1. Articles from Mario Iannaccone

    1-10 of 10
    1. Comparison between functional and intravascular imaging approaches guiding percutaneous coronary intervention: A network meta‐analysis of randomized and propensity matching studies

      Comparison between functional and intravascular imaging approaches guiding percutaneous coronary intervention: A network meta‐analysis of randomized and propensity matching studies

      Background The optimal approach to guide percutaneous coronary intervention (PCI) has yet to be defined. The aim of this study was to compare functional driven (fractional flow reserve) versus intravascular imaging (intravascular ultrasound, IVUS, and/or optical coherence tomography, OCT) versus standard (coronary angiography only, CA)‐guided PCI. Methods Randomized controlled trials (RCTs) and propensity score weight‐matched studies (PSWMs) comparing FFR versus IVUS versus OCT versus CA‐guided PCI were included. Major adverse cardiovascular event (MACE; a composite end point of death or myocardial infarction [MI] or revascularization) was the primary endpoint, whereas definite stent thrombosis (ST) and single ...

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    2. Clinical impact of optical coherence tomography findings on culprit plaque in acute coronary syndrome: The OCT‐FORMIDABLE study registry

      Clinical impact of optical coherence tomography findings on culprit plaque in acute coronary syndrome: The OCT‐FORMIDABLE study registry

      Background Aim of this study was to evaluate the clinical impact of the culprit plaque features assessed by optical coherence tomography (OCT) in patients with acute coronary syndrome (ACS). Methods The OCT‐FORMIDABLE register enrolled retrospectively all consecutive patients who perform OCT on culprit plaque in patients with ACS in nine European centres. The primary endpoint was the prevalence of culprit plaque rupture (CPR) in patients experiencing major adverse cardiovascular events (MACEs). Secondary endpoint was the prevalence necrotic core with macrophage infiltrations (NCMI) in the patients experiencing MACEs. Results Two‐hundred and nine patients were included in the study. Mean ...

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    3. Culprit plaque characteristics in younger versus older patients with acute coronary syndromes: An optical coherence tomography study from the FORMIDABLE registry

      Culprit plaque characteristics in younger versus older patients with acute coronary syndromes: An optical coherence tomography study from the FORMIDABLE registry

      Objectives Culprit plaque characteristics in young patients who experience an Acute Coronary Syndrome (ACS) evaluated by OCT (Optical Coherence Tomography) have to be defined. The OCT-FORMIDABLE is a multicentre retrospective registry enrolling consecutive patients with ACS who performed OCT in 9 European centres. Methods Patients were divided in two groups according to age at presentation: juvenile-ACS (age ≤ 50 years) and not juvenile-ACS (age > 50 years). Primary end-point was the prevalence of plaque rupture (PR). Secondary end point was the prevalence of thin cap fibro atheroma (TCFA), fibrocalcific and fibrotic plaque. Results 285 patients were included, 71 (24.9%) in juvenile-ACS ...

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    4. Effects of statins on plaque rupture assessed by optical coherence tomography in patients presenting with acute coronary syndromes: insights from the optical coherence tomography (OCT)-FORMIDABLE registry

      Effects of statins on plaque rupture assessed by optical coherence tomography in patients presenting with acute coronary syndromes: insights from the optical coherence tomography (OCT)-FORMIDABLE registry

      Aims Chronic pre-treatment with statins may reduce mortality and morbidity in patients experiencing acute coronary syndromes (ACS), but mechanisms accounting for these findings are not completely understood. Methods and results The optical coherence tomography (OCT)-Formidable registry retrospectively enrolled 285 consecutive patients with ACS undergoing OCT in 9 European centres. Mean age was 60.4 ± 12.8 years, 148 (51.9%) patients had hyperlipemia, 45 (15.8%) diabetes mellitus and 142 (49.8%) presented with ST Segment Elevation Myocardial Infarction (STEMI). Patients were stratified according to statin prescription: 150 (52.6%) were on chronic pre-treatment with statins before ACS and ...

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    5. Optical coherence tomography compared with fractional flow reserve guided approach in acute coronary syndromes: A propensity matched analysis

      Optical coherence tomography compared with fractional flow reserve guided approach in acute coronary syndromes: A propensity matched analysis

      Aim To compare in patients with ACS (Acute Coronary Syndromes) a PCI (Percutaneous Coronary Intervention) approach based on FFR (Fractional Flow Reserve) vs. one based on OCT (Optical Coherence Tomography). Methods and Results Consecutive patients admitted for ACS and treated with a PCI approach based on OCT or on FFR (recruited in two different studies) were compared and matched with propensity score analysis. Target Lesion revascularization (TLR) was the primary end point, while major adverse cardiovascular events [MACEs defined as the composite of death from cardiac causes, non- fatal MI, clinically driven target vessel revascularization (TVR), or re-hospitalization due to ...

