1. Articles from Richard F. Spaide

    1-24 of 52 1 2 3 »

    1. SWEPT-SOURCE OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY IMAGE COMPENSATION OF THE CHORIOCAPILLARIS INDUCES ARTIFACTS

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      SWEPT-SOURCE OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY IMAGE COMPENSATION OF THE CHORIOCAPILLARIS INDUCES ARTIFACTS

      Purpose: To analyze swept-source optical coherence angiography slab images acquired at the default level for the choriocapillaris from the Zeiss PLEX Elite 9000 before and after using a previously described imaging compensation technique. Methods: Eyes of normal subjects, in their 20 seconds and 30 seconds, were evaluated. Angiographic slab images, 20 µ m in thickness, were taken at the default location of 29 to 49 µ m below the retinal pigment epithelium. These images were evaluated, as were images that underwent a published compensation technique that adjusts for light penetration to the sampled layer. Each set of images was threshold at 1 ...

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      Mentions: Richard F. Spaide

    3. Novel biomarker of sphericity and cylindricity indices in volume-rendering optical coherence tomography angiography in normal and diabetic eyes: a preliminary study

      Explore Home - Springer Ophthalmology
      Novel biomarker of sphericity and cylindricity indices in volume-rendering optical coherence tomography angiography in normal and diabetic eyes: a preliminary study

      Purpose Preliminary to evaluate geometric indices (vessel sphericity and cylindricity) for volume-rendered optical coherence tomography angiography (OCTA) in healthy and diabetic eyes. Methods Twenty-six eyes of 13 healthy subjects and 12 eyes of patients with central ischemic, non-proliferative diabetic retinopathy were included. OCTA volume and surface area of the foveal vessels were measured and compared to determine OCTA sphericity and cylindricity indices and surface efficiency (SE). Results The overall average OCTA volume in healthy was 0.49 ± 0.09 mm 3 (standard deviation [SD]), compared to 0.44 ± 0.07 mm 3 (SD) in the diabetic eyes (difference in means ...

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      Mentions: University of Bonn Richard F. Spaide Hendrik P. N. Scholl

    4. New Proposal For The Pathophysiology Of Type 3 Neovascularization As Based On Multimodal Imaging Findings

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      New Proposal For The Pathophysiology Of Type 3 Neovascularization As Based On Multimodal Imaging Findings

      Purpose: To investigate the imaging characteristics of early Type 3 neovascularization and propose a new pathophysiologic sequence for early disease. Methods: Patients were evaluated with a comprehensive ophthalmologic examination to include fundus photography, optical coherence tomography , optical coherence tomography angiography, fluorescein angiography, and volume-rendered optical coherence tomography angiography. Relevant literature was also reviewed. Results: There were 10 eyes of 9 patients who had a mean age of 87 (range 79–93) years and 7 were women. The patients were seen to have distributed areas of cystoid macular edema, not necessarily contiguous with areas of fluorescein or optical coherence tomography angiographic ...

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      Mentions: Richard F. Spaide

    5. CHARACTERIZING RETINAL–CHOROIDAL ANASTOMOSIS IN MACULAR TELANGIECTASIA TYPE 2 WITH OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY

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      CHARACTERIZING RETINAL–CHOROIDAL ANASTOMOSIS IN MACULAR TELANGIECTASIA TYPE 2 WITH OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY

      Purpose: To characterize structural and angiographic findings in macular telangiectasia Type 2 (MacTel 2) and examine associations with visual acuity. Methods: MacTel 2 patients with complete ophthalmologic examination, including fundus photography, autofluorescence, spectral-domain optical coherence tomography, and projection-resolved optical coherence tomography angiography , were retrospectively evaluated. Results: There were 43 eyes of 22 patients with a mean age 63.9 (±10.3) years. Six patients had diabetes. Twenty-one eyes (48.8%) had retinal–choroidal anastomoses (RCAs) without any evidence of neovascularization extending laterally in a plane above or below the retinal pigment epithelium. None of the eyes had hemorrhage, lipid, or ...

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      Mentions: Columbia University Richard F. Spaide Lawrence A. Yannuzzi

    8. A Potential of Mechanism of Retinal Injury

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      A Potential of Mechanism of Retinal Injury

      Purpose: To investigate the structural optical coherence tomography and related microvascular flow characteristics in eyes with retinal vasculitis. Methods: Regions involved with perivascular infiltration in eyes with retinal vasculitis, but no evidence of large vessel occlusion were evaluated with optical coherence tomography (OCT), OCT angiography, and fluorescein angiography. Results: Ten eyes of 5 patients with a variety of etiologies of retinal vasculitis were evaluated. These patients did not have either cotton wool spots or deeper placoid areas of retinal ischemia. Around large vessels there was perivascular infiltration with leakage and staining seen during fluorescein angiography. Structural OCT showed slight thickening ...

