1. Articles from Giovanni Pellacani

    1-17 of 17
    1. Non – Invasive diagnostic techniques in the preoperative setting of Mohs micrographic surgery: a review of the literature

      Non – Invasive diagnostic techniques in the preoperative setting of Mohs micrographic surgery: a review of the literature

      Introduction Mohs micrographic surgery (MMS) is considered the gold standard treatment for skin cancers. Though the high cure rates it offers, MMS presents some disadvantages, as it is a relatively time – consuming procedure involving several professionals (physicians and technicians). A better definition of tumor margins in the pre-operative setting with any optical non-invasive diagnostic method may reduce the numbers of MMS steps and the overall duration of the procedure. Materials and Methods The present review was conducted and reported using validated search strategies from the following databases: PUBMED and Ovid MEDLINE. Results Our review describes the use of procedures such ...

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    2. Non-Melanoma Skin Cancer Clearance after Medical Treatment Detected with Noninvasive Skin Imaging: A Systematic Review and Meta-Analysis

      Non-Melanoma Skin Cancer Clearance after Medical Treatment Detected with Noninvasive Skin Imaging: A Systematic Review and Meta-Analysis

      Background/Objectives: Non-melanoma skin cancer (NMSC) treated with nonsurgical therapies can be monitored with noninvasive skin imaging. The precision of dermoscopy, reflectance confocal microscopy (RCM) and optical coherence tomography (OCT) in detecting clearance is unclear. We aim to report the proportion of persisting tumors identified with noninvasive technologies available in the literature. Methods: A systematic literature search was conducted on the PubMed and Cochrane Public Library Databases for articles published prior to November 2021. Statistical analyses were conducted with MedCalc 14.8.1 software. Results: A total of eight studies (352 lesions) reporting noninvasive imaging for NMSC clearance following nonsurgical ...

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    3. Assessing changes in facial skin quality using noninvasive in vivo clinical skin imaging techniques after use of a topical retinoid product in subjects with moderate-to-severe photodamage

      Assessing changes in facial skin quality using noninvasive in vivo clinical skin imaging techniques after use of a topical retinoid product in subjects with moderate-to-severe photodamage

      Background Studies utilizing reflectance confocal microscopy (RCM) and dynamic optical coherence tomography (D-OCT) to assess cosmetic skin changes are limited. Methods A 12-week, open-label study was conducted using RCM and D-OCT to evaluate the effects of a topical cosmetic retinol (RET05) on subjects with facial photodamage. Study endpoints included investigator grading, standardized (VISIA-CR) and 3D photography (Antera 3D), independent RCM (VivaScope1500) and D-OCT (VivoSight) image analysis, validated FACE-Q scales, and subject questionnaires. Results Twenty-three subjects, 45- to 68-year old, with Fitzpatrick skin types II–IV completed the study. After 12 weeks of repeated application, RET05 demonstrated significant corresponding cosmetic improvements ...

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    4. Dermoscopy, Reflectance Confocal Microscopy and Optical Coherence Tomography Features of Acne: A Systematic Review

      Dermoscopy, Reflectance Confocal Microscopy and Optical Coherence Tomography Features of Acne: A Systematic Review

      Noninvasive imaging techniques have recently outlined precise microscopic features of acne elementary lesions and accurate quantifications for disease severity staging and therapeutical efficacy follow-up. The aim of this review is to systematically describe current applications of dermoscopy, reflectance confocal microscopy (RCM), and optical coherence tomography (OCT) in acne vulgaris assessment and management. The study followed the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines. We included studies conducted on human subjects with elementary lesions of acne vulgaris, reporting assessment of the lesions with dermoscopy, RCM, and/or OCT. At present there are few large studies regarding acne and ...

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    5. Dermoscopy, confocal microscopy and optical coherence tomography features of main inflammatory and autoimmune skin diseases: A systematic review

      Dermoscopy, confocal microscopy and optical coherence tomography features of main inflammatory and autoimmune skin diseases: A systematic review

      Background/objectives: Non-invasive skin imaging features of main skin inflammatory and autoimmune diseases have been reported, although a comprehensive review of their correlation with histopathologic features is currently lacking. Therefore, the aim of this paper was to review the correlation of dermoscopic, reflectance confocal microscopy (RCM) and optical coherence tomography (OCT) criteria of main inflammatory and autoimmune skin diseases with their corresponding histopathologic criteria correlation. Methods: Studies on human subjects affected by main inflammatory and autoimmune diseases, defining the correlation of dermoscopic, RCM or OCT with histopathologic criteria, were included in the review. Five groups of diseases were identified and ...

