1. Articles from Zhongjiang Chen

    1-10 of 10
    1. Optical coherence hyperspectral microscopy with a single supercontinuum light source

      Optical coherence hyperspectral microscopy with a single supercontinuum light source

      In the paper, we have developed an optical coherence hyperspectral microscopy with a single supercontinuum light source. The microscopy consists of optical coherence tomography (OCT) and hyperspectral imaging (HSI), which can visualize the structural and functional characteristics of biological tissues. The 500-700 nm band is selected for HSI and OCT imaging, where HSI enables imaging of oxygen saturation and hemoglobin (Hb) content, while OCT acquires structural characteristics to assess the morphology of biological tissues. The system performance of the optical coherence hyperspectral microscopy is verified by normal mice ears, and the practical applications of the microscopy is further performed in ...

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    2. Towards quantitative assessment of burn based on photoacoustic and optical coherence tomography

      Towards quantitative assessment of burn based on photoacoustic and optical coherence tomography

      Accurate and timely assessment of the severity of burn is essential for the treatment of burns. Currently, although most first‐degree and third‐degree burns are easily diagnosed through visual inspection or auxiliary diagnostic methods, the second‐degree burn is still difficult to distinguish due to the ambiguity boundaries of second‐degree with first‐degree and third‐degree burns. In this study, we proposed a non‐invasive technique by combing photoacoustic imaging (PAI) and optical coherence tomography (OCT) to multi‐parameter quantitatively assess the burns. The feasibility and capacity of the dual‐mode PAT/OCT for assessing the burns was ...

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    3. Multi-parameter characterization of atherosclerotic plaques based on optical coherence tomography, photoacoustic and viscoelasticity imaging

      Multi-parameter characterization of atherosclerotic plaques based on optical coherence tomography, photoacoustic and viscoelasticity imaging

      Detection of atherosclerotic plaque vulnerability is the critical step in prevention of acute coronary events. Fibrous cap thickness, lipid core size, and inflammation extent are three key parameters for assessing plaque vulnerability. Here, we report on multimodality imaging of mice aortic plaques using a system that integrates optical coherence tomography (OCT), photoacoustic imaging (PAI), and photoacoustic viscoelasticity imaging (PAVEI). The thickness of fibrous cap is accurately evaluated by OCT, and PAI helps to determine the distribution and size of lipid core. The mechanical properties of plaques are closely related to the plaque compositions and the content and distribution of macrophages ...

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    4. Optical Biopsy of Melanoma and Basal Cell Carcinoma Progression by Noncontact Photoacoustic and Optical Coherence Tomography: In vivo Multi-parametric Characterizing Tumor Microenvironment

      Optical Biopsy of Melanoma and Basal Cell Carcinoma Progression by Noncontact Photoacoustic and Optical Coherence Tomography: In vivo Multi-parametric Characterizing Tumor Microenvironment

      Measuring the structural and functional status of tumor microenvironment for malignant melanoma (MM) and basal cell carcinoma (BCC) is of profound significance in understanding dermatological condition for biopsy. However, conventional optical imaging techniques are limited to visualize superficial skin features and parameter information is deficient to depict pathophysiology correlations of skin diseases. Here, we demonstrate a preclinical device, all-optically integrated photoacoustic and optical coherence tomography (AOPA/OCT), that, for the first time, can simultaneously provide label-free biomarkers of vascular patterns, temporal and spatial heterogeneity of blood flow, and tissue micro-structure changes during tumor growth with pathophysiological correlations in mice models ...

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    5. Co-impulse multispectral photoacoustic microscopy and optical coherence tomography system using a single supercontinuum laser

      Co-impulse multispectral photoacoustic microscopy and optical coherence tomography system using a single supercontinuum laser

      A combination of multispectral photoacoustic microscopy (PAM) and optical coherence tomography (OCT) by a single light source was previously realized discretely; however, this is unfavorable for visualizing vital physiological and pathological activities in vivo . Here, a co-impulse dual-mode imaging system that simultaneously enables multispectral PAM and OCT using a megahertz supercontinuum pulse laser in vivo is presented. The 500–600 nm band is used for functional PAM imaging, which can flexibly switch between different wavelengths, while the 600–840 nm band is selected for OCT imaging. A mimicking phantom experiment and in vivo imaging of normal and melanoma mouse ears ...

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    6. Optical biopsy approach to basal cell carcinoma and melanoma based on all-optically integrated photoacoustic and optical coherence tomography

      Optical biopsy approach to basal cell carcinoma and melanoma based on all-optically integrated photoacoustic and optical coherence tomography

      Basal cell carcinoma (BCC) and melanoma (MM), with the highest morbidity and mortality, respectively, are considered as two skin cancers of concern in dermatology. Histological studies have demonstrated that vascular patterns and collagenous stroma serve as key parameters for BCC and MM classification. In this Letter, we sought to identify BCC and MM based on the dual parameters of vascular patterns and scattering structures provided by all-optically integrated photoacoustic and optical coherence tomography (AOPA/OCT). The imaging capability of the AOPA/OCT was verified by the mimic phantoms. Furthermore, in vivo characterization of vasculatures and tissue structures from BCC and ...

