1. Articles from José Ignacio Fernández-Vigo

    1-24 of 28 1 2 »
    1. Prediction of the response to photodynamic therapy in patients with chronic central serous chorioretinopathy based on optical coherence tomography using deep learning.: Response to PDT in chronic CSCR by OCT using deep learning

      Prediction of the response to photodynamic therapy in patients with chronic central serous chorioretinopathy based on optical coherence tomography using deep learning.: Response to PDT in chronic CSCR by OCT using deep learning

      Purpose: To assess the prediction of the response to photodynamic therapy (PDT) in chronic central serous chorioretinopathy (CSCR) based on spectral-domain optical coherence tomography (SD-OCT) images using deep learning (DL). Methods: Retrospective study including 216 eyes of 175 patients with CSCR and persistent subretinal fluid (SRF) who underwent half-fluence PDT. SD-OCT macular examination was performed before (baseline) and 3 months after treatment. Patients were classified into groups by experts based on the response to PDT: Group 1, complete SRF resorption (n=100); Group 2, partial SRF resorption (n=66); and Group 3, absence of any SRF resorption (n=50). This ...

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    2. Peripapillary and macular vascular parameters by optical coherence tomography angiography in primary congenital glaucoma

      Peripapillary and macular vascular parameters by optical coherence tomography angiography in primary congenital glaucoma

      Objective: To evaluate the differences in peripapillary and macular vascular parameters by optical coherence tomography angiography (OCTA) between patients with primary congenital glaucoma (PCG) and healthy controls; and to determine their diagnostic accuracy. Material and methods: Observational, cross-sectional study including 39 eyes with PCG and 78 healthy eyes. Only one eye per patient was included. All included patients underwent a comprehensive ophthalmic examination and peripapillary and macular analysis were performed by Angioplex TM OCTA (Cirrus HD-OCT 5000) with a 4.5 × 4.5 mm optic nerve head scan and 6 × 6 mm macular scan. Global data and quadrant data from ...

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    3. Retinal and peripapillary vessel density increase in recovered COVID-19 children by optical coherence tomography angiography

      Retinal and peripapillary vessel density increase in recovered COVID-19 children by optical coherence tomography angiography

      Purpose To evaluate retinal vascular changes in children who have recovered from coronavirus disease (COVID-19) using optical coherence tomography angiography (OCTA) and to compare the results with age-matched healthy children. Methods In this cross-sectional case–control study, children 6-18 years of age with laboratory-confirmed SARS-CoV-2 infection were compared with historic healthy controls. All participants underwent ophthalmological examination, including fundus photography and OCTA of the macular region and optic disk. COVID-19 children were examined 4-8 weeks after COVID-19 diagnoses. Demographic data, medical history, and COVID-19 symptoms were noted. OCTA parameters in the superficial capillary plexus (SCP) were analyzed according to ETDRS ...

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    4. Dimensions of the limbus-ciliary sulcus region by optical coherence tomography and correlation study in a large population

      Dimensions of the limbus-ciliary sulcus region by optical coherence tomography and correlation study in a large population

      Purpose: To assess the dimensions of the limbus-sulcus region measured by swept-source optical coherence tomography (SS-OCT) and correlation study in a large healthy population. Setting: Centro Internacional de Oftalmología Avanzada. Design: Cross-sectional study. Methods: The dimensions of the limbus-sulcus region were measured in 625 eyes of 625 subjects in the temporal and nasal quadrants using a SS-OCT. The limbus-sulcus distance (LSD), the posterior iris line-ocular surface to limbus distance (PIOLD) and the angle to sulcus distance (ASD) were measured. These distances were then assessed for correlations with the factors age, sex, refractive error, anterior chamber angle (ACA), ciliary muscle ...

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    5. Assessment of the anterior scleral thickness in central serous chorioretinopathy patients by optical coherence tomography

      Assessment of the anterior scleral thickness in central serous chorioretinopathy patients by optical coherence tomography

      Purpose: To assess the anterior scleral thickness (AST) and describe the presence of a visible supraciliary space (SCS) in central serous chorioretinopathy (CSC) patients by swept-source optical coherence tomography (SS-OCT). Study design: Cross-sectional comparative study. Material and methods: Three groups were studied: 1) 64 eyes of 54 patients with CSC with persistent subretinal fluid (SRF); 2) 42 fellow eyes of CSC patients without SRF; 3) 65 eyes of 65 controls matched by age, sex and axial length (AL). The AST was measured in the temporal and nasal quadrants at 0, 1, and 2 mm from the scleral spur by SS-OCT ...