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      Mentions: Richard F. Spaide

    9. Enhanced Depth Imaging Spectral-Domain Optical Coherence Tomography

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      Enhanced Depth Imaging Spectral-Domain Optical Coherence Tomography

      Purpose To describe a method to obtain images of the choroid using conventional spectral-domain (SD) optical coherence tomography (OCT) and to evaluate choroidal thickness measurements using these images. Design Observational case series. Methods The images were obtained by positioning the SD OCT device close enough to the eye to obtain an inverted representation of the fundus in healthy volunteers who did not have pupillary dilation. Seven sections, each comprised of 100 averaged scans, were obtained within a 5- × 15-degree rectangle centered on the fovea. The choroidal thickness under the fovea in each image was measured by independent observers. Results The ...

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      Mentions: Hideki Koizumi LuEsther T. Mertz Retinal Research Center Richard F. Spaide

    10. Evaluation of Segmentation of the Superficial and Deep Vascular Layers of the Retina By Optical Coherence Tomography Angiography Instruments in Normal Eyes

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      Evaluation of Segmentation of the Superficial and Deep Vascular Layers of the Retina By Optical Coherence Tomography Angiography Instruments in Normal Eyes

      Importance Correct attribution of vascular features in optical coherence tomography (OCT) angiography depends on accurate segmentation of retinal layers. Objective To evaluate the segmentation of retinal layers among 3 OCT angiography instruments in the central macula, an area where the superficial and deep vascular plexuses terminate. Design, Setting, and Participants A retrospective review of a representative OCT angiogram from 1 patient and an evaluation of the vascular pattern in an autopsied eye were conducted at a community retina practice at a university laboratory. A set of 3 × 3-mm scans centered on the fovea using the Cirrus 5000, RTVue XR Avanti ...

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      Mentions: Optovue Topcon Medical Systems University of Alabama

    11. VOLUME-RENDERED ANGIOGRAPHIC AND STRUCTURAL OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY OF MACULAR TELANGIECTASIA TYPE 2

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      VOLUME-RENDERED ANGIOGRAPHIC AND STRUCTURAL OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY OF MACULAR TELANGIECTASIA TYPE 2

      Purpose: To evaluate multimodal imaging including volume-rendered angiographic and structural optical coherence tomography of macular telangiectasia Type 2 (MacTel2) for right-angle vein complexes, macular cavitations, and signs of deeper retinal vascular invasion. Methods: Retrospective review of imaging performed in a community-based retinal referral center. The eyes were scanned using optical coherence tomography using split-spectrum amplitude-decorrelation techniques to derive flow information. These data were extracted and used to create volume-rendered images of the retinal vasculature with integrated structural information derived from the component optical coherence tomographic images. Results: There were 24 eyes of 16 patients who had a mean age of ...

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      Mentions: Columbia University LuEsther T. Mertz Retinal Research Center Richard F. Spaide

    12. Choroidal Findings in Eyes With Birdshot Chorioretinitis Using Enhanced-Depth Optical Coherence Tomography

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      Choroidal Findings in Eyes With Birdshot Chorioretinitis Using Enhanced-Depth Optical Coherence Tomography

      Purpose : The purposes of this study were to describe choroidal findings observed using optical coherence tomography with enhanced depth imaging (EDI-OCT) in eyes with birdshot chorioretinitis (BSCR) and to test the hypothesis that these findings are related to participant demographics, clinical characteristics, and treatment. Methods : In a multicenter, cross-sectional study, 172 eyes of 86 individuals with BSCR underwent a standardized clinical evaluation, including defined protocols for EDI-OCT imaging, with macular and peripapillary volume scans. Choroidal findings were compared to demographic information, ophthalmic examination findings, and treatment history, using logistic regression models. EDI-OCT images were evaluated by two independent, masked graders ...

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      Mentions: Johns Hopkins University Duke University Northwestern University

    13. Volume Rendered Optical Coherence Tomography of Retinal Vein Occlusion Pilot Study

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      Volume Rendered Optical Coherence Tomography of Retinal Vein Occlusion Pilot Study

      Purpose To investigate the retinal vascular findings and associated cystoid edema in the central macula of eyes with retinal vein occlusion using volume rendered angiographic and structural optical coherence tomography. Study Design Observational case series. Methods In this retrospective study 12 eyes of 12 consecutive patients, 3 with branch and 9 with central retinal vein occlusion were imaged in 27 sessions with optical coherence tomography (OCT) using split-spectrum amplitude decorrelation. The structural OCT data were segmented for cystoid spaces, and integrated into the angiographic data for subsequent volume rendering. The inner and deep vascular plexus were analyzed in relation to ...

