1. Articles from Jost B. Jonas

    1-24 of 24
    1. Microvascular retinal changes in pre-clinical diabetic retinopathy as detected by optical coherence tomographic angiography

      Microvascular retinal changes in pre-clinical diabetic retinopathy as detected by optical coherence tomographic angiography

      Purpose To investigate microvascular abnormalities in diabetic patients without conventional clinical signs of diabetic retinopathy (DR). Methods In this cross-sectional observational cohort study, the study group included randomly chosen participants of a community-based cohort with diabetes type 2 without DR, and the control group consisted of non-diabetic individuals from a population-based study. All participants underwent optical coherence tomographic angiography (OCTA). Results Upon OCTA, 118 (40.4%) eyes of the study group ( n  = 292 eyes) showed microvascular abnormalities including foveal avascular zone erosion (95 (32.5%) eyes), non-perfusion areas in the superficial and deep retinal layers (39 (13.4%) eyes and ...

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    2. Optical coherent tomographic angiographic pattern of the deep choroidal layer and choriocapillaris after photodynamic therapy for central serous chorioretinopathy

      Optical coherent tomographic angiographic pattern of the deep choroidal layer and choriocapillaris after photodynamic therapy for central serous chorioretinopathy

      Purpose To study the changes in the choroidal vascular pattern of the deep choroidal layer and choriocapillaris in the eyes with central serous chorioretinopathy (CSC) before versus after photodynamic therapy (PDT) as visualized by optical coherence tomography angiography (OCTA). Methods This comparative case series study included patients who underwent a half-dose of PDT as a therapy for CSC. Using OCTA and manually shifting the reference level into the deep choroidal layer, we assessed the density of the deep choroidal vascular layer and choriocapillaris. Results The study included 20 patients (17 men; mean age, 43.3 ± 10.9 years), with two ...

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    3. Optical coherence tomography angiography in retinal vein occlusions

      Optical coherence tomography angiography in retinal vein occlusions

      Purpose To examine the vascular density in different retinal layers and in the choriocapillaris in eyes with retinal vein occlusions (RVO). Methods Applying optical coherence tomography angiography (OCTA), we examined patients with unilateral RVOs and normal individuals of a control group. Results The study group included 48 patients with unilateral RVO and the control group 17 normal individuals. Eyes affected by RVO as compared to the contralateral unaffected eyes (all P  < 0.001), and the contralateral unaffected eyes as compared to the eyes of the control group ( P  < 0.05), showed a lower vessel density in the superficial and deep ...

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      Mentions: Jost B. Jonas
    4. Optical Coherence Tomography Angiography Vessel Density Changes after Acute Intraocular Pressure Elevation

      Optical Coherence Tomography Angiography Vessel Density Changes after Acute Intraocular Pressure Elevation

      To investigate changes in retinal vessel density in optic nerve head (ONH) and macula after acute intraocular pressure (IOP) elevation, we conducted a prospective observational study. Eyes with IOP rise ≥5 mmHg after 2-hour dark room prone provocative test (DRPPT) were included. Vasculature of ONH and macula was examined by optical coherence tomography angiography (OCTA) at baseline and after DRPPT. Among the 65 eyes of 42 individuals, 40 eyes with qualified images were enrolled. Mean IOP rise was 9.6 ± 4.2 mmHg (5.0–23.3 mmHg) after DRPPT. Retinal vessel density did not differ after IOP rise for ...

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    5. Posterior Staphylomas in Pathologic Myopia Imaged by Widefield Optical Coherence Tomography

      Posterior Staphylomas in Pathologic Myopia Imaged by Widefield Optical Coherence Tomography

      Purpose : To examine posterior staphylomas by widefield optical coherence tomography (WF-OCT) and three-dimensional magnetic resonance imaging (3D-MRI). Methods : Highly myopic patients (myopic refractive error >8.0 diopters or axial length >26.5 mm) who had previously undergone orbital 3D-MRI were examined by WF-OCT. Results : The study included 100 eyes of 57 patients with a mean age of 67.9 ± 10.7 years (range, 44–85 years) and mean axial length of 30.0 ± 2.3 mm (range, 25.1–36.5 mm). All staphylomas detected on the 3D-MRI, except for two very large staphylomas, were visualized on the WF-OCT images ...

