1. Articles from Maria Vittoria Cicinelli

    1-24 of 24
    1. Optical coherence tomography angiography in diabetic patients without diabetic retinopathy

      Optical coherence tomography angiography in diabetic patients without diabetic retinopathy

      Purpose: To investigate a subset of diabetic patients without diabetic retinopathy with optical coherence tomography angiography, assessing the differences in macular perfusion between diseased eyes and healthy controls. Methods: Monocentric cross-sectional study, including 86 eyes from 43 diabetic patients with no clinical signs of diabetic retinopathy and 78 eyes from 39 controls. Patients underwent 3.0 × 3.0 mm and 4.5 × 4.5 mm swept-source optical coherence tomography angiography. Vessel density (%), foveal avascular zone area (mm 2 ), and avascular density (%) were provided for the superficial capillary plexus and the deep capillary plexus. Results: The foveal avascular zone area at ...

      Read Full Article
    2. An optical coherence tomography-based grading of diabetic maculopathy proposed by an international expert panel: The European School for Advanced Studies in Ophthalmology classification

      An optical coherence tomography-based grading of diabetic maculopathy proposed by an international expert panel: The European School for Advanced Studies in Ophthalmology classification

      Aims: To present an authoritative, universal, easy-to-use morphologic classification of diabetic maculopathy based on spectral domain optical coherence tomography. Methods: The first draft of the project was developed based on previously published classifications and a literature search regarding the spectral domain optical coherence tomography quantitative and qualitative features of diabetic maculopathy. This draft was sent to an international panel of retina experts for a first revision. The panel met at the European School for Advanced Studies in Ophthalmology headquarters in Lugano, Switzerland, and elaborated the final document. Results: Seven tomographic qualitative and quantitative features are taken into account and scored ...

      Read Full Article
    3. MULTIMODAL IMAGING AND TREATMENT OF SYPHILITIC CHOROIDAL NEOVASCULARIZATION

      MULTIMODAL IMAGING AND TREATMENT OF SYPHILITIC CHOROIDAL NEOVASCULARIZATION

      Purpose: To report a rare case of choroidal neovascularization (CNV) developed 2 years after successful treatment of ocular syphilis , identified by optical coherence tomography angiography . Methods: Case report. Results: A 31-year-old man with a history of syphilitic chorioretinitis developed a CNV 2 years after clinical remission of the infection. Structural optical coherence tomography (OCT) and optical coherence tomography angiography were helpful in providing detailed evidence of an extrafoveal CNV in an easy and noninvasive way. In comparison, the identification of CNV on fluorescein angiography was difficult because of the retinal blood barrier breakdown and intense choroidal background fluorescence for diffuse ...

      Read Full Article
    4. OCT Angiography in Acute Posterior Multifocal Placoid Pigment Epitheliopathy

      OCT Angiography in Acute Posterior Multifocal Placoid Pigment Epitheliopathy

      BACKGROUND AND OBJECTIVE: To describe retinal and choroidal findings in different stages of acute posterior multifocal placoid pigment epitheliopathy (APMPPE). PATIENTS AND METHODS: Retrospective, noncomparative case series studied by fundus biomicroscopy, fundus autofluorescence (FAF), fluorescein angiography (FA), indocyanine green angiography (ICGA), spectral-domain optical coherence tomographic (SD-OCT), and swept-source OCT angiography (SS-OCTA). RESULTS: Six eyes of three patients with bilateral APMPPE were included. FAF showed multifocal, branched patches of hyperautofluorescence with areas of hypoautofluorescence; FA disclosed early hypofluorescence, with late-phase hyperfluorescence; ICGA showed early and late-phase hypofluorescence. SD-OCT imaging revealed bilateral retinal thinning, external limiting membrane (ELM) disruption, and severe alteration ...

