1. Articles from Kenneth M. Marion

    1-9 of 9
    1. Optical coherence tomography risk factors for development of late age related macular degeneration in the fellow eyes of patients enrolled in the HARBOR Study

      Optical coherence tomography risk factors for development of late age related macular degeneration in the fellow eyes of patients enrolled in the HARBOR Study

      Purpose To evaluate the relationship between optical coherence tomography (OCT) features and the progression to late age related macular degeneration (AMD) in the fellow eyes of patients enrolled in the 24-month HARBOR study (NCT00891735) for neovascular AMD. Design post hoc analysis of a phase 3 multicenter, prospective, randomized, double-masked, active treatment-controlled clinical trial. Participants Evaluable subjects (N=501) with macular neovascularization (MNV) secondary to neovascular AMD and early or intermediate AMD in the fellow eye. Methods Volume OCT scans from 501 fellow eyes of 501 patients with MNV were reviewed. Baseline OCT features that were assessed included intraretinal hypereflective foci ...

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    2. Identification and Characterization of Imaging Technique Errors and Artifacts using Anterior Segment Optical Coherence Tomography for Irido-Corneal Angle Evaluations in Glaucom

      Identification and Characterization of Imaging Technique Errors and Artifacts using Anterior Segment Optical Coherence Tomography for Irido-Corneal Angle Evaluations in Glaucom

      Purpose Anterior segment optical coherence tomography (ASOCT) platforms provide non-invasive and quantifiable evaluations of anterior chamber angle (ACA) anatomy. Even though these ACA measurements have been validated with high repeatability and reproducibility, we are the first study to describe in detail the technique errors and artifacts that may occur during imaging of the ACA. The purpose of this study was to define the different types and quantify the frequency of imaging technique errors and artifacts that are seen in ACA evaluation of a large cohort of patients with open-angle glaucoma. Design Retrospective cross-sectional design. Subjects Five thousand and eighty-two eyes ...

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    3. Evaluation of Corneal Epithelial Thickness Imaged by High Definition Optical Coherence Tomography in Healthy Eyes

      Evaluation of Corneal Epithelial Thickness Imaged by High Definition Optical Coherence Tomography in Healthy Eyes

      Purpose: To evaluate corneal epithelial thickness (CET) and corneal thickness (CT) in healthy eyes using spectral domain optical coherence tomography. Methods: Thirty-six healthy eyes were imaged using the Cirrus high-definition (HD)-optical coherence tomography device. The average CET and CT were assessed using Cirrus Review Software within predefined concentric corneal ring-shaped zones. Specific regions of CET (superior, inferior, temporal, nasal, superonasal, inferotemporal, superotemporal, and inferonasal) were also assessed. The difference between zones was compared between males and females. Results: The average CET was 48.3, 47.1, 46.1, and 45.8 μm in the 4 concentric zones (0–2 ...

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    4. Evaluation of Corneal Epithelial Thickness Imaged by the High Definition Optical Coherence Tomography in Healthy Eyes

      Evaluation of Corneal Epithelial Thickness Imaged by the High Definition Optical Coherence Tomography in Healthy Eyes

      Purpose: To evaluate corneal epithelial thickness (CET) and corneal thickness (CT) in healthy eyes using spectral domain optical coherence tomography. Methods: Thirty-six healthy eyes were imaged using the Cirrus high-definition (HD)-optical coherence tomography device. The average CET and CT were assessed using Cirrus Review Software within predefined concentric corneal ring-shaped zones. Specific regions of CET (superior, inferior, temporal, nasal, superonasal, inferotemporal, superotemporal, and inferonasal) were also assessed. The difference between zones was compared between males and females. Results: The average CET was 48.3, 47.1, 46.1, and 45.8 μm in the 4 concentric zones (0–2 ...

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    5. Anterior Chamber Angle Morphometry Measurement Changes to Ambient Illumination Scaling in Visante Time Domain Optical Coherence Tomography

      Anterior Chamber Angle Morphometry Measurement Changes to Ambient Illumination Scaling in Visante Time Domain Optical Coherence Tomography

      Purpose : To test the effect of ambient illumination scaling on the reproducibility and reliability anterior chamber metrics using the Visante time domain optical coherence tomography (TD-OCT) instrument. Materials and methods : The inferior irido-corneal angles of 25 normal, healthy eyes were imaged twice with the Zeiss Visante TD-OCT under five strictly controlled ambient light conditions (foot candles (fc) measured with a light meter at camera/eye interface). Each eye was imaged 10 times totaling 250 assessments. Angle opening distance (AOD500/750), trabecular iris space area (TISA500/750), and scleral spur (SS) angle were graded twice by masked, trained graders at the ...