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    6. Optical Coherence Tomographic Imaging of Posterior Episclera and Tenon's Capsule

      Optical Coherence Tomographic Imaging of Posterior Episclera and Tenon's Capsule

      Purpose : To investigate structural features of the posterior episclera and Tenon's capsule in patients with high myopia. Methods : This hospital-based observational study included highly myopic eyes (myopic refractive error > −8 diopters or axial length ≥26.5 mm) in which the posterior sclera in its full thickness could be visualized on swept-source optical coherence tomography (OCT) images in all 12 radial scans centered on the fovea. We assessed the posterior episclera and Tenon's capsule. Results : The study included 278 eyes of 175 patients (mean age, 60.9 ± 11.4 years; range, 32–89 years; axial length, 30.7 ± 1 ...

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    7. Vascular Density in Retina and Choriocapillaris As Measured by Optical Coherence Tomography Angiography

      Vascular Density in Retina and Choriocapillaris As Measured by Optical Coherence Tomography Angiography

      Purpose To measure the density of the superficial retinal small vessel network (SRSVN), superficial retinal capillary network (SRCN), deep retinal capillary network (DRCN) and choriocapillaris, and the size of the foveal avascular zone (FAZ) in the superficial retinal layer in normal eyes. Design Prospective observational cross-sectional study. Methods In healthy Chinese volunteers, the retinal and choroidal vasculature was visualized by split-spectrum amplitude decorrelation angiography associated optical coherence tomography (RTVueXR Avanti device; Optovue Inc., Fremont, CA, USA). Results Among 105 healthy participants (age:35.9±13.8 years) mean FAZ measured 0.35±0.12mm 2 , and mean density of SRSVN ...

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    8. FEATURES OF OPTICAL COHERENCE TOMOGRAPHY FOR THE DIAGNOSIS OF VOGT-KOYANAGI-HARADA DISEASE

      FEATURES OF OPTICAL COHERENCE TOMOGRAPHY FOR THE DIAGNOSIS OF VOGT-KOYANAGI-HARADA DISEASE

      Background/Purpose: To examine the diagnostic value of optical coherence tomography (OCT) for the detection of acute Vogt-Koyanagi-Harada (VKH) disease. Methods: Clinical charts and OCT images were retrospectively reviewed for patients consecutively diagnosed with acute VKH, subacute VKH, multifocal central serous chorioretinopathy (CSCR), and posterior scleritis. All patients underwent OCT, fundus photography, and fluorescein angiography (FA) before treatment. The characteristics of OCT and FA were analyzed and recorded. Results: The study included 80 eyes with acute VKH, 32 eyes with subacute VKH, 33 eyes with CSCR, and 13 eyes with posterior scleritis. The most common OCT features of VKH disease ...

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    9. Macular Bruch’s Membrane Holes in Choroidal Neovascularization-Related Myopic Macular Atrophy by Swept-Source Optical Coherence Tomography

      Macular Bruch’s Membrane Holes in Choroidal Neovascularization-Related Myopic Macular Atrophy by Swept-Source Optical Coherence Tomography

      Purpose To determine frequency and associations of macular Bruch’s membrane defects in the region of macular atrophy developing after the onset of myopic choroidal neovascularization (CNV). Design Retrospective observational case series. Methods The study included all patients who were consecutively examined for high myopia (axial length ≥26.5mm) and CNV-related macular atrophy in the study period from June to July 2015. The patients underwent a comprehensive ophthalmologic examination including swept-source optical coherence tomography (OCT) of the macula. Main outcome measures were macular Bruch’s membrane defects. Results Out of 33 eyes (28 patients) with myopic CNV-related macular atrophy, 25 ...