      Read Full Article
    5. Prognostic role of optical coherence tomography after switch to dexamethasone in diabetic macular edema

      Prognostic role of optical coherence tomography after switch to dexamethasone in diabetic macular edema

      Aims To analyze the visual outcome after early switch to dexamethasone (DEX) in eyes with diabetic macular edema previously treated with ranibizumab (RNB), based on structural spectral-domain optical coherence tomography (SD-OCT) features. Methods Retrospective study of data from 28 eyes which underwent a loading dose of three monthly RNB injections and were then shifted to DEX implant injection. SD-OCT analysis was performed before switch to DEX (week 12, 12W) according to the presence of integrity of ellipsoid zone (EZ) and external limiting membrane (ELM), disorganization of retinal inner layers (DRIL), and quantity of hyper-reflective spots (HRS). Best-corrected visual acuity (BCVA ...

      Read Full Article
    6. New imaging systems in diabetic retinopathy

      New imaging systems in diabetic retinopathy

      Various imaging modalities are of significant utility in the screening, grading, treatment, and follow-up of the different stages of diabetic retinopathy (DR) and diabetic macular edema. Color stereographic photography, fluorescein angiography, and optical coherence tomography (OCT) have been the gold standard for DR imaging for years. Besides these tools, newer technologies are gaining validation and popularity, such as fundus autofluorescence and OCT angiography. Furthermore, widefield retinography and ultra-widefield retinography have been introduced for a more comprehensive evaluation of the medium-far and very-far retinal peripheries, which is crucial for the assessment of the diverse manifestations of the disease. The aim of ...

      Read Full Article
    7. Inner Retinal Layer and Outer Retinal Layer Findings after Macular Hole Surgery Assessed by means of Optical Coherence Tomography

      Inner Retinal Layer and Outer Retinal Layer Findings after Macular Hole Surgery Assessed by means of Optical Coherence Tomography

      Aim . To summarize the spectrum of optical coherence tomography (OCT) and OCT angiography (OCTA) features after full-thickness macular hole (MH) repair surgery. Methods . A PubMed engine search was carried out using the terms “Macular Hole,” “Optical Coherence Tomography,” and “Optical Coherence Tomography Angiography.” All reports published in English up to October 2018, irrespective of their publication status, were included. Tomographic signs analyzed were divided according to the involved portion of the retina in “inner retinal layers” and “external retinal layers.” Despite predominantly involving the inner retinal layers, cystoid macular edema (CME) has been treated as a separate entity. Finally, report ...

      Read Full Article
    8. SWEPT-SOURCE AND SPECTRAL DOMAIN OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY VERSUS DYE ANGIOGRAPHY IN THE MEASUREMENT OF TYPE 1 NEOVASCULARIZATION

      SWEPT-SOURCE AND SPECTRAL DOMAIN OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY VERSUS DYE ANGIOGRAPHY IN THE MEASUREMENT OF TYPE 1 NEOVASCULARIZATION

      Purpose: To compare the area of Type 1 neovascularization in patients with age-related macular degeneration calculated on spectral domain optical coherence tomography angiography (SD-OCTA), swept-source OCTA, and indocyanine green angiography (ICGA). Methods: Cross-sectional study enrolling patients with neovascular age-related macular degeneration with Type 1 neovascularization . During the same visit, ICGA (Spectralis HRA, Heidelberg, Germany), 3 × 3-mm or 6 × 6-mm SD-OCTA (CIRRUS AngioPlex model 5000; Carl Zeiss Meditec, Inc, Dublin, OH), and 3 × 3-mm or 6 × 6-mm swept-source OCTA (Plex Elite 9000; Carl Zeiss Meditec, Inc) were performed. Neovascularization areas were compared among the three instruments. The degree of consistency between ...