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    6. Efficacy Assessment of a TCA/H2O2 Compositum for Skin Aging Treatment by Confocal Laser Microscopy and Optical Coherence Tomography

      Efficacy Assessment of a TCA/H2O2 Compositum for Skin Aging Treatment by Confocal Laser Microscopy and Optical Coherence Tomography

      Skin ageing is a complex phenomenon linked to intrinsic and extrinsic factors, such as ultraviolet exposure, smoking, or pollution, 1-4 which involves all skin layers. 5,6,7 Ageing is characterised by a reduction of collagen synthesis, 4,8,9 a decreased hydration, 5,6 epidermal thickness variations 7 , and an accelerated breakdown and disorganization of collagen fibers 4,8,9 as well as loss of skin elasticity.

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    7. Combined reflectance confocal microscopy and optical coherence tomography to improve the diagnosis of equivocal lesions for basal cell carcinoma

      Combined reflectance confocal microscopy and optical coherence tomography to improve the diagnosis of equivocal lesions for basal cell carcinoma

      To the Editor: Small-sized (<10 mm) basal cell carcinomas (BCC) lacking specific dermoscopic features are challenging to diagnose. Even with reflectance confocal microscopy (RCM), the specificity remains low (37.5%-75.5%) 1 due to limited imaging depth (200 μm), en face visualization, and a lack of melanin contrast for non/lightly pigmented lesions. 2 A novel combined handheld RCM and optical coherence tomography (OCT) device (RCM-OCT) has been developed to overcome these limitations. RCM-OCT provides real-time en face RCM and vertical OCT 3 images simultaneously and has been shown to be confirmatory of a BCC diagnosis 4 ; however, it ...

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    8. A plea for standardization of confocal microscopy and optical coherence tomography parameters to evaluate physiological and para‐physiological skin conditions in cosmetic science

      A plea for standardization of confocal microscopy and optical coherence tomography parameters to evaluate physiological and para‐physiological skin conditions in cosmetic science

      Background: Non-invasive Reflectance Confocal Microscopy (RCM) and Optical Coherence Tomography (OCT) have been extended to the dermo-cosmetic field, for skin pathophysiology understanding and therapeutics monitoring. However, standardized methodology and parameters to interpret structures and changes in these settings are still lacking. Objective: to propose a validated standard methodology and a list of defined parameters for objective non-pathological skin assessments in the cosmetically sensitive cheekbone area of the face. Methods: OCT and RCM quantitative, semi-quantitative, and qualitative features were considered for assessments. Validation process included 50 sets of images divided into 2 age groups. Inter-rater reliability was explored to assess the ...

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    9. Visible characteristics and structural modifications relating to enlarged facial pores

      Visible characteristics and structural modifications relating to enlarged facial pores

      Background Many factors relate to enlargement and visibility of facial pores. However, how enlargement relates to modification of the skin structure is still poorly analysed. Therefore, our aim was to characterise the visible features and the micro‐environment of facial pores. Materials and Methods We recruited 160 women, half of them with normal‐size facial pores, the other half presenting enlarged pores. We analysed their right cheek using standardised photography, in vivo reflectance microscopy and optical coherence tomography. Results If the area of pores is indeed the most differentiating visible characteristic, enlarged facial pores are also denser and more contrasted ...

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    10. In vivo Imaging of Sarcoptes scabiei infestation using Line‐field Confocal Optical Coherence Tomography

      In vivo Imaging of Sarcoptes scabiei infestation using Line‐field Confocal Optical Coherence Tomography

      Scabies remains a worldwide spread disease of considerable health and economic burden with repeated outbreaks in community settings.(1) Scabies agent is the ectoparasite Sarcoptes scabiei var. hominis ; this invisible mite causes a progressive rash, which can be misdiagnosed with eczema or pruritus sine materia . Diagnosis is based on characteristic clinical features (intense nightly itch, inflammatory excoriated papules in typical sites) and history of contact to infected patients.

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    11. Actinic Keratosis and Non-Invasive Diagnostic Techniques: An Update

      Actinic Keratosis and Non-Invasive Diagnostic Techniques: An Update

      Actinic keratosis represents the earliest manifestation of non-melanoma skin cancer. Because of their risk of progression to invasive squamous cell carcinoma, an earlier diagnosis and treatment are mandatory. Their diagnosis sometimes could represent a challenge even for expert dermatologists. Dermoscopy, confocal laser microscopy and optical coherence tomography could help clinicians in diagnosis. .