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    10. Macular Bruch Membrane Holes in Choroidal Neovascularization–Related Myopic Macular Atrophy by Swept-Source Optical Coherence Tomography

      Macular Bruch Membrane Holes in Choroidal Neovascularization–Related Myopic Macular Atrophy by Swept-Source Optical Coherence Tomography

      Purpose To determine frequency and associations of macular Bruch membrane defects in the region of macular atrophy developing after the onset of myopic choroidal neovascularization (CNV). Design Retrospective observational case series. Methods The study included all patients who were consecutively examined for high myopia (axial length ≥26.5mm) and CNV-related macular atrophy in the study period from June to July 2015. The patients underwent a comprehensive ophthalmologic examination including swept-source optical coherence tomography (OCT) of the macula. Main outcome measures were macular Bruch membrane defects. Results Out of 33 eyes (28 patients) with myopic CNV-related macular atrophy, 25 eyes (76 ...

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    11. Retinal nerve fibre layer thickness measured by Spectralis spectral-domain optical coherence tomography: The Beijing Eye Study

      Retinal nerve fibre layer thickness measured by Spectralis spectral-domain optical coherence tomography: The Beijing Eye Study

      Purpose The aim of this study was to measure retinal nerve fibre layer thickness (RNFLT) and its associated factors in a population-based setting. Methods The population-based Beijing Eye Study 2011 included 3468 individuals. The study participants underwent spectral-domain optical coherence tomography (Spectralis ® ; Spectralis OCT)–assisted measurement of the RNFLT. For this study, exclusion criteria were glaucoma, pseudoexfoliation, best-corrected visual acuity of >0.5 logMAR, macular diseases, previous ocular surgery and known neurological diseases. The only inclusion criterion was an age of 50+ years. Results The inclusion criteria were fulfilled by 2548 participants. Mean RNFLT was 102 ± 11 μm. RNFLT was ...

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    12. Localized Retinal Nerve Fiber Layer Defects Detected by Optical Coherence Tomography: The Beijing Eye Study

      Localized Retinal Nerve Fiber Layer Defects Detected by Optical Coherence Tomography: The Beijing Eye Study

      Objective To assess the prevalence of localized retinal nerve fiber layer defects (LRNFLD) and associated factors in adult Chinese. Methods The population-based Beijing Eye Study 2011 included 3468 individuals (mean age: 64.6±9.8 years (range: 50–93 years)). The study participants underwent a detailed ophthalmological examination including spectral-domain optical coherence tomography (Spectralis R -OCT) assisted measurement of the RNFL. A LRNFLD was defined as a sector in which the RNFL contour line dipped into the red zone for a length of <180°. Results Readable OCT images were available for 3242 (93.5%) subjects. LRNFLDs were detected in 640 ...

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    13. Optical Coherence Tomography Assisted Enhanced Depth Imaging of Central Serous Chorioretinopathy

      Optical Coherence Tomography Assisted Enhanced Depth Imaging of Central Serous Chorioretinopathy

      PURPOSE: To describe characteristics of central serous chorioretinopathy (CSC) imaged by optical coherence tomography assisted enhanced depth imaging (EDI-OCT). METHODS: The prospective observational case series study consisted of patients with acute or chronic CSC. All subjects underwent fundus fluorescein angiography (FFA), indocyanine green angiography (ICGA), and EDI-OCT. RESULTS: The study included 68 eyes (68 patients) with 35 eyes showing signs of acute CSC. Mean subfoveal choroidal thickness was 478±114 μm was larger than the normative value from the Beijing Eye Study 2011 (254±107 μm) on the same ethnic group. In the hyperfluorescent ICGA areas, EDI-OCT revealed a thinning ...

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    14. Optical Coherence Tomographic Enhanced Depth Imaging of Polypoidal Choroidal Vasculopathy

      Optical Coherence Tomographic Enhanced Depth Imaging of Polypoidal Choroidal Vasculopathy

      Purpose: To assess the dimensions of hyporeflective choroidal lumina and choroidal thickness in patients with polypoidal choroidal vasculopathy (PCV) without subretinal hemorrhage. Methods: Chinese patients with PCV and without subretinal hemorrhage and subjects of a control group underwent enhanced depth imaging by optical coherence tomography. Choroidal thickness and the largest diameter of choroidal hyporeflective lumina as surrogates for choroidal vessels were measured. Results: The study included 18 eyes of Chinese patients with PCV and 19 subjects of a control group, with no significant difference in age (P = 0.10) or refractive error (P = 0.89) between the groups. Mean subfoveal ...