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    6. Optical coherence tomography angiography of choroidal nodules in neurofibromatosis type-1: A case series

      Optical coherence tomography angiography of choroidal nodules in neurofibromatosis type-1: A case series

      Purpose: To describe optical coherence tomography angiography (OCTA) findings in the retina and choroid of patients with neurofibromatosis type 1 (NF1). Methods: We describe a series of four patients diagnosed with NF1 and choroidal nodules who underwent a comprehensive ophthalmic evaluation including a retinal multimodal imaging study based on retinography, near-infrared reflectance imaging (NIR), enhanced depth imaging (EDI) optical coherence tomography (OCT) and OCTA. Results: Patients were three women and one man aged 36-47 years. In all patients, the choroidal nodules were not visible in retinographies but easily detectable with NIR, appearing as multiple bright patches. On OCTA, we observed ...

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    7. Impact of age, sex and refractive error on conjunctival and Tenon’s capsule thickness dimensions by swept-source optical coherence tomography in a large population

      Impact of age, sex and refractive error on conjunctival and Tenon’s capsule thickness dimensions by swept-source optical coherence tomography in a large population

      Purpose To evaluate conjunctival and Tenon’s capsule thickness (CTT) in a large healthy population using swept-source optical coherence tomography (SS-OCT), investigating the impact of age, sex and refractive error. Methods 630 healthy participants underwent a complete ophthalmological examination. CTT was manually measured in the temporal and nasal quadrants at 0, 1, 2 and 3 mm from the scleral spur using SS-OCT (CTT0, CTT1, CTT2 and CTT3, respectively). These dimensions were then assessed for associations in a multivariate regression model with age, sex, refractive error and anterior scleral thickness (AST). The reproducibility of the CTT measurements was determined in 30 ...

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    8. Anterior scleral thickness dimensions by swept-source optical coherence tomography

      Anterior scleral thickness dimensions by swept-source optical coherence tomography

      Clinical relevance : Given the association of scleral characteristics with many ophthalmological diseases, there is an important need to measure the anterior scleral thickness (AST). Background : This study examined the AST by swept-source optical coherence tomography (SS-OCT) in a large healthy population, assessing also the reproducibility of AST measurements and the correlation with different parameters. Methods : Cross-sectional study in 605 eyes of 605 subjects. AST measurements were made in the temporal and nasal quadrants at 1 (AST1) and 3 mm (AST3) from the scleral spur using SS-OCT. These dimensions were then assessed for associations in a multivariate model with the factors ...

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    9. Updates on the utility of anterior segment optical coherence tomography in the assessment of filtration blebs after glaucoma surgery

      Updates on the utility of anterior segment optical coherence tomography in the assessment of filtration blebs after glaucoma surgery

      The formation of filtration blebs is the main drainage mechanism for reducing intraocular pressure after traditional incisional glaucoma surgery such as trabeculectomy and non-penetrating deep sclerotomy. Early and short-lasting blebs may also occur after canaloplasty. Bleb formation also plays an important role after the implantation of glaucoma drainage devices, including Minimally Invasive Glaucoma Surgery devices. Anterior segment optical coherence tomography (AS-OCT) is a rapid and non-invasive high-resolution imaging technique that has evolved in recent years to become a routine examination. Anterior segment optical coherence tomography (AS-OCT) provides key information in the assessment and follow-up of glaucoma surgery, especially in the ...

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    10. Repeatability of macular and optic nerve head measurements by optical coherence tomography angiography in healthy children

      Repeatability of macular and optic nerve head measurements by optical coherence tomography angiography in healthy children

      Aims : To evaluate the repeatability of the peripapillary and macular vascular parameters using optical coherence tomography angiography (OCT-A) in healthy children. Material and methods : Cross-sectional study including 34 eyes of 34 healthy children. After a complete medical examination, two consecutive OCT-A exams were done using AngioPlex Cirrus 5000 (Carl Zeiss Meditec, Dublin, CA, USA) in the same session. The scan area used was 6x6 mm for the analysis of the superficial vascular plexus (SVP) in the macula, and 4.5x4.5 mm for the peripapillary plexus. To study the repeatability of the measurements, the intraclass correlation coefficient (ICC) and the ...

