1. Articles from W. M. Kuebler

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    1. 4D in vivo imaging of subpleural lung parenchyma by swept source optical coherence tomography

      4D in vivo imaging of subpleural lung parenchyma by swept source optical coherence tomography
      In this feasibility study we present a method for 4D imaging of healthy and injured subpleural lung tissue in a mouse model. We used triggered swept source optical coherence tomography with an A-scan frequency of 20 kHz to image murine subpleural alveoli during the ventilation cycle. The data acquisition was gated to the pulmonary airway pressure to take one B-scan in each ventilation cycle for different pressure levels. The acquired B-scans were combined offline to one C-scan for each pressure level. Due to the high acquisition rate of the used optical coherence tomography system, we are also able to perform ...
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    2. Three-dimensional Imaging of subpleural Alveoli by Fourier Domain Optical Coherence Tomography

      Understanding alveolar mechanics is essential to improve artificial ventilation strategies and hence minimize ventilator associated lung injury. The investigation of alveolar geometry changes during ventilation was performed by intravital microscopy (IVM) and 3D Fourier domain optical coherence tomography (3D-OCT) in an in-vivo mouse model and in isolated, perfused and ventilated rabbit lungs. Air pocket size of individual alveoli was quantified in the en-face view. For both imaging techniques, IVM and 3D-OCT, subpleural air-pocket size was positively correlated with the applied airway pressure (endinspiratory pressure or continuous positive airway pressure, respectively). No alveolar recruitment/derecruitment was observed. We conclude that in ...
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    1-2 of 2
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  2. Topics in the News

    1. (2 articles) Sven Meissner
    2. (2 articles) Edmund Koch
    3. (1 articles) Dresden University of Technology
    4. (1 articles) Julia Walther
    5. (1 articles) Sun Yat-Sen University
    6. (1 articles) National Institutes of Health
    7. (1 articles) University of Illinois at Urbana-Champaign
    8. (1 articles) Tianjin University
    9. (1 articles) Zhejiang University
    10. (1 articles) New York Eye and Ear Infirmary
    11. (1 articles) Eric J. Chaney
    12. (1 articles) Jun Zhang
    13. (1 articles) Robert Ritch
    14. (1 articles) Stephen A. Boppart
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