1. Articles from Nilesh Pareek

    1-3 of 3
    1. Plaque Burden Influences Accurate Classification of Fibrous Cap Atheroma by In-Vivo Optical Coherence Tomography in a Porcine Model of Advanced Coronary Atherosclerosis

      Plaque Burden Influences Accurate Classification of Fibrous Cap Atheroma by In-Vivo Optical Coherence Tomography in a Porcine Model of Advanced Coronary Atherosclerosis

      Aims: In-vivo validation of coronary optical coherence tomography (OCT) against histology and the effects of plaque burden (PB) on plaque classification remain unreported. We investigated this in a porcine model with human-like coronary atherosclerosis. Methods and results: Five female Yucatan D374Y-PCSK9 transgenic hypercholesterolemic mini-pigs were implanted with a coronary shear-modifying stent to induce advanced atherosclerosis. OCT frames (n=201) were obtained 34 weeks after implantation. Coronary arteries were perfusion-fixed, serially sectioned and co-registered with OCT using a validated algorithm. Lesions were adjudicated using the Virmani classification and PB assessed from histology. OCT had a high sensitivity, but modest specificity (92 ...

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    2. Intracoronary Imaging

      Intracoronary Imaging

      Two intracoronary imaging techniques are routinely available to complement angiography in the management of coronary artery disease, namely intravascular ultrasound (IVUS) and optical coherence tomography (OCT). The former has been in clinical use for >25 years and has directly informed the fundamentals of atherosclerotic plaque composition and arterial remodelling, as well as contemporary optimal stent implantation technique. 1 , 2 The latter, introduced 10 years ago, has only been more widely adopted with the development of the frequency domain (FD)-OCT imaging, which enables complete image acquisition over a 6–10 cm segment during a 3–5 s pullback period obtaining ...

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    3. Inducing Persistent Flow Disturbances Accelerates Atherogenesis and Promotes Thin Cap Fibroatheroma Development in D374Y-PCSK9 Hypercholesterolemic Minipigs

      Inducing Persistent Flow Disturbances Accelerates Atherogenesis and Promotes Thin Cap Fibroatheroma Development in D374Y-PCSK9 Hypercholesterolemic Minipigs

      Background— Although disturbed flow is thought to play a central role in the development of advanced coronary atherosclerotic plaques, no causal relationship has been established. We evaluated whether inducing disturbed flow would cause the development of advanced coronary plaques, including thin cap fibroatheroma. Methods and Results— D374Y -PCSK9 hypercholesterolemic minipigs (n=5) were instrumented with an intracoronary shear-modifying stent (SMS). Frequency-domain optical coherence tomography was obtained at baseline, immediately poststent, 19 weeks, and 34 weeks, and used to compute shear stress metrics of disturbed flow. At 34 weeks, plaque type was assessed within serially collected histological sections and coregistered to ...

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    1-3 of 3
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  2. Topics in the News

    1. (3 articles) Royal Brompton Hospital
    2. (2 articles) King Abdullah University of Science and Technology
    3. (2 articles) Columbia University
    4. (1 articles) University of Catania
    5. (1 articles) Imperial College London
    6. (1 articles) Aarhus University
    7. (1 articles) UCLA
    8. (1 articles) UC Davis
    9. (1 articles) NYU Grossman School of Medicine
    10. (1 articles) Massachusetts General Hospital
    11. (1 articles) Singapore Eye Research Institute
    12. (1 articles) Case Western Reserve University
    13. (1 articles) Washington University in St. Louis
    14. (1 articles) State University of New York at Buffalo
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    Inducing Persistent Flow Disturbances Accelerates Atherogenesis and Promotes Thin Cap Fibroatheroma Development in D374Y-PCSK9 Hypercholesterolemic Minipigs Intracoronary Imaging Plaque Burden Influences Accurate Classification of Fibrous Cap Atheroma by In-Vivo Optical Coherence Tomography in a Porcine Model of Advanced Coronary Atherosclerosis Precision of attenuation coefficient measurements by optical coherence tomography Machine learning classification of multiple sclerosis in children using optical coherence tomography Massachusetts General Hosptial Receives2 NIH Grant for Assessing Airway Smooth Muscle Tone in Asthma with Endobronchial Optical Coherence Tomography Washington University ReceivesNIH Grant  for Expansion Optical Coherence Microscopy (ExOCM) Case Western Reserve University Receives NIH Grant for Optically guided catheter ablation of atrial fibrillation Columbia University Receives NIH Grant for Multidimensional OCT Imaging Enabled by Compressed Sensing Subcellular Comparison of Visible-Light Optical Coherence Tomography and Electron Microscopy in the Mouse Outer Retina 3D-printed fiber-based zeroth- and high-order Bessel beam generator Correlation of Diabetic Disease Severity to Degree of Quadrant Asymmetry in En Face OCTA Metrics