1. Articles from Heleen van Beusekom

    1-7 of 7
    1. Motorized capsule for shadow-free OCT imaging and synchronous beam control

      Motorized capsule for shadow-free OCT imaging and synchronous beam control

      We demonstrate a tethered motorized capsule for unobstructed optical coherence tomography (OCT) imaging of the esophagus. By using a distal reflector design, we avoided the common shadow artifact induced by the motor wires. A synchronous driving technique features three types of beam-scanning modes of the capsule, i.e., circumferential beam scanning, localized beam scanning, and accurate beam positioning. We characterized these three modes and carried out ex vivo imaging experiments using the capsule. The results show that the capsule can potentially be a useful tool for diagnostic OCT imaging and OCT-guided biopsy and therapy of the esophagus.

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    2. Heartbeat OCT and Motion-Free 3D In Vivo Coronary Artery Microscopy

      Heartbeat OCT and Motion-Free 3D In Vivo Coronary Artery Microscopy

      Intravascular optical coherence tomography (IV-OCT) has gained widespread use over the past few years, offering highly detailed images of coronary artery pathologies and interventions (1) . In contrast to the cross-sectional view, longitudinal sections and 3-dimensional (3D) renderings are affected by cardiac motion artifacts and undersampling, complicating interpretation and measurements (2) . We developed Heartbeat OCT, a new OCT method that achieves up to 4,000 frames/s imaging speed for isotropically sampled volume datasets acquired within the diastolic phase of 1 cardiac cycle to restore 3D IV-OCT image fidelity. In this research letter, we present the first in vivo data acquired ...

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    3. Feature Of The Week 12/06/2015: Heartbeat Optical Coherence Tomography

      Feature Of The Week 12/06/2015: Heartbeat Optical Coherence Tomography

      Intravascular optical coherence tomography (IV-OCT) has gained widespread use over the past few years, offering highly detailed images of the coronary artery pathologies and interventions. In contrast to the cross-sectional view, longitudinal sections and three-dimensional (3D) renderings are affected by cardiac motion artifacts and undersampling, complicating interpretation and measurements. We developed Heartbeat OCT, a new OCT method that overcomes these issues. This study aims to demonstrate in vivo Heartbeat OCT in a preclinical setting, imaging eliminating cardiac motion artifacts, undersampling and non-uniform rotational distortion, to generate high-quality OCT volumes. Using a micro motor actuated catheter and a MHz sweep rate ...

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    4. Heartbeat OCT: in vivo intravascular megahertz-optical coherence tomography

      Heartbeat OCT: in vivo intravascular megahertz-optical coherence tomography

      Cardiac motion artifacts, non-uniform rotational distortion and undersampling affect the image quality and the diagnostic impact of intravascular optical coherence tomography (IV-OCT). In this study we demonstrate how these limitations of IV-OCT can be addressed by using an imaging system that we called “Heartbeat OCT”, combining a fast Fourier Domain Mode Locked laser, fast pullback, and a micromotor actuated catheter, designed to examine a coronary vessel in less than one cardiac cycle. We acquired in vivo data sets of two coronary arteries in a porcine heart with both Heartbeat OCT, working at 2.88 MHz A-line rate, 4000 frames/s ...

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    5. Angiographic and Optical Coherence Tomography Insights Into Bioresorbable Scaffold Thrombosis: Single-Center Experience

      Angiographic and Optical Coherence Tomography Insights Into Bioresorbable Scaffold Thrombosis: Single-Center Experience

      Background— As bioresorbable vascular scaffolds (BVSs) are being increasingly used in complex real-world lesions and populations, BVS thrombosis cases have been reported. We present angiographic and optical coherence tomography (OCT) findings in a series of patients treated in our center for definite bioresorbable scaffold thrombosis. Methods and Results— Up to June 2014, 14 patients presented with definite BVS thrombosis in our center. OCT was performed in 9 patients at the operator’s discretion. Angiographic and OCT findings were compared with a control group comprising 15 patients with definite metallic stent thrombosis. In the BVS group, time interval from index procedure ...