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    15. Reproducibility of Subfoveal Choroidal Thickness Measurements with Enhanced Depth Imaging By Spectral-Domain Optical Coherence Tomography

      Reproducibility of Subfoveal Choroidal Thickness Measurements with Enhanced Depth Imaging By Spectral-Domain Optical Coherence Tomography

      Purpose: To measure the interobserver reproducibility and intraobserver reproducibility of subfoveal choroidal thickness measurements performed by enhanced depth imaging of spectral-domain optical coherence tomography (EDI-OCT) in a population-based setting. Method: The Beijing Eye Study 2011 was a population-based study performed in rural and urban regions of Greater Beijing. The study included 3468 individuals with a mean age of 64.6±9.8 years (range: 50-93 years). The participants underwent EDI-OCT and the subfoveal choroidal thickness (SFCT) was measured. To examine the inter-observer variability, all images were assessed by two examiners independently of each other within 2 months. To examine the ...

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    16. Cotton-Wool Spot and Optical Coherence Tomography of a Retinal Nerve Fiber Layer Defect

      Cotton-Wool Spot and Optical Coherence Tomography of a Retinal Nerve Fiber Layer Defect

      A 53-year-old woman with severe arterial hypertension was concerned about flashes and a shadow in her left eye. Perimetry revealed an arc-shaped visual field defect in the superior hemisphere. Ophthalmoscopy showed a large cotton-wool spot inferior of the optic disc (Figure 1, above). Optical coherence tomography showed an edema of the retinal nerve fiber layer in the area of the cotton-wool spot. One year later, perimetry was unchanged. On ophthalmoscopy, an inferior wedge-shaped defect of the retinal nerve fiber layer was detected (Figure 2A, right, white arrows), while the cotton-wool spot completely vanished. Optical coherence tomography revealed a marked reduction ...

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    17. Reproducibility of Macular, Retinal Nerve Fiber Layer, and ONH Measurements by OCT in Rhesus Monkeys: The Beijing Intracranial and Intraocular Pressure (iCOP) Study

      Reproducibility of Macular, Retinal Nerve Fiber Layer, and ONH Measurements by OCT in Rhesus Monkeys: The Beijing Intracranial and Intraocular Pressure (iCOP) Study

      Purpose. We evaluated repeatability and reproducibility of measurements of the retinal nerve fiber layer thickness (RNFLT), optic nerve head (ONH), and macular inner retinal layer (MIRL) by RTVue spectral-domain optical coherence tomography (OCT) in normal Rhesus monkeys. Methods. The experimental study included 15 adult Rhesus macaque monkeys. RNFLT, ONH parameters (area of disc, cup, and rim; volume of cup and rim; and cup-to-disc ratios), and MIRL thickness were imaged at three separate examinations within one month. Each eye was imaged three times at the first examination, and once at each of the two following examinations. We determined the intra-session and ...

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    18. Measurement of Normal Optic Nerve Head Parameters

      Measurement of Normal Optic Nerve Head Parameters

      Abstract: All optic nerve pathologies, including the glaucomas and disorders such as non-arteritic ischemic optic neuropathy, affect the appearance of the optic nerve head. Morphological examination of the optic nerve head in a qualitative and quantitative manner is therefore clinically mandatory. With the advent of modern imaging modalities such as confocal scanning laser tomography and optical coherence tomography, new diagnostic avenues have opened up to further refine the examination. The new imaging devices are now becoming a major adjunct to the diagnosis and long-term management of optic nerve head pathology; before it is possible to identify an abnormal optic disk ...

