1. Articles from Michael Först

    1-6 of 6
    1. Pilot study: optical coherence tomography as a non-invasive diagnostic perspective for real time visualisation of onychomycosis

      Pilot study: optical coherence tomography as a non-invasive diagnostic perspective for real time visualisation of onychomycosis
      The objective of this study was to compare optical coherence tomography (OCT) with conventional techniques such as KOH-preparation, culture and histology in the identification of the fungal elements in the nail. A total of 18 patients were examined; 10 with clinically evident onychomycosis in toe nails, two with psoriatic nail lesions, one with nail affection caused by lichen planus and five healthy controls. Serial in vivo OCT analyses of onychomycosis was performed prior to KOH-preparation, culture and punch biopsy of the nail plate for consecutive histology. Fungal elements were detected non-invasively in vivo using OCT in all 10 patients with ...
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    2. High-resolution simultaneous dual-band spectral domain optical coherence tomography

      High-resolution simultaneous dual-band spectral domain optical coherence tomography
      A fiber-based spectral domain optical coherence tomography (OCT) system is described, imaging simultaneously at 740 and 1300 nm central wavelengths. Real-time imaging is demonstrated with axial resolutions3um and 5um, respectively. This technique allows for in vivo high-resolution functional OCT imaging withoutstanding spectroscopic contrast.
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    3. Dual femtosecond laser multiheterodyne optical coherence tomography

      Dual femtosecond laser multiheterodyne optical coherence tomography
      A time domain optical coherence tomography (OCT) system without moving parts is described, which is based on multiheterodyning utilizing two mode-locked femtosecond lasers. By synchronizing the two lasers to slightly different repetition rates and coupling to an interferometric OCT setup, we obtain amplitude-modulated beat signals representing the structure of the specimen under investigation. Our system is suitable for biological imaging as well as technical applications. We demonstrate high axial imaging depths of 150 mm with up to 5000 axial scans per second, achieving equivalent path scanning velocities of 750 m/s.
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    4. Visualization of the Basement Membrane Zone of the Bladder by Optical Coherence Tomography: Feasibility of Noninvasive Evaluation of Tumor Invasion

      Visualization of the Basement Membrane Zone of the Bladder by Optical Coherence Tomography: Feasibility of Noninvasive Evaluation of Tumor Invasion
      Visualization of the Basement Membrane Zone of the Bladder by Optical Coherence Tomography: Feasibility of Noninvasive Evaluation of Tumor Invasion Barbara Hermesa, Felix Spölerb, Amjad Naamia, Jörg Bornemannc, Michael Förstb, Joachim Grossec, Gerhard Jaksec, Ruth Knüchela Corresponding Author Information email address Received 24 October 2007; accepted 29 February 2008. published online 02 May 2008. Objectives Imaging techniques with high resolution are evolving rapidly for medical applications
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    5. Adaptive kernel algorithm for FPGA-based speckle reduction

      Image quality from ultrasound and optical coherence tomography (OCT) is degraded by speckle patterns, which limit the detection of small features and cause a loss of image contrast. To reduce speckle patterns, a novel adaptive kernel algorithm suitable for linearly scaled and log-compressed OCT and ultrasound images is presented. This algorithm combines region growing with a stick based approach. For each direction from the center of a square window to its border, a stick length is selected depending on a homogeneity criterion. Such a set of sticks forms an individual filter kernel for each image pixel. The current kernel size ...
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    6. Simultaneous dual-band ultra-high resolution optical coherence tomography

      Simultaneous dual-band ultra-high resolution optical coherence tomography
      Ultra-high resolution optical coherence tomography (OCT) imaging is demonstrated simultaneously at 840 nm and 1230 nm central wavelength using an off-the-shelf turn-key supercontinuum light source. Spectral filtering of the light source emission results in a double peak spectrum with average powers exceeding 100 mW and bandwidths exceeding 200 nm for each wavelength band. A free-space OCT setup optimized to support both wavelengths in parallel is introduced. OCT imaging of biological tissue ex vivo and in vivo is demonstrated with axial resolutions measured to be < 2 μm and < 4 μm at 840 nm and 1230 nm, respectively. This measuring scheme is ...
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    1-6 of 6
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    1. (6 articles) RWTH Aachen University
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    Visualization of the Basement Membrane Zone of the Bladder by Optical Coherence Tomography: Feasibility of Noninvasive Evaluation of Tumor Invasion Dual femtosecond laser multiheterodyne optical coherence tomography High-resolution simultaneous dual-band spectral domain optical coherence tomography Pilot study: optical coherence tomography as a non-invasive diagnostic perspective for real time visualisation of onychomycosis Simultaneous dual-band ultra-high resolution optical coherence tomography Optical Coherence Tomography of the Middle Ear Using Ossiview Role of Optical Coherence Tomography Angiography Imaging in Patients with Diabetes Vitreomacular Traction Surgery from the DISCOVER Study: Intraoperative OCT Utility, Ellipsoid Zone Dynamics, and Outcomes Investigation of Micro-motion Kinematics of Continuum Robots for Volumetric OCT and OCT-guided Visual Servoing Association of Myopia With Microvascular Alterations in Patients With Type 2 Diabetes: An Optical Coherence Tomography Angiography Study Accuracy of Total Corneal Power Calculation for Multifocal Toric Intraocular Lens Implantation: Swept-Source OCT-Based Biometer vs Scheimpflug Tomographer Evaluation of optical coherence tomography findings in adolescents with genetic generalized epilepsy