limitation of swept source optical coherence tomography by true logarithmic amplification

      Improvement in dynamic range limitation of swept source optical coherence tomography by true logarithmic amplification
      We previously demonstrated, with both theoretical and experimental studies, the dynamic range limitation with spectral domain optical coherence tomography (OCT) relative to time domain OCT. A significant portion of this limitation was due to the difference of analog/digital conversion. In this paper, a new method of true logarithmic amplification is discussed theoretically and tested experimentally to increase the dynamic range of a swept source OCT. With the current experimental setup, an increase of the dynamic range by about 6 dB was obtained.
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    12. Real-time and high-performance calibration method for high-speed swept-source optical coherence tomography

      Real-time and high-performance calibration method for high-speed swept-source optical coherence tomography
      For high-speed swept-source optical coherence tomography (SS-OCT), the real-time calibration process to convert the OCT signal to wave number space is highly essential. A novel calibration process/algorithm using a genetic algorithm and precise interpolation is developed. This algorithm is embedded and validated in a SS-OCT system with 16-kHz A-scan rate. The performance of the new algorithm is evaluated by measuring point spread functions at two distinct locations in the entire imaging range. The data is compared to the same system but embedded with a regular calibration algorithm, which demonstrates about 20% improvement in the axial resolution. The steady improvement ...
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    13. Comparison of artifact generation with catheter bending using different PS-OCT approaches

      Comparison of artifact generation with catheter bending using different PS-OCT approaches
      Optical coherence tomography (OCT) is a promising biomedical imaging tool for detecting pathology at a micron scale. In addition to performing structural imaging, other adjuvant techniques are available with OCT. In particular, polarization-sensitive optical coherence tomography (PS-OCT) can be used, either through a single or dual detector approach, to assess collagen concentration and organization. In this paper, we compare the ability of single and dual detector PS-OCT with respect to catheter bending artifacts. It was found that even severe catheter bending resulted in no significant difference in quantitative birefringence measurement with the single detector approach. However, when the dual detector ...
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    14. Nonlocal quantum macroscopic superposition in a high-thermal low-purity state

      Nonlocal quantum macroscopic superposition in a high-thermal low-purity state
      Quantum state exchange between light and matter is an important ingredient for future quantum information networks as well as other applications. Photons are the fastest and simplest carriers of information for transmission but in general, it is difficult to localize and store photons, so usually one prefers choosing matter as quantum memory elements. Macroscopic superposition and nonlocal quantum interactions have received considerable interest for this purpose over recent years in fields ranging from quantum computers to cryptography, in addition to providing major insights into physical laws. However, these experiments are generally performed either with equipment or under conditions that are ...
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    15. Experimental confirmation of potential swept source optical coherence tomography performance limitations

      Experimental confirmation of potential swept source optical coherence tomography performance limitations
      OCT has demonstrated considerable potential for a wide range of medical applications. Initial work was done in the time domain (TD-OCT) approach, but recent interest has been generated with spectral domain (SD-OCT) approaches. While SD-OCT offers higher data acquisition rates and no movable parts, we recently pointed out th eoretical inferior aspects to its performance relative to TD-OC T. In this paper we focus on specific limitations of swept source OCT (SS-OCT) as this is the more versatile of the two SD-OCT embodiments. We present experimental evidence of reduced imaging penetration, increased low frequency noise, higher multiple scattering (which can ...
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    16. Ultrasound-enhanced optical coherence tomography: improved penetration and resolution

      Ultrasound-enhanced optical coherence tomography: improved penetration and resolution
      Chuanyong Huang, Bin Liu, Mark E. Brezinski Increasing penetration remains one of the most important issues in optical coherence tomography (OCT) research, which we achieved with a parallel ultrasound beam. In addition to qualitative improvements of tissue imaging, quantitative improvements in resolution of up to 28%±2% was noted. At ... [J. Opt. Soc. Am. A 25, 938-946 (2008)]
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    1-16 of 16
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  2. Topics in the News

    1. (14 articles) Brigham and Women’s Hospital
    2. (8 articles) Harvard University
    3. (1 articles) Cardiovascular Research Foundation
    4. (1 articles) Harbin Medical University
    5. (1 articles) Capital Medical University
    6. (1 articles) FDA
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    8. (1 articles) Duke University
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    Ultrasound-enhanced optical coherence tomography: improved penetration and resolution Experimental confirmation of potential swept source optical coherence tomography performance limitations Nonlocal quantum macroscopic superposition in a high-thermal low-purity state Comparison of artifact generation with catheter bending using different PS-OCT approaches Real-time and high-performance calibration method for high-speed swept-source optical coherence tomography Improvement in dynamic range limitation of swept source optical coherence tomography by true logarithmic amplification In Vivo Micron-Scale Arthroscopic Imaging of Human Knee Osteoarthritis With Optical Coherence Tomography: Comparison With Magnetic Resonance Imaging and Arthroscopy Single-Detector Polarization-Sensitive Optical Coherence Tomography for Assessment of Rotator Cuff Tendon Integrity The Application of Optical Coherence Tomography in Musculoskeletal Disease Fossilized Teeth as a New Robust and Reproducible Standard for Polarization-Sensitive Optical Coherence Tomography Influence of scan direction on subfoveal choroidal vascularity index using optical coherence tomography Subthreshold Nanosecond Laser for Non-resolving Central Serous Chorioretinopathy: A Double-masked Sham-controlled Randomised Trial