1. Articles from Tarun Sharma

    1-12 of 12
    1. Optical Coherence Tomography (Book Chapter)

      Optical Coherence Tomography (Book Chapter)

      Optical coherence tomography (OCT) has enhanced our understanding and management of retinal diseases, ever since the time-domain OCT was introduced in the early 2000s. The introduction of spectral-domain OCT in the mid-2000s and the later introduction of swept-source OCT provided faster scanning strategies and high-resolution images of the retina and choroid.

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    2. Quantitative spectral domain optical coherence tomography thickness parameters in type II diabetes

      Quantitative spectral domain optical coherence tomography thickness parameters in type II diabetes

      Purpose: To elucidate the changes in retinal thickness and individual layer thickness in subjects with diabetic retinopathy (DR) using spectral domain optical coherence tomography (SDOCT). Materials and Methods: A total of 251 eyes from 170 subjects were included in this study. The study sample was subdivided into nondiabetic subjects; subjects with diabetes but no DR; subjects with mild, moderate, and severe nonproliferative DR (NPDR); and proliferative DR. Various retinal thickness parameters were assessed using SDOCT. Results: The mean age of the study population was 55.34 ± 9.02 years (range: 32-80 years) and 56.6% of the subjects were males ...

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    3. Imaging drusens using Spectral Domain Optical Coherence Tomography

      Imaging drusens using Spectral Domain Optical Coherence Tomography

      Purpose The purpose was to evaluate pathological changes of photoreceptor layer and retinal pigment epithelium in eyes with drusens using Spectral Domain Optical Coherence Tomography (SD-OCT). Methods Twenty-nine eyes of 29 patients with (drusens) dry age-related macular degeneration and 43 eyes of 43 controls were included in this study. All subjects underwent complete ophthalmic examination including SD-OCT. Central foveal thickness (CFT), photoreceptor layer (PRL) thickness and retinal pigment epithelial (RPE) thickness were measured and compared between the groups. P value < 0.05 was considered statistically significant. Results Best corrected visual acuity (BCVA) ranged between 20/20 and 20/200. RPE ...

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    4. Spectral domain optical coherence tomography characteristics in diabetic retinopathy

      Spectral domain optical coherence tomography characteristics in diabetic retinopathy

      Purpose: To report the appearance of diabetic retinopathy lesions using spectral domain optical coherence tomography (SD-OCT). Materials and Methods: A total of 287 eyes of 199 subjects were included. All the subjects underwent complete ophthalmic examination including SD-OCT. Results: The appearance of various lesions of diabetic retinopathy and the retinal layers involved were reported. In subjects with macular edema the prevalence of incomplete PVD was 55.6%. Conclusion: SD-OCT brings new insights into the morphological changes of the retina in diabetic retinopathy.

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    5. Macular Thickness Measurements using Copernicus Spectral Domain Optical Coherence Tomography

      Macular Thickness Measurements using Copernicus Spectral Domain Optical Coherence Tomography

      Purpose To provide normal macular thickness measurements using Spectral Domain Optical Coherence Tomography (SDOCT, Copernicus, Optopol Technologies, Zawierci, Poland). Methods Fifty eight eyes of 58 healthy subjects were included in this prospective study. All subjects had comprehensive ophthalmic examination including best-corrected visual acuity (BCVA). All the subjects underwent Copernicus SDOCT. Central foveal thickness (CFT) and photoreceptor layer (PRL) thickness were measured and expressed as mean and standard deviation. Mean retinal thickness for each of the 9 regions defined in the Early Treatment Diabetic Retinopathy Study were reported. The data was compared with published literature in Indians using Stratus and Spectralis ...

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    6. Communications between intraretinal and subretinal space on optical coherence tomography of neurosensory retinal detachment in diabetic macular edema

      Communications between intraretinal and subretinal space on optical coherence tomography of neurosensory retinal detachment in diabetic macular edema

      Background: The pathogenesis of development and progression of neurosensory retinal detachment (NSD) in diabetic macular edema (DME) is not yet fully understood. The purpose of this study is to describe the spectral domain optical coherence tomography (SD-OCT) morphological characteristics of NSD associated with DME in the form of outer retinal communications and to assess the correlation between the size of communications and various factors. Materials and Methods: This was an observational retrospective nonconsecutive case series in a tertiary care eye institute. We imaged NSD and outer retinal communications in 17 eyes of 16 patients having NSD associated with DME using ...

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    7. Optical Coherence Tomography Characteristics in Eyes With Optic Pit Maculopathy

      Optical Coherence Tomography Characteristics in Eyes With Optic Pit Maculopathy

      Purpose: To study the optical coherence tomography characteristics of optic pit maculopathy and propose the anatomical pathophysiology of fluid conduit from pit to macula. Methods: The charts of 32 patients (32 eyes) with the diagnosis of optic pit maculopathy were reviewed. Clinical variables that were studied included duration of visual impairment, initial visual acuity, and associated fundus features. Optical coherence tomography characteristics including communication with pit, layer of retina involved in schisis, and presence of subretinal fluid were noted. Results: The mean age of the patients was 27.8 years, and the mean duration of visual impairment was 21.8 ...

