Articles from Michael Leba

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  1. Effect of temperature on permeation of low-density lipoprotein particles through human carotid artery tissues

    Explore Article www3.interscience.wiley.com (Mar 11 2009) Cardiology

    Quantification of the diffusion of small molecules and large lipid transporting lipoproteins across arterial tissues could be useful in elucidating the mechanism(s) of atherosclerosis. Optical coherence tomography (OCT) was used to determine the effect of temperature on the rate of diffusion of glucose and low-density lipoproteins (LDL) in human carotid endarterectomy tissue in vitro. The permeability rate for glucose was calculated to be (3.51 ± 0.27) × 10-5 cm/s (n = 13) at 20 °C, and (3.70 ± 0.44) × 10-5 cm/s (n = 5) at 37 °C; for LDL the rate was (2.42 ± 0.33) × 10-5 cm/s (n ... (Read Full Article)

    Comment on Article Mentions:   Kirill V. Larin   University of Houston   Mohamad G. Ghosn

  2. Quantifying the effect of milli-molar glucose concentration on thickness of rabbit cornea with optical coherence tomography

    Explore Article SPIE Digital Library (Feb 20 2009) Ophthalmology

    The cornea contributes about 65% of the eye's ability to refract light. Thus, any fluctuation in corneal thickness can cause noticeable changes in vision. The presence of glucose molecules induces a driving force for water to leave the collagen fibrils in the cornea due to the concentration gradient created, thus changing its thickness. In this study, the effect of various milli-molar glucose concentrations on corneal thickness was explored using Optical Coherence Tomography. Whole rabbit eyes were placed in a specially designed dish while immersed in saline to ensure proper hydration of the eye. The cornea was imaged for 10 minutes. ... (Read Full Article)

    Comment on Article Mentions:   Kirill V. Larin   Mohamad G. Ghosn   University of Houston

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