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    11. Ciliary muscle dimensions measured by swept-source optical coherence tomography in eyes with primary open-angle glaucoma and healthy eyes

      Ciliary muscle dimensions measured by swept-source optical coherence tomography in eyes with primary open-angle glaucoma and healthy eyes

      Purpose To compare in vivo swept-source optical coherence tomography (SS-OCT) measurements of the ciliary muscle (CM) in patients with primary open-angle glaucoma (POAG) and healthy subjects, and examine correlations between CM dimensions and several covariates. Methods This was a cross-sectional study of the right eyes of 181 subjects: 89 POAG patients and 92 healthy subjects. Using the Triton SS-OCT device (Topcon, Tokyo, Japan), CM length (CML), area (CMA) and thickness measured 1000 µm (CMT1), 2000 µm (CMT2) and 3000 µm (CMT3) from the scleral spur were determined in the temporal and nasal quadrants. POAG patients were subjected to visual field ...

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    12. Normative database of peripapillary vessel density measured by optical coherence tomography angiography and correlation study

      Normative database of peripapillary vessel density measured by optical coherence tomography angiography and correlation study

      Purpose: To provide a normative data set of swept-source optical coherence tomography angiography (SS-OCTA) peripapillary vessel density (VD) measurements and assess correlations with age, gender, disc area and axial length (AL). Material and Methods: This was an observational cross-sectional study conducted on 346 right eyes of healthy subjects. Peripapillary SS-OCTA VD measurements were obtained in the retinal superficial capillary plexus (SCP), deep capillary plexus (DCP), and choriocapillaris (CC) in all four quadrants using the Triton device (Topcon, Nagoya, Japan). AL measurements were made by optical biometry. Results: Mean participant age was 37.7 ±19.8 years (range 5 – 83), AL ...

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    13. Correlation Between Optical Coherence Tomography and Magnetic Resonance Imaging of Rectus Muscle Thickness Measurements in Graves' Ophthalmopathy

      Correlation Between Optical Coherence Tomography and Magnetic Resonance Imaging of Rectus Muscle Thickness Measurements in Graves' Ophthalmopathy

      PURPOSE: To assess the correlation between optical coherence tomography (OCT) and magnetic resonance imaging (MRI) measurements of extraocular rectus muscle thickness in patients with Graves' ophthalmopathy. METHODS: This was a cross-sectional observational study conducted in 62 eyes of 31 patients with Graves' ophthalmopathy. The disease phase was inactive in 20 patients and active in the remaining 11. The OCT measurements obtained were: medial rectus thickness at 7.2 and 9.2 mm from the limbus and lateral rectus thickness at 8.5 mm from the limbus. MRI measurements were maximum transversal diameter (T-MRI), craniocaudal diameter (CC-MRI), and muscle area (A-MRI ...

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    14. Reproducibility of macular and optic nerve head vessel density measurements by swept-source optical coherence tomography angiography

      Reproducibility of macular and optic nerve head vessel density measurements by swept-source optical coherence tomography angiography

      Purpose: To assess the reproducibility of swept-source optical coherence tomography angiography (SS-OCTA) for macular and optic nerve head (ONH) vessel density (VD). Methods: Cross-sectional study using the Triton OCTA (Topcon, Tokyo, Japan), for VD (%) measurements in 40 eyes of 40 healthy subjects on two 6 × 6 mm scans of the macula and ONH across five subfields (central, superior, inferior, temporal, and nasal) at different segmentation levels: superficial capillary plexus (SCP), deep capillary plexus (DCP), outer retina, and choriocapillaris. Reproducibility values were summarized as intraclass correlation coefficients (ICCs) and coefficients of variations (CV). Results: ICCs for the macular VD measurements in ...

