1. Articles from Jeremy Brown

    1-4 of 4
    1. Systems and methods for swept-source optical coherence tomographic vibrography

      Systems and methods for swept-source optical coherence tomographic vibrography

      Systems and methods are provided for performing OCT vibrography based on the synchronization of components of the OCT vibrography system. An A-scan trigger is employed to synchronize the operation of the scanning subsystem that scans the sample beam and an acoustic stimulus source that generates an acoustic stimulus for vibrographic measurements. The acoustic stimulus source is controlled such that when the scanning subsystem dwells on an imaging line selected for vibrography measurements, the acoustic stimulus is generated over a plurality of A-scans and the phase of the acoustic stimulus is locked to the A-scan trigger, such that the phase of ...

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    2. Long-range, wide-field swept-source optical coherence tomography with GPU accelerated digital lock-in Doppler vibrography for real-time, in vivo middle ear diagnostics

      Long-range, wide-field swept-source optical coherence tomography with GPU accelerated digital lock-in Doppler vibrography for real-time, in vivo middle ear diagnostics

      We present the design, implementation and validation of a swept-source optical coherence tomography (OCT) system for real-time imaging of the human middle ear in live patients. Our system consists of a highly phase-stable Vernier-tuned distributed Bragg-reflector laser along with a real-time processing engine implemented on a graphics processing unit. We use the system to demonstrate, for the first time in live subjects, real-time Doppler measurements of middle ear vibration in response to sound, video rate 2D B-mode imaging of the middle ear and 3D volumetric B-mode imaging. All measurements were performed non-invasively through the intact tympanic membrane demonstrating that the ...

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    3. Optical Coherence Tomography for Clinical Otology

      Optical Coherence Tomography for Clinical Otology

      Optical Coherence Tomography (OCT) is an interferometric imaging technique used to produce high-resolution depth-resolved images in tissue. By probing tissue with light, tissue morphology can be determined from the characteristics of an interference pattern produced by any light that is backscattered by sub-surface structures. OCT can be thought of as the optical analog to ultrasound. The middle ear is a unique part of the human body that is well-suited to diagnostic imaging using OCT. The eardrum, located at the end of the external ear canal, drives the bony ossicular chain (malleus, incus, stapes) to conduct sound to the inner ear ...

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    4. Optical coherence tomography system requirements for clinical diagnostic middle ear imaging

      Optical coherence tomography system requirements for clinical diagnostic middle ear imaging

      Noninvasive middle ear imaging using optical coherence tomography (OCT) presents some unique challenges for real-time, clinical use in humans. We present results from a two-dimensional/three-dimensional OCT system built to assess the imaging requirements of clinical middle ear imaging, and the technical challenges associated with them. These include the need to work at a low numerical aperture, the deleterious effects of transtympanic imaging on image quality at the ossicles, sensitivity requirements for clinical fidelity of images at real-time rates, and the high dynamic-range requirements of the ear. We validated the system by imaging cadaveric specimens with simulated disorders to show ...

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    1-4 of 4
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  2. Topics in the News

    1. (3 articles) Dalhousie University
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    Optical coherence tomography system requirements for clinical diagnostic middle ear imaging Optical Coherence Tomography for Clinical Otology Long-range, wide-field swept-source optical coherence tomography with GPU accelerated digital lock-in Doppler vibrography for real-time, in vivo middle ear diagnostics Systems and methods for swept-source optical coherence tomographic vibrography Trojan-Horse Diameter-Reducible Nanotheranostics for Macroscopic/Microscopic Imaging-Monitored Chemo-Antiangiogenic Therapy Thickness of retinal pigment epithelium–Bruch’s membrane complex in adult Chinese using optical coherence tomography Interocular symmetry of optical coherence tomography parameters in healthy children and adolescents Fluorescein Leakage and Optical Coherence Tomography Angiography Features of Microaneurysms in Diabetic Retinopathy Cross-free in both lateral and axial directions Fourier-domain full-field optical coherence tomography Microperimetry, Humphrey field analyzer, and optical coherence tomography in detecting glaucoma: a comparative performance study Scanning optimization of an electrothermally-actuated MEMS mirror for applications in optical coherence tomography endoscopy Near-infrared active superparamagnetic iron oxide nanoparticles for magnetomotive optical coherence tomography imaging and magnetic hyperthermia therapeutic applications