1. Articles from Richard F. Spaide

    1-24 of 58 1 2 3 »

    1. Negative Vessel Remodeling in Stargardt Disease Quantified with Volume-Rendered Optical Coherence Tomography Angiography

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      Negative Vessel Remodeling in Stargardt Disease Quantified with Volume-Rendered Optical Coherence Tomography Angiography

      Purpose: To quantify retinal vasculature changes in Stargardt disease1 with volume-rendered optical coherence tomography angiography (OCTA). Methods: OCTA volumes from heathy subjects and two subgroups of STGD1 patients with the presence/absence of definitely decreased autofluorescence (DDAF) areas were compared. OCTA vessel surface area (VSA) and vessel volume (VV) were measured in central zones (Z) of 1, 2 and 3mm diameter. Results: 29 eyes of 15 STGD1 patients (20/9 eyes with/without DDAF) and 30 eyes of 15 controls contributed data. An enlarged foveal avascular zone was found in STGD1 patients without and even more with DDAF associated with ...

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      Mentions: Richard F. Spaide University of Freiburg University of Erlangen

    2. Swept Source Optical Coherence Tomography Angiography Imaging of the Choriocapillaris

      Explore LWW Online Ophthalmology
      Swept Source Optical Coherence Tomography Angiography Imaging of the Choriocapillaris

      Purpose: To analyze swept source optical coherence angiography (SS-OCTA) images acquired at different depths above and below the default location of the Zeiss PLEX Elite 9000. Methods: Normal eyes of subjects in their 20s and 30s were evaluated. Angiographic slab images were taken at the default location of 29-49 µm below the retinal pigment epithelium (RPE) as well as 21-41 µm through 52-72 µm below in steps. The images were processed using the projection removal function from the device´s software. Raw images were evaluated, as were images that underwent a published compensation technique that adjusts for light penetration to ...

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      Mentions: Richard F. Spaide

    3. Deliberations of an International Panel of Experts on OCTA Nomenclature of nAMD

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      Deliberations of an International Panel of Experts on OCTA Nomenclature of nAMD

      A panel of imaging experts was assembled to review neovascular age-related macular degeneration optical coherence tomography angiography descriptors published to date, and test agreement on use of these terms, which was found to be low. Optical coherence tomography angiography (OCTA) has been used to identify and characterize macular neovascularization (MNV) secondary to age-related macular degeneration (AMD). 1-4 Many studies have explored OCTA morphological features of MNV that might serve as biomarkers to assess disease activity and response to treatment. 1-6 The proliferation of studies however has resulted in an OCTA terminology that has been variable and inconsistent. To address inconsistency ...

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      Mentions: Philip J. Rosenfeld Massachusetts Institute of Technology James G. Fujimoto

    4. Differential reperfusion patterns in retinal vascular plexuses following increase in intraocular pressure an OCT angiography study

      Explore Nature Publishing Group Ophthalmology
      Differential reperfusion patterns in retinal vascular plexuses following increase in intraocular pressure an OCT angiography study

      To describe patterns of reperfusion in the superficial vascular plexus (SVP), deep capillary plexus (DCP) and choriocapillaris (CC) as detected on optical coherence tomography (OCTA) in cynomogulus macaque monkey model following increase in intraocular pressure by an intravitreal injection. Animal imaging study. Two cynomogulus macaque monkeys. A 100 µL intravitreal injection (IVI) of saline was given in one eye of each monkey. Serial OCTA using a Zeiss Plex Elite 9000 was used to evaluate reperfusion patterns within the SCP, DCP, and CC. OCTA evidence of perfusion. Pulsation of the central retinal artery was detected after the intraocular pressure was elevated ...

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      Mentions: Singapore Eye Research Institute University of Sydney Richard F. Spaide

    5. The Varying Optical Coherence Tomography Appearance of the Inner Choroid with Age: Possible Explanation and Histologic Correlate

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      The Varying Optical Coherence Tomography Appearance of the Inner Choroid with Age: Possible Explanation and Histologic Correlate

      Purpose: To investigate the reflectivity of the structural optical coherence tomography images of the inner choroid as it relates to potential structural composition. Methods: The reflectivity of slab images 29 – 49 µm and 45 – 65 µm below the RPE, obtained with the Zeiss Plex Elite 9000, were evaluated. The mean and standard deviation of a group of subjects with no ocular disorders were determined. Binarization of the images was done a threshold level established at the mean plus one standard deviation for each slab depth. The proportion of area binarized was evaluated with generalized estimating equations. Representative histologic images obtained ...

