1. Articles from Youbo Zhao

    1-3 of 3
    1. Noise characterization of broadband fiber Cherenkov radiation as a visible-wavelength source for optical coherence tomography and two-photon fluorescence microscopy

      Noise characterization of broadband fiber Cherenkov radiation as a visible-wavelength source for optical coherence tomography and two-photon fluorescence microscopy

      Optical sources in the visible region immediately adjacent to the near-infrared biological optical window are preferred in imaging techniques such as spectroscopic optical coherence tomography of endogenous absorptive molecules and two-photon fluorescence microscopy of intrinsic fluorophores. However, existing sources based on fiber supercontinuum generation are known to have high relative intensity noise and low spectral coherence, which may degrade imaging performance. Here we compare the optical noise and pulse compressibility of three high-power fiber Cherenkov radiation sources developed recently, and evaluate their potential to replace the existing supercontinuum sources in these imaging techniques.

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    2. Imaging and tracking of bone marrow-derived immune and stem cells

      Imaging and tracking of bone marrow-derived immune and stem cells

      Bone marrow (BM)-derived stem and immune cells play critical roles in maintaining the health, regeneration, and repair of many tissues. Given their important functions in tissue regeneration and therapy, tracking the dynamic behaviors of BM-derived cells has been a long-standing research goal of both biologists and engineers. Because of the complex cellular-level processes involved, real-time imaging technologies that have sufficient spatial and temporal resolution to visualize them are needed. In addition, in order to track cellular dynamics, special attention is needed to account for changes in the microenvironment where the cells reside, for example, tissue contraction, stretching, development, etc ...

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    3. Integrated multimodal optical microscopy for structural and functional imaging of engineered and natural skin

      Integrated multimodal optical microscopy for structural and functional imaging of engineered and natural skin

      An integrated multimodal optical microscope is demonstrated for high-resolution, structural and functional imaging of engineered and natural skin. This microscope incorporates multiple imaging modalities including optical coherence (OCM), multi-photon (MPM), and fluorescence lifetime imaging microscopy (FLIM), enabling simultaneous visualization of multiple contrast sources and mechanisms from cells and tissues. Spatially co-registered OCM/MPM/FLIM images of multi-layered skin tissues are obtained, which are formed based on complementary information provided by different modalities, i.e., scattering information from OCM, molecular information from MPM, and functional cellular metabolism states from FLIM. Cellular structures in both the dermis and epidermis, especially different morphological ...

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    1-3 of 3
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  2. Topics in the News

    1. (3 articles) University of Illinois at Urbana-Champaign
    2. (3 articles) Youbo Zhao
    3. (3 articles) Stephen A. Boppart
    4. (1 articles) Haohua Tu
    5. (1 articles) Eric J. Chaney
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    Integrated multimodal optical microscopy for structural and functional imaging of engineered and natural skin Imaging and tracking of bone marrow-derived immune and stem cells Noise characterization of broadband fiber Cherenkov radiation as a visible-wavelength source for optical coherence tomography and two-photon fluorescence microscopy The multi-spectral signal properties of multiple reference optical coherence tomography (Thesis) Calibration-free time-stretch optical coherence tomography with large imaging depth Does Projection Artifact Removal Improve Visualization of Images in Optical Coherence Tomography Angiography? Spectral‐domain optical coherence tomography of retinal vessels in Waldenström's macroglobulinemia Optical coherence tomography imaging of oral mucosa bullous diseases: a preliminary study The use of anterior segment optical coherence tomography (ASOCT) in demonstrating recurrence of vitreoretinal lymphoma (VRL) in the anterior vitreous PHD POSITION – OPTICAL COHERENCE TOMOGRAPHY ON AGRO-FOOD PRODUCTS Hot topics in interventional cardiology: Proceedings from the Society for Cardiovascular Angiography and Interventions (SCAI) 2019 Think Tank Optical coherence tomography angiography of foveal neovascularisation in proliferative diabetic retinopathy