1. Articles from Ming Ding

    1-6 of 6
    1. Optical coherence tomography for identification of malignant pulmonary nodules based on random forest machine learning algorithm

      Optical coherence tomography for identification of malignant pulmonary nodules based on random forest machine learning algorithm

      Objective: To explore the feasibility of using random forest (RF) machine learning algorithm in assessing normal and malignant peripheral pulmonary nodules based on in vivo endobronchial optical coherence tomography (EB-OCT). Methods: A total of 31 patients with pulmonary nodules were admitted to Department of Respiratory Medicine, Zhongda Hospital, Southeast University, and underwent chest CT, EB-OCT and biopsy. Attenuation coefficient and up to 56 different image features were extracted from A-line and B-scan of 1703 EB-OCT images. Attenuation coefficient and 29 image features with significant p-values were used to analyze the differences between normal and malignant samples. A RF classifier was ...

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    2. Significances of spirometry and impulse oscillometry for detecting small airway disorders assessed with endobronchial optical coherence tomography in COPD

      Significances of spirometry and impulse oscillometry for detecting small airway disorders assessed with endobronchial optical coherence tomography in COPD

      Background: Spirometry confers limited value for identifying small-airway disorders (SADs) in early-stage COPD, which can be detected with impulse oscillometry (IOS) and endobronchial optical coherence tomography (EB-OCT). Whether IOS is useful for reflecting small-airway morphological abnormalities in COPD remains unclear. Objectives: To compare the diagnostic value of spirometry and IOS for identifying SADs in heavy-smokers and COPD based on the objective assessment with EB-OCT. Methods: We recruited 59 COPD patients (stage I, n=17; stage II, n=18; stage III–IV, n=24), 26 heavy-smokers and 21 never-smokers. Assessments of clinical characteristics, spirometry, IOS and EB-OCT were performed. Receiver operation ...

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    3. Measuring Airway Remodeling in Patients with Different COPD Staging Using Endobronchial Optical Coherence Tomography

      Measuring Airway Remodeling in Patients with Different COPD Staging Using Endobronchial Optical Coherence Tomography

      Background Although forced expiratory volume in one second (FEV 1 ) remains the gold standard for staging COPD, the association between airway remodeling and airflow limitation remains unclear. Objective Endobronchial optical coherence tomography (EB-OCT) was performed to assess the association between disorders of large- and medium-to-small-sized airways and COPD staging. We also evaluated small-airway architecture in heavy-smokers with normal FEV 1 (S NL ) and healthy never-smokers. Methods We recruited 48 COPD patients (stage Ⅰ, n=14; stage Ⅱ, n=15; stage Ⅲ-Ⅳ, n=19), 21 S NL , and 17 healthy never-smokers. Smoking history inquiry, spirometry, chest computed tomography, bronchoscopy and EB-OCT ...

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    4. Validation of Human Small Airway Measurements Using Endobronchial Optical Coherence Tomography

      Validation of Human Small Airway Measurements Using Endobronchial Optical Coherence Tomography

      PURPOSE: To evaluate the usefulness of endobronchial optical coherence tomography (EB-OCT) in assessing small airways morphology in vivo. METHODS: Twelve patients with pulmonary nodules scheduled for lung resection underwent spirometry, multidetector computed tomography (MDCT) and EB-OCT. We measured Dmean (mean luminal diameter), Ai (inner luminal area), Aw (airway wall area) and Aw% [Aw/(Ai+Aw) ×100%] from the 3rd to 5th generation bronchi of RB9 segment by MDCT. Dmean, Ai, Aw and Aw% from the 3rd to 9th generation bronchi of RB9 segment were measured by EB-OCT and histology. The correlations of these 4 parameters, measured by the three methods ...

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    5. Validation of human small-airway measurements using endobronchial optical coherence tomography: an observational study

      Validation of human small-airway measurements using endobronchial optical coherence tomography: an observational study

      Background Small-airway remodelling is the cardinal pathological feature underlying chronic obstructive pulmonary disease (COPD). Identification of early-stage pathological changes is crucial for the diagnosis, treatment, and prognosis of respiratory diseases. Our study aimed to investigate the usefulness of endobronchial optical coherence tomography (EB-OCT) in assessment of small-airways morphology in patients with pulmonary nodules who were scheduled for lung resection surgery (four had COPD, four were smokers with normal lung function, and four were life-long non-smokers). Patients with respiratory diseases other than COPD were excluded. Methods 12 patients with pulmonary nodules scheduled for lung resection underwent spirometry, multidetector CT (MDCT), and ...

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    6. Validation of human small airway measurements using endobronchial optical coherence tomography

      Validation of human small airway measurements using endobronchial optical coherence tomography

      Background Small airway remodeling is the cardinal feature underlying chronic airway diseases. There is no modality which identifies small airway pathological changes, which is crucial for early diagnosis, efficacy and prognostic assessment. Objective To evaluate the usefulness of endobronchial optical coherence tomography (EB-OCT) in assessing small airways morphology in vivo . Methods Twelve patients with pulmonary nodules scheduled for lung resection underwent spirometry, multi-detector computed tomography (MDCT) and EB-OCT. We measured D mean (mean luminal diameter), Ai (inner luminal area), Aw (airway wall area) and Aw% [Aw/(Ai + Aw) × 100%] from the 3rd to 5th generation bronchi of RB9 segment by ...

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    1-6 of 6
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    Validation of human small airway measurements using endobronchial optical coherence tomography Validation of human small-airway measurements using endobronchial optical coherence tomography: an observational study Validation of Human Small Airway Measurements Using Endobronchial Optical Coherence Tomography Measuring Airway Remodeling in Patients with Different COPD Staging Using Endobronchial Optical Coherence Tomography Significances of spirometry and impulse oscillometry for detecting small airway disorders assessed with endobronchial optical coherence tomography in COPD Optical coherence tomography for identification of malignant pulmonary nodules based on random forest machine learning algorithm Editorial – Optical Coherence Tomography Angiography: Considerations Regarding Diagnostic Parameters Imaging of the optic nerve: technological advances and future prospects Optical coherence tomography assessment of pulmonary vascular remodeling in advanced heart failure. The OCTOPUS-CHF study Systems and methods for automated widefield optical coherence tomography angiography OCT signal processing device and recording medium Application of optical coherence tomography angiography to assess systemic severity in patients with hereditary transthyretin amyloidosis