      Read Full Article
    9. Comparison of methods to quantify macular and peripapillary vessel density in optical coherence tomography angiography

      Comparison of methods to quantify macular and peripapillary vessel density in optical coherence tomography angiography

      Purpose To compare macular and peripapillary vessel density values calculated on optical coherence tomography angiography (OCT-A) images with different algorithms, elaborate conversion formula, and compare the ability to discriminate healthy from affected eyes. Methods Cross-sectional study of healthy subjects, patients with diabetic retinopathy, and glaucoma patients (44 eyes in each group). Vessel density in the macular superficial capillary plexus (SCP), deep capillary plexus (DCP), and the peripapillary radial capillary plexus (RCP) were calculated with seven previously published algorithms. Systemic differences, diagnostic properties, reliability, and agreement of the methods were investigated. Results Healthy eyes exhibited higher vessel density values in all ...

      Read Full Article
    10. Optical Coherence Tomography Angiography of Pigmented Paravenous Retinochoroidal Atrophy

      Optical Coherence Tomography Angiography of Pigmented Paravenous Retinochoroidal Atrophy

      A 58-year-old man with bilateral pigmented paravenous retinochoroidal atrophy (PPRCA) associated with macular coloboma in the right eye underwent color fundus photography and fundus autofluorescence with the California ultra-widefield retinal imaging system (Optos, Dunfermline, UK), spectral-domain optical coherence tomography (SD-OCT) (Heidelberg Spectralis HRA + OCT; Heidelberg Engineering, Heidelberg, Germany), and en face OCT angiography (OCTA) (AngioPlex, Cirrus HD-OCT 5000; Carl Zeiss Meditec, Dublin, CA). The patient presented with a visual acuity of counting fingers in the right eye and 20/32 in the left eye. Fundus examination and SD-OCT showed typical PPRCA alterations in both eyes and a macular coloboma in ...

      Read Full Article
    11. Optical Coherence Tomography Angiography versus Dye Angiography in Age-Related Macular Degeneration: Sensitivity and Specificity Analysis

      Optical Coherence Tomography Angiography versus Dye Angiography in Age-Related Macular Degeneration: Sensitivity and Specificity Analysis

      Introduction . Optical coherence tomography angiography (OCTA) could be a valid tool to detect choroidal neovascularization (CNV) in neovascular age-related macular degeneration (nAMD), allowing the analysis of the type, the morphology, and the extension of CNV in most of the cases. Purpose . To determine the sensitivity and specificity of OCTA in detecting CNV secondary to nAMD, compared to fluorescein angiography (FA) and indocyanine green angiography (ICGA). Methods . Prospective observational study. Patients with suspected nAMD were recruited between May and December 2016. Patients underwent FA, ICGA, spectral domain OCT, and OCTA (AngioVue, Optovue, Inc.). Sensitivity and specificity of FA, with or without ...

      Read Full Article
    12. Retinal vascular alterations in reticular pseudodrusen with and without outer retinal atrophy assessed by optical coherence tomography angiography

      Retinal vascular alterations in reticular pseudodrusen with and without outer retinal atrophy assessed by optical coherence tomography angiography

      Purpose To investigate the intraretinal structural and vascular alterations in patients featuring reticular pseudodrusen (RPD), RPD with outer retinal atrophy (ORA), and drusen. Design Observational cross-sectional study. Methods Clinical practice study including 68 eyes of 57 patients (22 eyes of 17 patients with RPD; 24 eyes of 21 patients with RPD+ORA; 22 eyes of 19 patients with drusen). Each patient underwent spectral-domain optical coherence tomography (OCT) and OCT angiography (OCT-A). Measurement of retinal layers’ thickness was obtained by the automated segmentation protocol of the Spectralis OCT (Heidelberg Eye Explorer V.1.9.10.0). The superficial capillary plexus (SCP ...

      Read Full Article
    13. Macular Perfusion Parameters in Different Angiocube Sizes: Does The Size Matter in Quantitative Optical Coherence Tomography Angiography?

      Macular Perfusion Parameters in Different Angiocube Sizes: Does The Size Matter in Quantitative Optical Coherence Tomography Angiography?