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      Mentions: Richard F. Spaide

    6. NOVEL METHOD FOR IMAGE AVERAGING OF OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY IMAGES

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      NOVEL METHOD FOR IMAGE AVERAGING OF OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY IMAGES

      Purpose: To develop a method of averaging optical coherence tomography (OCT) angiography to improve visualization of choriocapillaris structure. Methods: A stack of OCT angiographic data from vascular layers were placed into the red-green-blue channels of a conventional digital color image. The superficial plexus was placed in the blue channel, choriocapillaris in the green, and deep vascular plexus in the red channel. The red-green-blue images derived from nine separate OCT angiographic scans were registered using an automatic registration sequence and the images were averaged. The averaged red-green-blue image was then split into the three averaged component layers. The technique is flexible ...

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      Mentions: Richard F. Spaide

    7. SWEPT-SOURCE OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY IMAGE COMPENSATION OF THE CHORIOCAPILLARIS INDUCES ARTIFACTS

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      SWEPT-SOURCE OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY IMAGE COMPENSATION OF THE CHORIOCAPILLARIS INDUCES ARTIFACTS

      Purpose: To analyze swept-source optical coherence angiography slab images acquired at the default level for the choriocapillaris from the Zeiss PLEX Elite 9000 before and after using a previously described imaging compensation technique. Methods: Eyes of normal subjects, in their 20 seconds and 30 seconds, were evaluated. Angiographic slab images, 20 µ m in thickness, were taken at the default location of 29 to 49 µ m below the retinal pigment epithelium. These images were evaluated, as were images that underwent a published compensation technique that adjusts for light penetration to the sampled layer. Each set of images was threshold at 1 ...

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      Mentions: Richard F. Spaide

    9. Novel biomarker of sphericity and cylindricity indices in volume-rendering optical coherence tomography angiography in normal and diabetic eyes: a preliminary study

      Explore Home - Springer Ophthalmology
      Novel biomarker of sphericity and cylindricity indices in volume-rendering optical coherence tomography angiography in normal and diabetic eyes: a preliminary study

      Purpose Preliminary to evaluate geometric indices (vessel sphericity and cylindricity) for volume-rendered optical coherence tomography angiography (OCTA) in healthy and diabetic eyes. Methods Twenty-six eyes of 13 healthy subjects and 12 eyes of patients with central ischemic, non-proliferative diabetic retinopathy were included. OCTA volume and surface area of the foveal vessels were measured and compared to determine OCTA sphericity and cylindricity indices and surface efficiency (SE). Results The overall average OCTA volume in healthy was 0.49 ± 0.09 mm 3 (standard deviation [SD]), compared to 0.44 ± 0.07 mm 3 (SD) in the diabetic eyes (difference in means ...

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      Mentions: University of Bonn Richard F. Spaide Hendrik P. N. Scholl

    10. New Proposal For The Pathophysiology Of Type 3 Neovascularization As Based On Multimodal Imaging Findings

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      New Proposal For The Pathophysiology Of Type 3 Neovascularization As Based On Multimodal Imaging Findings

      Purpose: To investigate the imaging characteristics of early Type 3 neovascularization and propose a new pathophysiologic sequence for early disease. Methods: Patients were evaluated with a comprehensive ophthalmologic examination to include fundus photography, optical coherence tomography , optical coherence tomography angiography, fluorescein angiography, and volume-rendered optical coherence tomography angiography. Relevant literature was also reviewed. Results: There were 10 eyes of 9 patients who had a mean age of 87 (range 79–93) years and 7 were women. The patients were seen to have distributed areas of cystoid macular edema, not necessarily contiguous with areas of fluorescein or optical coherence tomography angiographic ...

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      Mentions: Richard F. Spaide

    11. CHARACTERIZING RETINAL–CHOROIDAL ANASTOMOSIS IN MACULAR TELANGIECTASIA TYPE 2 WITH OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY

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      CHARACTERIZING RETINAL–CHOROIDAL ANASTOMOSIS IN MACULAR TELANGIECTASIA TYPE 2 WITH OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY

      Purpose: To characterize structural and angiographic findings in macular telangiectasia Type 2 (MacTel 2) and examine associations with visual acuity. Methods: MacTel 2 patients with complete ophthalmologic examination, including fundus photography, autofluorescence, spectral-domain optical coherence tomography, and projection-resolved optical coherence tomography angiography , were retrospectively evaluated. Results: There were 43 eyes of 22 patients with a mean age 63.9 (±10.3) years. Six patients had diabetes. Twenty-one eyes (48.8%) had retinal–choroidal anastomoses (RCAs) without any evidence of neovascularization extending laterally in a plane above or below the retinal pigment epithelium. None of the eyes had hemorrhage, lipid, or ...

