1. Articles from Lin Yang

    1-3 of 3
    1. Tracking the invasion of breast cancer cells in paper-based 3D cultures by OCT motility analysis

      Tracking the invasion of breast cancer cells in paper-based 3D cultures by OCT motility analysis

      3D paper-based cultures (PBCs) are easy-to-use and provide a biologically representative microenvironment. By stacking a sheet of cell-laden paper below sheets containing cell-free hydrogel, we form an assay capable of segmenting cells by the distance they invaded from the original cell-seeded layer. These invasion assays are limited to end-point analyses with fluorescence-based readouts due to the highly scattering nature of the paper scaffolds. Here we demonstrate that optical coherence tomography (OCT) can distinguish living cells from the surrounding extracellular matrix (ECM) or paper fibers based upon their intracellular motility amplitude ( M ). M is computed from fluctuation statistics of the sample ...

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    2. Characterizing optical coherence tomography speckle fluctuation spectra of mammary organoids during suppression of intracellular motility

      Characterizing optical coherence tomography speckle fluctuation spectra of mammary organoids during suppression of intracellular motility

      Background: An understanding of how the mammary gland responds to toxicant and drug exposures can shed light on mechanisms of breast cancer initiation/progression and therapeutic effectiveness, respectively. In this study, we employed noninvasive, label-free and high-throughput optical coherence tomography speckle fluctuation spectroscopy (OCT-SFS) to track exposure-response relationships in three-dimensional (3D) mammary epithelial organoid models. Methods: OCT-SFS is sensitive to relatively high speed (~0.16–8 µm/min) motions of subcellular light scattering components occurring over short (~2–114 s) time scales, termed “intracellular motility.” In this study, OCT speckle fluctuation spectra are quantified by two metrics: the intracellular motility ...

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    3. Depth-Resolved Imaging Based on Optical Sampling by Cavity Tuning

      Depth-Resolved Imaging Based on Optical Sampling by Cavity Tuning

      We report here a demonstration of depth-resolved optical imaging based on optical sampling by cavity tuning (OSCAT). Both optical coherence tomography and three-dimensional surface mapping are performed using an OSCAT imager. Limitations on axial resolution and pulse repetition-rate stability are discussed and viable solutions are provided. Compared with other ultrafast laser-based schemes, such as asynchronous optical sampling, OSCAT provides a simple, cost-effective solution for rapid, large-depth noninvasive imaging.

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    1-3 of 3
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  2. Topics in the News

    1. (2 articles) University of North Carolina
    2. (1 articles) University of Alabama
    3. (1 articles) University of Sydney
    4. (1 articles) Sun Yat-Sen University
    5. (1 articles) National Institutes of Health
    6. (1 articles) Massachusetts Eye and Ear Infirmary
    7. (1 articles) Duke University
    8. (1 articles) National Research Council Canada
    9. (1 articles) University of Toronto
    10. (1 articles) MedLumics
    11. (1 articles) Alcon
    12. (1 articles) Abbott
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    Depth-Resolved Imaging Based on Optical Sampling by Cavity Tuning Characterizing optical coherence tomography speckle fluctuation spectra of mammary organoids during suppression of intracellular motility Tracking the invasion of breast cancer cells in paper-based 3D cultures by OCT motility analysis Prediction of Retinal Ganglion Cell Counts Considering Various Displacement Methods From OCT-Derived Ganglion Cell-Inner Plexiform Layer Thickness Changes of blood flow in macular zone of patients with diabetic retinopathy at different stages evaluated by optical coherence tomography angiography Very late stent thrombosis lacking findings of the typical causes on optical coherence tomography in a patient with SARS-CoV-2 Coarsening of choriocapillaris on optical coherence tomography angiography as a sign of acute idiopathic blind spot enlargement Valve-Like Outflow System Behavior With Motion Slowing in Glaucoma Eyes: Findings Using a Minimally Invasive Glaucoma Surgery-MIGS-Like Platform and Optical Coherence Tomography Imaging Optical Coherence Tomography Evaluation of Carotid Artery Stenosis and Stenting in Patients With Previous Cervical Radiotherapy The Effect of Radiologically Isolated Syndrome on Retinal and Choroidal Hemodynamics - An Optical Coherence Tomography Angiography Study The missing link in the recognition of corneal abnormalities MEEI Receives NIH Grant for Measuring and Modeling the Cochlear Motions that Drive the Inner and Outer Hair Cells and Produce Otoacoustic Emissions