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      Mentions: Richard F. Spaide

    14. Macular Bruch’s Membrane Holes in Choroidal Neovascularization-Related Myopic Macular Atrophy by Swept-Source Optical Coherence Tomography

      Explore American Journal of Ophthalmology Ophthalmology
      Macular Bruch’s Membrane Holes in Choroidal Neovascularization-Related Myopic Macular Atrophy by Swept-Source Optical Coherence Tomography

      Purpose To determine frequency and associations of macular Bruch’s membrane defects in the region of macular atrophy developing after the onset of myopic choroidal neovascularization (CNV). Design Retrospective observational case series. Methods The study included all patients who were consecutively examined for high myopia (axial length ≥26.5mm) and CNV-related macular atrophy in the study period from June to July 2015. The patients underwent a comprehensive ophthalmologic examination including swept-source optical coherence tomography (OCT) of the macula. Main outcome measures were macular Bruch’s membrane defects. Results Out of 33 eyes (28 patients) with myopic CNV-related macular atrophy, 25 ...

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      Mentions: University of Heidelberg Jost B. Jonas Richard F. Spaide

    15. Macular Bruch Membrane Holes in Choroidal Neovascularization–Related Myopic Macular Atrophy by Swept-Source Optical Coherence Tomography

      Explore American Journal of Ophthalmology Ophthalmology
      Macular Bruch Membrane Holes in Choroidal Neovascularization–Related Myopic Macular Atrophy by Swept-Source Optical Coherence Tomography

      Purpose To determine frequency and associations of macular Bruch membrane defects in the region of macular atrophy developing after the onset of myopic choroidal neovascularization (CNV). Design Retrospective observational case series. Methods The study included all patients who were consecutively examined for high myopia (axial length ≥26.5mm) and CNV-related macular atrophy in the study period from June to July 2015. The patients underwent a comprehensive ophthalmologic examination including swept-source optical coherence tomography (OCT) of the macula. Main outcome measures were macular Bruch membrane defects. Results Out of 33 eyes (28 patients) with myopic CNV-related macular atrophy, 25 eyes (76 ...

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      Mentions: Jost B. Jonas Richard F. Spaide Kyoko Ohno-Matsui

    17. VOLUME-RENDERED ANGIOGRAPHIC AND STRUCTURAL OPTICAL COHERENCE TOMOGRAPHY

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      VOLUME-RENDERED ANGIOGRAPHIC AND STRUCTURAL OPTICAL COHERENCE TOMOGRAPHY

      Purpose: To demonstrate combined and integrated volume rendering of the retinal vasculature and selected structural abnormalities information derived from optical coherence tomography. Methods: The eyes were scanned using optical coherence tomography using split-spectrum amplitude-decorrelation techniques to derive flow information. Various sublayers could be color coded as needed. The corresponding structural optical coherence tomography information was segmented for salient anatomic structures of interest, such as areas of edema fluid or intraretinal lipid deposits. The angiographic and structural data were integrated on a plane-by-plane basis and used to create volume-rendered images. The combined volume-rendered angiographic and structural optical coherence tomography data could ...

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      Mentions: Richard F. Spaide

    19. Volume Rendered Optical Coherence Tomography of Diabetic Retinopathy Pilot Study - American Journal of Ophthalmology

      Explore American Journal of Ophthalmology Ophthalmology
      Volume Rendered Optical Coherence Tomography of Diabetic Retinopathy Pilot Study - American Journal of Ophthalmology

      Purpose To investigate the retinal vascular findings and associated anatomic abnormalities in the central macula of eyes with diabetic retinopathy using volume rendered angiographic and structural optical coherence tomography. Study Design Observational case series. Methods In this retrospective study 25 eyes of 14 consecutive patients were imaged with optical coherence tomography (OCT) using split-spectrum amplitude decorrelation. The structural OCT data were segmented for cystoid spaces, and integrated into the angiographic data for subsequent volume rendering. The opacity of various vascular layers could be decreased to improve visualization of deeper structures and the images could be rotated about 3 axes. The ...

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      Mentions: Richard F. Spaide

    20. Volume-Rendering Optical Coherence Tomography Angiography of Macular Telangiectasia Type 2

      Explore Ophthalmology Ophthalmology
      Volume-Rendering Optical Coherence Tomography Angiography of Macular Telangiectasia Type 2

      Purpose To evaluate the vascular structure of eyes with macular telangiectasia type 2 (MacTel2) using volume-rendered optical coherence tomography angiography (OCTA). Design Retrospective cross-sectional study. Participants A total of 14 consecutive patients (20 eyes) with MacTel2 who had a signal strength score ≥55 and could maintain fixation during the scan process. Methods The eyes were scanned using optical coherence tomography with split-spectrum amplitude decorrelation techniques to derive flow information. Data were extracted and used to create volume-rendered images of the retinal vasculature that could be rotated about 3 different axes for evaluation. Main Outcome Measures Descriptive appraisal of the vascular ...

