1. Articles from Claus Zimmer

    1-2 of 2
    1. Optical coherence tomography angiography indicates associations of the retinal vascular network and disease activity in multiple sclerosis

      Optical coherence tomography angiography indicates associations of the retinal vascular network and disease activity in multiple sclerosis

      Background: Patients with multiple sclerosis (MS) and clinically isolated syndrome (CIS) may show alterations of retinal layer architecture as measured by optical coherence tomography. Little is known about changes in the retinal vascular network during MS. Objective: To characterize retinal vessel structures in patients with MS and CIS and to test for associations with MS disease activity. Method: In all, 42 patients with MS or CIS and 50 healthy controls underwent retinal optical coherence tomography angiography (OCT-A) with analysis of the superficial and deep vascular plexuses and the choriocapillaries. We tested OCT-A parameters for associations with retinal layer volumes, history ...

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    2. Optical coherence tomography indicates disease activity prior to clinical onset of central nervous system demyelination

      Optical coherence tomography indicates disease activity prior to clinical onset of central nervous system demyelination

      Background: Establishing biomarkers for predicting disease activity in demyelinating disease of the central nervous system is crucial for designing appropriate disease modifiying treatment strategies. Objective: To investigate retinal findings and disease activity in patients with radiologically isolated and clinically isolated syndromes. Methods: We performed retinal optical coherence tomography and cerebral magnetic resonance imaging in healthy control individuals ( n =19), in individuals with non-specific white matter lesions ( n =18), and in patients with clinically isolated syndromes ( n =18) and radiologically isolated syndromes ( n =20). Results: Reduced volume of retinal nerve fibre layer and increased volume of inner nuclear layer at baseline ...

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    1-2 of 2
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  2. Topics in the News

    1. (1 articles) Technical University of Munich
    2. (1 articles) Ludwig-Maximilians University
    3. (1 articles) Jikei University School of Medicine
    4. (1 articles) VU University Amsterdam
    5. (1 articles) University of Toronto
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