1. Articles from S. Meissner

    1-6 of 6
    1. Four-dimensional optical coherence tomography imaging of subpleural alveoli in mice

      Four-dimensional optical coherence tomography imaging of subpleural alveoli in mice

      The development of protective ventilation strategies for patients suffering from life-threatening lung diseases and the promotion of numerical simulation of lung tissue mechanics requires detailed knowledge about the three-dimensional alveolar micro-structure, their dynamics and elastic properties. Subpleural lung tissue can be observed in animal models utilizing optical coherence tomography (OCT) with a high spatial resolution. We present four-dimensional high-speed OCT imaging of single alveoli as a suitable technique for the visualization of the temporal changes of the three-dimensional structure during the ventilation with a temporal resolution of 17 stacks per ventilation cycle. The acquired four-dimensional information allows a quantitative evaluation ...

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    2. 4D in vivo imaging of subpleural lung parenchyma by swept source optical coherence tomography

      4D in vivo imaging of subpleural lung parenchyma by swept source optical coherence tomography
      In this feasibility study we present a method for 4D imaging of healthy and injured subpleural lung tissue in a mouse model. We used triggered swept source optical coherence tomography with an A-scan frequency of 20 kHz to image murine subpleural alveoli during the ventilation cycle. The data acquisition was gated to the pulmonary airway pressure to take one B-scan in each ventilation cycle for different pressure levels. The acquired B-scans were combined offline to one C-scan for each pressure level. Due to the high acquisition rate of the used optical coherence tomography system, we are also able to perform ...
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    3. Analysis of Murine Vascular Function In Vivo by Optical Coherence Tomography in Response to High-fat Diet

      In this study, we demonstrate the application of optical coherence tomography (OCT) as a contactless imaging technique to analyze vasodynamics in small blood vessels in vivo. The transluminal OCT imaging of vessels avoids micro traumata in the endothelium and circumvents surgical intervention. It can be performed in the intact perfused vessel and provides a new method to measure vascular function and dynamics in vivo. The resolution of 10 μm and the velocity of image acquisition are adequate to detect differences in the inner diameter, the maximal velocity, or the time to half-maximal diameter change of small vessels. We applied this ...
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    4. Three-dimensional Imaging of subpleural Alveoli by Fourier Domain Optical Coherence Tomography

      Understanding alveolar mechanics is essential to improve artificial ventilation strategies and hence minimize ventilator associated lung injury. The investigation of alveolar geometry changes during ventilation was performed by intravital microscopy (IVM) and 3D Fourier domain optical coherence tomography (3D-OCT) in an in-vivo mouse model and in isolated, perfused and ventilated rabbit lungs. Air pocket size of individual alveoli was quantified in the en-face view. For both imaging techniques, IVM and 3D-OCT, subpleural air-pocket size was positively correlated with the applied airway pressure (endinspiratory pressure or continuous positive airway pressure, respectively). No alveolar recruitment/derecruitment was observed. We conclude that in ...
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    1-6 of 6
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  2. Topics in the News

    1. (6 articles) Edmund Koch
    2. (6 articles) Sven Meissner
    3. (5 articles) Dresden University of Technology
    4. (2 articles) Julia Walther
    5. (1 articles) Alexander Krüger
    6. (1 articles) Henning Morawietz
    7. (1 articles) Lars Kirsten
    8. (1 articles) Maria Gaertner
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