1. Articles from Dimitris Tousoulis

    1-6 of 6
    1. Optical Coherence Tomography For the Detection of the Vulnerable Plaque

      Optical Coherence Tomography For the Detection of the Vulnerable Plaque

      Morphological characteristics of the atheromatous plaque have been associated with the development of plaque rupture and the pathogenesis of acute coronary syndromes (ACS). Plaques with a specific morphological phenotype that are at high risk of causing ACS are called vulnerable plaques, and can be identified in vivo through the use of intracoronary imaging. Optical coherence tomography (OCT) is a high-resolution intravascular imaging modality that enables detailed visualization of atheromatous plaques. Consequently, OCT is a valuable research tool for examining the role of morphological characteristics of atheromatous plaques in the progression of coronary artery disease and plaque destabilisation, which leads to ...

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    2. Optical Coherence Tomography For the Detection of the Vulnerable Plaque

      Optical Coherence Tomography For the Detection of the Vulnerable Plaque

      Morphological characteristics of the atheromatous plaque have been associated with the development of plaque rupture and the pathogenesis of acute coronary syndromes (ACS). Plaques with a specific morphological phenotype that are at high risk of causing ACS are called vulnerable plaques, and can be identified in vivo through the use of intracoronary imaging. Optical coherence tomography (OCT) is a high-resolution intravascular imaging modality that enables detailed visualization of atheromatous plaques. Consequently, OCT is a valuable research tool for examining the role of morphological characteristics of atheromatous plaques in the progression of coronary artery disease and plaque destabilisation, which leads to ...

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    3. Association of global and local low endothelial shear stress with high-risk plaque using intracoronary 3D optical coherence tomography: Introduction of ‘shear stress score’

      Association of global and local low endothelial shear stress with high-risk plaque using intracoronary 3D optical coherence tomography: Introduction of ‘shear stress score’

      Aims The association of low endothelial shear stress (ESS) with high-risk plaque (HRP) has not been thoroughly investigated in humans. We investigated the local ESS and lumen remodelling patterns in HRPs using optical coherence tomography (OCT), developed the shear stress score , and explored its association with the prevalence of HRPs and clinical outcomes. Methods and results A total of 35 coronary arteries from 30 patients with stable angina or acute coronary syndrome (ACS) were reconstructed with three dimensional (3D) OCT. ESS was calculated using computational fluid dynamics and classified into low, moderate, and high in 3-mm-long subsegments. In each subsegment ...

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    4. Optical Coherence Tomography guided treatment of recurrent drug-eluting stent failure using drug-eluting balloon

      Optical Coherence Tomography guided treatment of recurrent drug-eluting stent failure using drug-eluting balloon

      A 52-year old gentleman was admitted to our department to undergo catheterization due to recent onset stable angina in minimal effort. He had a history of myocardial infarction 10 years ago, with coronary artery bypass graft surgery 8 years ago. A left internal mammary artery (LIMA) graft had been anastomosed in the mid left anterior descending (LAD) artery and two saphenous vein grafts (SVGs) in the left circumflex (LCx) and the right coronary artery (RCA), respectively. Six years ago, he underwent percutaneous coronary intervention (PCI) of the native LCx, with implantation of two overlapping second generation drug-eluting stents (DES), due ...

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    5. Metabolic syndrome predicts plaque rupture in patients with acute myocardial infarction. An optical coherence study

      Metabolic syndrome predicts plaque rupture in patients with acute myocardial infarction. An optical coherence study

      The metabolic syndrome (MS) is conceptualized as a clustering of risk factors-including insulin resistance, dyslipidemia, central adiposity, and elevated blood pressure (BP)-that increase the risk for cardiovascular disease and type 2 diabetes mellitus (DM) [1]. Metabolic syndrome is known to be a low-grade systemic inflammatory condition with its origins in the perinatal period and childhood, while recent evidence suggests that markers of systemic inflammation may be included in the definition of the syndrome and play some role in its pathogenesis

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    6. Vulnerable plaque imaging: updates on new pathobiological mechanisms

      Vulnerable plaque imaging: updates on new pathobiological mechanisms

      Early identification of vulnerable, rupture-prone atherosclerotic plaques with the optimal goal of cardiovascular event prevention is a field of vigorous research. Despite the advances in imaging modalities and the in vivo identification of many characteristics of vulnerability, few of these plaques actually rupture and even fewer lead to clinical events, questioning the predictive value of the above techniques in clinical practice. Factors causing the higher local vulnerability of the culprit plaque within a prothrombotic environment of widespread inflammation are generally unknown. Newly recognized local features, including microcalcifications and biomechanical factors, seem to contribute. In this review article, we target on ...

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    1-6 of 6
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  2. Topics in the News

    1. (5 articles) Konstantinos Toutouzas
    2. (3 articles) Antonios Karanasos
    3. (1 articles) University of Athens
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    5. (1 articles) Bern University of Applied Sciences
    6. (1 articles) Medical University of Vienna
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    Vulnerable plaque imaging: updates on new pathobiological mechanisms Metabolic syndrome predicts plaque rupture in patients with acute myocardial infarction. An optical coherence study Optical Coherence Tomography guided treatment of recurrent drug-eluting stent failure using drug-eluting balloon Association of global and local low endothelial shear stress with high-risk plaque using intracoronary 3D optical coherence tomography: Introduction of ‘shear stress score’ Optical Coherence Tomography For the Detection of the Vulnerable Plaque Optical Coherence Tomography For the Detection of the Vulnerable Plaque Hybrid registration of retinal fluorescein angiography and optical coherence tomography images of patients with diabetic retinopathy Optical Coherence Tomography Angiography Quality Across Three Multicenter Clinical Studies of Diabetic Retinopathy The Role of Optical Coherence Tomography Angiography(OCTA) in Detecting Choroidal Neovascularization in DifferentStages of Best Macular Dystrophy: A Case Series Discrimination of diabetic retinopathy from optical coherence tomography angiography images using machine learning methods Quantitative analysis of vascular changes during photoimmunotherapy using speckle variance optical coherence tomography (SV-OCT) High-resolution, depth-resolved vascular leakage measurements using contrast-enhanced, correlation-gated optical coherence tomography in mice