1. Articles from Christopher Schütze

    1-15 of 15
    1. Clinical evaluation of neovascular and non-neovascular chronic central serous chorioretinopathy (CSC) diagnosed by swept source optical coherence tomography angiography (SS OCTA)

      Clinical evaluation of neovascular and non-neovascular chronic central serous chorioretinopathy (CSC) diagnosed by swept source optical coherence tomography angiography (SS OCTA)

      Purpose To evaluate the clinical characteristics of eyes with chronic central serous chorioretinopathy based on swept source optical coherence tomography angiography (SS OCTA). Methods Twenty-nine eyes presenting with chronic central serous chorioretinopathy (CSC) were examined with the Topcon SS OCTA, using the DRI optical coherence tomography (OCT) Triton machine, and were classified as neovascular or non-neovascular CSC depending on whether a vascular pattern was detected in the outer retina on OCT angiogram. The two groups were compared based on the following clinical findings: best corrected distance and reading visual acuity (BCDVA, best corrected reading acuity (BCRA)), rate of subretinal fluid ...

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    2. Polarisation-sensitive OCT is useful for evaluating retinal pigment epithelial lesions in patients with neovascular AMD

      Polarisation-sensitive OCT is useful for evaluating retinal pigment epithelial lesions in patients with neovascular AMD

      Background/aims To examine the reproducibility of lesion dimensions of the retinal pigment epithelium (RPE) in neovascular age-related macular degeneration (AMD) with polarisation-sensitive optical coherence tomography (PS-OCT), specifically imaging the RPE. Methods Twenty-six patients (28 eyes) with neovascular AMD were included in this study, and examined by a PS-OCT prototype. Each patient was scanned five times at a 1-day visit. The PS-OCT B-scan located closest to the macular centre presenting with RPE atrophy was identified, and the longitudinal diameter of the lesion was quantified manually using AutoCAD 2008. This procedure was followed for the identical B-scan position in all five ...

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    3. RETINAL PIGMENT EPITHELIUM FINDINGS IN PATIENTS WITH ALBINISM USING WIDE-FIELD POLARIZATION-SENSITIVE OPTICAL COHERENCE TOMOGRAPHY

      RETINAL PIGMENT EPITHELIUM FINDINGS IN PATIENTS WITH ALBINISM USING WIDE-FIELD POLARIZATION-SENSITIVE OPTICAL COHERENCE TOMOGRAPHY

      Purpose: To investigate pigmentation characteristics of the retinal pigment epithelium (RPE) in patients with albinism using wide-field polarization-sensitive optical coherence tomography compared with intensity-based spectral domain optical coherence tomography and fundus autofluorescence imaging. Methods: Five patients (10 eyes) with previously genetically diagnosed albinism and 5 healthy control subjects (10 eyes) were imaged by a wide-field polarization-sensitive optical coherence tomography system (scan angle: 40 x 40[degrees] on the retina), sensitive to melanin contained in the RPE, based on the polarization state of backscattered light. Conventional intensity-based spectral domain optical coherence tomography and fundus autofluorescence examinations were performed. Retinal pigment epithelium-pigmentation ...

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    4. Lesion Size Detection in Geographic Atrophy by Polarization-sensitive Optical Coherence Tomography and Correlation to Conventional Imaging Techniques

      Lesion Size Detection in Geographic Atrophy by Polarization-sensitive Optical Coherence Tomography and Correlation to Conventional Imaging Techniques

      Purpose: To investigate the reproducibility of automated lesion size detection in patients with geographic atrophy (GA) using polarization-sensitive spectral domain-OCT (PS-OCT) and to compare findings with scanning laser ophthalmoscopy (SLO), fundus autofluorescence (FAF), and intensity based SD-OCT. Methods: 29 eyes of 22 patients with GA were examined by PS-OCT, selectively identifying the retinal pigment epithelium (RPE). A novel segmentation algorithm was applied, automatically detecting and quantifying areas of RPE atrophy. The reproducibility of the algorithm was assessed and lesion sizes were correlated with manually delineated SLO, FAF and intensity based SD-OCT images to validate the clinical applicability of PS-OCT in ...