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    6. Intracoronary Optical Coherence Tomography and Histology at 1 Month and 2, 3, and 4 Years After Implantation of Everolimus-Eluting Bioresorbable Vascular Scaffolds in a Porcine Coronary Artery Model. An Attempt to Decipher the Human OCT Images in the ABSO

      Intracoronary Optical Coherence Tomography and Histology at 1 Month and 2, 3, and 4 Years After Implantation of Everolimus-Eluting Bioresorbable Vascular Scaffolds in a Porcine Coronary Artery Model. An Attempt to Decipher the Human OCT Images in the ABSO

      Background—With the use of optical coherence tomography (OCT), alterations of the reflectance characteristics of everolimus-eluting bioresorbable vascular scaffold (BVS) struts have been reported in humans. In the absence of histology, the interpretation of the appearances of the struts by OCT remains speculative. We therefore report OCT findings with corresponding histology in the porcine coronary artery model immediately after and at 28 days and 2, 3, and 4 years after BVS implantation. Methods and Results—Thirty-five polymeric BVS (3.0x12.0 mm) were singly implanted in the main coronary arteries of 17 pigs that underwent OCT and were then euthanized ...

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    7. Novelties in cardiac imaging – Optical Coherence Tomography (OCT)

      Novelties in cardiac imaging – Optical Coherence Tomography (OCT)

      In order to improve our understanding of late stent thrombosis an dto access the individual risk of a patient or lesion, there is clinical need to assess vascular healing after stenting in vivo. We will discuss the potential and limitations of Optical Coherence Tomography (OCT) for imaging of drug eluting stents (DES).

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    1-7 of 7
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  2. Topics in the News

    1. (6 articles) Heleen M. M. Van Beusekom
    2. (6 articles) Evelyn Regar
    3. (5 articles) Erasmus University
    4. (4 articles) Robert A. Huber
    5. (4 articles) Gijs van Soest
    6. (4 articles) Tianshi Wang
    7. (4 articles) Geert Springeling
    8. (4 articles) Anton F. W. van der Steen
    9. (3 articles) Delft University of Technology
    10. (3 articles) Chinese Academy of Sciences
    11. (1 articles) Cardiovascular Research Foundation
    12. (1 articles) University of Tsukuba
    13. (1 articles) Wakayama Medical University
    14. (1 articles) Georgetown University
    15. (1 articles) Takashi Tanimoto
    16. (1 articles) Gary S. Mintz
    17. (1 articles) Atsushi Tanaka
    18. (1 articles) Takashi Akasaka
    19. (1 articles) Hector M. Garcia-Garcia
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    Novelties in cardiac imaging – Optical Coherence Tomography (OCT) Intracoronary Optical Coherence Tomography and Histology at 1 Month and 2, 3, and 4 Years After Implantation of Everolimus-Eluting Bioresorbable Vascular Scaffolds in a Porcine Coronary Artery Model. An Attempt to Decipher the Human OCT Images in the ABSO Angiographic and Optical Coherence Tomography Insights Into Bioresorbable Scaffold Thrombosis: Single-Center Experience Heartbeat OCT: in vivo intravascular megahertz-optical coherence tomography Feature Of The Week 12/06/2015: Heartbeat Optical Coherence Tomography Heartbeat OCT and Motion-Free 3D In Vivo Coronary Artery Microscopy Motorized capsule for shadow-free OCT imaging and synchronous beam control Deep learning differentiates between healthy and diabetic mouse ears from optical coherence tomography angiography images Spectral-Domain Optical Coherence Tomography For Evaluating Palisades of Vogt in Ocular Surface Disorders With Limbal Involvement Oral cancer detection using optical coherence tomography – A detailed review Increased crystalline lens coverage in optical coherence tomography with oblique scanning and volume stitching Imaging Hyperreflective Foci as an Inflammatory Biomarker after Anti-VEGF Treatment in Neovascular Age-Related Macular Degeneration Patients with Optical Coherence Tomography Angiography