1. Articles from Raphael Sznitman

    1-8 of 8
    1. Expert-level Automated Biomarker Identification in Optical Coherence Tomography Scans

      Expert-level Automated Biomarker Identification in Optical Coherence Tomography Scans

      In ophthalmology, retinal biological markers, or biomarkers , play a critical role in the management of chronic eye conditions and in the development of new therapeutics. While many imaging technologies used today can visualize these, Optical Coherence Tomography (OCT) is often the tool of choice due to its ability to image retinal structures in three dimensions at micrometer resolution. But with widespread use in clinical routine, and growing prevalence in chronic retinal conditions, the quantity of scans acquired worldwide is surpassing the capacity of retinal specialists to inspect these in meaningful ways. Instead, automated analysis of scans using machine learning algorithms ...

      Read Full Article
    2. Comparison of Choroidal Thickness Measurements Using Spectral Domain Optical Coherence Tomography in Six Different Settings and With Customized Automated Segmentation Software

      Comparison of Choroidal Thickness Measurements Using Spectral Domain Optical Coherence Tomography in Six Different Settings and With Customized Automated Segmentation Software

      Purpose : We investigate which spectral domain-optical coherence tomography (SD-OCT) setting is superior when measuring subfoveal choroidal thickness (CT) and compared results to an automated segmentation software. Methods : Thirty patients underwent enhanced depth imaging (EDI)-OCT. B-scans were extracted in six different settings (W+N = white background/normal contrast 9; W+H = white background/maximum contrast 16; B+N = black background/normal contrast 12; B+H = black background/maximum contrast 16; C+N = Color-encoded image on black background at predefined contrast of 9, and C+H = Color-encoded image on black background at high/maximal contrast of 16), resulting in 180 images ...

      Read Full Article
    3. Efficient OCT volume reconstruction from slitlamp microscopes

      Efficient OCT volume reconstruction from slitlamp microscopes

      Since its introduction 25 years ago, Optical Coherence Tomography (OCT) has contributed tremendously to diagnostic and monitoring capabilities of pathologies in the field of ophthalmology. Despite rapid progress in hardware and software technology however, the price of OCT devices has remained high, limiting their use in private practice and in screening examinations. In this paper, we present a slitlamp-integrated OCT device, built with off-the-shelf components, which can generate high-quality volumetric images of the posterior eye segment. To do so, we present a novel strategy for 3D image reconstruction in this challenging domain that allows for state-ofthe- art OCT volumes to ...

      Read Full Article
    4. Automatic assessment of time-resolved OCT images for selective retina therapy

      Automatic assessment of time-resolved OCT images for selective retina therapy

      Purpose In recent years, selective retina laser treatment (SRT), a sub-threshold therapy method, avoids widespread damage to all retinal layers by targeting only a few. While these methods facilitate faster healing, their lack of visual feedback during treatment represents a considerable shortcoming as induced lesions remain invisible with conventional imaging and make clinical use challenging. To overcome this, we present a new strategy to provide location-specific and contact-free automatic feedback of SRT laser applications. Methods We leverage time-resolved optical coherence tomography (OCT) to provide informative feedback to clinicians on outcomes of location-specific treatment. By coupling an OCT system to SRT ...

      Read Full Article
    5. Time-Resolved Ultra–High Resolution Optical Coherence Tomography for Real-Time Monitoring of Selective Retina Therapy

      Time-Resolved Ultra–High Resolution Optical Coherence Tomography for Real-Time Monitoring of Selective Retina Therapy

      Purpose : Selective retina therapy (SRT) is a novel treatment for retinal pathologies, solely targeting the RPE. During SRT, the detection of an immediate tissue reaction is challenging, as tissue effects remain limited to intracellular RPE photodisruption. Time-resolved ultra-high axial resolution optical coherence tomography (OCT) is thus evaluated for the monitoring of dynamic optical changes at and around the RPE during SRT. Methods : An experimental OCT system with an ultra-high axial resolution of 1.78 μm was combined with an SRT system and time-resolved OCT M-scans of the target area were recorded from four patients undergoing SRT. Optical coherence tomography scans ...