      Purpose : To investigate the macular quantitative parameters interchangeability of three different optical coherence tomography angiography (OCT-A) angiocubes (i.e., 3 × 3, 6 × 6, and 12 × 12 mm) on healthy subjects and patients affected by diabetic retinopathy (DR) and to assess the interrater reliability of such indices across the different scan protocols. Methods : Retrospective study involving 20 eyes of healthy subjects and 20 eyes with DR. All eyes underwent swept-source OCT-A with 3 × 3-, 6 × 6-, and 12 × 12-mm angiocubes centered on the fovea. Foveal avascular zone (FAZ) area and vessel density on 3 × 3-, 6 × 6-, and 12 × 12-mm macular ...

      Read Full Article
    14. Retinal Vascular Impairment in Best Vitelliform Macular Dystrophy Assessed by Means of Optical Coherence Tomography Angiography

      Retinal Vascular Impairment in Best Vitelliform Macular Dystrophy Assessed by Means of Optical Coherence Tomography Angiography

      Purpose To evaluate vascular abnormalities at superficial (SCP), deep (DCP) capillary plexuses and choriocapillaris (CC) in patients with Best vitelliform macular dystrophy (BVMD) by means of optical coherence tomography angiography (OCT-A). Design Cross-sectional case series. Methods Sixty-six eyes of 33 patients with BVMD (sixteen males) and 33 controls were consecutively enrolled. Patients were subdivided in classic stages and underwent best-corrected visual acuity (BCVA), fundus autofluorescence and spectral domain-optical coherence tomography (Spectralis HRA+OCT; Heidelberg Engineering), and 4.5x4.5-mm Swept Source OCT-A (Triton DRI OCT; Topcon Corporation). Choroidal neovascularization (CNV) and capillary dilations were qualitatively assessed by two masked ophthalmologists ...

      Read Full Article
    15. Refining Coats’ disease by ultra-widefield imaging and optical coherence tomography angiography

      Refining Coats’ disease by ultra-widefield imaging and optical coherence tomography angiography

      Purpose The purpose of our study was to describe ultra-widefield (UWF) imaging and optical coherence tomography angiography (OCT-A) findings in affected and fellow eyes of patients with Coats’ disease. Methods Consecutive patients affected by Coats’ disease were prospectively recruited at the Department of Ophthalmology, San Raffaele Hospital, Milan, Italy in this cross-sectional, observational study. Patients underwent UWF color fundus photographs, UWF green autofluorescence, UWF fluorescein angiography (FA), optical coherence tomography (OCT), with 3 × 3 mm and 6 × 6 mm OCT-A scans of the macula. Images were qualitatively evaluated by two independent operators for the presence of pathology. Results Eleven patients ...

      Read Full Article
    16. Optical Coherence Tomography Angiography in Dry Age-related Macular Degeneration

      Optical Coherence Tomography Angiography in Dry Age-related Macular Degeneration

      Optical coherence tomography angiography (OCT-A) is a new imaging modality that provides non-invasive characterization and quantification of the microvasculature in different retinal conditions. The purpose of this paper is to give an updated review of the features of dry age-related macular degeneration investigated by means of new generation OCT-A. We searched PubMed and Medline using the terms “optical coherence tomography angiography” associated with “age-related macular degeneration”, “drusen”, “reticular pseudodrusen,” and “geographic atrophy” and reviewed publications up to January, 2017.

      Read Full Article
    17. Optical Coherence Tomography Angiography of Venous Loops in Diabetic Retinopathy

      Optical Coherence Tomography Angiography of Venous Loops in Diabetic Retinopathy

      Venous loops are relatively rare manifestations of diabetic retinopathy. The authors describe a case characterized by the development of a venous loop during a 3-year period. Optical coherence tomography angiography (OCTA) revealed a hyperintense signal from the lesion, attesting an ordinary flow into the venous loop. OCTA also showed an area of capillary loss in proximity of the lesion, which is in agreement with the proposed pathogenesis for venous loops, developed to bypass an area of retinal vessels occlusion.

