1. Articles from Jiqiang Kang

    1-5 of 5
    1. Optical coherence tomography with balanced signal strength across the depth for pearl inspection

      Optical coherence tomography with balanced signal strength across the depth for pearl inspection

      Optical coherence tomography (OCT) relies on the reflection of light from structures in different layers to interferometrically reconstruct the volumetric image of the sample. However, light returned from multiple layers suffers from imbalanced attenuation owing to the optical path difference and inhomogeneous tissue absorption. We report an optimization algorithm to improve signal strength in deep tissue for swept-source (SS)-OCT imaging. This algorithm utilizes the attenuation coefficient of consecutive layers within the sample and combines them to compensate for the signal intensity loss from deep tissue. We stacked 170-µm thick cover slides as a standard sample for benchmark testing ...

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    2. Video-rate centimeter-range optical coherence tomography based on dual optical frequency combs by electro-optic modulators

      Video-rate centimeter-range optical coherence tomography based on dual optical frequency combs by electro-optic modulators

      Imaging speed and range are two important parameters for optical coherence tomography (OCT). A conventional video-rate centimeter-range OCT requires an optical source with hundreds of kHz repetition rate and needs the support of broadband detectors and electronics (>1 GHz). In this paper, a type of video-rate centimeter-range OCT system is proposed and demonstrated based on dual optical frequency combs by leveraging electro-optic modulators. The repetition rate difference between dual combs, i.e. the A-scan rate of dual-comb OCT, can be adjusted within 0~6 MHz. By down-converting the interference signal from optical domain to radio-frequency domain through dual comb beating ...

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    3. Sensitivity enhancement in swept-source optical coherence tomography by parametric balanced detector and amplifier

      Sensitivity enhancement in swept-source optical coherence tomography by parametric balanced detector and amplifier

      We proposed a sensitivity enhancement method of the interference-based signal detection approach and applied it on a swept-source optical coherence tomography (SS-OCT) system through all-fiber optical parametric amplifier (FOPA) and parametric balanced detector (BD). The parametric BD was realized by combining the signal and phase conjugated idler band that was newly-generated through FOPA, and specifically by superimposing these two bands at a photodetector. The sensitivity enhancement by FOPA and parametric BD in SS-OCT were demonstrated experimentally. The results show that SS-OCT with FOPA and SS-OCT with parametric BD can provide more than 9 dB and 12 dB sensitivity improvement, respectively ...

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    4. Tri-band optical coherence tomography for lipid and vessel spectroscopic imaging

      Tri-band optical coherence tomography for lipid and vessel spectroscopic imaging

      Optical coherence tomography (OCT) has been utilized for various functional imaging applications. One of its highlights comes from spectroscopic imaging, which can simultaneously obtain both morphologic and spectroscopic information. Assisting diagnosis and therapeutic intervention of coronary artery disease is one of the major directions in spectroscopic OCT applications. Previously Tanaka et al. have developed a spectral domain OCT (SDOCT) to image lipid distribution within blood vessel [1]. In the meantime, Fleming et al. have demonstrated optical frequency domain imaging (OFDI) by a 1.3-μm swept source and quadratic discriminant analysis model [2]. However, these systems suffered from burdensome computation ...

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    5. Tri-band spectroscopic optical coherence tomography based on optical parametric amplification for lipid and vessel visualization

      Tri-band spectroscopic optical coherence tomography based on optical parametric amplification for lipid and vessel visualization

      A tri-band spectroscopic optical coherence tomography (SOCT) system has been implemented for visualization of lipid and blood vessel distribution. The tri-band swept source, which covers output spectrum in 1.3, 1.5, and 1.6μ m wavelength windows, is based on a dual-band Fourier domain mode-locked laser and a fiber optical parametric amplifier. This tri-band SOCT can further differentiate materials, e.g., lipid and artery, qualitatively by contrasting attenuation coefficients difference within any two of these bands. Furthermore, ex vivo imaging of both porcine artery with artificial lipid plaque phantom and mice with coronary artery disease were demonstrated to showcase ...

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    1-5 of 5
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  2. Topics in the News

    1. (4 articles) Kenneth K. Y. Wong
    2. (3 articles) University of Hong Kong
    3. (2 articles) Kevin K. Tsia
    4. (2 articles) Massachusetts General Hospital
    5. (1 articles) Harvard University
    6. (1 articles) The Chinese University of Hong Kong
    7. (1 articles) University of Miami
    8. (1 articles) VU University Amsterdam
    9. (1 articles) David A. Boas
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    12. (1 articles) Frank D. Verbraak
    13. (1 articles) Apollo Medical Optics
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    Tri-band spectroscopic optical coherence tomography based on optical parametric amplification for lipid and vessel visualization Tri-band optical coherence tomography for lipid and vessel spectroscopic imaging Sensitivity enhancement in swept-source optical coherence tomography by parametric balanced detector and amplifier Video-rate centimeter-range optical coherence tomography based on dual optical frequency combs by electro-optic modulators Optical coherence tomography with balanced signal strength across the depth for pearl inspection Optical Coherence Tomography: Critical Tool to Manage Expectations after Cataract Extraction Improving the characterization of ex vivo human brain optical properties using high numerical aperture optical coherence tomography by spatially constraining the confocal parameters Choroidal, macular and ganglion cell layer thickness assessment in Caucasian children measured with spectral domain optical coherence tomography Examination of retinal vascular density changes via optical coherence tomography angiography in patients with glaucoma 3D reconstruction of coronary artery bifurcations from coronary angiography and optical coherence tomography: feasibility, validation, and reproducibility Age- and refraction-related changes in anterior segment anatomical structures measured by swept-source anterior segment OCT The evaluation of juvenile ocular hypertension by optical coherence tomography angiography