1. Articles from Sihua Yang

    1-6 of 6
    1. NIR-II dual-modal optical coherence tomography and photoacoustic imaging-guided dose-control cancer chemotherapy

      NIR-II dual-modal optical coherence tomography and photoacoustic imaging-guided dose-control cancer chemotherapy

      In this study, an organic nano-drug delivery platform was constructed as a biocompatible cancer chemotherapeutic system, in which clini-cally approved sorafenib was loaded in the redox-responsive polymeric micelles, enabling dose-control release of drug to cancer tissues. In addition, visualizing tumor microenvironment changes is also essential for cancer chemotherapy, which can provide a priori and feedback control of drug delivery with reduced side effect. Therefore, second near-infrared window (NIR-II) dual-modal optical coherence tomogra-phy (OCT) and photoacoustic imaging were performed for real-time visualizing tumor microenvironment changes in vivo during chemo-therapy. In particular, the tumor angiogenesis, the vascular networks density change, and the ...

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    2. Optical biopsy approach to basal cell carcinoma and melanoma based on all-optically integrated photoacoustic and optical coherence tomography

      Optical biopsy approach to basal cell carcinoma and melanoma based on all-optically integrated photoacoustic and optical coherence tomography

      Basal cell carcinoma (BCC) and melanoma (MM), with the highest morbidity and mortality, respectively, are considered as two skin cancers of concern in dermatology. Histological studies have demonstrated that vascular patterns and collagenous stroma serve as key parameters for BCC and MM classification. In this Letter, we sought to identify BCC and MM based on the dual parameters of vascular patterns and scattering structures provided by all-optically integrated photoacoustic and optical coherence tomography (AOPA/OCT). The imaging capability of the AOPA/OCT was verified by the mimic phantoms. Furthermore, in vivo characterization of vasculatures and tissue structures from BCC and ...

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    3. Simultaneous imaging of atherosclerotic plaque composition and structure with dual-mode photoacoustic and optical coherence tomography

      Simultaneous imaging of atherosclerotic plaque composition and structure with dual-mode photoacoustic and optical coherence tomography

      The composition of plaque is a major determinant of coronary-related clinical syndromes. By combining photoacoustic tomography (PAT) and optical coherence tomography (OCT), the optical absorption and scattering properties of vascular plaque can be revealed and subsequently used to distinguish the plaque composition and structure. The feasibility and capacity of the dual-mode PAT-OCT technique for resolving vascular plaque was first testified by plaque composition mimicking experiment. PAT obtained lipid information due to optical absorption differences, while owing to scattering differences, OCT achieved imaging of collagen. Furthermore, by combining PAT and OCT, the morphological characteristic and scattering difference of normal and lipid-rich ...

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    4. All-optically integrated multimodality imaging system: combined photoacoustic microscopy, optical coherence tomography, and fluorescence imaging

      All-optically integrated multimodality imaging system: combined photoacoustic microscopy, optical coherence tomography, and fluorescence imaging

      We have developed a multimodality imaging system by optically integrating all-optical photoacoustic microscopy (AOPAM), optical coherence tomography (OCT) and fluorescence microscopy (FLM) to provide complementary information including optical absorption, optical back-scattering and fluorescence contrast of biological tissue. By sharing the same low-coherence Michelson interferometer, AOPAM and OCT could be organically optically combined to obtain the absorption and scattering information of the biological tissues. Also, owing to using the same laser source and objective lens, intrinsically registered photoacoustic and fluorescence signals are obtained to present the radiative and nonradiative transition process of absorption. Simultaneously photoacoustic angiography, tissue structure and fluorescence molecular ...

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    5. Optically integrated trimodality imaging system: combined all-optical photoacoustic microscopy, optical coherence tomography, and fluorescence imaging

      Optically integrated trimodality imaging system: combined all-optical photoacoustic microscopy, optical coherence tomography, and fluorescence imaging

      We have developed a trimodality imaging system by optically integrating all-optical photoacoustic microscopy (AOPAM), optical coherence tomography (OCT), and fluorescence microscopy (FLM) to provide complementary information including optical absorption, optical back-scattering, and fluorescence contrast of biological tissue. By sharing the same low-coherence Michelson interferometer, AOPAM and OCT could be organically optically combined. Also, owing to using the same laser source and objective lens, intrinsically registered photoacoustic and fluorescence signals are obtained in a single pulse. Simultaneously photoacoustic angiography, tissue structure, and fluorescence molecular in vivo images of mouse ear were acquired to demonstrate the capabilities of the optically integrated trimodality ...

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    6. All-optically integrated photo-acoustic microscopy and optical coherence tomography based on a single Michelson detector

      All-optically integrated photo-acoustic microscopy and optical coherence tomography based on a single Michelson detector

      An all-optically noncontact dual-mode imaging system using a single Michelson detector that simultaneously achieved photo-acoustic microscopy (PAM) and optical coherence tomography (OCT) is presented. The pulse laser-induced photo-acoustic signals and the back-scattered photons were alternately detected by a single Michelson detector. The spatial resolution and imaging capability of the dual-mode imaging system were testified by scattering phantoms. Furthermore, in vivo images of the mouse ear demonstrated that the PAM-OCT can provide complementary anatomical and functional information for imaging of biological tissues, which could be the best co-imaging strategy of PAM and OCT in biomedicine

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      Mentions: Yi Wang UC Irvine
    1-6 of 6
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  2. Topics in the News

    1. (4 articles) South China Normal University
    2. (1 articles) UC Irvine
    3. (1 articles) Yi Wang
    4. (1 articles) Jikei University School of Medicine
    5. (1 articles) Macquarie University
    6. (1 articles) Medical University of Vienna
    7. (1 articles) University of Florence
    8. (1 articles) National Institutes of Health
    9. (1 articles) Beth Israel Deaconess Medical Center
    10. (1 articles) Giacomo Savini
    11. (1 articles) Bernhard Baumann
    12. (1 articles) Antonia Lichtenegger
    13. (1 articles) Movu
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