1. Articles from Varvara V. Dudenkova

    1-3 of 3
    1. Quantitative evaluation of atherosclerotic plaques using cross-polarization optical coherence tomography, nonlinear, and atomic force microscopy

      Quantitative evaluation of atherosclerotic plaques using cross-polarization optical coherence tomography, nonlinear, and atomic force microscopy

      A combination of approaches to the image analysis in cross-polarization optical coherence tomography (CP OCT) and high-resolution imaging by nonlinear microscopy and atomic force microscopy (AFM) at the different stages of atherosclerotic plaque development is studied. This combination allowed us to qualitatively and quantitatively assess the disorganization of collagen in the atherosclerotic arterial tissue (reduction and increase of CP backscatter), at the fiber (change of the geometric distribution of fibers in the second-harmonic generation microscopy images) and fibrillar (violation of packing and different nature of a basket-weave network of fibrils in the AFM images) organization levels. The calculated CP channel-related ...

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    2. Characterization of atherosclerotic plaques by cross-polarization optical coherence tomography

      Characterization of atherosclerotic plaques by cross-polarization optical coherence tomography

      We combined cross-polarization optical coherence tomography (CP OCT) and non-linear microscopy based on second harmonic generation (SHG) and two-photon-excited fluorescence (2PEF) to assess collagen and elastin fibers in the development of the atherosclerotic plaque (AP). The study shows potential of CP OCT for the assessment of collagen and elastin fibers condition in atherosclerotic arteries. Specifically, the additional information afforded by CP OCT, related to birefringence and cross-scattering properties of arterial tissues, may improve the robustness and accuracy of assessment about the microstructure and composition of the plaque for different stages of atherosclerosis.

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    3. Multi-modal optical imaging characterization of atherosclerotic plaques

      Multi-modal optical imaging characterization of atherosclerotic plaques

      We combined cross-polarization optical coherence tomography (CP OCT) and non-linear microscopy based on second harmonic generation (SHG) and two-photon-excited fluorescence (2PEF) to assess collagen and elastin fibers and other vascular structures in the development of atherosclerosis, including identification of vulnerable plaques, which remains an important clinical problem and imaging application. CP OCT's ability to visualize tissue birefringence and cross-scattering adds new information about the microstructure and composition of the plaque. However its interpretation can be ambiguous, because backscattering contrast may have a similar appearance to the birefringence related fringes. Our results represent a step towards minimally invasive characterization and ...

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    1-3 of 3
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  2. Topics in the News

    1. (3 articles) Nizhny Novgorod State Medical Academy
    2. (3 articles) Grigory V. Gelikonov
    3. (3 articles) Felix I. Feldchtein
    4. (3 articles) Natalia D. Gladkova
    5. (3 articles) Elena B. Kiseleva
    6. (2 articles) Institute of Applied Physics
    7. (2 articles) University of Toronto
    8. (2 articles) Ontario Cancer Institute
    9. (2 articles) I. Alex Vitkin
    10. (1 articles) Valentin M. Gelikonov
    11. (1 articles) University College London
    12. (1 articles) University of North Carolina
    13. (1 articles) Bern University Hospital
    14. (1 articles) Nieves Gonzalo
    15. (1 articles) Fernando Alfonso
    16. (1 articles) Santiago Jiménez-Valero
    17. (1 articles) Amy L. Oldenburg
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