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    5. Large-field high-speed polarization sensitive spectral domain OCT and its applications in ophthalmology

      Large-field high-speed polarization sensitive spectral domain OCT and its applications in ophthalmology
      We present a novel spectral domain polarization sensitive OCT system (PS-OCT) that operates at an A-scan rate of 70 kHz and supports scan angles of up to 40° × 40°. The high-speed imaging allows the acquisition of up to 1024 × 250 A-scans per 3D scan, which, together with the large field of view, considerably increases the informative value of the images. To demonstrate the excellent performance of the new PS-OCT system, we imaged several healthy volunteers and patients with various diseases such as glaucoma, AMD, Stargardt’s disease, and albinism. The results are compared with clinically established methods such as scanning ...
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    6. Polarization sensitive optical coherence tomography of melanin provides intrinsic contrast based on depolarization

      Polarization sensitive optical coherence tomography of melanin provides intrinsic contrast based on depolarization

      Polarization sensitive optical coherence tomography (PS-OCT) is a functional extension of OCT. In addition to imaging based on tissue reflectivity, PS-OCT also enables depth-resolved mapping of sample polarization properties such as phase-retardation, birefringent axis orientation, Stokes vectors, and degree of polarization uniformity (DOPU). In this study, PS-OCT was used to investigate the polarization properties of melanin. In-vitro measurements in samples with varying melanin concentrations revealed polarization scrambling, i.e. depolarization of backscattered light. Polarization scrambling in the PS-OCT images was more pronounced for higher melanin concentrations and correlated with the concentration of the melanin granules in the phantoms. Moreover, in-vivo ...

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    7. Evaluation of Segmentation Procedures Using Spectral Domain Optical Coherence Tomography in Exudative Age-Related Macular Degeneration

      Evaluation of Segmentation Procedures Using Spectral Domain Optical Coherence Tomography in Exudative Age-Related Macular Degeneration
      Purpose: The purpose of this study was to evaluate standardized automated segmentation procedures of spectral domain optical coherence tomography (SD-OCT) in imaging of age-related macular degeneration. Methods: Twenty-nine eyes of 29 patients with neovascular age-related macular degeneration were included. Three groups were assigned, according to the predominant localization of extravasated fluid in the intra-, subretinal, and subretinal pigment epithelium (RPE) compartment. Automated segmentation procedures were evaluated in B scans of 512 × 128 × 1024 and 200 × 200 × 1024 scan patterns using SD-OCT (Cirrus). Alignment errors at the internal limiting membrane, actual RPE, and extrapolation of the physiologic RPE (RPE fit) were ...
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    8. Performance of Drusen Detection by Spectral-Domain Optical Coherence Tomography

      Performance of Drusen Detection by Spectral-Domain Optical Coherence Tomography
      Purpose. To evaluate the performance of automated analyses integrated in three spectral-domain optical coherence tomography (SD-OCT) devices to identify drusen in eyes with early (i.e., nonatrophic and nonneovascular) age-related macular degeneration (AMD). Methods. Twelve eyes of 12 AMD patients, classified as AREDS 2 and 3 and having a mean count of 113 drusen were examined with three clinical SD-OCT devices (Cirrus [Carl Zeiss Meditec, Dublin CA], 3DOCT-1000 [Topcon, Tokyo, Japan], and Spectralis [Heidelberg Engineering, GmbH, Heidelberg, Germany]) and five different scan patterns. After standard automated segmentation of the RPE was performed, every druse in each B-scan was identified and ...
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    9. Segmentation and quantification of retinal lesions in age-related macular degeneration using polarization-sensitive optical coherence tomography

      Segmentation and quantification of retinal lesions in age-related macular degeneration using polarization-sensitive optical coherence tomography
      We present polarization-sensitive optical coherence tomography (PS-OCT) for quantitative assessment of retinal pathologies in age-related macular degeneration (AMD). On the basis of the polarization scrambling characteristics of the retinal pigment epithelium, novel segmentation algorithms were developed that allow one to segment pathologic features such as drusen and atrophic zones in dry AMD as well as to determine their dimensions. Results from measurements in the eyes of AMD patients prove the ability of PS-OCT for quantitative imaging based on the retinal features polarizing properties. Repeatability measurements were performed in retinas diagnosed with drusen and geographic atrophy in order to evaluate the ...
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    10. Performance of OCT segmentation procedures to assess morphology and extension in geographic atrophy

