1. Articles from Edward Zhang

    1-4 of 4
    1. Non-invasive multimodal optical coherence and photoacoustic tomography for human skin imaging

      Non-invasive multimodal optical coherence and photoacoustic tomography for human skin imaging

      The cutaneous vasculature is involved in many diseases. Current clinical examination techniques, however, cannot resolve the human vasculature with all plexus in a non-invasive manner. By combining an optical coherence tomography system with angiography extension and an all optical photoacoustic tomography system, we can resolve in 3D the blood vessels in human skin for all plexus non-invasively. With a customized imaging unit that permits access to various parts of patients’ bodies, we applied our multimodality imaging system to investigate several different types of skin conditions. Quantitative vascular analysis is given for each of the dermatological conditions to show the potential ...

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    2. Comprehensive vascular imaging using optical coherence tomography-based angiography and photoacoustic tomography

      Comprehensive vascular imaging using optical coherence tomography-based angiography and photoacoustic tomography

      Studies have proven the relationship between cutaneous vasculature abnormalities and dermatological disorders, but to image vasculature noninvasively in vivo , advanced optical imaging techniques are required. In this study, we imaged a palm of a healthy volunteer and three subjects with cutaneous abnormalities with photoacoustic tomography (PAT) and optical coherence tomography with angiography extension (OCTA). Capillaries in the papillary dermis that are too small to be discerned with PAT are visualized with OCTA. From our results, we speculate that the PA signal from the palm is mostly from hemoglobin in capillaries rather than melanin, knowing that melanin concentration in volar skin ...

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    3. Combined multi-modal photoacoustic tomography, optical coherence tomography (OCT) and OCT angiography system with an articulated probe for in vivo human skin structure and vasculature imaging

      Combined multi-modal photoacoustic tomography, optical coherence tomography (OCT) and OCT angiography system with an articulated probe for in vivo human skin structure and vasculature imaging

      Cutaneous blood flow accounts for approximately 5% of cardiac output in human and plays a key role in a number of a physiological and pathological processes. We show for the first time a multi-modal photoacoustic tomography (PAT), optical coherence tomography (OCT) and OCT angiography system with an articulated probe to extract human cutaneous vasculature in vivo in various skin regions. OCT angiography supplements the microvasculature which PAT alone is unable to provide. Co-registered volumes for vessel network is further embedded in the morphologic image provided by OCT. This multi-modal system is therefore demonstrated as a valuable tool for comprehensive non-invasive ...

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    4. In vivo dual-modality photoacoustic and optical coherence tomography imaging of human dermatological pathologies

      In vivo dual-modality photoacoustic and optical coherence tomography imaging of human dermatological pathologies

      Vascular abnormalities serve as a key indicator for many skin diseases. Currently available methods in dermatology such as histopathology and dermatoscopy analyze underlying vasculature in human skin but are either invasive, time-consuming, and laborious or incapable of providing 3D images. In this work, we applied for the first time dual-modality photoacoustic and optical coherence tomography that provides complementary information about tissue morphology and vasculature of patients with different types of dermatitis. Its noninvasiveness and relatively short imaging time and the wide range of diseases that it can detect prove the merits of the dual-modality imaging system and show the great ...

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    1-4 of 4
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  2. Topics in the News

    1. (4 articles) Medical University of Vienna
    2. (4 articles) Wolfgang Drexler
    3. (3 articles) University College London
    4. (3 articles) Michael P. Minneman
    5. (3 articles) Mengyang Liu
    6. (3 articles) Rainer A. Leitgeb
    7. (3 articles) Insight Photonic Solutions
    8. (1 articles) Harald Sattmann
    9. (1 articles) Boris Hermann
    10. (1 articles) Marco Bonesi
    11. (1 articles) University of Minnesota
    12. (1 articles) Samsung
    13. (1 articles) Tsinghua University
    14. (1 articles) University of Illinois at Urbana-Champaign
    15. (1 articles) Sungkyunkwan University
    16. (1 articles) Università Vita-Salute San Raffaele
    17. (1 articles) Hanyang University
    18. (1 articles) Taner Akkin
    19. (1 articles) Wei Chang
    20. (1 articles) Stephen A. Boppart
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    In vivo dual-modality photoacoustic and optical coherence tomography imaging of human dermatological pathologies Combined multi-modal photoacoustic tomography, optical coherence tomography (OCT) and OCT angiography system with an articulated probe for in vivo human skin structure and vasculature imaging Comprehensive vascular imaging using optical coherence tomography-based angiography and photoacoustic tomography Non-invasive multimodal optical coherence and photoacoustic tomography for human skin imaging IMAGING TECHNIQUE FROM BECKMAN LAB NAMED TOP 10 MICROSCOPY INNOVATION Optical coherence refraction tomography University of Southern California Receives NIH Grant for Imaging Cerebral and Retinal Microvasculature in Cerebral Small Vessel Disease Columbia University Receives NIH Grant  for Measures of Human Receptor and post Receptor Activity Multimodal Imaging of Multiple Evanescent White Dot Syndrome: A New Interpretation MULTIMODAL IMAGING AND TREATMENT OF SYPHILITIC CHOROIDAL NEOVASCULARIZATION Highly coherent supercontinuum generation in CS2 infiltrated single-core optical fiber Glioma cell migration dynamics in brain tissue assessed by multimodal optical imaging