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    8. Morphological and functional changes in spectral domain optical coherence tomography and microperimetry in macular microhole variants: Spectral domain optical coherence tomography and microperimetry correlation

      Morphological and functional changes in spectral domain optical coherence tomography and microperimetry in macular microhole variants: Spectral domain optical coherence tomography and microperimetry correlation
      Purpose: To evaluate the relationship between the morphology and retinal function of macular microhole (MMH) variants. Materials and Methods: We evaluated 12 eyes of 11 patients with defects in the IS/OS junction of photoreceptor layer with SD-OCT. All patients underwent comprehensive ophthalmic examination including spectral domain optical coherence tomography (SD-OCT) and microperimetry. Results: The mean logMAR visual acuity in the affected eye was 0.15 ± 0.17 (range 0.00-0.5). Mean horizontal diameter of the MMH was 163 ± 99 μm; the mean retinal sensitivity in the area corresponding to the MMH was 13.79 ± 4.6 dB. Negative ...
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    9. Spectral domain optical coherence tomography and microperimetry in foveal hypoplasia

      Spectral domain optical coherence tomography and microperimetry in foveal hypoplasia
      A case of foveal hypoplasia associated with ocular albinism with anatomic and functional changes by various techniques using spectral domain optical coherence tomography (SD-OCT), microperimeter and confocal scanning laser ophthalmoscope is described. This case highlights the importance of microperimeter in detecting the functional abnormalities of vision and SD-OCT in identifying the retinal laminar abnormalities in foveal hypoplasia.
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    10. Evaluation of In Vivo Human Retinal Morphology and Function in Myopes

      Evaluation of In Vivo Human Retinal Morphology and Function in Myopes
      Purpose: To compare the retinal sensitivity, using Microperimeter and the morphological changes in retinal layers, using Spectral Domain Optical Coherence Tomography (SD-OCT), between myopes and age-matched emmetropes. Methods: Twenty-nine myopic eyes and 29 emmetropic eyes were enrolled in this prospective case control study. All subjects underwent subjective refraction as part of the ophthalmic examination and in addition, SDOCT and Microperimetry were performed. Based on the reflectivity on the OCT cross sections, the thickness of the retinal layers was measured 2.5 mm on either side of the fovea. Results: The mean retinal sensitivity was significantly (p = 0.001) reduced in ...
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    11. High-resolution optical coherence tomography correlates in ischemic radiation retinopathy

      Purpose: To find the abnormalities in various retinal layers caused by radiation retinopathy using spectral domain optical coherence tomography (SD-OCT). Methods: We report a case of radiation retinopathy that was imaged using SD-OCT Copernicus (Optopol, Zawiercie, Poland). Analysis and synthesis of the OCT image were done using information both at the fovea and 2.5mm temporal to the fovea. Results: The layers that were reduced in thickness included the inner plexiform layer (47μm vs. 74μm), the inner nuclear layer (17μm vs. 48μm), and the outer plexiform layer (25μm vs. 45μm), whereas the layers with comparable thickness included the nerve fiber ...
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    12. Spectral-Domain OCT and Microperimeter Characterization of Morphological and Functional Changes in X-linked Retinoschisis

      A case of X-linked retinoschisis with anatomic and functional issues correlated by a constellation of methods, including spectral-domain optical coherence tomography, microperimeter, electroretinography, and multifocal electroretinography, is described. This case highlights the importance of microperimetry in the presence of normal or subtle abnormalities in full-field electroretinography. The ability of spectral-domain optical coherence tomography in diagnosis and follow-up in cases with X-linked retinoschisis is demonstrated. [Ophthalmic Surg Lasers Imaging 2009;40:71-74.]
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    1-12 of 12
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    Evaluation of In Vivo Human Retinal Morphology and Function in Myopes Spectral domain optical coherence tomography and microperimetry in foveal hypoplasia Morphological and functional changes in spectral domain optical coherence tomography and microperimetry in macular microhole variants: Spectral domain optical coherence tomography and microperimetry correlation Optical Coherence Tomography Characteristics in Eyes With Optic Pit Maculopathy Communications between intraretinal and subretinal space on optical coherence tomography of neurosensory retinal detachment in diabetic macular edema Spectral domain optical coherence tomography characteristics in diabetic retinopathy Macular Thickness Measurements using Copernicus Spectral Domain Optical Coherence Tomography Imaging drusens using Spectral Domain Optical Coherence Tomography Both speckle reduction and contrast enhancement for optical coherence tomography via sequential optimization in the logarithmic domain based on a refined Retinex model OCT parameters of the optic nerve head and the retina as surrogate markers of brain volume in a normal population, a pilot study Choroidal vessel density in unilateral hyperopic amblyopia using en-face optical coherence tomography Association between food and nutrients intakes and coronary plaque vulnerability in patients with coronary heart disease: An optical coherence tomography study