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    7. Simultaneous imaging of atherosclerotic plaque composition and structure with dual-mode photoacoustic and optical coherence tomography

      Simultaneous imaging of atherosclerotic plaque composition and structure with dual-mode photoacoustic and optical coherence tomography

      The composition of plaque is a major determinant of coronary-related clinical syndromes. By combining photoacoustic tomography (PAT) and optical coherence tomography (OCT), the optical absorption and scattering properties of vascular plaque can be revealed and subsequently used to distinguish the plaque composition and structure. The feasibility and capacity of the dual-mode PAT-OCT technique for resolving vascular plaque was first testified by plaque composition mimicking experiment. PAT obtained lipid information due to optical absorption differences, while owing to scattering differences, OCT achieved imaging of collagen. Furthermore, by combining PAT and OCT, the morphological characteristic and scattering difference of normal and lipid-rich ...

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    8. All-optically integrated multimodality imaging system: combined photoacoustic microscopy, optical coherence tomography, and fluorescence imaging

      All-optically integrated multimodality imaging system: combined photoacoustic microscopy, optical coherence tomography, and fluorescence imaging

      We have developed a multimodality imaging system by optically integrating all-optical photoacoustic microscopy (AOPAM), optical coherence tomography (OCT) and fluorescence microscopy (FLM) to provide complementary information including optical absorption, optical back-scattering and fluorescence contrast of biological tissue. By sharing the same low-coherence Michelson interferometer, AOPAM and OCT could be organically optically combined to obtain the absorption and scattering information of the biological tissues. Also, owing to using the same laser source and objective lens, intrinsically registered photoacoustic and fluorescence signals are obtained to present the radiative and nonradiative transition process of absorption. Simultaneously photoacoustic angiography, tissue structure and fluorescence molecular ...

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    9. Optically integrated trimodality imaging system: combined all-optical photoacoustic microscopy, optical coherence tomography, and fluorescence imaging

      Optically integrated trimodality imaging system: combined all-optical photoacoustic microscopy, optical coherence tomography, and fluorescence imaging

      We have developed a trimodality imaging system by optically integrating all-optical photoacoustic microscopy (AOPAM), optical coherence tomography (OCT), and fluorescence microscopy (FLM) to provide complementary information including optical absorption, optical back-scattering, and fluorescence contrast of biological tissue. By sharing the same low-coherence Michelson interferometer, AOPAM and OCT could be organically optically combined. Also, owing to using the same laser source and objective lens, intrinsically registered photoacoustic and fluorescence signals are obtained in a single pulse. Simultaneously photoacoustic angiography, tissue structure, and fluorescence molecular in vivo images of mouse ear were acquired to demonstrate the capabilities of the optically integrated trimodality ...

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    10. All-optically integrated photo-acoustic microscopy and optical coherence tomography based on a single Michelson detector

      All-optically integrated photo-acoustic microscopy and optical coherence tomography based on a single Michelson detector

      An all-optically noncontact dual-mode imaging system using a single Michelson detector that simultaneously achieved photo-acoustic microscopy (PAM) and optical coherence tomography (OCT) is presented. The pulse laser-induced photo-acoustic signals and the back-scattered photons were alternately detected by a single Michelson detector. The spatial resolution and imaging capability of the dual-mode imaging system were testified by scattering phantoms. Furthermore, in vivo images of the mouse ear demonstrated that the PAM-OCT can provide complementary anatomical and functional information for imaging of biological tissues, which could be the best co-imaging strategy of PAM and OCT in biomedicine

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      Mentions: UC Irvine
    1-10 of 10
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    1. (9 articles) South China Normal University
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    All-optically integrated photo-acoustic microscopy and optical coherence tomography based on a single Michelson detector Optically integrated trimodality imaging system: combined all-optical photoacoustic microscopy, optical coherence tomography, and fluorescence imaging All-optically integrated multimodality imaging system: combined photoacoustic microscopy, optical coherence tomography, and fluorescence imaging Simultaneous imaging of atherosclerotic plaque composition and structure with dual-mode photoacoustic and optical coherence tomography Optical biopsy approach to basal cell carcinoma and melanoma based on all-optically integrated photoacoustic and optical coherence tomography Co-impulse multispectral photoacoustic microscopy and optical coherence tomography system using a single supercontinuum laser Optical Biopsy of Melanoma and Basal Cell Carcinoma Progression by Noncontact Photoacoustic and Optical Coherence Tomography: In vivo Multi-parametric Characterizing Tumor Microenvironment Multi-parameter characterization of atherosclerotic plaques based on optical coherence tomography, photoacoustic and viscoelasticity imaging Towards quantitative assessment of burn based on photoacoustic and optical coherence tomography Optical coherence hyperspectral microscopy with a single supercontinuum light source Anterior segment optical coherence tomography findings in leukemic iris infiltration Monitoring for glaucoma progression with SAP, electroretinography (PERG and PhNR) and OCT