      Read Full Article
    6. Quantitative Analysis of Mouse Retinal Layers Using Automated Segmentation of Spectral Domain Optical Coherence Tomography Images

      Quantitative Analysis of Mouse Retinal Layers Using Automated Segmentation of Spectral Domain Optical Coherence Tomography Images

      Purpose : Quantification of retinal layers using automated segmentation of optical coherence tomography (OCT) images allows for longitudinal studies of retinal and neurological disorders in mice. The purpose of this study was to compare the performance of automated retinal layer segmentation algorithms with data from manual segmentation in mice using the Spectralis OCT. Methods : Spectral domain OCT images from 55 mice from three different mouse strains were analyzed in total. The OCT scans from 22 C57Bl/6, 22 BALBc, and 11 C3A.Cg- Pde6b + Prph2 Rd2 /J mice were automatically segmented using three commercially available automated retinal segmentation algorithms and compared ...

      Read Full Article
    7. Automatic estimation of noise parameters in Fourier-domain optical coherence tomography cross sectional images using statistical information

      Automatic estimation of noise parameters in Fourier-domain optical coherence tomography cross sectional images using statistical information

      Steiner, Patrick; Kowal, Jens H; Pova?ay, Boris; Meier, Christoph; Sznitman, We present an application and sample independent method for the automatic discrimination of noise and signal in optical coherence tomography Bscans. The proposed algorithm models the observed noise probabilistically and allows for a dynamic determination of image noise parameters and the choice of appropriate image rendering parameters. This overcomes the observer variability and the need for a priori information about the content of sample images, both of which are challenging to estimate systematically with current systems. As such, our approach has the advantage of automatically determining crucial parameters for ...

      Read Full Article
    8. Assessment of ultra-high resolution optical coherence tomography for monitoring tissue effects caused by laser photocoagulation of ex-vivo porcine retina

      Assessment of ultra-high resolution optical coherence tomography for monitoring tissue effects caused by laser photocoagulation of ex-vivo porcine retina

      Retinal laser photocoagulation is an established and successful treatment for a variety of retinal diseases. While being a valuable treatment modality, laser photocoagulation shows the drawback of employing high energy lasers which are capable of physically destroying the neural retina. For reliable therapy, it is therefore crucial to closely monitor the therapy effects caused in the retinal tissue. A depth resolved representation of optical tissue properties as provided by optical coherence tomography may provide valuable information about the treatment effects in the retinal layers if recorded simultaneously to laser coagulation. Therefore, in this work, the use of ultra-high resolution optical ...

      Read Full Article
    1-8 of 8
  1. Categories

    1. Applications:

      Art, Cardiology, Dentistry, Dermatology, Developmental Biology, Gastroenterology, Gynecology, Microscopy, NDE/NDT, Neurology, Oncology, Ophthalmology, Other Non-Medical, Otolaryngology, Pulmonology, Urology
    2. Business News:

      Acquisition, Clinical Trials, Funding, Other Business News, Partnership, Patents
    3. Technology:

      Broadband Sources, Probes, Tunable Sources
    4. Miscellaneous:

      Jobs & Studentships, Student Theses, Textbooks
  2. Topics in the News

    1. (8 articles) University of Bern
    2. (5 articles) Sebastian Wolf
    3. (4 articles) Patrick Steiner
    4. (3 articles) Christoph Meier
    5. (3 articles) Martin S. Zinkernagel
    6. (2 articles) Bern University Hospital
    7. (2 articles) Jens H. Kowal
    8. (2 articles) Boris Považay
    9. (1 articles) Bern University of Applied Sciences
    10. (1 articles) University of Lübeck
    11. (1 articles) Xincheng Yao
  3. Popular Articles

  4. Picture Gallery

    Assessment of ultra-high resolution optical coherence tomography for monitoring tissue effects caused by laser photocoagulation of ex-vivo porcine retina Automatic estimation of noise parameters in Fourier-domain optical coherence tomography cross sectional images using statistical information Quantitative Analysis of Mouse Retinal Layers Using Automated Segmentation of Spectral Domain Optical Coherence Tomography Images Time-Resolved Ultra–High Resolution Optical Coherence Tomography for Real-Time Monitoring of Selective Retina Therapy Automatic assessment of time-resolved OCT images for selective retina therapy Efficient OCT volume reconstruction from slitlamp microscopes Comparison of Choroidal Thickness Measurements Using Spectral Domain Optical Coherence Tomography in Six Different Settings and With Customized Automated Segmentation Software Expert-level Automated Biomarker Identification in Optical Coherence Tomography Scans Postdoctoral Openings in Biomedical Optics and Retinal Imaging Laboratory at University of Illinois at Chicago Devices and arrangements for performing coherence range imaging using a common path interferometer Scan error correction in low coherence scanning interferometry Optical imaging techniques could offer non-invasive method to measure swelling within the brain, new study finds