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    12. Speckled variance optical coherence tomography for the assessment of nail involvement in acrodermatitis continua of Hallopeau: A case study

      Speckled variance optical coherence tomography for the assessment of nail involvement in acrodermatitis continua of Hallopeau: A case study

      Noninvasive techniques for nail imaging would be useful for confirming diagnosis and monitoring treatment response at the microscopic level in patients with nail psoriasis. However, the use of ultrasound and high-resolution magnetic resonance imaging in nail evaluation is limited. Optical coherence tomography (OCT) produces high-resolution images of transversal tissue sections and represents an optimal approach to the study of the nail. This study used a multibeam OCT instrument to produce speckled variance OCT (SV-OCT) blood-flow images, which were used to measure the degree of change over successive scans. Nail changes, inflammation and response to therapy were evaluated in a 75-year-old ...

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    13. Methods of Melanoma Detection

      Methods of Melanoma Detection

      Detection and removal of melanoma, before it has metastasized, dramatically improves prognosis and survival. The purpose of this chapter is to (1) summarize current methods of melanoma detection and (2) review state-of-the-art detection methods and technologies that have the potential to reduce melanoma mortality. Current strategies for the detection of melanoma range from population-based educational campaigns and screening to the use of algorithm-driven imaging technologies and performance of assays that identify markers of transformation. This chapter will begin by describing state-of-the-art methods for educating and increasing awareness of at-risk individuals and for performing comprehensive screening examinations. Standard and advanced photographic ...

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    14. Optical coherence tomography (OCT) features of nevi and melanomas and their association with intraepidermal or dermal involvement: A pilot study

      Optical coherence tomography (OCT) features of nevi and melanomas and their association with intraepidermal or dermal involvement: A pilot study

      To the Editor: Optical coherence tomography (OCT) was shown to be an useful tool for the fast evaluation of nonmelanocytic tumors of the skin. 1 There are few reports in the literature studying melanocytic lesions with OCT, with variable and sometimes contrasting results. 2 , 3 A constant need for reducing costs and cosmetic concerns of unnecessary excisions of suspicious melanocytic lesions lead us to further investigate this new technology. 4 We used OCT (Vivosight OCT Scanner, Michelson Diagnostics Ltd, Orpington, Kent, United Kingdom) to evaluate a total of 39 lesions: 19 melanomas (10 in situ and 9 invasive, with Breslow ...

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    15. Advances in non-invasive techniques as aids to the diagnosis and monitoring of therapeutic response in plaque psoriasis: a review

      Advances in non-invasive techniques as aids to the diagnosis and monitoring of therapeutic response in plaque psoriasis: a review

      Plaque psoriasis is a common, chronic, inflammatory disease with a multifactorial etiopathogenesis. Although its diagnosis is often based on clinical features, in ambiguous cases a biopsy with histopathologic confirmation may be necessary. Advanced high-definition imaging techniques may be useful in the study of skin properties in vivo and may facilitate therapeutic monitoring. Available imaging tools vary in their resolution, depth of penetration and visual representation (horizontal, vertical, three-dimensional), and in the type of skin structures visualized. The purpose of this review is to analyze a variety of non-invasive techniques that may assist in establishing definitive diagnoses, as well as in ...

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    1-17 of 17
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    1. (2 articles) Sapienza University of Rome
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    Advances in non-invasive techniques as aids to the diagnosis and monitoring of therapeutic response in plaque psoriasis: a review Optical coherence tomography (OCT) features of nevi and melanomas and their association with intraepidermal or dermal involvement: A pilot study Methods of Melanoma Detection Speckled variance optical coherence tomography for the assessment of nail involvement in acrodermatitis continua of Hallopeau: A case study Actinic Keratosis and Non-Invasive Diagnostic Techniques: An Update In vivo Imaging of Sarcoptes scabiei infestation using Line‐field Confocal Optical Coherence Tomography A headstrong case of folliculitis decalvans: treatment options and evaluation with dermoscopy, reflectance confocal microscopy and optical coherence tomography Red dye-related tattoo reactions: Could optical coherence tomography be of help? Visible characteristics and structural modifications relating to enlarged facial pores Combined reflectance confocal microscopy and optical coherence tomography to improve the diagnosis of equivocal lesions for basal cell carcinoma The truth about invisible posterior vitreous structures Increased Macrophage-like Cell Density in Retinal Vein Occlusion as Characterized by en Face Optical Coherence Tomography