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    15. Utility of optical coherence tomography angiography in detecting vascular retinal damage caused by arterial hypertension

      Utility of optical coherence tomography angiography in detecting vascular retinal damage caused by arterial hypertension

      Objective: To evaluate the potential utility of perfusion density measurements to discriminate patients with arterial hypertension by cardiovascular risk category. Methods: In this cross-sectional study, one eye per subject was evaluated (N = 73). The study cohort was divided into three groups according to the clinical criteria established by the European Guidelines for Arterial Hypertension: 26 controls, 24 patients with low cardiovascular risk, and 23 patients with very high cardiovascular risk. All patients were examined using RS-3000 Advance optical coherence tomography angiography to analyze macular and peripapillary perfusion density. Results: There were no differences among the three risk groups by sex ...

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    16. Optical Coherence Tomography Thickness Measurements of the Extraocular Rectus Muscle Tendons in Graves' Ophthalmopathy

      Optical Coherence Tomography Thickness Measurements of the Extraocular Rectus Muscle Tendons in Graves' Ophthalmopathy

      PURPOSE: To examine extraocular rectus muscle tendons in patients with Graves' ophthalmopathy using optical coherence tomography (OCT). METHODS: This was a cross-sectional observational study conducted with 55 healthy controls, 45 patients with clinically inactive Graves' ophthalmopathy, and 12 patients with clinically active Graves' ophthalmopathy. Scanning was performed at the 3- and 9-o'clock positions. The medial rectus tendon thickness was measured at 7.2 and 9.2 mm from the limbus and the lateral rectus tendon thickness was measured at 8.5 and 10.5 mm from the limbus. RESULTS: The 9.2-mm medial rectus, 8.5-mm lateral rectus, and ...

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    17. Impacts of Implantable Collamer Lens V4c Placement on Angle Measurements Made by Optical Coherence Tomography: Two-Year Follow-up

      Impacts of Implantable Collamer Lens V4c Placement on Angle Measurements Made by Optical Coherence Tomography: Two-Year Follow-up

      We appreciate the comments made by Galvis and associates regarding our recently published article in which we report anterior chamber angle narrowing in response to implantable collamer lens (ICL) placement. The mean angle narrowing observed was approximately 39%–41% for the whole population. In response to the first question, in patients with a vault larger than 750 μm, angle reduction was 55.2%–56.7%, compared with 34.7%–38.3% produced in patients with a vault ≤ 750 μm. It is well known that vault is an important determinant of anterior chamber angle, and, as we describe in our article ...

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    18. Impacts of implantable collamer lens V4c placement on angle measurements made by optical coherence tomography: two-year follow up

      Impacts of implantable collamer lens V4c placement on angle measurements made by optical coherence tomography: two-year follow up

      Purpose To determine iridocorneal angle changes produced after two years of implantable collamer lens ® (ICL) V4c (STAAR Surgical AG) placement by Fourier-domain optical coherence tomography (FD-OCT). Design Prospective interventional case series. Methods In 54 eyes of 27 myopic subjects FD-OCT (RTVue ® , Optovue Inc.) iridocorneal angle measurements were made before, and 1 month, 3 months, 1 year and 2 years after ICL implant. Trabecular-iris angle (TIA), angle opening distance 500 μm from the scleral spur (AOD 500 ) and iridotrabecular contact length (TICL) were compared among these time points and the quadrants nasal, temporal and inferior. Results Preoperative TIAs were 49.5 ...

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    19. Agreement Between Three Optical Coherence Tomography Devices to Assess the Insertion Distance and Thickness of Horizontal Rectus Muscles

      Agreement Between Three Optical Coherence Tomography Devices to Assess the Insertion Distance and Thickness of Horizontal Rectus Muscles

      PURPOSE: To assess the agreement between two different spectral domain (SD-OCT) and one swept source (SS-OCT) optical coherence tomography device to measure the insertion distance and the thickness of the horizontal rectus muscles. . METHODS: Seventy eyes from 35 healthy patients were studied. Three OCT instruments—Spectralis (Heidelberg Engineering Inc., Heidelberg, Germany), Cirrus 5000 (Carl Zeiss Meditec, Dublin, CA), and Triton (Topcon, Inc., Tokyo, Japan)—were used to measure the limbus insertion distance and the thickness of the lateral rectus and medial rectus muscles. The intraclass correlation coefficient (ICC) was calculated to determine the reproducibility and the agreement between the three ...

