1. Articles from Elliott Daniel SoRelle

    1-4 of 4
    1. Spatiotemporal Tracking of Brain-Tumor-Associated Myeloid Cells in Vivo through Optical Coherence Tomography with Plasmonic Labeling and Speckle Modulation

      Spatiotemporal Tracking of Brain-Tumor-Associated Myeloid Cells in Vivo through Optical Coherence Tomography with Plasmonic Labeling and Speckle Modulation

      By their nature, tumors pose a set of profound challenges to the immune system with respect to cellular recognition and response coordination. Recent research indicates that leukocyte subpopulations, especially tumor-associated macrophages (TAMs), can exert substantial influence on the efficacy of various cancer immunotherapy treatment strategies. To better study and understand the roles of TAMs in determining immunotherapeutic outcomes, significant technical challenges associated with dynamically monitoring single cells of interest in relevant live animal models of solid tumors must be overcome. However, imaging techniques with the requisite combination of spatiotemporal resolution, cell-specific contrast, and sufficient signal-to-noise at increasing depths in tissue ...

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    2. Real-time detection of circulating tumor cells in living animals using functionalized large gold nanorods

      Real-time detection of circulating tumor cells in living animals using functionalized large gold nanorods

      Optical coherence tomography (OCT) can be utilized with significant speckle reduction techniques and highly-scattering contrast agents for noninvasive, contrast-enhanced imaging of living tissues at the cellular scale. The advantages of reduced speckle noise and improved targeted contrast can be harnessed to track objects as small as 2 μm in vivo, which enables applications for cell tracking and quantification in living subjects. Here we demonstrate the use of Large Gold Nanorods (LGNRs) as contrast agents for detecting individual micron-sized polystyrene beads and single myeloma cells in blood circulation using speckle modulating-OCT (SM-OCT). This report marks the first time that OCT has ...

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    3. Gold Nanoprisms as Optical Coherence Tomography Contrast Agents in the Second Near-Infrared Window for Enhanced Angiography in Live Animals

      Gold Nanoprisms as Optical Coherence Tomography Contrast Agents in the Second Near-Infrared Window for Enhanced Angiography in Live Animals

      Optical coherence tomography angiography (OCTA) is an important tool for investigating vascular networks and microcirculation in living tissue. Traditional OCTA detects blood vessels via intravascular dynamic scattering signals derived from the movements of red blood cells (RBCs). However, the low hematocrit and long latency between RBCs in capillaries make these OCTA signals discontinuous, leading to incomplete mapping of the vascular networks. OCTA imaging of microvascular circulation is particularly challenging in tumors due to the abnormally slow blood flow in angiogenic tumor vessels and strong attenuation of light by tumor tissue. Here, we demonstrate in vivo that gold nanoprisms (GNPRs) can ...

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    4. Biofunctionalization of Large Gold Nanorods Realizes Ultrahigh-Sensitivity Optical Imaging Agents

      Biofunctionalization of Large Gold Nanorods Realizes Ultrahigh-Sensitivity Optical Imaging Agents

      Gold nanorods (GNRs, ~50 x 15 nm) have been used ubiquitously in biomedicine for their optical properties, and many biofunctionalization methods have been described for them. Recently, the synthesis of larger-than-usual GNRs (LGNRs, ~100 x 30 nm) has been demonstrated. However, LGNRs have not been biofunctionalized and therefore remain absent from biomedical literature to date. Here we report the first biofunctionalization of LGNRs, resulting in highly stable particles with a narrow spectral peak (FWHM ~100 nm). We further demonstrated that functionalized LGNRs can be used as highly sensitive contrast agents for Optical Coherence Tomography (OCT), visualizing individual LGNRs in clear ...

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    1-4 of 4
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  2. Topics in the News

    1. (4 articles) Stanford University
    2. (4 articles) Adam de la Zerda
    3. (4 articles) Elliott D. SoRelle
    4. (4 articles) Orly Liba
    5. (1 articles) Siavash Yousefi
    6. (1 articles) University of Milan
    7. (1 articles) Columbia University
    8. (1 articles) Università Vita-Salute San Raffaele
    9. (1 articles) Taner Akkin
    10. (1 articles) Giovanni Gregori
    11. (1 articles) Philip J. Rosenfeld
    12. (1 articles) Giovanni Staurenghi
    13. (1 articles) Conavi Medical Inc.
    14. (1 articles) Canon Medical Systems
    15. (1 articles) Fujifilm Medical Systems
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    Biofunctionalization of Large Gold Nanorods Realizes Ultrahigh-Sensitivity Optical Imaging Agents Gold Nanoprisms as Optical Coherence Tomography Contrast Agents in the Second Near-Infrared Window for Enhanced Angiography in Live Animals Real-time detection of circulating tumor cells in living animals using functionalized large gold nanorods Spatiotemporal Tracking of Brain-Tumor-Associated Myeloid Cells in Vivo through Optical Coherence Tomography with Plasmonic Labeling and Speckle Modulation University of Southern California Receives NIH Grant for Imaging Cerebral and Retinal Microvasculature in Cerebral Small Vessel Disease Columbia University Receives NIH Grant  for Measures of Human Receptor and post Receptor Activity Multimodal Imaging of Multiple Evanescent White Dot Syndrome: A New Interpretation MULTIMODAL IMAGING AND TREATMENT OF SYPHILITIC CHOROIDAL NEOVASCULARIZATION Highly coherent supercontinuum generation in CS2 infiltrated single-core optical fiber Glioma cell migration dynamics in brain tissue assessed by multimodal optical imaging Optical Coherence Tomography Angiography in Monitoring Proliferative Macular Telangiectasia Type 2 Treatment Response Effect of Hemodialysis on Anterior Chamber Angle Measured by Anterior Segment Optical Coherence Tomography