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      Mentions: LuEsther T. Mertz Retinal Research Center Richard F. Spaide Lawrence A. Yannuzzi

    21. RefMoB, a Reflectivity Feature Model-Based Automated Method for Measuring Four Outer Retinal Hyperreflective Bands in Optical Coherence Tomography

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      RefMoB, a Reflectivity Feature Model-Based Automated Method for Measuring Four Outer Retinal Hyperreflective Bands in Optical Coherence Tomography

      Purpose. : To validate a model-driven method (RefMoB) of automatically describing the four outer retinal hyperreflective bands revealed by spectral-domain optical coherence tomography (SDOCT), for comparison with histology of normal macula; to report thickness and position of bands, particularly band 2 (ellipsoid zone [EZ], commonly called IS/OS). Methods. : Foveal and superior perifoveal scans of seven SDOCT volumes of five individuals aged 28 to 69 years with healthy maculas were used (seven eyes for validation, five eyes for measurement). RefMoB determines band thickness and position by a multistage procedure that models reflectivities as a summation of Gaussians. Band thickness and positions ...

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      Mentions: University of Alabama Richard F. Spaide Pooja Godara

    22. COLOCALIZATION ERROR BETWEEN THE SCANNING LASER OPHTHALMOSCOPE INFRARED REFLECTANCE AND OPTICAL COHERENCE TOMOGRAPHY IMAGES OF THE HEIDELBERG SPECTRALIS

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      COLOCALIZATION ERROR BETWEEN THE SCANNING LASER OPHTHALMOSCOPE INFRARED REFLECTANCE AND OPTICAL COHERENCE TOMOGRAPHY IMAGES OF THE HEIDELBERG SPECTRALIS

      Purpose: To examine the colocalization error between the infrared reflectance (IR) scanning laser ophthalmoscope (SLO) and spectral domain optical coherence tomography (SD-OCT) images of the Heidelberg Spectralis. Methods: The IR and corresponding horizontal raster SD-OCT images were compared in 10 healthy volunteers examined with 3 Heidelberg Spectralis + OCT instruments. The center points of retinal vessels selected by random uniform sampling in scanning laser ophthalmoscope-IR images were compared with colocalizing points in corresponding SD-OCT images by two masked readers. The error of colocalization was measured in the SD-OCT image. The point positions were recorded using Cartesian coordinates measured in microns. The ...

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      Mentions: Heidelberg Engineering LuEsther T. Mertz Retinal Research Center Richard F. Spaide

    23. TYPE 3 NEOVASCULARIZATION: Evolution, Association With Pigment Epithelial Detachment, and Treatment Response as Revealed by Spectral Domain Optical Coherence Tomography

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      TYPE 3 NEOVASCULARIZATION: Evolution, Association With Pigment Epithelial Detachment, and Treatment Response as Revealed by Spectral Domain Optical Coherence Tomography

      Purpose: To demonstrate the evolution and treatment response of Type 3 neovascularization using spectral domain optical coherence tomography. Methods: We retrospectively analyzed 40 eyes treated with intravitreal anti-vascular endothelial growth factor therapy for Type 3 neovascularization over a variable follow-up period. Results: In 17 eyes, spectral domain optical coherence tomography captured the development of Type 3 neovascularization from punctate hyperreflective foci that preceded any outer retinal defect. The more mature Type 3 lesions were associated with outer retinal disruption and adjacent cystoid macular edema. In addition, 37 of 40 Type 3 lesions (93%) were associated with an underlying pigment epithelial ...

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      Mentions: University of Southern California LuEsther T. Mertz Retinal Research Center Richard F. Spaide

    24. COLOCALIZATION OF PSEUDODRUSEN AND SUBRETINAL DRUSENOID DEPOSITS USING HIGH-DENSITY EN FACE SPECTRAL DOMAIN OPTICAL COHERENCE TOMOGRAPHY

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      COLOCALIZATION OF PSEUDODRUSEN AND SUBRETINAL DRUSENOID DEPOSITS USING HIGH-DENSITY EN FACE SPECTRAL DOMAIN OPTICAL COHERENCE TOMOGRAPHY

      Purpose: To determine if pseudodrusen seen in fundus photography, particularly infrared scanning laser ophthalmoscopy, colocalize with subretinal drusenoid deposits imaged by optical coherence tomography. Methods: The patients were scanned with spectral domain optical coherence tomography having an A-scan spacing of 5.9 [mu]m and a B-scan spacing of 11 [mu]m. En face slabs were derived from this data set at distances 50 [mu]m to 90 [mu]m above the Bruch membrane reference plane to image the subretinal drusenoid deposit and also 6 [mu]m below Bruch membrane to image the level of the choriocapillaris. The corresponding infrared ...

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      Mentions: Richard F. Spaide
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