1. Articles from Thomas Korn

    1-5 of 5
    1. Optimal intereye difference thresholds by optical coherence tomography in multiple sclerosis: An international study

      Optimal intereye difference thresholds by optical coherence tomography in multiple sclerosis: An international study

      Objective To determine the optimal thresholds for intereye differences in retinal nerve fiber and ganglion cell + inner plexiform layer thicknesses for identifying unilateral optic nerve lesions in multiple sclerosis. Current international diagnostic criteria for multiple sclerosis do not include the optic nerve as a lesion site despite frequent involvement. Optical coherence tomography detects retinal thinning associated with optic nerve lesions. Methods In this multicenter international study at 11 sites, optical coherence tomography was measured for patients and healthy controls as part of the International Multiple Sclerosis Visual System Consortium. High‐ and low‐contrast acuity were also collected in a subset ...

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    2. Optimal Inter‐Eye Difference Thresholds by OCT in MS: An International Study

      Optimal Inter‐Eye Difference Thresholds by OCT in MS: An International Study

      Objective To determine the optimal thresholds for inter‐eye differences in retinal nerve fiber and ganglion cell+inner plexiform layer thicknesses for identifying unilateral optic nerve lesions in multiple sclerosis. Background Current international diagnostic criteria for multiple sclerosis do not include the optic nerve as a lesion site despite frequent involvement. Optical coherence tomography detects retinal thinning associated with optic nerve lesions. Methods In this multi‐center international study at 11 sites, optical coherence tomography was measured for patients and healthy controls as part of the International Multiple Sclerosis Visual System Consortium. High‐ and low‐contrast acuity were also collected ...

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    3. Multiple sclerosis: is it all black and white in optical coherence tomography?

      Multiple sclerosis: is it all black and white in optical coherence tomography?

      This scientific commentary refers to ‘Brain and retinal atrophy in African-Americans versus Caucasian-Americans with multiple sclerosis: a longitudinal study’, by Gonzalez Caldito et al. (doi: 10.1093/brain/awy245 ). ... Multiple sclerosis is an inflammatory demyelinating disease of the CNS. Histopathologically, degenerative processes have also been identified early in the disease course and independent of the demyelinating white matter disease. MRI of brain atrophy is currently the gold standard to assess neurodegeneration in vivo . However, longitudinal MRI of brain atrophy is difficult at the individual level owing to great interscan variability. Thus, alternative proxies for neurodegenerative processes that can predict future ...

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    4. Optical coherence tomography angiography indicates associations of the retinal vascular network and disease activity in multiple sclerosis

      Optical coherence tomography angiography indicates associations of the retinal vascular network and disease activity in multiple sclerosis

      Background: Patients with multiple sclerosis (MS) and clinically isolated syndrome (CIS) may show alterations of retinal layer architecture as measured by optical coherence tomography. Little is known about changes in the retinal vascular network during MS. Objective: To characterize retinal vessel structures in patients with MS and CIS and to test for associations with MS disease activity. Method: In all, 42 patients with MS or CIS and 50 healthy controls underwent retinal optical coherence tomography angiography (OCT-A) with analysis of the superficial and deep vascular plexuses and the choriocapillaries. We tested OCT-A parameters for associations with retinal layer volumes, history ...

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    5. Optical coherence tomography indicates disease activity prior to clinical onset of central nervous system demyelination

      Optical coherence tomography indicates disease activity prior to clinical onset of central nervous system demyelination

      Background: Establishing biomarkers for predicting disease activity in demyelinating disease of the central nervous system is crucial for designing appropriate disease modifiying treatment strategies. Objective: To investigate retinal findings and disease activity in patients with radiologically isolated and clinically isolated syndromes. Methods: We performed retinal optical coherence tomography and cerebral magnetic resonance imaging in healthy control individuals ( n =19), in individuals with non-specific white matter lesions ( n =18), and in patients with clinically isolated syndromes ( n =18) and radiologically isolated syndromes ( n =20). Results: Reduced volume of retinal nerve fibre layer and increased volume of inner nuclear layer at baseline ...

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    1-5 of 5
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    1. (2 articles) Johns Hopkins University
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    Optical coherence tomography indicates disease activity prior to clinical onset of central nervous system demyelination Optical coherence tomography angiography indicates associations of the retinal vascular network and disease activity in multiple sclerosis Multiple sclerosis: is it all black and white in optical coherence tomography? Optimal Inter‐Eye Difference Thresholds by OCT in MS: An International Study Optimal intereye difference thresholds by optical coherence tomography in multiple sclerosis: An international study New World Resources and Perimeter Medical Imaging Provide Updates Regarding Their Amalgamation Transaction and Announce Amended and Restated Arrangement Agreement Retinal Vessel Density in Exudative and Non-Exudative Age-Related Macular Degeneration on Optical Coherence Tomography Angiography Use of Optical Coherence Tomography in a Patient with Erosive Oral Lichen Planus Treated with Low-Level Laser Therapy. Preliminary Findings Selective retinex enhancement based on the clustering algorithm and block-matching 3D for optical coherence tomography images Artificial intelligence, the internet of things, and virtual clinics: ophthalmology at the digital translation forefront Detecting glaucoma based on spectral domain optical coherence tomography imaging of peripapillary retinal nerve fiber layer: a comparison study between hand-crafted features and deep learning model Comparison of line‐field confocal optical coherence tomography images with histological sections: Validation of a new method for in vivo and non‐invasive quantification of superficial dermis thickness