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      Mentions: Columbia University Richard F. Spaide Lawrence A. Yannuzzi

    14. A Potential of Mechanism of Retinal Injury

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      A Potential of Mechanism of Retinal Injury

      Purpose: To investigate the structural optical coherence tomography and related microvascular flow characteristics in eyes with retinal vasculitis. Methods: Regions involved with perivascular infiltration in eyes with retinal vasculitis, but no evidence of large vessel occlusion were evaluated with optical coherence tomography (OCT), OCT angiography, and fluorescein angiography. Results: Ten eyes of 5 patients with a variety of etiologies of retinal vasculitis were evaluated. These patients did not have either cotton wool spots or deeper placoid areas of retinal ischemia. Around large vessels there was perivascular infiltration with leakage and staining seen during fluorescein angiography. Structural OCT showed slight thickening ...

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      Mentions: Richard F. Spaide

    15. Enhanced Depth Imaging Spectral-Domain Optical Coherence Tomography

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      Enhanced Depth Imaging Spectral-Domain Optical Coherence Tomography

      Purpose To describe a method to obtain images of the choroid using conventional spectral-domain (SD) optical coherence tomography (OCT) and to evaluate choroidal thickness measurements using these images. Design Observational case series. Methods The images were obtained by positioning the SD OCT device close enough to the eye to obtain an inverted representation of the fundus in healthy volunteers who did not have pupillary dilation. Seven sections, each comprised of 100 averaged scans, were obtained within a 5- × 15-degree rectangle centered on the fovea. The choroidal thickness under the fovea in each image was measured by independent observers. Results The ...

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      Mentions: Hideki Koizumi LuEsther T. Mertz Retinal Research Center Richard F. Spaide

    16. Evaluation of Segmentation of the Superficial and Deep Vascular Layers of the Retina By Optical Coherence Tomography Angiography Instruments in Normal Eyes

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      Evaluation of Segmentation of the Superficial and Deep Vascular Layers of the Retina By Optical Coherence Tomography Angiography Instruments in Normal Eyes

      Importance Correct attribution of vascular features in optical coherence tomography (OCT) angiography depends on accurate segmentation of retinal layers. Objective To evaluate the segmentation of retinal layers among 3 OCT angiography instruments in the central macula, an area where the superficial and deep vascular plexuses terminate. Design, Setting, and Participants A retrospective review of a representative OCT angiogram from 1 patient and an evaluation of the vascular pattern in an autopsied eye were conducted at a community retina practice at a university laboratory. A set of 3 × 3-mm scans centered on the fovea using the Cirrus 5000, RTVue XR Avanti ...

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      Mentions: Optovue Topcon Medical Systems University of Alabama

    17. VOLUME-RENDERED ANGIOGRAPHIC AND STRUCTURAL OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY OF MACULAR TELANGIECTASIA TYPE 2

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      VOLUME-RENDERED ANGIOGRAPHIC AND STRUCTURAL OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY OF MACULAR TELANGIECTASIA TYPE 2

      Purpose: To evaluate multimodal imaging including volume-rendered angiographic and structural optical coherence tomography of macular telangiectasia Type 2 (MacTel2) for right-angle vein complexes, macular cavitations, and signs of deeper retinal vascular invasion. Methods: Retrospective review of imaging performed in a community-based retinal referral center. The eyes were scanned using optical coherence tomography using split-spectrum amplitude-decorrelation techniques to derive flow information. These data were extracted and used to create volume-rendered images of the retinal vasculature with integrated structural information derived from the component optical coherence tomographic images. Results: There were 24 eyes of 16 patients who had a mean age of ...

