1. Articles from Joseph W. Villard

    1-5 of 5
    1. Depth resolved photothermal OCT detection of macrophages in tissue using nanorose

      Depth resolved photothermal OCT detection of macrophages in tissue using nanorose

      Application of photothermal Optical Coherence Tomography (OCT) to detect macrophages in ex vivo rabbit arteries which have engulfed nanoclusters of gold coated iron oxide (nanorose) is reported. Nanorose engulfed by macrophages associated with atherosclerotic lesions in rabbit arteries absorb incident laser (800nm) energy and cause optical pathlength (OP) variation which is measured using photothermal OCT. OP variation in polydimethyl siloxane tissue phantoms containing varying concentrations of nanorose match values predicted from nanoparticle and material properties. Measurement of OP variation in rabbit arteries in response to laser excitation provides an estimate of nanorose concentration in atherosclerotic lesions of 2.5x109 particles ...

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    2. Methods and compositions to reduce scattering of light during therapeutic and diagnostic imaging procedures

      Methods and compositions to reduce scattering of light during therapeutic and diagnostic imaging procedures

      Disclosed are improved methods and compositions for use in light-based in vivo imaging and treatment. The techniques described involve the use of low-scattering, oxygen-carrying blood substitutes in imaging and treatment methods, including OCT imaging. The invention has particular advantages in imaging within the cardiovascular system and highly vascularized or oxygen-dependent tissues.

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    1-5 of 5
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    1. (4 articles) University of Texas Health Science Center
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    Methods and compositions to reduce scattering of light during therapeutic and diagnostic imaging procedures Depth resolved photothermal OCT detection of macrophages in tissue using nanorose Safety and efficacy of frequency domain optical coherence tomography in pigs Normative data and associations of Optical Coherence Tomography Angiography measurements of the macula: The Singapore Malay Eye Study Automatic Segmentation and Measurement of Choroid Layer in High Myopia for OCT Imaging Using Deep Learning In-process monitoring in laser grooving with line-shaped femtosecond pulses using optical coherence tomography Three-dimensional opto-thermo-mechanical model for predicting photo-thermal optical coherence tomography responses in multilayer geometries The role of optical coherence tomography angiography in moderate and advanced primary open-angle glaucoma OCT-angiography follow-up of choroidal neovascularization treated with treat- and- extend aflibercept regimen to avoid over-treatment A Review of Spectroscopic and Non-Spectroscopic Techniques for Diagnosing Breast Cancer Collaboration Between Seno Medical and Cogmedix Drives GOLDEN Results for Innovative Medical Breast Imaging System Prediction of Retinal Ganglion Cell Counts Considering Various Displacement Methods From OCT-Derived Ganglion Cell-Inner Plexiform Layer Thickness