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    20. Quantification of trabecular-iris contact and its prevalence by optical coherence tomography in a healthy Caucasian population

      Quantification of trabecular-iris contact and its prevalence by optical coherence tomography in a healthy Caucasian population

      To determine the prevalence of trabecular-iris contact (TIC) and quantify this contact in healthy Caucasian individuals using Fourier-domain optical coherence tomography (FD-OCT). For this cross-sectional study, 2,012 eyes of 1,006 healthy subjects were recruited among individuals undergoing a routine ophthalmologic checkup. In each participant, age, sex, intraocular pressure, and spherical refractive error were first recorded along with anterior chamber depth and volume, central corneal thickness measured with the Pentacam, and axial length with the IOLMaster. Anterior chamber angle variables and the presence of TIC in the horizontal quadrants were determined by anterior segment FD-OCT (RTVue 100®). When TIC ...

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    21. Lower Tear Meniscus Measurements Using a New Anterior Segment Swept-Source Optical Coherence Tomography and Agreement With Fourier-Domain Optical Coherence Tomography

      Lower Tear Meniscus Measurements Using a New Anterior Segment Swept-Source Optical Coherence Tomography and Agreement With Fourier-Domain Optical Coherence Tomography

      Purpose: To assess intraobserver repeatability and interobserver and intersession reproducibility of lower tear meniscus height (LTMH) measurements obtained using a new anterior segment swept-source optical coherence tomography (SS-OCT) device. Agreement with Fourier-domain (FD) OCT (Spectralis) was also examined. Methods: In an observational cross-sectional study, one eye of 29 healthy subjects was randomly imaged with both devices at our center. Two examiners then randomly measured the LTMH using the software's calipers. To assess intraobserver repeatability and interobserver and intersession reproducibility, within-subject standard deviation (Sw), test-retest repeatability, coefficients of variation (CoV), and intraclass correlation coefficients (ICCs) were calculated. Agreement between both ...

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    22. Spectral domain optical coherence tomography to assess the insertion of extraocular rectus muscles

      Spectral domain optical coherence tomography to assess the insertion of extraocular rectus muscles

      Purpose To determine the distance of the horizontal rectus muscle insertion to the limbus using spectral domain optical coherence tomography (SD-OCT) and to evaluate whether results are correlated with sex, age, or axial length. Methods The right eyes of healthy, white subjects were imaged with SD-OCT. Subjects’ sex and age were recorded, and axial length was measured using an optical biometer. The distance from the horizontal rectus insertion to the limbus was measured. The intraclass correlation coefficient (ICC) was used to assess the reproducibility of the measurements with a subset of images. A multivariate model was adjusted to analyze whether ...

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    1-24 of 28 1 2 »
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    Assessment of lower tear meniscus measurements obtained with Keratograph and agreement with Fourier-domain optical-coherence tomography Morphometry of the trabecular meshwork in vivo in a healthy population using Fourier domain optical coherence tomography Effects of Implantable Collamer Lens V4c placement on iridocorneal angle measurements by Fourier domain optical coherence tomography Fourier domain optical coherence tomography to assess the iridocorneal angle and correlation study in a large Caucasian population Spectral domain optical coherence tomography to assess the insertion of extraocular rectus muscles Lower Tear Meniscus Measurements Using a New Anterior Segment Swept-Source Optical Coherence Tomography and Agreement With Fourier-Domain Optical Coherence Tomography Quantification of trabecular-iris contact and its prevalence by optical coherence tomography in a healthy Caucasian population Agreement Between Three Optical Coherence Tomography Devices to Assess the Insertion Distance and Thickness of Horizontal Rectus Muscles Impacts of implantable collamer lens V4c placement on angle measurements made by optical coherence tomography: two-year follow up Optical Coherence Tomography Thickness Measurements of the Extraocular Rectus Muscle Tendons in Graves' Ophthalmopathy Massachusetts General Hosptial Receives NIH Grant for Screening for Barrett's Esophagus Progressors with Multimodality Tethered Capsule Image-Guided Biopsy Duke University Receives NIH Grant for Robotic Point-of-Care OCT