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      Mentions: Columbia University LuEsther T. Mertz Retinal Research Center Richard F. Spaide

    18. Choroidal Findings in Eyes With Birdshot Chorioretinitis Using Enhanced-Depth Optical Coherence Tomography

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      Choroidal Findings in Eyes With Birdshot Chorioretinitis Using Enhanced-Depth Optical Coherence Tomography

      Purpose : The purposes of this study were to describe choroidal findings observed using optical coherence tomography with enhanced depth imaging (EDI-OCT) in eyes with birdshot chorioretinitis (BSCR) and to test the hypothesis that these findings are related to participant demographics, clinical characteristics, and treatment. Methods : In a multicenter, cross-sectional study, 172 eyes of 86 individuals with BSCR underwent a standardized clinical evaluation, including defined protocols for EDI-OCT imaging, with macular and peripapillary volume scans. Choroidal findings were compared to demographic information, ophthalmic examination findings, and treatment history, using logistic regression models. EDI-OCT images were evaluated by two independent, masked graders ...

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      Mentions: Johns Hopkins University Duke University Northwestern University

    19. Volume Rendered Optical Coherence Tomography of Retinal Vein Occlusion Pilot Study

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      Volume Rendered Optical Coherence Tomography of Retinal Vein Occlusion Pilot Study

      Purpose To investigate the retinal vascular findings and associated cystoid edema in the central macula of eyes with retinal vein occlusion using volume rendered angiographic and structural optical coherence tomography. Study Design Observational case series. Methods In this retrospective study 12 eyes of 12 consecutive patients, 3 with branch and 9 with central retinal vein occlusion were imaged in 27 sessions with optical coherence tomography (OCT) using split-spectrum amplitude decorrelation. The structural OCT data were segmented for cystoid spaces, and integrated into the angiographic data for subsequent volume rendering. The inner and deep vascular plexus were analyzed in relation to ...

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      Mentions: Richard F. Spaide

    20. Macular Bruch’s Membrane Holes in Choroidal Neovascularization-Related Myopic Macular Atrophy by Swept-Source Optical Coherence Tomography

      Explore American Journal of Ophthalmology Ophthalmology
      Macular Bruch’s Membrane Holes in Choroidal Neovascularization-Related Myopic Macular Atrophy by Swept-Source Optical Coherence Tomography

      Purpose To determine frequency and associations of macular Bruch’s membrane defects in the region of macular atrophy developing after the onset of myopic choroidal neovascularization (CNV). Design Retrospective observational case series. Methods The study included all patients who were consecutively examined for high myopia (axial length ≥26.5mm) and CNV-related macular atrophy in the study period from June to July 2015. The patients underwent a comprehensive ophthalmologic examination including swept-source optical coherence tomography (OCT) of the macula. Main outcome measures were macular Bruch’s membrane defects. Results Out of 33 eyes (28 patients) with myopic CNV-related macular atrophy, 25 ...

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      Mentions: University of Heidelberg Jost B. Jonas Richard F. Spaide

    21. Macular Bruch Membrane Holes in Choroidal Neovascularization–Related Myopic Macular Atrophy by Swept-Source Optical Coherence Tomography

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      Macular Bruch Membrane Holes in Choroidal Neovascularization–Related Myopic Macular Atrophy by Swept-Source Optical Coherence Tomography

      Purpose To determine frequency and associations of macular Bruch membrane defects in the region of macular atrophy developing after the onset of myopic choroidal neovascularization (CNV). Design Retrospective observational case series. Methods The study included all patients who were consecutively examined for high myopia (axial length ≥26.5mm) and CNV-related macular atrophy in the study period from June to July 2015. The patients underwent a comprehensive ophthalmologic examination including swept-source optical coherence tomography (OCT) of the macula. Main outcome measures were macular Bruch membrane defects. Results Out of 33 eyes (28 patients) with myopic CNV-related macular atrophy, 25 eyes (76 ...

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      Mentions: Jost B. Jonas Richard F. Spaide Kyoko Ohno-Matsui

    23. VOLUME-RENDERED ANGIOGRAPHIC AND STRUCTURAL OPTICAL COHERENCE TOMOGRAPHY

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      VOLUME-RENDERED ANGIOGRAPHIC AND STRUCTURAL OPTICAL COHERENCE TOMOGRAPHY

      Purpose: To demonstrate combined and integrated volume rendering of the retinal vasculature and selected structural abnormalities information derived from optical coherence tomography. Methods: The eyes were scanned using optical coherence tomography using split-spectrum amplitude-decorrelation techniques to derive flow information. Various sublayers could be color coded as needed. The corresponding structural optical coherence tomography information was segmented for salient anatomic structures of interest, such as areas of edema fluid or intraretinal lipid deposits. The angiographic and structural data were integrated on a plane-by-plane basis and used to create volume-rendered images. The combined volume-rendered angiographic and structural optical coherence tomography data could ...

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      Mentions: Richard F. Spaide
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