      Read Full Article
    18. Choroid morphometric analysis in non-neovascular age-related macular degeneration by means of optical coherence tomography angiography

      Choroid morphometric analysis in non-neovascular age-related macular degeneration by means of optical coherence tomography angiography

      Aims To describe the vascular changes in patients affected by non-neovascular age-related macular degeneration (AMD), featuring reticular pseudodrusen (RPD), drusen, or both RPD and drusen by means of optical coherence tomography angiography (OCT-A). Methods Cross-sectional observational case series. Patients with non-neovascular AMD presenting at the Medical Retina Service of the Department of Ophthalmology, University Vita-Salute San Raffaele in Milan were recruited. Patients underwent best-corrected visual acuity, biomicroscopy, infrared reflectance, short-wavelength fundus autofluorescence and OCT-A (AngioPlex, CIRRUS HD-OCT 5000, Carl Zeiss Meditech, Dublin, USA). Main outcome was quantification of vessel density, stromal tissue, and vascular/stromal (V/S) ratio at the ...

      Read Full Article
    19. Optical coherence tomography angiography of polypoidal neovascularization associated with choroidal nevus

      Optical coherence tomography angiography of polypoidal neovascularization associated with choroidal nevus

      To report a case of juxtapapillary polypoidal choroidal neovascularization (PCNV) associated with choroidal nevus investigated by means of optical coherence tomography angiography (OCT-A). Case report. A 72-year-old woman presented with visual loss and metamorphopsia in her left eye for 5 days secondary to PCNV that developed on the border of a juxtapapillary choroidal nevus. Fluorescein angiography, indocyanine green angiography, and spectral-domain OCT confirmed the diagnosis. En face OCT-A disclosed a large tangled hyperreflective PCNV spreading from the optic disc at different levels of the choriocapillaris; the polyp lumina appeared hyporeflective. The patient was treated with 3 intravitreal injections of anti-vascular ...

      Read Full Article
    20. Vascular abnormalities in patients with Stargardt disease assessed with optical coherence tomography angiography

      Vascular abnormalities in patients with Stargardt disease assessed with optical coherence tomography angiography

      Aims To describe the vascular abnormalities in patients affected by Stargardt disease (STGD1) by means of optical coherence tomography angiography (OCT-A). Methods Cross-sectional case series, with the following inclusion criteria: diagnosis of STGD1, clear ocular media, and stable fixation. Patients underwent best-corrected visual acuity (BCVA), biomicroscopy, applanation tonometry, short-wavelength fundus autofluorescence (SW-FAF) (HRA Heidelberg, Germany), 3×3 Swept Source OCT-A (Topcon Corporation, Japan). Foveal avascular zone (FAZ) area was manually outlined and removed from the vessel density analysis (ImageJ). Main outcome was vessel density assessment in the superficial capillary plexus (SCP), in the deep capillary plexus (DCP), and in the ...

      Read Full Article
    21. Optical coherence tomography angiography: a useful tool for diagnosis of treatment-naïve quiescent choroidal neovascularization

      Optical coherence tomography angiography: a useful tool for diagnosis of treatment-naïve quiescent choroidal neovascularization

      Purpose To describe the optical coherence tomography angiography (OCT-A) features of treatment-naïve quiescent choroidal neovascularization (CNV) secondary to age-related macular degeneration, and to estimate the detection rate for neovascularization by means of OCT-A. Design Diagnostic tool validity assessment. Methods Treatment-naïve quiescent CNV were identified from a pool of patients at 2 retina referral centers. Patients underwent a complete ophthalmologic examination including fluorescein angiography, indocyanine green angiography, spectral-domain OCT and OCT-A. Detection rates of CNV by means of OCT-A were estimated with a second cohort of patients without CNV (negative controls) Results Twenty-two eyes of 20 consecutive patients with ...