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    19. Reproducibility of Macular, Retinal Nerve Fiber Layer and Optic Nerve Head Measurements by Optical Coherence Tomography in Rhesus Monkeys

      Reproducibility of Macular, Retinal Nerve Fiber Layer and Optic Nerve Head Measurements by Optical Coherence Tomography in Rhesus Monkeys

      Purpose. To evaluate repeatability and reproducibility of measurements of the retinal nerve fiber layer thickness (RNFLT), optic nerve head (ONH) and macular inner retinal layer (MIRL) by spectral-domain optical coherence tomography (OCT) (RTVue) in normal Rhesus monkeys. Method. The experimental study included 15 adult rhesus macaque monkeys. RNFLT, ONH parameters (area of disc, cup and rim; volume of cup and rim; cup/disc ratios) and MIRL thickness were imaged at three separate examinations within one month. Each eye was imaged three times at the first examination, and once at each of the two following examinations. We determined the intra-session and ...

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    20. Anterior segment optical coherence tomography of acute primary angle closure

      Anterior segment optical coherence tomography of acute primary angle closure
      Background To assess anterior segment optical coherence tomographic measurements of patients after acute unilateral primary angle closure (APAC) compared with those of normal subjects. Methods The clinical observational study included 41 hospital-based patients after unilateral APAC, their unaffected contralateral eyes, and 205 subjects. These were selected from the population-based Beijing Eye Study, and were matched with the APAC group for age, gender, and refractive error. All study participants underwent slit-lamp adapted optical coherence tomography (OCT). Results Compared with the unaffected contralateral eyes, eyes with APAC had a significantly shallower anterior chamber (P < 0.001), smaller chamber angle (P < 0.001 ...
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    21. The Beijing Eye Study

      Purpose: This review presents and summarizes the findings of the Beijing Eye Study. Methods: The Beijing Eye Study is a population-based study which included 4439 of 5324 subjects (aged ≥ 40 years) who were initially examined in 2001. The study was repeated in 2006, when 3251 (73.2% of 4439, or 61.1% of 5324) of the original subjects participated. Participants underwent a series of examinations including: refractometry; pneumotonometry; biomicroscopy assisted by slit-lamp; optical coherence tomography of the anterior segment; photography of the cornea, lens, optic disc, macula and fundus; blood sampling for laboratory tests; blood pressure measurements, and determinations of ...
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    22. Central corneal thickness in adult Chinese. Association with ocular and general parameters. The Beijing Eye Study

      Abstract Background  To evaluate the distribution of central corneal thickness and its associations in the adult Chinese population. Methods  The Beijing Eye Study 2006 is a population-based study including 3,251 (73.3%) subjects (aged 45+ years) out of 4,439 subjects who participated in the survey in 2001 and who returned for re-examination. Central corneal thickness (CCT) measurements were performed by slit lamp-based optical coherence tomography. Results  Central corneal thickness measurement data were available for 3,100 (95.4%) subjects. Mean CCT was 556.2±33.1 μm (median: 553 μm; range: 429–688 μm). In multiple regression analysis ...
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    1-24 of 24
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    Anterior segment optical coherence tomography of acute primary angle closure Reproducibility of Macular, Retinal Nerve Fiber Layer and Optic Nerve Head Measurements by Optical Coherence Tomography in Rhesus Monkeys Measurement of Normal Optic Nerve Head Parameters Reproducibility of Macular, Retinal Nerve Fiber Layer, and ONH Measurements by OCT in Rhesus Monkeys: The Beijing Intracranial and Intraocular Pressure (iCOP) Study Cotton-Wool Spot and Optical Coherence Tomography of a Retinal Nerve Fiber Layer Defect Reproducibility of Subfoveal Choroidal Thickness Measurements with Enhanced Depth Imaging By Spectral-Domain Optical Coherence Tomography Localized Retinal Nerve Fiber Layer Defects Detected by Optical Coherence Tomography: The Beijing Eye Study Retinal nerve fibre layer thickness measured by Spectralis spectral-domain optical coherence tomography: The Beijing Eye Study In vivo dynamic characterization of the human tympanic membrane using pneumatic optical coherence tomography Negative Vessel Remodeling in Stargardt Disease Quantified with Volume-Rendered Optical Coherence Tomography Angiography Spectral Domain – Optical Coherence Tomography findings in Triple-A Syndrome – A case series from Pakistan Feasibility of microscope-integrated swept-source optical coherence tomography in canaloplasty