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    6. Effects of Light Variation on Schwalbe's Line-based Anterior Chamber Angle Metrics Measured with Cirrus Spectral Domain Optical Coherence Tomography

      Effects of Light Variation on Schwalbe's Line-based Anterior Chamber Angle Metrics Measured with Cirrus Spectral Domain Optical Coherence Tomography

      Background Evaluate the impact of variations in ambient lighting conditions on the reproducibility/reliability of Schwalbe's Line (SL)-based anterior chamber angle (ACA) metrics using spectral domain optical coherence tomography (SD-OCT). Design Images were taken at Doheny Eye Centers-UCLA clinic, which were randomized, masked, and graded twice by dual reading center graders. Participants 25 normal/healthy participants with open-angles Methods Inferior angles were imaged using Cirrus SD-OCT under five light levels (foot-candles(fc) measured at camera-eye interface with Sper light-meter) with the instrument's Corneal Illumination function set to default level of 50(CIdef) and low 5(CIlow). Each ...

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    7. Agreement in Quantitative Anterior Chamber Angle Metrics between RTVue and Cirrus Spectral Domain Optical Coherence Tomography

      Agreement in Quantitative Anterior Chamber Angle Metrics between RTVue and Cirrus Spectral Domain Optical Coherence Tomography

      Purpose: To investigate the agreement between two spectral domain optical coherence tomography (SD-OCT) instruments in Schwalbe’s line (SL) based anterior chamber angle parameters and to evaluate their repeatability and reproducibility. Methods: The inferior irido-corneal angle of 114 eyes from 59 participants (29 glaucoma and 30 normal) were scanned twice with the Optovue SD-OCT and Cirrus SD-OCT under controlled low luminance conditions. SL angle opening distance (SL-AOD) and SL trabecular-iris-space area (SL-TISA) were graded by masked certified graders at the Doheny Image Reading Center. Results: The mean SL-AOD/SL-TISA was 623±271µm/ 0.221 ± 0.106 mm2 for the ...

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    8. Reproducibility and Agreement Between 2 Spectral Domain Optical Coherence Tomography Devices for Anterior Chamber Angle Measurements

      Reproducibility and Agreement Between 2 Spectral Domain Optical Coherence Tomography Devices for Anterior Chamber Angle Measurements

      Purpose: To compare anterior chamber angle parameters based on the location of Schwalbe line (SL) from 2 spectral domain optical coherence tomography (SD-OCT) instruments and to measure their reproducibility. Methods: Forty-two eyes from 21 normal, healthy participants underwent imaging of the inferior irido-corneal angle with the Spectralis and Cirrus SD-OCT under tightly controlled low-light conditions. SL-angle opening distance (SL-AOD) and SL-trabecular iris space area (SL-TISA) were measured by masked, certified graders at the Doheny Imaging Reading Center using customized grading software. Interinstrument and intrainstrument, as well as interobserver and intraobserver reproducibility of SL-AOD and SL-TISA measurements were evaluated by intraclass ...

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    9. Comparison of Physiologic versus Pharmacologic Mydriasis on Anterior Chamber Angle Measurements Using Spectral Domain Optical Coherence Tomography

      Comparison of Physiologic versus Pharmacologic Mydriasis on Anterior Chamber Angle Measurements Using Spectral Domain Optical Coherence Tomography

      Purpose. To compare the effects of physiologic versus pharmacologic pupil dilation on anterior chamber angle (ACA) measurements obtained with spectral domain optical coherence tomography (SD-OCT). Methods. Forty eyes from 20 healthy, phakic individuals with open angles underwent anterior segment OCT imaging under 3 pupillary states: (1) pupil constricted under standard room lighting, (2) physiologic mydriasis in a darkened room, and (3) postpharmacologic mydriasis. Inferior angle Schwalbe’s line-angle opening distance (SL-AOD) and SL-trabecular-iris-space area (SL-TISA) were computed for each eye and pupillary condition by masked, certified Reading Center graders using customized grading software. Results. SL-AOD and SL-TISA under pupillary constriction ...

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    1-9 of 9
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    Comparison of Physiologic versus Pharmacologic Mydriasis on Anterior Chamber Angle Measurements Using Spectral Domain Optical Coherence Tomography Reproducibility and Agreement Between 2 Spectral Domain Optical Coherence Tomography Devices for Anterior Chamber Angle Measurements Agreement in Quantitative Anterior Chamber Angle Metrics between RTVue and Cirrus Spectral Domain Optical Coherence Tomography Effects of Light Variation on Schwalbe's Line-based Anterior Chamber Angle Metrics Measured with Cirrus Spectral Domain Optical Coherence Tomography Anterior Chamber Angle Morphometry Measurement Changes to Ambient Illumination Scaling in Visante Time Domain Optical Coherence Tomography Evaluation of Corneal Epithelial Thickness Imaged by the High Definition Optical Coherence Tomography in Healthy Eyes Evaluation of Corneal Epithelial Thickness Imaged by High Definition Optical Coherence Tomography in Healthy Eyes Identification and Characterization of Imaging Technique Errors and Artifacts using Anterior Segment Optical Coherence Tomography for Irido-Corneal Angle Evaluations in Glaucom Optical coherence tomography risk factors for development of late age related macular degeneration in the fellow eyes of patients enrolled in the HARBOR Study Measurement of the Shrinkage of Natural and Simulated Lesions on Root Surfaces using CP-OCT Optic-Net: A Novel Convolutional Neural Network for Diagnosis of Retinal Diseases from Optical Tomography Images Double layer sign: A new optical coherence tomography finding in active tubercular serpiginous-like choroiditis to monitor activity