      Performance of OCT segmentation procedures to assess morphology and extension in geographic atrophy
      Purpose: Investigating segmentation procedures and morphological findings in time domain (TD) and current spectral domain (SD) optical coherence tomography (OCT) devices in patients with geographic atrophy (GA).Methods: Fifty eyes of 46 patients with GA secondary to AMD and 15 control eyes were examined in this prospective noninterventional comparative case series. All patients underwent Stratus (model 3000), Cirrus (Carl Zeiss Meditec), Spectralis (Spectralis HRA+OCT; Heidelberg Engineering) and 3D-OCT-1000 (Topcon). Automated segmentation analyses were compared. An overlay of scanning laser ophthalmoscope (SLO) and three-dimensional retinal thickness (RT) maps were used to investigate whether areas of retinal thinning correspond to areas ...
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    11. Quantification of retinal lesions by polarization sensitive optical coherence tomography

      Quantification of retinal lesions by polarization sensitive optical coherence tomography
      Segmentation of retinal structures is an important step for quantitative diagnostic applications of optical coherence tomography (OCT) in ophthalmology. Contrary to previous segmentation algorithms that are based on intensity images, we use the tissue specific contrast provided by polarization sensitive (PS) OCT for segmentation of retinal layers and lesions. Our algorithms exploit the polarization scrambling property of the retinal pigment epithelium (RPE) in a first step to segment the RPE. The RPE is then used as a "backbone" to identify further structures like the normal RPE position (indicating Bruch's membrane) or the posterior tips of the photoreceptors. In a ...
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    12. Imaging of the retinal pigment epithelium in age-related macular degeneration using polarization sensitive optical coherence tomography

      Purpose: Spectral-domain optical coherence tomography (SD-OCT) provided new insights into the understanding of age-related macular degeneration (AMD) but provides limited information on the nature of hyperreflective tissue at the level of the retinal pigment epithelium (RPE). Therefore, a polarization-sensitive SD-OCT (PS-SD-OCT) was used to identify and characterize typical RPE-findings in AMD. Methods: 44 eyes of 44 AMD-patients were included into this prospective case series representing the entire AMD-spectrum from drusen (n=11), geographic atrophy (GA, n=11), neovascular AMD (nAMD, n=11) to fibrotic scars (n=11). Cirrus (Carl-Zeiss-Meditec), Spectralis (Heidelberg) and 3D-OCT-1000 (Topcon) were used for comparative imaging. A ...
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    13. Quantitative measurement of the degree of polarization uniformity of light backscattered by retinal layers by polarization sensitive OCT

      We report on an extension of our previously presented polarization sensitive optical coherence tomography (PS-OCT) technique towards quantitative measurements and imaging of depolarization of light backscattered by the various layers of the human ocular fundus in vivo. We use a state of the art spec ... [Proc. SPIE 7168, 716814 (2009)] published Tue Feb 24, 2009.
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    14. Imaging the human retina in vivo with combined spectral-domain polarization-sensitive optical coherence tomography and scanning laser ophthalmoscopy

      Polarization-sensitive (PS) optical coherence tomography (OCT) allows for depth-resolved measurement of light polarizing properties of different layers in the human retina. Since their inherent polarizing properties are different, the retinal structures can be identified using PS-OCT. We present an ... [Proc. SPIE 7163, 71630N (2009)] published Wed Feb 18, 2009.
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    1-15 of 15
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    1. (14 articles) Medical University of Vienna
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    Quantitative assessment of retinal disorders using polarization-sensitive optical coherence tomography Quantification of retinal lesions by polarization sensitive optical coherence tomography Performance of OCT segmentation procedures to assess morphology and extension in geographic atrophy Segmentation and quantification of retinal lesions in age-related macular degeneration using polarization-sensitive optical coherence tomography Performance of Drusen Detection by Spectral-Domain Optical Coherence Tomography Evaluation of Segmentation Procedures Using Spectral Domain Optical Coherence Tomography in Exudative Age-Related Macular Degeneration Polarization sensitive optical coherence tomography of melanin provides intrinsic contrast based on depolarization AI-Assisted In Situ Detection of Human Glioma Infiltration Using a Novel Computational Method for Optical Coherence Tomography Motorized capsule for shadow-free OCT imaging and synchronous beam control Notal Vision Diagnostic Clinic reports completion of 6 million ForeseeHome AMD home-monitoring tests Monitoring retinal responses to acute intraocular pressure elevation in rats with visible light optical coherence tomography Optical Coherence Tomography-Angiography of Different Choroidal Neovascularization Subtypes in Wet Age-related Macular Degeneration