1. Articles from Joseph M. Schmitt

    25-39 of 39 « 1 2
    1. Endoscopic 3D-OCT reveals buried glands following radiofrequency ablation of Barrett's esophagus

      Endoscopic 3D-OCT reveals buried glands following radiofrequency ablation of Barrett's esophagus

      Barrett's esophagus (BE) with high-grade dysplasia is generally treated by endoscopic mucosal resection or esophagectomy. Radiofrequency ablation (RFA) is a recent treatment that allows broad and superficial ablation for BE. Endoscopic three-dimensional optical coherence tomography (3D-OCT) is a volumetric imaging technique that is uniquely suited for follow-up surveillance of RFA treatment. 3D-OCT uses a thin fiberoptic imaging catheter placed down the working channel of a conventional endoscope. 3D-OCT enables en face and cross-sectional evaluation of the esophagus for detection of residual BE, neo-squamous mucosa, or buried BE glands. Patients who had undergone RFA treatment with the BARRX HALO90 system ...

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    2. Quantitative Methods For Obtaining Tissue Characteristics From Optical Coherence Tomography Images (Wo 2009/149131)

      Quantitative Methods For Obtaining Tissue Characteristics From Optical Coherence Tomography Images (Wo 2009/149131)
      A method and apparatus for determining properties of a tissue or tissues imaged by optical coherence tomography (OCT). In one embodiment the backscatter and attenuation of the OCT optical beam is measured and based on these measurements and indicium such as color is assigned for each portion of the image corresponding to the specific value of the backscatter and attenuation for that portion. The image is then displayed with the indicia and a user can then determine the tissue characteristics. In an alternative embodiment the tissue characteristics is classified automatically by a program given the combination of backscatter and attenuation ...
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    3. Effective treatment of chronic radiation proctitis using radiofrequency ablation

      Effective treatment of chronic radiation proctitis using radiofrequency ablation

      Endoscopic argon plasma coagulation and bipolar electrocautery are currently preferred treatments for chronic radiation proctitis, but ulcerations and strictures frequently occur. Radiofrequency ablation (RFA) has been successful for mucosal ablation in the esophagus. Here we report the efficacy of RFA with the BarRx Halo90 system in three patients with bleeding from chronic radiation proctitis. In all cases, the procedure was well tolerated and hemostasis was achieved after 1 or 2 RFA sessions. Re-epithelialization of squamous mucosa was observed over areas of prior hemorrhage. No stricturing or ulceration was seen on follow-up up to 19 months after RFA treatment. Real-time endoscopic ...

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    4. LightLab Imaging: Uncovering Diseases in Hard-to-Reach Places

      LightLab Imaging: Uncovering Diseases in Hard-to-Reach Places
      LightLab Imaging was founded on a leap of faith - the belief that a tiny amount of light reflected from just below the surface of a tissue carries a wealth of diagnostic information. When Imaging was founded in 1998, optical coherence tomography had not yet been established as a technique for developing micrometer resolution cross-sectional images inside biological tissue. (April Issue of Optics & Photonics News)
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    5. Current and future developments in intracoronary optical coherence tomography imaging

      Current and future developments in intracoronary optical coherence tomography imaging
      Optical Coherence Tomography (OCT) has become a key intracoronary imaging modality able to tranerse some of the limitations of angiography and intravascular ultrasound. In vivo imaging with high resolution (around 15 um) has given unique insights into not only atherosclerotic plaque, but also to the understanding of tissue responses underlying stent implantation.
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    6. Methods And Apparatus For Swept-Source Optical Coherence Tomography (Wo 2008/086017)

      Methods And Apparatus For Swept-Source Optical Coherence Tomography (Wo 2008/086017)
      In one embodiment of the invention, a semiconductor optical amplifier (SOA) in a laser ring is chosen to provide low polarization-dependent gain (PDG) and a booster semiconductor optical amplifier, outside of the ring, is chosen to provide high polarization-dependent gain. The use of a semiconductor optical amplifier with low polarization-dependent gain nearly eliminates variations in the polarization state of the light at the output of the laser, but does not eliminate the intra-sweep variations in the polarization state at the output of the laser, which can degrade the performance of the SS-OCT system.
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    7. Characterization of atherosclerosis plaques by measuring both backscattering and attenuation coefficients in optical coherence tomography

      Chenyang Xu, Joseph M. Schmitt, Stephane G. Carlier et al. Intravascular optical coherence tomography (OCT) has been proven a powerful diagnostic tool for cardiovascular diseases. However, the optical mechanism for the qualitative observations are still absent. We address the fundamental issues that underlie the tissue characterization of OCT images obtaine ... [J. Biomed. Opt. 13, 034003 (2008)] published Thu Jun 5, 2008.
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    8. Effects of axial resolution improvement on optical coherence tomography (OCT) imaging of gastrointestinal tissues

      Effects of axial resolution improvement on optical coherence tomography (OCT) imaging of gastrointestinal tissues

