1. Articles from Rong Wen

    1-5 of 5
    1. Visible-light optical coherence tomography-based multimodal system for quantitative fundus autofluorescence imaging

      Visible-light optical coherence tomography-based multimodal system for quantitative fundus autofluorescence imaging

      Fundus autofluorescence (FAF) imaging is commonly used in ophthalmic clinics for diagnosis and monitoring of retinal diseases. Lipofuscin in the retinal pigment epithelium (RPE), with A2E as its most abundant component and a visual cycle by-product, is the major fluorophore of FAF. Lipofuscin accumulates with age and is implicated in degenerative retinal diseases. The amount of lipofuscin in RPE can be assessed by quantitative measurement of FAF. However, the currently available FAF imaging technologies are not capable of quantifying the absolute intensity of FAF, which is essential for comparing images from different individuals, and from the same individual over time ...

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    2. Visible-light optical coherence tomography-based multimodal retinal imaging for improvement of fluorescent intensity quantification

      Visible-light optical coherence tomography-based multimodal retinal imaging for improvement of fluorescent intensity quantification

      We developed a spectral-domain visible-light optical coherence tomography (VIS-OCT) based multimodal imaging technique which can accomplish simultaneous OCT and fluorescence imaging with a single broadband light source. Phantom experiments showed that by using the simultaneously acquired OCT images as a reference, the effect of light attenuation on the intensity of the fluorescent images by materials in front of the fluorescent target can be compensated. This capability of the multimodal imaging technique is of high importance for achieving quantification of the true intensities of autofluorescence (AF) imaging of the retina. We applied the technique in retinal imaging including AF imaging of ...

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    3. Optical coherence photoacoustic microscopy (OC-PAM) with an intensity-modulated continuous-wave broadband light source

      Optical coherence photoacoustic microscopy (OC-PAM) with an intensity-modulated continuous-wave broadband light source

      We developed an optical coherence photoacoustic microscopy system using an intensity-modulated continuous-wave superluminescent diode with a center wavelength of 840 nm. The system can accomplish optical coherence tomography (OCT) and photoacoustic microscopy (PAM) simultaneously. Compared to the system with a pulsed light source, this system is able to achieve OCT imaging with quality as high as conventional spectral-domain OCT. Since both of the OCT and PAM images are generated from the same group of photons, they are intrinsically registered in the lateral directions. The system was tested for multimodal imaging the vasculature of mouse ear in vivo by using gold ...

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    4. Feature Of The Week 4/20/2015: Optical Coherence Photoacoustic Microscopy for In Vivo Multimodal Retinal Imaging

      Feature Of The Week 4/20/2015: Optical Coherence Photoacoustic Microscopy for In Vivo Multimodal Retinal Imaging

      We developed an optical coherence photoacoustic microscopy (OC-PAM) system, which can accomplish optical coherence tomography (OCT) and photoacoustic microscopy (PAM) simultaneously by using a single pulsed broadband light source. With a center wavelength of 800 nm and a bandwidth of 30 nm, the system is suitable for imaging the retina. Generated from the same group of photons, the OCT and PAM images are intrinsically registered in the lateral directions. To test the capabilities of the system on multimodal ophthalmic imaging, we imaged the retina of pigmented rats. The OCT images showed the retinal structures with quality similar to conventional OCT ...

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    5. Optical coherence photoacoustic microscopy for in vivo multimodal retinal imaging

      Optical coherence photoacoustic microscopy for in vivo multimodal retinal imaging

      We developed an optical coherence photoacoustic microscopy (OC-PAM) system, which can accomplish optical coherence tomography (OCT) and photoacoustic microscopy (PAM) simultaneously by using a single pulsed broadband light source. With a center wavelength of 800 nm and a bandwidth of 30 nm, the system is suitable for imaging the retina. Generated from the same group of photons, the OCT and PAM images are intrinsically registered in the lateral directions. To test the capabilities of the system on multimodal ophthalmic imaging, we imaged the retina of pigmented rats. The OCT images showed the retinal structures with quality similar to conventional OCT ...

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    1-5 of 5
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  2. Topics in the News

    1. (5 articles) Shuliang Jiao
    2. (4 articles) University of Miami
    3. (4 articles) Florida International University
    4. (2 articles) University of Southern California
    5. (2 articles) Northwestern University
    6. (2 articles) Carmen A. Puliafito
    7. (2 articles) Hao F. Zhang
    8. (2 articles) Massachusetts General Hospital
    9. (2 articles) Harvard University
    10. (2 articles) Guillermo J. Tearney
    11. (1 articles) Minshan Jiang
    12. (1 articles) University of São Paulo
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    Optical coherence photoacoustic microscopy for in vivo multimodal retinal imaging Feature Of The Week 4/20/2015: Optical Coherence Photoacoustic Microscopy for In Vivo Multimodal Retinal Imaging Optical coherence photoacoustic microscopy (OC-PAM) with an intensity-modulated continuous-wave broadband light source Visible-light optical coherence tomography-based multimodal retinal imaging for improvement of fluorescent intensity quantification Visible-light optical coherence tomography-based multimodal system for quantitative fundus autofluorescence imaging Postdoctoral Research Fellowships (Optical Coherence Tomography) at Massachusetts General Hosptial Postdoctoral Research Fellowships (In Vivo Microscopy) At Massachusetts General Hospital Circumpapillary and macular vessel density assessment by optical coherence tomography angiography in eyes with temporal hemianopia from chiasmal compression. Correlation with retinal neural and visual field loss Miniaturizing medical imaging, sensing technology On-chip tunable photonic delay line Canon Xephilio OCT-A1 Optical Coherence Tomography Device Receives FDA 510(k) Clearance Subintimal Versus Intraplaque Recanalization of Coronary Chronic Total Occlusions: Mid-Term Angiographic and OCT Findings From the ISAR-OCT-CTO Registry