1. Articles from Ian Wimpenny

    1-3 of 3
    1. Study of optical properties and proteoglycan content of tendons by polarization sensitive optical coherence tomography

      Study of optical properties and proteoglycan content of tendons by polarization sensitive optical coherence tomography

      The highly orientated collagen fibers in tendons play a critical role for transferring tensile stress, and they demonstrate birefringent optical properties. However, the influence that proteoglycans (PGs) have on the optical properties of tendons is yet to be fully elucidated. PGs are the essential components of the tendon extracellular matrix; the changes in their quantities and compositions have been associated with tendinopathies. In this study, polarization sensitive optical coherence tomography (PS-OCT) has been used to reveal the relationship between PG content/location and birefringence properties of tendons. Fresh chicken tendons were imaged at regular intervals by PS-OCT and polarization light ...

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      Mentions: Ying Yang
    2. Investigation of a tissue engineered tendon model by PS-OCT

      Investigation of a tissue engineered tendon model by PS-OCT
      A few native tissues, such as tendon, skin and eye, possess highly organized collagenous matrices. In particular, the collagen fibers in tendon are organized into a hierarchical and unidirectional format, which gives rise to the high tissuespecific mechanical properties. This organization has been clearly revealed by a conventional polarized light microscope. The newly developed polarization-sensitive optical coherence tomography (PS-OCT) technique allows non-invasive visualization of birefringence images arising from orientated structures in a three dimensional format. Our previous studies of native tendon and tissue engineered tendon by PS-OCT demonstrate that tissue engineered tendon has a far less perfect collagen fiber organization ...
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      Mentions: Ying Yang
    3. Monitoring the effect of magnetically aligned collagen scaffolds on tendon tissue engineering by Psoct

      As the repair of injured or degenerated tendon is often compromised by the shortage of suitable donor tissue, other procedures need to be developed. The application of a functional tissue engineered tendon could prove to be a promising alternative therapy. Due to their good biocompatibility, collagen hydrogel based scaffolds have been considered to be potentially suitable for engineering tendon tissue in vitro. One of the major limitations of collagen hydrogels for engineering tissues is the difficulty in controlling their architecture and collagen concentration which results in poor mechanical strength. This study aims to overcome these limitations by creating a highly ...
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      Mentions: Ying Yang
    1-3 of 3
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    1. (3 articles) Ying Yang
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