      Yu Chen, Aaron D. Aguirre, Pei-Lin Hsiung, Shu-Wei Huang, Hiroshi Mashimo, Joseph M. Schmitt, James G. Fujimoto. Optical coherence tomography (OCT) is an emerging medical imaging technology which generates high resolution, cross-sectional images in situ, without the need for excisional biopsy. Previous clinical studies using endoscopic OCT with standard 10-15 μm axial resolution have demonstrated its ... [Opt. Express 16, 2469-2485 (2008)]

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    9. Thinking inside the graft: applications of optical coherence tomography in coronary artery bypass grafting

      Emile N. Brown, Nicholas S. Burris, Junyan Gu et al. Recent advances in catheter-based optical coherence tomography (OCT) have provided the necessary resolution and acquisition speed for high-quality intravascular imaging. Complications associated with clearing blood from the vessel of a living patient have prevented its wider acceptance. We identify ... [J. Biomed. Opt. 12, 051704 (2007)] published Wed Oct 24, 2007.
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    10. Scanning Miniature Optical Probes With Optical Distortion Correction And Rotational Control (Wo 2004/010856)

      Scanning Miniature Optical Probes With Optical Distortion Correction And Rotational Control (Wo 2004/010856)
      The invention relates to an optical probe (130) including a sheath; a flexible, bi-directionally rotatable optical tansmission system (10, 135, 137) positioned within the sheath (44); and a viscous damping fluid (140) located in the sheath. The optical transmission system is capable of transmitting, focussing and collecting lignt of a predetermined range of wavelengths. the sheath and the viscous damping fluid are transpatent to at least some of the wavelengths of that light. The index of refracion of the viscous fluid is typically chosen to remove the optical effects induces by propagation through said sheath. Optical probes having a diameter ...
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    11. Broadband light source system and method and light source combiner

      A system for generating a source of broadband light includes, in one embodiment, a plurality of light sources such as SLEDs or edge-emitting luminescent diodes (ELEDs) whose outputs are combined in at least one combiner unit. The combiner unit combines light from a plurality of light sources into a single mode output beam. In one embodiment, the single mode output beam is the input beam to an interferometer for optical coherence tomography. In another embodiment, a time-gain compensation (TGC) unit is in communication with the plurality of light sources. The TGC unit controls the plurality of light sources independently and ...
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    12. Optical Coherence Tomography (OCT): A Review

      Summary:This paper reviews the state of the art of optical coherence tomography (OCT), an interferometric imaging technique that provides cross-sectional views of the subsurface microstructure of biological tissue. Following a discussion of the basic theory of OCT, an overview of the issues involved in the design of the main components of OCT systems is presented. The review concludes by introducing new imaging modes being developed to extract additional diagnostic information
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    13. OCT elastography: imaging microscopic deformation and strain of tissue

      OCT elastography: imaging microscopic deformation and strain of tissue
      Optical coherence tomography (OCT) has been applied to the study of the microscopic deformation of biological tissue under compressive stress. We describe the hardware and theory of operation of an OCT elastography system that measures internal displacements as small as a few micrometers by using 2D cross-correlation speckle tracking. Results obtained from gelatin scattering models, pork meat, and intact skin suggest possible medical applications of the technique.
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    25-39 of 39 « 1 2
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    1. (38 articles) Joseph M. Schmitt
    2. (37 articles) St. Jude Medical
    3. (11 articles) Desmond C. Adler
    4. (8 articles) Massachusetts Institute of Technology
    5. (8 articles) James G. Fujimoto
    6. (7 articles) Chao Zhou
    7. (7 articles) Tsung-Han Tsai
    8. (7 articles) Hiroshi Mashimo
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    Scanning miniature optical probes with optical distortion correction and rotational control Effects of axial resolution improvement on optical coherence tomography (OCT) imaging of gastrointestinal tissues Current and future developments in intracoronary optical coherence tomography imaging Endoscopic 3D-OCT reveals buried glands following radiofrequency ablation of Barrett's esophagus Features of Sub-Epithelial Glandular Structures on Three-Dimensional Endoscopic Optical Coherence Tomography (3D-EOCT) After Endoscopic Mucosal Ablation Semiautomatic segmentation and quantification of calcified plaques in intracoronary optical coherence tomography images Characterization of buried glands before and after radiofrequency ablation by using 3-dimensional optical coherence tomography (with videos) Comparison of Tissue Architectural Changes between Radiofrequency Ablation and Cryospray Ablation in Barrett’s Esophagus Using Endoscopic Three-Dimensional Optical Coherence Tomography Close Assessment and Testing for Chronic Graft Versus Host Disease, CATCH Study GaAs-Based InPBi Quantum Dots for High Efficiency Super-Luminescence Diodes Pearls and Pitfalls of Optical Coherence Tomography Angiography Image Interpretation Novel optical coherence tomography findings in idiopathic choroidal folds