      Read Full Article
    22. Vessel density analysis in patients with retinitis pigmentosa by means of optical coherence tomography angiography

      Vessel density analysis in patients with retinitis pigmentosa by means of optical coherence tomography angiography

      Aims To describe the vascular abnormalities in patients affected by retinitis pigmentosa (RP) by means of optical coherence tomography angiography (OCT-A). Methods Cross-sectional case series; patients with RP presenting at the Medical Retina Service of the Department of Ophthalmology, University Vita-Salute San Raffaele in Milan were recruited. Inclusion criteria were: diagnosis of RP, clear ocular media, adequate pupillary dilation, and stable fixation. Patients underwent best-corrected visual acuity (BCVA), biomicroscopy, short-wavelength fundus autofluorescence (SW-FAF), and 3×3 Swept Source OCT-A. 30 healthy subjects were chosen as controls. The main outcome was identification of abnormalities in density of the superficial capillary plexus ...

      Read Full Article
    23. Optical coherence tomography and pathological myopia: an update of the literature

      Optical coherence tomography and pathological myopia: an update of the literature

      The purpose of this paper is to give an updated review of the last clinical entities in pathological myopia proposed by means of new generation optical coherence tomography (OCT), including enhanced depth imaging (EDI-OCT) and swept source OCT (SS-OCT). PubMed and Google engine search were carried out using the terms “pathological myopia” associated with “coherence tomography,” “enhanced depth imaging,” and “swept source OCT.” Latest publications up to Jan 2015 about myopia-related complications, including open-angle chronic glaucoma, peripapillary retinal changes, acquired macular diseases, and choroidal neovascularization, have been reviewed. New OCT technologies have led to a greater insight in pathophysiology of ...

      Read Full Article
    1-24 of 24
  1. Categories

    1. Applications:

      Art, Cardiology, Dentistry, Dermatology, Developmental Biology, Gastroenterology, Gynecology, Microscopy, NDE/NDT, Neurology, Oncology, Ophthalmology, Other Non-Medical, Otolaryngology, Pulmonology, Urology
    2. Business News:

      Acquisition, Clinical Trials, Funding, Other Business News, Partnership, Patents
    3. Technology:

      Broadband Sources, Probes, Tunable Sources
    4. Miscellaneous:

      Jobs & Studentships, Student Theses, Textbooks
  2. Topics in the News

    1. (18 articles) Francesco Bandello
    2. (14 articles) Università Vita-Salute San Raffaele
    3. (13 articles) Giuseppe Querques
    4. (6 articles) San Raffaele Scientfic Institute
    5. (5 articles) Centre Hospitalier Intercommunal de Créteil
    6. (4 articles) Luisa Pierro
    7. (3 articles) Heidelberg Spectralis
    8. (2 articles) Marco Gagliardi
    9. (2 articles) Carl Zeiss Meditec
    10. (2 articles) Zeiss Cirrus HD-OCT
    11. (1 articles) FDA
    12. (1 articles) Brian K. Courtney
    13. (1 articles) Conavi Medical Inc.
  3. Popular Articles

  4. Picture Gallery

    Optical coherence tomography and pathological myopia: an update of the literature Swept source optical coherence tomography of a vitreal pocket entrapped in myelinated retinal nerve fibers Vessel density analysis in patients with retinitis pigmentosa by means of optical coherence tomography angiography Optical coherence tomography angiography: a useful tool for diagnosis of treatment-naïve quiescent choroidal neovascularization Vascular abnormalities in patients with Stargardt disease assessed with optical coherence tomography angiography Optical coherence tomography angiography of polypoidal neovascularization associated with choroidal nevus Choroid morphometric analysis in non-neovascular age-related macular degeneration by means of optical coherence tomography angiography Optical Coherence Tomography Angiography of Venous Loops in Diabetic Retinopathy Optical Coherence Tomography Angiography in Dry Age-related Macular Degeneration Refining Coats’ disease by ultra-widefield imaging and optical coherence tomography angiography Conavi Medical and Japan Lifeline Announce MHLW Approval of Novasight Hybrid Intravascular Imaging System for Japanese Market Capsule Endomicroscopy for Visualization of the Small Intestine in EED Population in Pakistan