1. Articles from Michael CROSE

    1-7 of 7
    1. First Clinical Application of Low-Cost OCT

      First Clinical Application of Low-Cost OCT

      Purpose : We present the design of a new low-cost optical coherence tomography (OCT) system and compare its retinal imaging capabilities to a standard commercial system through a clinical study. Methods : A spectral-domain OCT system was designed using various cost-reduction techniques to be low-cost, highly portable, and completely stand-alone. Clinical imaging was performed on 120 eyes of 60 patients (60 eyes of normal volunteers and 60 eyes with retinal disease) using both the low-cost OCT and a Heidelberg Engineering Spectralis OCT. Contrast-to-noise ratio (CNR) was measured from resulting images to determine system performance. Results : The low-cost OCT system was successfully applied ...

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    2. Design and implementation of a low-cost, portable OCT system

      Design and implementation of a low-cost, portable OCT system

      Optical coherence tomography (OCT) is a widely used biomedical imaging tool, primarily in ophthalmology to diagnose and stage retinal diseases. In order to increase access for a wider range of applications and in low resource settings, we developed a portable, low-cost OCT system that has comparable imaging performance to commercially available systems. Here, we present the system design and characterization and compare the system performance to other commercially available OCT systems. In addition, future cost reductions and potential additional applications of the low-cost OCT system are discussed.

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      Mentions: Duke University
    3. Real-time speckle reduction in optical coherence tomography using the dual window method

      Real-time speckle reduction in optical coherence tomography using the dual window method

      Speckle is an intrinsic noise of interferometric signals which reduces contrast and degrades the quality of optical coherence tomography (OCT) images. Here, we present a frequency compounding speckle reduction technique using the dual window (DW) method. Using the DW method, speckle noise is reduced without the need to acquire multiple frames. A ~25% improvement in the contrast-to-noise ratio (CNR) was achieved using the DW speckle reduction method with only minimal loss (~17%) in axial resolution. We also demonstrate that real-time speckle reduction can be achieved at a B-scan rate of ~21 frames per second using a graphic processing unit (GPU ...

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      Mentions: Duke University
    4. Dual-axis optical coherence tomography for deep tissue imaging

      Dual-axis optical coherence tomography for deep tissue imaging

      We have developed dual-axis optical coherence tomography (DA-OCT) which enables deep tissue imaging by using a novel off-axis illumination/detection configuration. DA-OCT offers a 100-fold speed increase compared with its predecessor, multispectral multiple-scattering low coherence interferometry (ms2/LCI), by using a new beam scanning mechanism based on a microelectro-mechanical system (MEMS) mirror. The data acquisition scheme was altered to take advantage of this scanning speed, producing tomographic images at a rate of 4 frames (B-scans) per second. DA-OCT differs from ms2/LCI in that the dual axes intersect at a shallower depth ( ∼ 1    mm ∼1  mm ). This difference, coupled with ...

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      Mentions: Duke University
    5. Optical coherence tomography imaging systems and methods

      Optical coherence tomography imaging systems and methods

      Optical coherence tomography imaging systems and methods are disclosed. According to an aspect, an optical coherence tomography imaging system includes a scanner configured to obtain images and to convert the images to electrical signals. The system also includes a computing device comprising an OCT module configured to receive the electrical signals, to apply an OCT imaging technique, and to generate imaging data.

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    6. Analyzing spatial correlations in tissue using angle-resolved low coherence interferometry measurements guided by co-located optical coherence tomography

      Analyzing spatial correlations in tissue using angle-resolved low coherence interferometry measurements guided by co-located optical coherence tomography

      Angle-resolved low coherence interferometry (a/LCI) is an optical technique used to measure nuclear morphology in situ . However, a/LCI is not an imaging modality and can produce ambiguous results when the measurements are not properly oriented to the tissue architecture. Here we present a 2D a/LCI system which incorporates optical coherence tomography imaging to guide the measurements. System design and characterization are presented, along with example cases which demonstrate the utility of the combined measurements. In addition, future development and applications of this dual modality approach are discussed.

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    7. Optical Coherence Tomography Imaging Systems And Methods

      Optical Coherence Tomography Imaging Systems And Methods

      Optical coherence tomography imaging systems and methods are disclosed. According to an aspect, an optical coherence tomography imaging system includes a scanner configured to obtain images and to convert the images to electrical signals. The system also includes a computing device comprising an OCT module configured to receive the electrical signals, to apply an OCT imaging technique, and to generate imaging data.

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      Mentions: Lumedica
    1-7 of 7
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  2. Topics in the News

    1. (5 articles) Duke University
    2. (1 articles) University of North Carolina
    3. (1 articles) University of Wisconsin
    4. (1 articles) Lumedica
    5. (1 articles) National Institutes of Health
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    Optical Coherence Tomography Imaging Systems And Methods Analyzing spatial correlations in tissue using angle-resolved low coherence interferometry measurements guided by co-located optical coherence tomography Optical coherence tomography imaging systems and methods Dual-axis optical coherence tomography for deep tissue imaging Real-time speckle reduction in optical coherence tomography using the dual window method Design and implementation of a low-cost, portable OCT system First Clinical Application of Low-Cost OCT The Structural and Comparative Analysis of Intravitreal Dexamethasone Implant (Ozurdex) and Anti-VEGF Injection in Branched Retinal Vein Occlusion Patients by Optical Coherence Tomography Angiography Images Quantitation Vascular Responses to First-Generation Sirolimus-Eluting Stents and Bare-Metal Stents Beyond 10 Years Ocular Parameters Evaluation in Relation to the Refractive Error using Optical Coherence Topography Micro Optical Coherence Tomography for Coronary Imaging Macular Vessel Density in Diabetic Retinopathy Patients: How Can We Accurately Measure and What Can It Tell Us?