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    6. Impact of an optical coherence tomography guided approach in acute coronary syndromes: A propensity matched analysis from the international FORMIDABLE-CARDIOGROUP IV and USZ registry

      Impact of an optical coherence tomography guided approach in acute coronary syndromes: A propensity matched analysis from the international FORMIDABLE-CARDIOGROUP IV and USZ registry

      Aim. To determine the potential clinical impact of OCT (Optical Coherence Tomography) during primary percutaneous coronary intervention in patients presenting with ACS (Acute Coronary Syndrome). Methods and Results. FORMIDABLE is a multicentre retrospective registry enrolling all patients presenting with ACS and treated with an OCT-guided approach, while the USZ registry enrolled patients treated with a standard angiography guided approach. Multivariate adjustment was performed via a propensity score matching. The number stents useds was the primary outcome, while the incidence of MACE (a composite of death, myocardial infarction, target vessel revascularization, and stent thrombosis) was the secondary endpoint. A total of ...

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    7. Optical coherence tomography evaluation of intermediate-term healing of different stent types: systemic review and meta-analysis

      Optical coherence tomography evaluation of intermediate-term healing of different stent types: systemic review and meta-analysis

      Aims The intermediate-term incidence of strut malapposition (SM) and uncovered struts (US), and the degree of neointimal thickness (NIT) according to stent type have not been characterized. Methods and results All studies of >50 patients in which optical coherence tomography was performed between 6 and 12 months after stent implantation were included. The incidences of SM and US were the co-primary end points, while NIT was the secondary end point. A total of 458 citations were initially appraised at the abstract level, and 11 full-text studies (280 652 analysed struts, 921 patients) were assessed. The 6–12 months incidences of ...

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    8. Prevalence and predictors of culprit plaque rupture at OCT in patients with coronary artery disease: a meta-analysis

      Prevalence and predictors of culprit plaque rupture at OCT in patients with coronary artery disease: a meta-analysis

      Aims The prevalence of plaque rupture at the culprit lesion identified by optical coherence tomography (OCT) in different clinical subset of patients undergoing coronary angiography and its clinical predictors remain to be defined. Methods All studies including patients with OCT evaluation of the culprit coronary plaque were included. The prevalence of culprit plaque rupture (CPR) and thin-cap fibro-atheroma (TCFA) were the primary endpoints. The factors associated with these findings were studied in a subset of patients with different clinical presentations [ST-elevation myocardial (STEMI) vs. nonST-elevation myocardial infarction (NSTEMI) vs. unstable angina (UA) vs. stable angina pectoris (SAP)]. Results One hundred ...

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    9. The butler did it! A very late stent thrombosis of TAXUS evaluated with Optical Coherence Tomography

      The butler did it! A very late stent thrombosis of TAXUS evaluated with Optical Coherence Tomography

      A 64 years old male smoker, obese, diabetic non-insulin dependent, dyslipidaemia, presented to our Emergency Department for new onset typical chest pain and EKG signs of an acute anterior ST elevation myocardial infarction. He had an history of a percutaneous coronary interventions to his three vessels with stents TAXUS in 2006 when he presented with stable angina. He performed dual antiplatelet therapy (DAT) for six months, then he assumed aspirin alone.

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    10. Clinical perspective of Optical Coherence Tomography and Intravascular Ultrasound in STEMI patients

      Clinical perspective of Optical Coherence Tomography and Intravascular Ultrasound in STEMI patients

      In the last years, the Intravascular Ultrasound Study (IVUS) and further the Optical Coherence Tomography (OCT) became two helpful tools to characterize of the atherosclerotic plaque. These new technologies made possible to analyse in vivo the pathophysiologic mechanisms that previously were just speculated or observed post-mortem (1). Recently Dr. Higum and Prof. Jang published an interesting article named “A combined OCT and IVUS on plaque rupture, plaque erosion and calcified nodule in patients with STEMI”, useful to describe the different presentation of culprit lesions in STelevation myocardial infarction (2). In this paper the authors describe the findings about 112 STEMI ...

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    1-10 of 10
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    The butler did it! A very late stent thrombosis of TAXUS evaluated with Optical Coherence Tomography Prevalence and predictors of culprit plaque rupture at OCT in patients with coronary artery disease: a meta-analysis Clinical perspective of Optical Coherence Tomography and Intravascular Ultrasound in STEMI patients Optical coherence tomography evaluation of intermediate-term healing of different stent types: systemic review and meta-analysis Impact of an optical coherence tomography guided approach in acute coronary syndromes: A propensity matched analysis from the international FORMIDABLE-CARDIOGROUP IV and USZ registry Optical coherence tomography compared with fractional flow reserve guided approach in acute coronary syndromes: A propensity matched analysis Effects of statins on plaque rupture assessed by optical coherence tomography in patients presenting with acute coronary syndromes: insights from the optical coherence tomography (OCT)-FORMIDABLE registry Culprit plaque characteristics in younger versus older patients with acute coronary syndromes: An optical coherence tomography study from the FORMIDABLE registry Clinical impact of optical coherence tomography findings on culprit plaque in acute coronary syndrome: The OCT‐FORMIDABLE study registry Comparison between functional and intravascular imaging approaches guiding percutaneous coronary intervention: A network meta‐analysis of randomized and propensity matching studies Miniaturizing medical imaging, sensing technology On-chip tunable photonic delay line